EKS-ORN-00513

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00513

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/PDGFR	538.1	1.4E-161	595	948	354

Status

Unreviewed

Ensembl Protein

ENSONIP00000016438

UniProt Accession

I3K5P3;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

PDGFRB (1 of 2)

Gene Synonyms/Alias

PDGFRB (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000013070	ENSONIP00000016438	ENSONIT00000016453

Organism

Oreochromis niloticus

Functional Description

Protein Length

1105

Protein Sequence
(FASTA)

AAVSVTSILT FFCLAVQTAA LLCFCTELRC LEITPGDKEF VLAKGSSLTL TCSGSGETTW 60

KFKMDDVPYF QLEPSKPGHR SYEIVQSGAT SSVLTLFNVS WKHTGVYQCV DQRTQDTEEV 120

AVFVPDPDVW FIESSHGMVT KTSEESTIPC VVTNPKITVT LHERDTDIPV SGVYVPSEGY 180

KAPVEDRNYV CRGELNGEER ESQDFYVISI VVPEAIDAYI NASKTVLKQG EPLTVNCTVH 240

GLELVNFSWD IPNRGLDFYE PLTDVLSPTS MRSCLIFSQA TVDHSGKYVC HVHEGIQDQS 300

ASASVNITVL ENGFVDIKPP QQRNISVKLQ ENVELRVAME AYPPPQVYWT KDGATIKGDK 360

IITMRQEHEI SYVSVLTLVR VRTDQKGLYT VLVTNGDDTK EMTFDLEVQV PAQIKDLTDH 420

SLKGKRHLVT CVAEGVPAPT IQWYSCGSML KCSNQTEVWK PLTPEPEVLS IHTNVSYNET 480

RKVSQVRSQL TFQTPQQVIV RCETSNQEGL ISRRDIKLVF SSLFSQVAVL AAVLALVVIV 540

IMSFIILIAI WRKKPRYEIR WKVIESVSQD GHEYIYVDPI HLPYDLAWEM RRDHLVLGRT 600

LGSGAFGRVV EATAYGLTDS QSSTKVAVKM LKSTARRSET QALMSELKIM SHLGPHLNIV 660

NLLGACTKHG PLYLVTEYCR YGDLVDYLHR NKHTFLQYYA EKNQDYSCLI SRGSTPLSQS 720

YVSFGSESDG GYMDMSKDEP SVYVPMQEQI DSIKYADIQP SPYESLYQHG FYQEQGGNSL 780

DLVISDSPSL TYEDLLGFSY QVAKGMEFLA SKNCVHRDLA ARNVLICEGK LVKICDFGLA 840

RDIMHDSNYI SKGSTFLPLK WMAPESIFHN LYTTLSDVWS YGILLWEIFT LGGTPYPDLP 900

MNELFYSALK GGYRMAKPTH ASDEVYEIMK KCWDEKFEKR PEFSFLVHSV GNMLTDSYKK 960

KYNQVNENFM KSDHPAVART KPRLTSPFPV ANPAFGTPSP VTLQSPLDAY NQNSRPRQDF 1020

RQEAQEVIPS YNEYIIPIPD PKPEDAFTDM PSESPGSSVG LGAETDSMSQ DTADTLPEED 1080

RLEETSERDA LLGSSGTPEV EDSFL 1105

Nucleotide Sequence
(FASTA)

