EKS-ORN-00021
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00021
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph416.05.5E-125633891259
StatusUnreviewed
Ensembl ProteinENSONIP00000016158
UniProt AccessionI3K4W3;
Protein Name
Protein Synonyms/Alias
Gene NameEPHB6
Gene Synonyms/Alias EPHB6;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000012839ENSONIP00000016158ENSONIT00000016173
OrganismOreochromis niloticus
Functional Description
Protein Length997
Protein Sequence
(FASTA)
VSCLFFLTFS LSLLLRLTVM LLDTTESTSE LGWITYPDTG WDEVSVLDDR GKLIRTFEVC 60
NVNQNPRQQD NWLATPFLYR HSAPRVFVTL RFSVRDCASL RSPSPTCRET LTLYYKQADS 120
QREPSSGERE TREGWVKIDT IAADKSFSKV EPSSPHQYQP NRYSRINIKT RSFAPLTRKG 180
FVLAIVDSGA CVSLMGVSIF YRRCPATSLY LASYPPTPSG AEPTALVPVT GTCVPHSKAQ 240
GDTPPRMHCN AEGEWMVPVG GCVCDEGYEP NLNGSACLAC PVGYFKSISG SIPCTVCPSN 300
SRTSHEGSSV CECRSGFYRA ASDANSSACT TPPSAPVSLT WEYESGDGGV SLRWRPPVDM 360
GGRSEVWYGV VCRICPSPTF TNSALCSWCG EGVTFSPSQT NLKQTKVTLN NLLTRVTYLI 420
QVQAMNEVSA LSPFPVRYSS INFTTSQSVP STVPMMHQLS RAPDSITLSW PQPDRPNGDI 480
LEYQLRYYDK GSDVDSALTV YSETNTVTVK SLIPGSIYAF QIRARNERGY GPYSNTIYFT 540
TLPLEEHSQQ IQTRLPLLVG SVMGGAAFLL VVAAIVVVVV FRSKRRESPY SDRLQRYISN 600
RGGVKYYVDP STYEDPSEAV KEFAREIDPT HLKIEEVIGA AQFGEVSRGR YRPLGRREVL 660
VAVKTLRWGA SDRERGMFLS EAGVLGQFDH PNVLKLEGVI TRTPPERIVT EFMENGPLDA 720
FLRENEGQFS VLQLVGMLRG VGAGMRYLSE RNFVHRDLAA RNVLVNSNLV CKVSDFGLSR 780
LMRGLDHNIP TYTASLGSKI PVRWTAPEAF QHRKFSSASD VWSFGILMWE VMSYGERPYW 840
DMSNQEVMKA VADQYRLPAP HNCPPALHSL MLQCWQADRA DRPGFDSVLS SLDRLIRHPA 900
SLKAEPTRYR SCSQPLLSPT PTDLSSVATV SDWLKALRME RYQDEFDRAH LDTLDRVSKL 960
TMEDVQDLGV NLLGHQRKIV SAAQQLRAHL TQGQVEV 997
Nucleotide Sequence
(FASTA)
GTTTCCTGTC TGTTTTTTCT AACTTTTTCT TTGTCTCTGC TTCTTCGTCT CACAGTGATG 60
CTGCTGGACA CAACAGAGTC TACCTCAGAG CTGGGCTGGA TCACCTATCC AGATACAGGG 120
TGGGATGAGG TCAGCGTCCT AGATGACCGA GGGAAGCTCA TACGAACCTT TGAAGTCTGC 180
AATGTCAACC AAAATCCCCG TCAGCAGGAC AACTGGTTGG CTACTCCTTT CCTGTACCGC 240
CACTCGGCTC CACGGGTGTT TGTCACGTTG CGTTTCTCTG TGCGAGACTG CGCGAGCCTG 300
CGTTCACCGT CGCCCACCTG CAGGGAGACA CTCACTCTAT ACTACAAGCA GGCCGACTCC 360
CAGAGGGAGC CATCGAGTGG GGAGAGGGAG ACCAGGGAGG GCTGGGTAAA GATTGACACC 420
ATCGCAGCCG ATAAGAGTTT TTCCAAGGTG GAGCCCAGCT CACCTCACCA GTATCAGCCC 480
AACAGATACA GCCGTATCAA CATTAAAACA CGCAGCTTTG CCCCCCTCAC ACGCAAAGGA 540
TTTGTCTTGG CCATCGTCGA CAGCGGAGCT TGCGTTTCCC TCATGGGGGT GTCTATCTTC 600
