EKS-ORN-00363

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00363

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	414.5	2.9E-124	195	482	288

Status

Unreviewed

Ensembl Protein

ENSONIP00000015461

UniProt Accession

I3K2W5;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2A (1 of 2)

Gene Synonyms/Alias

ACVR2A (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000012275	ENSONIP00000015460	ENSONIT00000015473
ENSONIG00000012275	ENSONIP00000015461	ENSONIT00000015474

Organism

Oreochromis niloticus

Functional Description

Protein Length

516

Protein Sequence
(FASTA)

SGSNAKLTRN FFVLFCSSSA ILGRSETQEC AYYNSSWEKE RTNRSGIEPC YGEKDKRRHC 60

FATWKNVSGT VEIVKQGCWL DDVNCYDSNE CVERKESPDV FFCCCEGNMC NERFLYAPEA 120

SFMQVSKATS NPFSQKPQLF STLLYSLVPI IGLAAVVLFS FWMWRHHKLA YPAALVPTHD 180

PGPSPPSPIL GHKPLQLIEV KARGRFGCVW KAQLLNEYMA VKIFPIQDKL SWQNEYEIYS 240

VSGMKHENIL HFIGVEKRNN NLDLELWLIT AYHDKGSLTD YLKANVVSWN ELCHIAQSAA 300

RGLAYLHEDI PGHKDGHKPS IAHRDIKSKN VLLKNNLTAC IADFGLALKF EAGKSAGDTH 360

GQVGTRRYMA PEVLEGAINF QRDSFLRIDM YAFGLVLWEL ASRCTAADGP VDEYMLPFEE 420

EVGQHPSLED MQEVVVHKKL RPCLRDCWQK HTGLAMLCET IEDCWDHEAE ARLSAGCVEE 480

RIGQMQRQAP VIGPEEIVTV VTMVTNVDLP PKESSL 516

Nucleotide Sequence
(FASTA)

