EKS-ORN-00432

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00432

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	310.4	1.3E-92	393	642	250

Status

Unreviewed

Ensembl Protein

ENSONIP00000015342

UniProt Accession

I3K2J6;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK6 (1 of 2)

Gene Synonyms/Alias

PAK6 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000012179	ENSONIP00000015343	ENSONIT00000015356
ENSONIG00000012179	ENSONIP00000015341	ENSONIT00000015354
ENSONIG00000012179	ENSONIP00000015342	ENSONIT00000015355

Organism

Oreochromis niloticus

Functional Description

Protein Length

665

Protein Sequence
(FASTA)

MFRKKKKKRP EISAPKNFEH RVHTSFDAKR GCFVGLPTQW QSLIENLRRP KPMVDPSRIT 60

EVELRPKKTI VRGSMIGHGD YIAAMINDMS RLSVTSSNSL RKSSPSARKR AQSLGRLGEE 120

QWRNRARNIH SETNTPYLGM KKSITLQPNG ILPKATSTYE VGVSSLEGPS HPAQSQNIQM 180

PSHGAYMSSD MGSPQERVIW KRDFQLSRGM PPNQRPVACF YSPAMTVQPP QGDQGTVTTE 240

LRPNIPILKI MKCGFMVPGE SAVRYHSGFL PTGTSSPLVG GIRPQRTVRS SASYTLGLSP 300

NMGLRPTGPD PFLRHSGCPN PPYPRQDSPS QPRPSPTGSL ATSPPGTCSP AFRPPQHPSP 360

RPPPDPPKVT HEQFKAALQM VVDKGDPRSY LENFVKIGEG STGVVCIATE KHSGRQVAVK 420

MMDLRRQQRR ELLFNEVVIM RDYQHRNVVE MFKSALVEEE LWVIMEYLQG GALTNIVSET 480

RLSEEQIATV CEAVLQALAY LHSQGVIHRD IKSDSILLTL DGRVKLSDFG FCAQISKDIP 540

KRKSLVGTPY WMAPEVISKS PYGTEVDIWS MGVMVVEMVD GEPPYFSETP VAAMKRLRDE 600

PAPTVRNVSQ VSPVLKDFLD RMLTRDPLER ASATDLLEHP FLLQSGSPQC LVPLVEQYRK 660

RMSRC 665

Nucleotide Sequence
(FASTA)

