EKS-ORN-00181

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00181

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	558.0	3.8E-168	478	753	276

Status

Unreviewed

Ensembl Protein

ENSONIP00000015556

UniProt Accession

I3K361;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR3

Gene Synonyms/Alias

FGFR3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000012350	ENSONIP00000015556	ENSONIT00000015569

Organism

Oreochromis niloticus

Functional Description

Protein Length

818

Protein Sequence
(FASTA)

MLSKLESGLA ALRLTSSSRG MTALWCSLWL SLLLPLCAVP ARLPTAQPTD PVSSETAFLE 60

DYVLGIGDTL EMSCDPEEQE DHSEPIVWFK DGAGLVPCNR IRLGQRMLRI INVSYDDSGV 120

YSCRLARSNA LLSNYTIRVT DSLSSGDDED YDEDPEGAEA PYWTRPERMD KKLLAVPAAN 180

TVKFRCAASG NPPPTIHWLK NGKEFKGEQR MGGIKLRHQQ WSLVMESAVP SDRGNYTCVV 240

QNKYGSISHT YQLDVLERSP HRPILQAGLP ANQTVVVGSN VEFHCKVYSD AQPHIQWLKH 300

IEVNGSRFGH DGVPYVSVLK TAGINTTDKE LEVLLLTNVS FEDAGEYTCL AGNSIGYSYH 360

SAWLTVLPAV SPQKEDYYAD ILIYVTGCVL FILAVVIAIL CRMRMTTQKT LPTPPVQKLS 420

KFPLKRQQVS LDSNSSMNSN TPLVRIARLS SSDGPTLANV SELELPSDPK WEFPRTRLTL 480

GKPLGEGCFG QVVMAEAVGI DKEKPNKSLT VAVKMLKDDA TDKDLSDLVS EMEMMKMIGK 540

HKNIINLLGA CTQDGPLYVL VEYASKGNLR EYLRARRPPG MDYSFDTCKI PDEQLTFKDL 600

VSCAYQVARG MEYLASQKCI HRDLAARNVL VTEDNVMKIA DFGLARDVHN IDYYKKTTNG 660

RLPVKWMAPE ALFDRVYTHQ SDVWSYGVLL WEIFTLGGSP YPGIPVEELF KLLKEGHRMD 720

KPANCTHELY MIMRECWHAV PSQRPTFRQL VEDHDRILSM TSTDEYLDLS VPFEQYSPTC 780

QDSNSTCSSG DDSVFAHDPL PDEPCLPKQL PSNGVIRT 818

Nucleotide Sequence
(FASTA)