GCTGCAGTCT CTGTGACCTC CATCCTGACC TTTTTTTGTC TTGCTGTGCA AACTGCAGCT 60

CTGCTGTGTT TCTGCACTGA GCTGCGCTGC CTGGAGATCA CGCCCGGCGA CAAAGAGTTT 120

GTTCTGGCCA AGGGCTCCTC TCTTACCCTT ACCTGCAGCG GCTCAGGGGA GACCACGTGG 180

AAGTTTAAGA TGGACGACGT GCCGTACTTT CAGCTGGAAC CATCTAAACC GGGTCACCGG 240

AGCTACGAGA TCGTGCAAAG CGGAGCCACA TCCAGCGTTC TGACATTGTT CAATGTGAGC 300

TGGAAGCACA CAGGCGTGTA TCAGTGCGTT GATCAGCGCA CTCAAGACAC AGAGGAGGTG 360

GCTGTGTTTG TCCCAGATCC TGACGTGTGG TTCATAGAGA GCTCTCACGG CATGGTAACA 420

AAGACCAGTG AGGAAAGCAC CATCCCCTGT GTGGTCACCA ATCCAAAAAT CACTGTCACC 480

TTGCACGAGA GGGACACTGA CATACCCGTA AGTGGGGTGT ATGTTCCTAG TGAGGGCTAC 540

AAGGCGCCGG TGGAGGACAG GAATTACGTG TGTCGGGGAG AGCTGAACGG GGAAGAGAGA 600

GAGTCTCAGG ACTTCTATGT CATCAGCATT GTGGTCCCAG AGGCCATTGA CGCCTACATC 660

AATGCTTCGA AGACGGTCCT GAAGCAGGGT GAACCACTGA CAGTAAACTG CACAGTGCAC 720

GGACTGGAGC TGGTGAATTT TTCTTGGGAT ATTCCCAACA GAGGGCTTGA CTTCTACGAG 780

CCACTGACTG ATGTCCTGTC CCCCACGAGC ATGCGCTCCT GCCTCATCTT CTCCCAGGCC 840

ACGGTGGACC ACAGTGGAAA ATATGTCTGC CACGTCCATG AGGGTATACA AGACCAGAGC 900

GCCTCTGCCA GCGTCAACAT CACTGTGCTT GAAAACGGCT TTGTGGACAT CAAACCTCCT 960

CAGCAACGAA ACATTTCAGT CAAGCTACAA GAGAACGTGG AGCTGAGAGT GGCGATGGAG 1020

GCGTACCCTC CCCCACAGGT TTACTGGACC AAGGATGGTG CCACCATCAA GGGAGACAAA 1080

ATCATCACCA TGAGACAAGA GCATGAAATA AGTTATGTCA GTGTCCTCAC CTTGGTGAGG 1140

GTGAGGACAG ACCAGAAGGG CCTCTACACT GTCCTTGTTA CCAATGGAGA TGACACAAAG 1200

GAAATGACCT TTGACCTGGA GGTCCAAGTT CCCGCTCAGA TTAAAGACCT GACTGACCAC 1260

AGTCTCAAAG GGAAAAGACA CTTGGTGACC TGTGTTGCTG AAGGGGTCCC AGCCCCAACC 1320

ATACAGTGGT ACAGCTGTGG CAGCATGCTC AAGTGTAGCA ACCAGACAGA GGTGTGGAAG 1380

CCGCTGACAC CAGAGCCAGA GGTGCTGAGC ATCCATACGA ACGTGAGCTA CAATGAGACA 1440

AGAAAGGTCA GTCAGGTGCG CAGCCAGCTG ACCTTCCAGA CACCTCAGCA GGTCATAGTT 1500

CGGTGTGAGA CCAGCAACCA AGAGGGGCTC ATCAGCAGGC GGGACATCAA ACTGGTATTC 1560

AGCTCCCTTT TCTCCCAGGT GGCAGTGTTG GCTGCTGTTT TAGCTTTAGT GGTCATTGTT 1620

ATCATGTCTT TCATCATCCT CATTGCAATC TGGAGGAAGA AACCTCGCTA TGAGATCAGA 1680

TGGAAGGTGA TAGAATCTGT CAGCCAGGAT GGACATGAGT ATATCTACGT GGATCCCATC 1740

CACCTGCCCT ATGACCTGGC CTGGGAAATG CGTCGTGACC ACCTAGTGCT GGGTCGCACT 1800

CTTGGATCAG GAGCGTTTGG CAGGGTGGTC GAGGCAACTG CATATGGTCT CACAGATTCG 1860

CAGTCAAGCA CAAAGGTGGC AGTGAAAATG CTGAAATCTA CAGCGAGAAG GAGCGAAACT 1920

CAGGCCCTGA TGTCAGAGTT AAAGATCATG AGTCACCTGG GTCCTCACCT CAACATCGTG 1980

AACTTGCTAG GGGCTTGTAC CAAACATGGC CCTCTGTACC TGGTGACTGA GTACTGTCGC 2040

TATGGCGACC TGGTGGATTA CCTGCACAGG AACAAGCACA CGTTCCTGCA GTACTATGCT 2100

GAGAAAAACC AGGACTACAG CTGTCTCATC TCCAGAGGAA GCACCCCTCT CAGCCAGAGC 2160

TATGTGTCTT TCGGAAGTGA GAGTGATGGA GGATACATGG ACATGAGCAA AGATGAGCCC 2220

TCAGTCTACG TTCCCATGCA AGAGCAGATA GATTCCATCA AATATGCAGA TATCCAGCCT 2280

TCTCCGTACG AGTCTCTCTA CCAACACGGC TTCTACCAGG AACAAGGAGG CAACAGTTTA 2340

GACCTGGTGA TCAGCGACTC TCCCAGTCTC ACCTACGAAG ATCTTTTAGG ATTCAGCTAC 2400

CAAGTGGCAA AGGGGATGGA GTTCCTCGCC TCTAAGAACT GCGTCCATCG TGACCTGGCT 2460

GCCAGGAACG TCCTGATCTG TGAGGGCAAA CTGGTGAAGA TTTGTGACTT CGGCCTGGCC 2520

AGAGACATCA TGCATGACTC CAACTACATC TCCAAAGGCA GCACTTTCCT TCCCTTGAAG 2580

TGGATGGCAC CTGAAAGCAT TTTCCATAAT TTGTATACCA CCCTAAGCGA TGTGTGGTCA 2640

TATGGCATTC TTCTTTGGGA GATTTTCACA CTGGGAGGGA CCCCCTACCC TGATTTGCCC 2700

ATGAATGAAT TATTCTACAG TGCTTTGAAG GGAGGCTACC GAATGGCCAA ACCCACCCAT 2760

GCCTCCGATG AAGTTTATGA GATTATGAAG AAATGCTGGG ATGAAAAGTT TGAGAAAAGG 2820

CCCGAGTTCT CATTTCTGGT CCACAGCGTG GGGAATATGC TGACAGACAG CTATAAAAAG 2880