ATGTTTCGCA AAAAGAAAAA GAAGAGGCCT GAGATATCAG CGCCCAAGAA TTTTGAGCAC 60

CGAGTTCACA CCTCTTTTGA TGCTAAGCGG GGCTGCTTTG TGGGCCTGCC GACACAGTGG 120

CAAAGCTTGA TAGAGAACCT GCGAAGGCCC AAACCCATGG TGGACCCTTC CAGGATCACA 180

GAGGTGGAGT TGAGACCAAA GAAGACCATT GTGCGTGGGA GCATGATCGG ACACGGAGAC 240

TACATCGCAG CCATGATCAA TGACATGAGC CGTCTGTCTG TGACCAGTTC CAACTCTTTG 300

CGGAAGAGCA GCCCTTCAGC CAGGAAGAGA GCCCAGTCTC TGGGAAGGTT GGGGGAGGAA 360

CAGTGGAGGA ATAGGGCCAG GAACATCCAC AGTGAGACCA ACACCCCCTA CTTGGGCATG 420

AAGAAGAGCA TCACTCTGCA ACCTAATGGG ATTTTGCCTA AGGCCACGTC CACCTATGAA 480

GTTGGGGTCA GCTCTCTCGA GGGCCCGTCA CATCCTGCTC AGTCCCAGAA CATCCAGATG 540

CCAAGTCACG GGGCTTATAT GAGTAGTGAT ATGGGCAGTC CTCAGGAGAG AGTGATATGG 600

AAGAGAGATT TCCAGCTGTC AAGGGGAATG CCGCCAAATC AAAGGCCTGT AGCTTGTTTC 660

TACAGCCCTG CTATGACGGT ACAGCCACCC CAGGGAGATC AAGGCACAGT CACCACAGAA 720

CTCCGACCCA ATATACCGAT ACTAAAAATA ATGAAATGTG GGTTTATGGT GCCAGGAGAA 780

TCAGCAGTGA GGTACCACTC TGGTTTCCTG CCCACCGGCA CCAGCAGTCC TCTGGTGGGA 840

GGCATCAGAC CCCAGCGGAC TGTTCGCTCC TCAGCCAGCT ACACCTTGGG TCTGTCTCCT 900

AATATGGGAC TGAGGCCCAC TGGACCAGAC CCCTTTCTCA GACACTCCGG ATGCCCCAAC 960

CCTCCCTATC CCAGACAAGA CAGCCCTTCC CAACCTCGAC CTTCACCTAC AGGCTCATTA 1020

GCCACCAGTC CTCCAGGCAC CTGCTCCCCT GCCTTCAGAC CCCCGCAACA CCCATCACCC 1080

AGACCCCCAC CCGACCCACC TAAAGTGACA CATGAACAGT TCAAGGCGGC CCTGCAGATG 1140

GTGGTGGACA AAGGAGATCC CCGCTCTTAT CTGGAGAACT TTGTGAAGAT CGGAGAGGGC 1200

TCCACAGGAG TGGTGTGTAT CGCAACAGAG AAGCACAGCG GCCGGCAAGT GGCAGTGAAG 1260

ATGATGGACC TGCGGCGGCA GCAGAGGCGA GAACTACTCT TTAATGAGGT GGTCATCATG 1320

AGGGACTATC AGCACAGAAA TGTGGTGGAG ATGTTTAAGT CTGCTCTGGT GGAGGAAGAG 1380

CTGTGGGTCA TCATGGAGTA CTTGCAGGGT GGAGCACTGA CTAACATTGT TTCTGAAACC 1440

AGGCTGAGTG AAGAGCAGAT TGCTACAGTG TGTGAAGCTG TGCTGCAAGC CCTGGCCTAT 1500

CTCCATTCAC AGGGAGTCAT TCACAGAGAC ATCAAAAGTG ACTCTATACT ACTTACGTTA 1560

GATGGAAGGG TCAAGCTTTC AGACTTTGGC TTCTGTGCTC AGATCAGTAA GGACATCCCT 1620

AAGAGGAAGT CTCTAGTGGG GACACCTTAT TGGATGGCGC CTGAGGTCAT ATCCAAGTCG 1680

CCATATGGCA CTGAAGTCGA TATATGGTCG ATGGGCGTCA TGGTGGTTGA GATGGTGGAT 1740

GGAGAGCCGC CGTACTTCAG TGAAACCCCT GTAGCAGCGA TGAAGAGGCT GAGGGATGAG 1800

CCAGCTCCTA CTGTTCGAAA CGTCAGTCAG GTCTCCCCAG TCCTTAAAGA CTTCCTGGAC 1860

CGTATGCTGA CTCGAGACCC CCTAGAGAGA GCCAGCGCCA CTGACTTGTT GGAGCACCCC 1920

TTCCTGCTGC AGAGCGGCTC ACCTCAGTGC CTGGTCCCAC TGGTGGAGCA ATACCGCAAG 1980

CGCATGTCCC GCTGCTGA 1998

Domain Profile

S: 3     lleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpniveyl  62

          + +ig+G++g v++a+ek++g++va+k+++l++q++ e+l++e+ ++++++h+n+ve++

Q: 393   NFVKIGEGSTGVVCIATEKHSGRQVAVKMMDLRRQQRRELLFNEVVIMRDYQHRNVVEMF  452

         5679********************************************************

S: 63    esflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHr  122

         +s l+eeelw++meyl+gG+l+++v+   +++l+Eeqia++++ vl+aL+ylHs++viHr

Q: 453   KSALVEEELWVIMEYLQGGALTNIVS---ETRLSEEQIATVCEAVLQALAYLHSQGVIHR  509

         **************************...9******************************

S: 123   dikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdekaD  182

         dik+++iLlt +g+VkLsdfg++aq++k+  krk++vgtpywmAPEvi+  ++ Y +++D

Q: 510   DIKSDSILLTLDGRVKLSDFGFCAQISKDIPKRKSLVGTPYWMAPEVIS--KSPYGTEVD  567

         *************************************************..9********

S: 183   iwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqknp  242

         iws+G++++e+++gepP+++++p+ a+ +  ++++p++++ +++s+ +k+f++++l+++p

Q: 568   IWSMGVMVVEMVDGEPPYFSETPVAAMKRLRDEPAPTVRNVSQVSPVLKDFLDRMLTRDP  627

         ************************************************************

S: 243   ekRpsasellkhkFl  257

          +R+sa++ll+h+Fl

Q: 628   LERASATDLLEHPFL  642

         **************7

Domain Sequence
(FASTA)

NFVKIGEGST GVVCIATEKH SGRQVAVKMM DLRRQQRREL LFNEVVIMRD YQHRNVVEMF 60

KSALVEEELW VIMEYLQGGA LTNIVSETRL SEEQIATVCE AVLQALAYLH SQGVIHRDIK 120

SDSILLTLDG RVKLSDFGFC AQISKDIPKR KSLVGTPYWM APEVISKSPY GTEVDIWSMG 180

VMVVEMVDGE PPYFSETPVA AMKRLRDEPA PTVRNVSQVS PVLKDFLDRM LTRDPLERAS 240

ATDLLEHPFL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013