EKS-ORN-00515
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00515
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR523.44.0E-157586917332
StatusUnreviewed
Ensembl ProteinENSONIP00000016428
UniProt AccessionI3K5N4;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameCSF1R (1 of 2)
Gene Synonyms/Alias CSF1R (1 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000013065ENSONIP00000016429ENSONIT00000016444
ENSONIG00000013065ENSONIP00000016428ENSONIT00000016443
OrganismOreochromis niloticus
Functional Description
Protein Length975
Protein Sequence
(FASTA)
MLSYLMLWLV ASAASAEWRR PVIKLNSKVV KSAEVVVRAG SPLDLRCEGE APVIWQTRLP 60
KHRRYISKGN GTVRTFKVDR PTAEFTGTYK CYYTNGSHRD SSVYVYVKDP SHVFWTSSTS 120
LQVVVKEGES YLLPCLLTDP EATDISLRMN NGTSVPPGMN FTIFRHRGIL IHSLHPSFNA 180
DYICTARVNG VEKTSKAFSI NVIQKLRFPP YVFLETEEYV RIVGEKLKIP CTTHNPNFYY 240
NVTWKYTTKS VPKIAEIVRS NGENRLDIES TLTIAAVDLA DTGNISCIGS NEAGVNTSTT 300
YLLVVDKPYI RLSPQLSPKL AHEGLSVEVN EGDDLELSVL IEAYPHITKH RWDTPISPNT 360
ATQEHKLIRY NNRYHAILQL KRMNIQEQGQ YTFYAQSEMA NASITFQVQM YQRPIAVVKW 420
ENVTTLTCTS HGYPPPRIIW YQCFGIRPTC NENNSGLQMA IPLQAPTVEV QREEYGAVEV 480
ESVLTVAFSN RRMTVECVAF NLAGVSSDTL AMNVNDWPFT SLLIGAAAIL TILLVLLIFL 540
FYKYKQKPRY EIRWKIIEAR DGNNYTFIDP TQLPYNEKWE FPRDKLKLGK ILGAGAFGKV 600
VEATAYGLGK EDNVMRVAVK MLKASAHSDE REALMSELKI LSHLGHHQNI VNLLGACTYG 660
GPVLVITEYC CLGDLLNFLR QKAETFVNFV MNIPDIMENS TDYKNICNQK QFIRSDSGIS 720
SETSSTYLEM RPSRLAELPT VESSEDPVCE ESGDWPLDID DLLRFSFQVA QGLDFLASKN 780
CIHRDVAARN VLLTSRREAK ICDFGLARDI MNDSNYVVKG NARLPVKWMA PESIFDCVYT 840
VQSDVWSYGI LLWEIFSLGK SPYPSMAVDT RFYKMVKRGY QMSQPDFAPP EIYGIMKMCW 900
HLEPTERPTF SKICHMIQRL LGDQPEQEQL TYQNVQQQVT EGEGCDECFD GPCDQSCDHQ 960
EEEQPLMKTN NYQFC 975
Nucleotide Sequence
(FASTA)
ATGCTGTCCT ACCTTATGCT GTGGCTTGTG GCCTCTGCTG CTTCAGCTGA GTGGAGGCGT 60
CCAGTGATCA AGTTAAACTC CAAGGTGGTT AAGAGCGCTG AGGTGGTGGT CAGAGCTGGA 120
AGCCCTCTGG ATCTGAGGTG TGAGGGTGAA GCGCCTGTAA TCTGGCAAAC CAGACTACCC 180
AAACACAGAC GCTACATATC CAAGGGCAAT GGGACTGTCC GTACTTTTAA AGTTGACCGT 240
CCCACCGCAG AATTCACTGG AACGTACAAG TGTTATTACA CCAATGGGTC ACATCGTGAC 300
TCCTCAGTGT ATGTGTATGT AAAAGATCCA AGTCATGTTT TCTGGACTAG CAGCACATCC 360
CTGCAGGTGG TAGTGAAGGA GGGTGAGAGC TACCTGCTGC CTTGCCTACT GACCGACCCA 420
GAAGCTACAG ACATAAGCCT GCGCATGAAC AATGGCACTT CTGTGCCACC AGGAATGAAC 480
TTTACCATCT TCAGACACCG CGGCATTCTC ATCCACAGCC TTCACCCCAG CTTTAATGCT 540
GACTACATCT GCACGGCCAG GGTCAACGGA GTGGAGAAGA CCTCTAAGGC CTTTTCCATC 600
AATGTCATTC AGAAGCTCCG TTTCCCTCCA TACGTCTTCT TGGAGACAGA GGAATATGTG 660
CGCATAGTTG GGGAAAAACT CAAGATCCCA TGCACAACAC ACAATCCCAA CTTCTACTAC 720