TACCGCCGCT GTCCAGCCAC AAGCCTCTAC CTAGCTTCGT ATCCACCGAC TCCCTCGGGT 660
GCCGAGCCAA CAGCTTTAGT GCCTGTGACC GGGACGTGTG TCCCTCACAG TAAGGCACAA 720
GGAGACACGC CCCCTCGCAT GCACTGCAAT GCTGAAGGAG AGTGGATGGT GCCCGTCGGT 780
GGATGCGTCT GTGATGAAGG TTATGAGCCG AACCTCAATG GATCTGCCTG TCTGGCCTGT 840
CCCGTGGGCT ACTTTAAGTC CATTTCAGGC TCTATTCCCT GCACTGTGTG CCCATCCAAC 900
AGCCGAACCA GCCATGAGGG ATCGAGTGTG TGTGAATGTC GCAGCGGCTT TTACCGGGCC 960
GCCAGCGATG CCAACTCTTC TGCCTGCACA ACTCCTCCGT CTGCTCCAGT CTCTCTGACC 1020
TGGGAGTATG AGAGCGGCGA TGGTGGGGTT TCCTTGAGGT GGCGCCCTCC GGTGGACATG 1080
GGAGGCCGAA GTGAGGTGTG GTACGGGGTG GTGTGTCGCA TCTGTCCGTC ACCGACCTTC 1140
ACCAACTCGG CTTTGTGCTC TTGGTGTGGG GAGGGCGTCA CCTTCAGCCC CTCCCAGACC 1200
AACCTGAAAC AAACCAAGGT CACCCTCAAC AACCTGCTGA CCAGAGTCAC GTATCTCATA 1260
CAGGTGCAAG CCATGAATGA AGTGTCAGCT TTGAGTCCTT TTCCAGTTCG ATACTCAAGC 1320
ATCAATTTCA CTACGAGCCA GTCAGTTCCC AGTACCGTTC CTATGATGCA CCAGCTGAGC 1380
CGGGCCCCGG ACTCCATCAC TCTGTCGTGG CCTCAGCCAG ACAGGCCTAA TGGAGACATC 1440
CTGGAGTATC AGCTCAGATA CTATGACAAG GGTTCAGATG TGGACAGCGC ATTGACTGTG 1500
TACAGTGAGA CTAACACAGT GACCGTCAAG TCTCTGATTC CCGGCTCCAT CTACGCCTTC 1560
CAGATCAGAG CTCGGAATGA GCGAGGCTAC GGGCCCTACA GCAACACCAT CTACTTCACG 1620
ACGCTGCCTC TAGAGGAGCA TTCACAGCAA ATCCAGACTC GGCTTCCTCT GCTGGTGGGC 1680
TCGGTCATGG GTGGGGCGGC GTTTCTCCTT GTCGTGGCAG CCATTGTGGT CGTGGTGGTA 1740
TTTCGCAGTA AGAGGAGGGA GAGTCCATAC AGTGACCGAC TCCAGAGGTA CATCAGTAAC 1800
AGAGGTGGAG TTAAGTATTA CGTTGACCCA TCCACTTATG AGGACCCCAG TGAGGCGGTC 1860
AAAGAATTTG CCCGTGAGAT CGACCCCACT CACCTCAAGA TCGAGGAGGT GATTGGTGCA 1920
GCCCAATTTG GTGAGGTTTC CCGCGGTCGA TACCGTCCGC TGGGTCGCAG GGAAGTGCTG 1980
GTAGCAGTGA AGACTCTGCG GTGGGGAGCG TCGGACAGAG AGAGGGGGAT GTTCCTCAGT 2040
GAAGCAGGAG TCCTGGGACA GTTTGACCAC CCCAATGTGC TGAAACTAGA GGGTGTTATC 2100
ACCCGTACCC CTCCAGAGAG GATCGTCACT GAGTTCATGG AGAACGGGCC CCTGGATGCC 2160
TTCCTCAGGG AGAACGAAGG TCAGTTCAGT GTCCTCCAGC TTGTCGGGAT GCTCAGGGGA 2220
GTTGGAGCAG GGATGCGTTA CCTCTCTGAG AGAAACTTTG TTCACCGAGA CCTGGCGGCC 2280
AGGAACGTGT TGGTTAACTC CAACCTGGTC TGTAAAGTGT CCGATTTTGG CCTCTCCAGG 2340
CTTATGAGGG GCTTGGACCA CAACATACCA ACTTACACTG CCTCACTGGG CAGTAAGATT 2400
CCTGTGAGGT GGACGGCACC TGAAGCATTT CAGCATCGCA AGTTCAGCTC AGCTAGTGAT 2460
GTCTGGAGCT TTGGAATACT GATGTGGGAA GTTATGTCCT ACGGAGAGCG TCCGTACTGG 2520
GACATGAGCA ATCAAGAGGT GATGAAGGCA GTAGCAGATC AGTACCGTCT CCCGGCCCCC 2580
CACAACTGCC CCCCTGCCCT CCACTCTCTA ATGCTTCAGT GTTGGCAGGC CGACCGGGCA 2640
