EKS-ORN-00185
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00185
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR523.41.3E-157392668277
StatusUnreviewed
Ensembl ProteinENSONIP00000015869
UniProt AccessionI3K424;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR1 (2 of 2)
Gene Synonyms/Alias FGFR1 (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000012609ENSONIP00000015869ENSONIT00000015884
OrganismOreochromis niloticus
Functional Description
Protein Length710
Protein Sequence
(FASTA)
MSCPCRLLLV LLILLVHDPP AQSRPATEDT HTAEAVKSSE DEEDDESSSE ENKLSDELST 60
SSEKLQQPLE PQWVTPDKME KLLHAVPAST TVRFRCQAMG NPLPSLRWYK NGNELRKDQR 120
IGGYKIRDHM WTLIMESVVP SDKGNYTCVV ENEYGSLRHT YQLDVVERSP HRPILQAGLP 180
ANQTAVVGSN VEFVCRVFSD PQPHIKWFKH IIINGSKVSP DGLPYARVLK SANVNTTDRE 240
MEVLNLRNVT LEDSGEYTCM AANSIGVSHH SAWLTVVNDP PPSPLTSQAY LEIFIYCLGF 300
FIIVVLTATA VICRLCCAPK KSDFSNQLVV QKLAKSMPLR RQVSVESSSS LQSGMCLMRQ 360
SRLSSAATTV LLGASQYELP YDPAWELPRD RLTLGKPLGE GCFGQVVLAE AIGIDKNKPT 420
RVTKVAVKML KADATEKDLS DLISEMEMMK MIGKHKNIIN LVGACTQDGP LYVVVEYAAQ 480
GNLREYLRAR RPVGAEYWSG SRQASLGSLE VRELVSAAYQ VARGMAYLAS KKCIHRDLAA 540
RNVLVTEDSV MKIADFGLAR DIHHIDYYKK TTNGRLPVKW MAPEALFDRI YTHQSDVWSF 600
GVLLWEIFTL GGSPYPGVPV EELFKLLKEG HRMEKPSACP QELYLMMRDC WHAVPSRRPT 660
FQQLVEDLDR TVSIMANQDY LDLAVPLIQY TPVQYSPVST SSSAYTSIST 710
Nucleotide Sequence
(FASTA)
ATGTCCTGCC CTTGCCGCCT CCTGCTGGTT CTGCTAATTC TGCTGGTTCA CGACCCTCCG 60
GCTCAGTCCA GGCCAGCCAC AGAGGACACG CACACAGCAG AGGCAGTGAA ATCCTCCGAA 120
GACGAAGAAG ATGATGAGTC TTCGTCAGAG GAAAACAAGC TGTCCGACGA GCTGTCGACG 180
AGCAGCGAGA AGCTGCAGCA GCCGCTGGAG CCACAGTGGG TGACGCCAGA CAAGATGGAG 240
AAGCTCCTTC ACGCCGTTCC TGCCAGCACG ACGGTGAGGT TTCGATGCCA AGCAATGGGA 300
AACCCGCTTC CCTCCCTGCG CTGGTACAAG AACGGGAACG AGCTGAGGAA GGACCAACGA 360
ATCGGAGGCT ACAAGATCAG AGACCACATG TGGACTCTAA TAATGGAGTC AGTGGTTCCT 420
TCTGATAAAG GGAACTACAC CTGTGTGGTG GAGAACGAAT ATGGAAGCCT GCGACACACT 480
TACCAGCTGG ACGTAGTCGA GCGCTCTCCT CACAGGCCCA TCCTGCAGGC CGGGCTGCCG 540
GCCAACCAGA CGGCAGTGGT TGGCAGCAAC GTGGAGTTTG TGTGCCGCGT GTTCAGCGAC 600
CCACAGCCTC ACATCAAGTG GTTCAAACAC ATCATCATCA ACGGCAGCAA AGTGAGCCCG 660
GATGGACTGC CCTACGCTCG TGTTCTCAAA AGTGCCAACG TGAATACCAC AGACAGAGAG 720
ATGGAGGTGC TGAATCTGAG GAATGTAACT CTGGAAGACT CTGGAGAGTA CACCTGCATG 780
GCCGCAAACT CCATTGGGGT GTCGCACCAC TCTGCATGGC TCACTGTGGT CAATGACCCT 840
CCGCCCTCCC CACTGACCTC GCAGGCGTAC CTGGAGATCT TCATCTACTG CCTTGGGTTT 900
TTCATCATCG TCGTCCTCAC CGCCACGGCA GTCATCTGCA GGCTCTGCTG TGCCCCGAAG 960
AAAAGTGACT TCAGCAACCA GCTGGTCGTG CAGAAATTAG CCAAGAGCAT GCCTCTAAGG 1020
AGACAGGTGT CAGTCGAGTC GTCGTCCTCG CTGCAGTCGG GGATGTGTTT GATGCGTCAG 1080
TCTCGTCTCT CCAGCGCGGC CACCACCGTC CTGTTGGGCG CCTCGCAGTA CGAACTTCCC 1140
TACGACCCTG CGTGGGAGCT GCCTCGTGAC CGGCTGACTC TGGGGAAGCC TCTGGGCGAA 1200