ATGTTGTCTA AGTTGGAGTC GGGCCTCGCT GCTCTGCGTC TGACCTCTTC GTCCAGAGGA 60

ATGACTGCTC TGTGGTGCTC ACTCTGGCTT TCTCTCCTCC TTCCTCTCTG CGCCGTTCCA 120

GCCAGGCTGC CCACTGCTCA GCCCACAGAC CCTGTGTCCA GCGAGACGGC CTTCCTGGAG 180

GACTATGTTC TGGGCATCGG GGACACTCTG GAAATGTCAT GTGATCCAGA AGAGCAGGAA 240

GACCACTCGG AGCCTATTGT GTGGTTCAAA GACGGCGCTG GACTTGTGCC TTGCAACCGG 300

ATACGGTTGG GCCAGAGGAT GCTCCGCATT ATCAATGTGT CGTATGACGA CTCCGGGGTC 360

TACTCGTGCC GGCTCGCCCG GAGCAACGCG CTGCTCAGCA ACTACACCAT CAGGGTGACA 420

GATTCTCTGT CGTCTGGTGA TGATGAAGAT TACGATGAAG ACCCAGAAGG TGCAGAAGCG 480

CCATATTGGA CCAGGCCAGA ACGAATGGAC AAGAAATTAT TGGCTGTTCC TGCGGCCAAC 540

ACCGTCAAAT TCCGCTGCGC TGCGTCTGGA AACCCACCGC CAACCATACA CTGGCTGAAG 600

AATGGCAAAG AGTTCAAGGG AGAGCAGAGG ATGGGAGGCA TCAAGCTGAG ACACCAGCAG 660

TGGAGTCTGG TGATGGAGAG CGCCGTGCCG TCAGACCGGG GAAACTACAC TTGCGTGGTG 720

CAAAACAAAT ACGGCTCCAT CAGCCACACC TACCAGCTCG ACGTGCTCGA GCGTTCACCT 780

CACAGGCCCA TCCTTCAGGC TGGTCTGCCG GCCAATCAGA CGGTGGTGGT GGGCAGCAAT 840

GTGGAGTTTC ATTGTAAGGT TTACAGCGAC GCCCAGCCGC ACATCCAGTG GCTCAAACAC 900

ATTGAGGTGA ACGGCAGCCG CTTTGGCCAC GACGGTGTTC CCTACGTCAG CGTGCTGAAG 960

ACGGCTGGCA TTAACACTAC AGATAAGGAG CTAGAGGTTC TCTTGTTGAC CAATGTGTCT 1020

TTTGAGGATG CGGGCGAGTA CACTTGTCTC GCAGGGAACT CTATCGGCTA TTCTTACCAC 1080

TCTGCTTGGC TGACGGTGCT TCCAGCAGTG AGTCCACAGA AGGAAGACTA CTACGCCGAC 1140

ATCCTTATCT ACGTGACAGG CTGCGTGCTC TTCATCCTCG CCGTGGTCAT CGCAATCCTC 1200

TGTCGTATGA GGATGACCAC GCAGAAGACT CTGCCCACGC CTCCCGTGCA AAAACTGTCA 1260

AAGTTCCCCC TCAAGAGACA GCAGGTGTCC TTGGATTCCA ACTCCTCCAT GAACTCAAAC 1320

ACGCCGCTGG TCAGGATCGC CCGTCTGTCG TCCAGCGACG GGCCGACGCT CGCCAACGTC 1380

TCGGAGCTGG AGCTGCCCTC CGACCCCAAA TGGGAGTTTC CTCGGACACG GCTAACTCTG 1440

GGTAAACCTC TGGGAGAGGG CTGCTTCGGT CAGGTGGTTA TGGCTGAGGC TGTTGGCATC 1500

GACAAAGAGA AGCCCAACAA GTCGCTCACT GTTGCTGTGA AAATGTTGAA AGATGACGCC 1560

ACAGATAAAG ATTTATCAGA CCTGGTGTCA GAAATGGAGA TGATGAAGAT GATTGGGAAA 1620

CACAAAAACA TCATCAACCT ACTCGGAGCC TGCACGCAGG ATGGTCCTCT GTATGTCCTG 1680

GTGGAATACG CCTCCAAAGG CAACCTGAGG GAGTACCTGC GTGCACGGCG GCCACCGGGC 1740

ATGGACTACT CCTTCGACAC GTGCAAAATC CCCGATGAGC AGCTCACATT CAAAGACCTG 1800

GTGTCCTGTG CCTACCAGGT TGCCCGAGGC ATGGAGTATC TTGCTTCACA GAAGTGCATC 1860

CACAGAGACC TGGCAGCCAG AAACGTCCTT GTGACGGAGG ACAACGTTAT GAAGATCGCC 1920

GACTTCGGCC TCGCCAGAGA CGTGCACAAT ATAGACTACT ACAAAAAGAC CACAAATGGT 1980

CGTCTCCCCG TGAAATGGAT GGCTCCAGAG GCTCTCTTCG ACCGGGTCTA CACGCACCAG 2040

AGCGATGTGT GGTCTTATGG GGTACTGCTG TGGGAGATCT TCACCTTGGG AGGCTCGCCG 2100

TACCCAGGGA TCCCAGTGGA AGAACTCTTT AAACTGCTGA AGGAAGGACA TCGAATGGAC 2160

AAGCCTGCCA ACTGCACCCA TGAACTGTAC ATGATCATGA GGGAGTGTTG GCACGCTGTG 2220

CCGTCGCAGA GGCCGACCTT CAGACAGCTG GTAGAAGATC ACGACCGGAT TTTATCAATG 2280

ACCTCCACAG ACGAGTACCT GGACCTGTCG GTGCCCTTCG AGCAGTACTC GCCCACCTGT 2340

CAGGACTCCA ACAGCACCTG CTCCTCAGGG GACGACTCCG TGTTCGCCCA CGACCCGCTG 2400

CCTGACGAGC CCTGTCTTCC CAAACAGCTT CCCAGTAACG GGGTGATTAG GACATAA 2457

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+aea+g+dk+k++k+ tvavkmlk+datdkdl+dlvseme++k+

Q: 478   LTLGKPLGEGCFGQVVMAEAVGIDKEKPNKSLTVAVKMLKDDATDKDLSDLVSEMEMMKM  537

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyv+veya+kGnlre+lrarrp+g+++s d++k+++eqlt+

Q: 538   IGKHKNIINLLGACTQDGPLYVLVEYASKGNLREYLRARRPPGMDYSFDTCKIPDEQLTF  597

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+ayqvarGmeylas+kcihrdlaarnvlvtednv+kiadfGlardvh+idyykkt

Q: 598   KDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNIDYYKKT  657

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdrvyt+qsdvws+Gvllwei+tlGgspypgi+veelfkllkeGh

Q: 658   TNGRLPVKWMAPEALFDRVYTHQSDVWSYGVLLWEIFTLGGSPYPGIPVEELFKLLKEGH  717

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlved  276

         rm+kpa+ct+ely++mrecwha++s+rptf+qlved

Q: 718   RMDKPANCTHELYMIMRECWHAVPSQRPTFRQLVED  753

         **********************************97

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVMAEA VGIDKEKPNK SLTVAVKMLK DDATDKDLSD LVSEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVLVEYASKG NLREYLRARR PPGMDYSFDT CKIPDEQLTF 120

KDLVSCAYQV ARGMEYLASQ KCIHRDLAAR NVLVTEDNVM KIADFGLARD VHNIDYYKKT 180

TNGRLPVKWM APEALFDRVY THQSDVWSYG VLLWEIFTLG GSPYPGIPVE ELFKLLKEGH 240

RMDKPANCTH ELYMIMRECW HAVPSQRPTF RQLVED 276

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR013151	; Immunoglobulin.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF00047	; ig; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013