AGCGGCAGCA ATGCTAAACT GACAAGGAAC TTTTTTGTTT TGTTTTGTTC CTCCAGTGCC 60

ATCCTGGGAC GCTCAGAGAC GCAGGAGTGC GCCTACTACA ACTCCAGCTG GGAGAAGGAG 120

CGGACTAACC GCAGCGGCAT CGAACCCTGC TACGGCGAGA AAGACAAGAG GCGGCACTGT 180

TTCGCCACAT GGAAAAATGT CTCCGGGACC GTGGAGATTG TCAAGCAGGG ATGCTGGTTG 240

GATGATGTCA ACTGCTACGA CAGTAACGAG TGTGTGGAGA GGAAGGAGAG TCCCGATGTT 300

TTCTTCTGCT GCTGTGAAGG CAACATGTGC AACGAGAGGT TCCTGTACGC CCCTGAAGCG 360

TCTTTTATGC AGGTTAGTAA AGCCACCTCC AACCCATTCT CCCAGAAGCC CCAGCTCTTC 420

AGCACCCTGC TTTACTCCCT GGTTCCCATC ATAGGCCTGG CCGCTGTCGT CCTCTTCTCC 480

TTCTGGATGT GGAGGCACCA CAAACTGGCG TACCCAGCTG CTCTCGTCCC CACACATGAT 540

CCCGGACCCT CACCCCCGTC CCCAATTCTG GGACACAAAC CTCTGCAGCT GATCGAGGTG 600

AAAGCCAGGG GGCGCTTCGG CTGTGTGTGG AAGGCGCAAC TGCTGAATGA ATACATGGCT 660

GTTAAGATCT TTCCCATCCA GGACAAGCTG TCTTGGCAGA ACGAGTACGA GATCTACAGC 720

GTGAGCGGCA TGAAGCACGA AAACATCCTC CACTTTATCG GCGTGGAGAA GAGGAACAAC 780

AACCTGGACC TGGAGCTGTG GCTCATCACC GCCTACCACG ACAAGGGCTC GCTGACAGAC 840

TACCTGAAGG CCAATGTGGT GTCCTGGAAC GAGCTCTGCC ACATCGCTCA GTCAGCAGCC 900

CGCGGCCTCG CCTACCTCCA CGAAGACATC CCAGGACACA AGGACGGGCA CAAGCCCTCC 960

ATCGCTCACA GGGACATTAA AAGTAAGAAT GTGTTGTTGA AGAATAACCT GACAGCCTGC 1020

ATAGCTGACT TTGGCCTCGC TCTGAAGTTT GAGGCAGGAA AATCAGCAGG AGACACACAC 1080

GGACAGGTGG GAACACGACG TTACATGGCT CCCGAAGTCC TGGAGGGAGC AATCAACTTC 1140

CAGCGTGATT CCTTTTTGCG CATCGATATG TACGCCTTTG GCCTCGTCCT GTGGGAGCTG 1200

GCATCGCGGT GCACCGCTGC CGACGGACCA GTAGATGAGT ACATGCTCCC CTTTGAGGAG 1260

GAGGTGGGTC AGCACCCATC TCTGGAGGAC ATGCAGGAGG TGGTGGTGCA TAAGAAACTG 1320

CGGCCCTGCC TGCGAGACTG CTGGCAGAAA CACACGGGTC TGGCCATGCT TTGTGAAACC 1380

ATCGAGGACT GCTGGGACCA CGAGGCCGAG GCACGCCTGT CCGCCGGCTG CGTCGAAGAG 1440

CGCATCGGAC AGATGCAACG CCAGGCACCC GTCATCGGCC CTGAGGAGAT CGTCACTGTT 1500

GTCACCATGG TGACAAACGT GGACCTCCCA CCCAAGGAGT CCAGCTTATG A 1551

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+l+e+ ++Gr+g+Vwka+l +e++AvKif+ +d+ sw++E eiy++  ++henil+fi+

Q: 195   LQLIEVKARGRFGCVWKAQLLNEYMAVKIFPIQDKLSWQNEYEIYSVSGMKHENILHFIG  254

         689*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

          +k+++++  el+l+t+yh+kgsL+dyLk+++++++el+++a+s+a+Gla+LHe+i+g+k

Q: 255   VEKRNNNLDLELWLITAYHDKGSLTDYLKANVVSWNELCHIAQSAARGLAYLHEDIPGHK  314

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         + +Kp+iaHRD+kskN+l+k++lt+ciaD+GLalk+e+ k++ d  ++ qvGt+RYmaPE

Q: 315   DGHKPSIAHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPE  372

         *****************************************888..79************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vle+a+n+++ ++f r+D+Y++gLvlWE+asRc+++d+ v+ey+lpfee+vg++Psle+m

Q: 373   VLEGAINFQR-DSFLRIDMYAFGLVLWELASRCTAADGPVDEYMLPFEEEVGQHPSLEDM  431

         *********9.9************************************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +evvv+kklrP +++ w+k+  l++l++++e+cWd+++eaRl+a +v++r+

Q: 432   QEVVVHKKLRPCLRDCWQKHTGLAMLCETIEDCWDHEAEARLSAGCVEERI  482

         ************************************************985

Domain Sequence
(FASTA)

LQLIEVKARG RFGCVWKAQL LNEYMAVKIF PIQDKLSWQN EYEIYSVSGM KHENILHFIG 60

VEKRNNNLDL ELWLITAYHD KGSLTDYLKA NVVSWNELCH IAQSAARGLA YLHEDIPGHK 120

DGHKPSIAHR DIKSKNVLLK NNLTACIADF GLALKFEAGK SAGDTHGQVG TRRYMAPEVL 180

EGAINFQRDS FLRIDMYAFG LVLWELASRC TAADGPVDEY MLPFEEEVGQ HPSLEDMQEV 240

VVHKKLRPCL RDCWQKHTGL AMLCETIEDC WDHEAEARLS AGCVEERI 288

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013