GGCTGCTTTG GTCAGGTGGT TCTGGCCGAG GCCATCGGGA TCGACAAAAA CAAACCGACA 1260
CGGGTCACCA AAGTCGCCGT GAAGATGCTC AAAGCTGATG CCACGGAGAA GGATCTGTCT 1320
GACCTCATCT CTGAAATGGA AATGATGAAG ATGATCGGCA AACACAAGAA CATCATTAAC 1380
CTGGTGGGCG CCTGCACGCA GGACGGTCCT CTCTACGTGG TGGTGGAGTA TGCTGCGCAG 1440
GGTAATCTGA GGGAGTATCT GCGAGCTCGC CGGCCGGTCG GGGCAGAGTA CTGGAGCGGC 1500
TCCAGGCAGG CGTCGCTGGG CAGCCTGGAG GTCAGGGAGC TGGTGTCGGC AGCGTACCAG 1560
GTGGCCCGAG GGATGGCATA CCTCGCATCA AAGAAGTGCA TTCACAGAGA CTTGGCGGCC 1620
CGGAACGTTC TAGTCACTGA AGACAGCGTA ATGAAGATCG CCGACTTTGG TCTGGCTCGA 1680
GACATCCACC ACATCGACTA CTACAAGAAG ACCACCAATG GTCGGTTGCC AGTGAAGTGG 1740
ATGGCGCCGG AAGCTTTGTT TGACCGAATC TACACACACC AGAGCGACGT CTGGTCCTTC 1800
GGGGTCCTGT TGTGGGAGAT CTTCACCCTC GGGGGGTCTC CGTACCCCGG CGTCCCTGTC 1860
GAGGAGCTCT TCAAGCTGCT GAAGGAGGGA CACCGCATGG AGAAGCCATC GGCGTGCCCT 1920
CAGGAGCTGT ATCTGATGAT GCGGGACTGC TGGCACGCCG TCCCGTCCCG CAGGCCGACC 1980
TTCCAGCAGC TGGTCGAGGA TTTGGATCGA ACTGTCTCCA TCATGGCCAA CCAGGACTAC 2040
CTGGACCTGG CCGTCCCTCT GATCCAGTAC ACTCCAGTCC AGTACTCCCC GGTCAGCACC 2100
TCCTCCTCAG CTTACACCTC TATCTCCACA TAA 2133
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l+lgk+lGeG+fGqvv aeaig+dk+k+++ ++vavkmlk dat+kdl+dl+seme++k+
Q: 392   LTLGKPLGEGCFGQVVLAEAIGIDKNKPTRVTKVAVKMLKADATEKDLSDLISEMEMMKM  451
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinl+Gactq+Gplyv+veyaa+Gnlre+lrarrp g e+ + +++as  +l  
Q: 452   IGKHKNIINLVGACTQDGPLYVVVEYAAQGNLREYLRARRPVGAEYWSGSRQASLGSLEV  511
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         ++lvs ayqvarGm ylaskkcihrdlaarnvlvted+v+kiadfGlard+h+idyykkt
Q: 512   RELVSAAYQVARGMAYLASKKCIHRDLAARNVLVTEDSVMKIADFGLARDIHHIDYYKKT  571
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh
Q: 572   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  631
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rmekp+ c++ely +mr+cwha++s rptf+qlvedl
Q: 632   RMEKPSACPQELYLMMRDCWHAVPSRRPTFQQLVEDL  668
         ***********************************97
Domain Sequence
(FASTA)
LTLGKPLGEG CFGQVVLAEA IGIDKNKPTR VTKVAVKMLK ADATEKDLSD LISEMEMMKM 60
IGKHKNIINL VGACTQDGPL YVVVEYAAQG NLREYLRARR PVGAEYWSGS RQASLGSLEV 120
RELVSAAYQV ARGMAYLASK KCIHRDLAAR NVLVTEDSVM KIADFGLARD IHHIDYYKKT 180
TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240
RMEKPSACPQ ELYLMMRDCW HAVPSRRPTF QQLVEDL 277
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Caenorhabditis elegans"; ?>Gasterosteus aculeatus"; ?>Oryzias latipes"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-CAE-00120
EKS-GAA-00176
EKS-ORL-00173
EKS-TAR-00194
EKS-TEN-00187
EKS-XIM-00179
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008284; P:positive regulation of cell proliferation
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 2.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013