AAATACAACC AAGTCAATGA AAACTTCATG AAGAGTGACC ACCCGGCAGT CGCCCGCACC 2940

AAACCTCGGC TGACCTCACC CTTTCCAGTC GCCAACCCAG CATTTGGCAC CCCATCTCCT 3000

GTCACACTCC AATCTCCACT GGATGCCTAC AACCAAAACT CAAGGCCTAG ACAAGACTTC 3060

AGACAAGAGG CACAGGAAGT CATACCGTCA TACAACGAGT ACATCATTCC CATTCCGGAC 3120

CCCAAGCCAG AAGACGCTTT CACTGACATG CCGTCGGAAA GTCCTGGAAG CTCTGTGGGT 3180

CTGGGGGCGG AGACCGACTC CATGTCTCAG GACACTGCTG ACACCCTTCC AGAGGAGGAC 3240

CGGCTGGAAG AGACCAGCGA GAGAGACGCT CTGTTGGGCT CCTCCGGGAC ACCCGAGGTA 3300

GAAGACAGCT TCCTGTAG 3318

Domain Profile

S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60

         l+lG++lGsGafG+vveatayGl+ s+++ kvavkmlkstar se +almselki+shlG

Q: 595   LVLGRTLGSGAFGRVVEATAYGLTDSQSSTKVAVKMLKSTARRSETQALMSELKIMSHLG  654

         78**********************************************************

S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120

         +h+nivnllGactk Gp+y++teyc+yGdl++yl+r++++fl+ ++ek+++ +  ++  +

Q: 655   PHLNIVNLLGACTKHGPLYLVTEYCRYGDLVDYLHRNKHTFLQYYAEKNQDYSCLISRGS  714

         ************************************************888877776664

S: 121   lladkslrsksslssesseeyvdlkkd................vsdvssskadklasekk  164

                +s++s+ ses++ y+d++kd                ++d+++s +++l+++

Q: 715   T---PLSQSYVSFGSESDGGYMDMSKDepsvyvpmqeqidsikYADIQPSPYESLYQHGF  771

         4...4568999********************************************99998

S: 165   ksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGk  224

          + +  +  + ++ + s +l++edll fsyqvakGmeflaskncvhrdlaarnvl++eGk

Q: 772   YQEQGGNSLDLVISD-SPSLTYEDLLGFSYQVAKGMEFLASKNCVHRDLAARNVLICEGK  830

         777777777777766.9*******************************************

S: 225   vvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifs  284

         +vkicdfGlardim+dsny++kG+++lp+kwmapesif++lyt+ sdvwsyGillweif+

Q: 831   LVKICDFGLARDIMHDSNYISKGSTFLPLKWMAPESIFHNLYTTLSDVWSYGILLWEIFT  890

         ************************************************************

S: 285   lGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlve  342

         lG+tpyp+l++++ fy ++k Gyrma+p++a++e+yeim+kcw++++ekrp f+ lv+

Q: 891   LGGTPYPDLPMNELFYSALKGGYRMAKPTHASDEVYEIMKKCWDEKFEKRPEFSFLVH  948

         *****************************************************98875

Domain Sequence
(FASTA)

LVLGRTLGSG AFGRVVEATA YGLTDSQSST KVAVKMLKST ARRSETQALM SELKIMSHLG 60

PHLNIVNLLG ACTKHGPLYL VTEYCRYGDL VDYLHRNKHT FLQYYAEKNQ DYSCLISRGS 120

TPLSQSYVSF GSESDGGYMD MSKDEPSVYV PMQEQIDSIK YADIQPSPYE SLYQHGFYQE 180

QGGNSLDLVI SDSPSLTYED LLGFSYQVAK GMEFLASKNC VHRDLAARNV LICEGKLVKI 240

CDFGLARDIM HDSNYISKGS TFLPLKWMAP ESIFHNLYTT LSDVWSYGIL LWEIFTLGGT 300

PYPDLPMNEL FYSALKGGYR MAKPTHASDE VYEIMKKCWD EKFEKRPEFS FLVH 354

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005021	; F:vascular endothelial growth factor-activated receptor activity
GO:0048010	; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084	; P:vascular endothelial growth factor signaling pathway

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR013151	; Immunoglobulin.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016243	; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824	; Tyr_kinase_rcpt_3_CS.
IPR009134	; Tyr_kinase_VEGFR_rcpt_N.

Pfam

PF07679	; I-set; 1.
PF00047	; ig; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 4.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00240	; RECEPTOR_TYR_KIN_III; 1.

Prints

PR01832

; VEGFRECEPTOR.

Created Date

20-Feb-2013