AACGTCACCT GGAAATACAC AACCAAATCA GTCCCAAAAA TTGCTGAGAT AGTTCGCTCC 780
AATGGCGAAA ATCGCCTGGA CATAGAGAGC ACACTGACTA TCGCTGCTGT GGACCTGGCC 840
GACACAGGAA ACATCTCCTG CATTGGTTCT AACGAAGCAG GGGTGAACAC TTCGACCACG 900
TACCTGCTGG TTGTGGACAA GCCTTACATC AGACTATCAC CCCAGCTGTC GCCTAAGCTG 960
GCCCACGAGG GCCTCTCAGT GGAGGTGAAC GAGGGAGACG ATCTGGAGCT CAGCGTGCTC 1020
ATCGAAGCAT ACCCCCACAT CACAAAGCAC AGATGGGACA CGCCGATATC TCCCAACACA 1080
GCCACACAGG AGCACAAGCT CATCCGATAC AACAACAGAT ACCATGCTAT TCTGCAGCTG 1140
AAGAGAATGA ACATACAGGA GCAGGGCCAG TACACCTTTT ATGCTCAGAG TGAAATGGCC 1200
AATGCATCCA TCACATTTCA AGTCCAGATG TATCAGAGAC CAATTGCTGT CGTGAAATGG 1260
GAAAATGTAA CCACACTCAC TTGCACTTCG CATGGCTATC CGCCTCCCAG AATCATCTGG 1320
TATCAGTGTT TTGGAATCCG ACCCACGTGC AATGAAAACA ATAGCGGACT GCAGATGGCA 1380
ATCCCTCTCC AAGCTCCTAC AGTGGAGGTC CAGAGGGAGG AGTACGGGGC TGTGGAAGTG 1440
GAGAGCGTCC TCACTGTGGC GTTTTCCAAC AGGAGGATGA CGGTTGAGTG TGTGGCCTTC 1500
AACCTCGCTG GCGTCAGCAG TGACACTCTT GCCATGAACG TTAACGACTG GCCCTTTACT 1560
TCCCTTCTGA TTGGAGCGGC AGCAATTTTG ACCATCCTTC TTGTTCTCCT CATTTTCCTG 1620
TTTTACAAAT ACAAGCAGAA ACCGAGGTAT GAGATCCGCT GGAAGATCAT TGAGGCGAGA 1680
GATGGGAACA ATTACACCTT CATTGACCCC ACGCAGCTGC CCTACAATGA AAAGTGGGAG 1740
TTCCCTAGAG ACAAGCTCAA ACTAGGGAAG ATCCTGGGTG CAGGCGCATT CGGAAAAGTT 1800
GTTGAGGCCA CGGCTTATGG ACTGGGAAAG GAAGACAATG TGATGCGTGT AGCTGTGAAA 1860
ATGTTAAAAG CCAGTGCCCA TTCAGATGAG AGGGAGGCTC TAATGTCTGA ACTGAAGATC 1920
CTGAGTCACC TGGGTCACCA CCAGAACATC GTCAACCTAC TTGGAGCCTG CACCTACGGA 1980
GGTCCAGTGC TTGTGATCAC TGAGTACTGC TGCCTCGGCG ACCTGCTGAA CTTCCTTCGC 2040
CAGAAGGCAG AGACGTTTGT GAACTTTGTC ATGAATATTC CCGACATCAT GGAAAATTCT 2100
ACCGACTACA AGAACATCTG CAATCAGAAG CAGTTCATTC GAAGCGACAG CGGGATCTCC 2160
AGTGAAACCT CCAGCACCTA CTTGGAGATG AGACCCAGCC GCTTAGCAGA GTTGCCAACT 2220
GTGGAATCAT CTGAAGACCC TGTCTGTGAG GAGAGTGGTG ACTGGCCGCT GGATATTGAT 2280
GACCTGCTCA GATTTTCCTT CCAAGTCGCT CAGGGCCTCG ACTTTTTGGC CAGCAAAAAT 2340
TGTATTCACA GAGATGTGGC TGCGAGGAAT GTGCTCCTGA CCAGTCGCAG AGAGGCAAAG 2400
ATCTGTGACT TCGGTCTGGC ACGGGACATC ATGAATGACT CCAACTATGT GGTGAAGGGC 2460
AATGCACGTC TGCCAGTGAA GTGGATGGCT CCCGAGAGCA TCTTTGACTG CGTGTACACC 2520
GTCCAGAGTG ACGTCTGGTC CTATGGCATC CTCTTGTGGG AAATCTTCTC TTTAGGCAAA 2580
AGCCCCTACC CCAGCATGGC TGTGGACACT AGGTTCTACA AGATGGTGAA GCGTGGCTAC 2640
CAGATGTCCC AACCAGACTT TGCTCCACCT GAAATCTACG GTATCATGAA GATGTGCTGG 2700
CATCTGGAGC CGACAGAGCG TCCCACCTTC AGCAAAATCT GTCACATGAT ACAAAGGCTA 2760
CTTGGGGACC AACCTGAGCA GGAACAGTTA ACATACCAGA ATGTGCAGCA GCAGGTCACG 2820
GAGGGTGAAG GGTGTGACGA GTGCTTCGAC GGCCCCTGTG ACCAGTCTTG TGACCACCAA 2880
GAAGAGGAGC AGCCTCTGAT GAAGACCAAC AACTACCAGT TTTGTTGA 2928