GACCGACCAG GTTTCGACTC AGTCCTGTCT TCTCTGGATC GACTCATCAG GCACCCCGCA 2700
TCCCTCAAAG CTGAGCCAAC TCGTTACAGA AGCTGCTCCC AGCCGCTGCT CAGCCCCACT 2760
CCCACAGACT TATCGTCAGT GGCGACGGTC AGTGATTGGC TGAAAGCGCT GAGGATGGAG 2820
AGGTATCAGG ATGAGTTTGA TCGAGCGCAC CTGGACACGT TAGACAGAGT CAGCAAGCTT 2880
ACGATGGAAG ACGTCCAGGA TCTCGGCGTG AACCTGCTGG GACACCAGAG GAAGATCGTC 2940
AGCGCAGCCC AGCAGCTCAG GGCTCACCTG ACACAGGGGC AGGTGGAGGT CTGA 2994
Domain Profile
S: 2     kiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhpn  61
         kie+viGa +fGev +Gr +  g+re+ va+ktl+ g+++++r  flsea +lGqfdhpn
Q: 633   KIEEVIGAAQFGEVSRGRYRPLGRREVLVAVKTLRWGASDRERGMFLSEAGVLGQFDHPN  692
         89**********************************************************
S: 62    iirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdmg  121
         +++leGv+t++ p  ivte+meng ld+flr+++gqf+v+qlvgmlrG+++gm+yls+ +
Q: 693   VLKLEGVITRTPPERIVTEFMENGPLDAFLRENEGQFSVLQLVGMLRGVGAGMRYLSERN  752
         ************************************************************
S: 122   yvhrdlaarnilvnsnlvckvsdfGlsrvle..ddseaaytts.ggkipirwtapeaiay  178
         +vhrdlaarn+lvnsnlvckvsdfGlsr +   d++ ++yt+s g+kip+rwtapea ++
Q: 753   FVHRDLAARNVLVNSNLVCKVSDFGLSRLMRglDHNIPTYTASlGSKIPVRWTAPEAFQH  812
         *****************************962245589***988****************
S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238
         rkf+sasdvws+Gi++wev+syGerpywdmsnq+v+ka+ ++yrlp+p +cp al+ lml
Q: 813   RKFSSASDVWSFGILMWEVMSYGERPYWDMSNQEVMKAVADQYRLPAPHNCPPALHSLML  872
         ************************************************************
S: 239   dcwqkdraerpkfeqivsi  257
         +cwq dra+rp f+++ s 
Q: 873   QCWQADRADRPGFDSVLSS  891
         **************99876
Domain Sequence
(FASTA)
KIEEVIGAAQ FGEVSRGRYR PLGRREVLVA VKTLRWGASD RERGMFLSEA GVLGQFDHPN 60
VLKLEGVITR TPPERIVTEF MENGPLDAFL RENEGQFSVL QLVGMLRGVG AGMRYLSERN 120
FVHRDLAARN VLVNSNLVCK VSDFGLSRLM RGLDHNIPTY TASLGSKIPV RWTAPEAFQH 180
RKFSSASDVW SFGILMWEVM SYGERPYWDM SNQEVMKAVA DQYRLPAPHN CPPALHSLML 240
QCWQADRADR PGFDSVLSS 259
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Danio rerio"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Oryzias latipes"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-DAR-00017
EKS-GAM-00005
EKS-GAA-00019
EKS-ORL-00019
EKS-TAR-00020
EKS-TEN-00020
EKS-XIM-00018
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013