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lGk+lG+GafGkvveatayGl+k+d v++vavkmlk +a+s+e+ealmselkilshlG
Q: 586   LKLGKILGAGAFGKVVEATAYGLGKEDNVMRVAVKMLKASAHSDEREALMSELKILSHLG  645
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGact gGp++viteycc Gdlln+lr+k+e+f++  +++    e+++d+k+
Q: 646   HHQNIVNLLGACTYGGPVLVITEYCCLGDLLNFLRQKAETFVNFVMNIPDIMENSTDYKN  705
         ************************************************999*********
S: 121   l.ladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleee  179
         +  +++ +rs+s +sse+s++y+++++  s + +  +           +e++  ++ ee 
Q: 706   IcNQKQFIRSDSGISSETSSTYLEMRP--SRLAELPT-----------VESSEDPVCEES  752
         *7788899*******************..33332222...........222334556677
S: 180   dsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimk  239
          + +l+++dll fs+qva+G++flasknc+hrd+aarnvllt+ + +kicdfGlardim+
Q: 753   GDWPLDIDDLLRFSFQVAQGLDFLASKNCIHRDVAARNVLLTSRREAKICDFGLARDIMN  812
         789*********************************************************
S: 240   dsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskf  299
         dsnyvvkGnarlpvkwmapesifd++ytv+sdvwsyGillweifslG +pyp + vd++f
Q: 813   DSNYVVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGKSPYPSMAVDTRF  872
         ************************************************************
S: 300   yklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         yk++k+Gy+m+qp++a+ eiy im+ cw+ ep++rp+f+++++++
Q: 873   YKMVKRGYQMSQPDFAPPEIYGIMKMCWHLEPTERPTFSKICHMI  917
         ******************************************986
Domain Sequence
(FASTA)
LKLGKILGAG AFGKVVEATA YGLGKEDNVM RVAVKMLKAS AHSDEREALM SELKILSHLG 60
HHQNIVNLLG ACTYGGPVLV ITEYCCLGDL LNFLRQKAET FVNFVMNIPD IMENSTDYKN 120
ICNQKQFIRS DSGISSETSS TYLEMRPSRL AELPTVESSE DPVCEESGDW PLDIDDLLRF 180
SFQVAQGLDF LASKNCIHRD VAARNVLLTS RREAKICDFG LARDIMNDSN YVVKGNARLP 240
VKWMAPESIF DCVYTVQSDV WSYGILLWEI FSLGKSPYPS MAVDTRFYKM VKRGYQMSQP 300
DFAPPEIYGI MKMCWHLEPT ERPTFSKICH MI 332
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00376
EKS-ANC-00391
EKS-BOT-00405
EKS-CAF-00405
EKS-CAP-00434
EKS-DAR-00788
EKS-EQC-00397
EKS-FEC-00389
EKS-GAG-00342
EKS-GAA-00492
EKS-GOG-00397
EKS-HOS-00411
EKS-ICT-00384
EKS-LAC-00420
EKS-LOA-00414
EKS-MAM-00404
EKS-MEG-00336
EKS-MOD-00393
EKS-MUM-00437
EKS-MUP-00398
EKS-MYL-00400
EKS-ORC-00380
EKS-ORL-00473
EKS-OTG-00407
EKS-PES-00359
EKS-PTV-00115
EKS-RAN-00419
EKS-SAH-00375
EKS-SUS-00355
EKS-TAG-00474
EKS-TAR-00511
EKS-TEN-00512
EKS-TUT-00118
EKS-XET-00514
EKS-XIM-00507
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013