EKS-ORN-00368

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00368

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	367.8	4.7E-110	185	483	299

Status

Unreviewed

Ensembl Protein

ENSONIP00000016618

UniProt Accession

I3K673;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR2 (1 of 2)

Gene Synonyms/Alias

BMPR2 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000013213	ENSONIP00000016618	ENSONIT00000016633

Organism

Oreochromis niloticus

Functional Description

Protein Length

1006

Protein Sequence
(FASTA)

AALGEVRECA FIDQQQQWEV ERVAGGEGRV SPENTTIRCA KGSHCFGLWE KTPPGEVRLV 60

KQGCWTHLGD NQACRDDRCV VTNLPPQIQN GTYHFCCCGS DMCNVNFTED FPLPSPTTAQ 120

PIHPRTLGYK ETVIIALATV SVLAVVAAAA FFGYRMMHGD GKQGLHNLNM MEAAGSESSL 180

DLDNLKLLEL IGRGRYGAVY CGSLDERPVA VKVFTAANRQ NFLNECSIYR LPLLEHDNIA 240

RFVAADERTG PEGRTEYLLV MDYYPHGSLS RYLSIQTNEW VGSCRLAHSV TRGLAYLHTE 300

LFKGDLYKPA VSHRDLNSRN ILVKADGTCV IIDFGLSMKL TGNRAARHGE EENAAISEVG 360

TIRYMAPEVL EGAVNLRDCE AALKQVDMYA LGLVYWETFM RCTDLFPGES VPEYQMAFQA 420

EAGNHPTFED MQVLVSREKQ RPKFPEAWKE NSLAVRSLKE TMEDCWDQDA EARLTAQCAE 480

ERLAELLLIW DRSKSVSPTL NPMSTTLHNE RQVSTNRMTP KSGLYTDHSS TYIEEHEGVA 540

KNTQVDATSS LTGRVVVGTG ERNRNSINQE RQQQANARLP SPESSTTSMG MRGSPSASTT 600

TTTIISESEG LAGATTVPVC LHLTQEDLET TKLDPKEVDK NLKESSDENL MEHSQKQFCS 660

PDPLSPGSSS LLYPLIKMAS EVSGTSDTAA TMPTTIFPLP KQQNLPKRPS SLPLRNKPVK 720

KESSSSSLRF KFGRSGKSNL RQVEGTKMNI STVTGTNLAG EVHRGTGTNN LPVRRDTHAN 780

AAINGTVNGH VSAGISSIVT GGATGFGGSN ITHNGSGALR SDDSRLSLGV ITASPDEHEP 840

LLSQEREQPD QRDASTNVTA LRSARPNTNN NNSNTGHGQG DGDSGGESDE GEPEPRARRP 900

ERPNSLDLSF TTQDLASLGD GLVQPDGALG TGDKIKKRVK TPYSLKKWRP TTWVISTDTR 960

GPEVNNNGST RGQSHSQNRP KSSSAIYLRG GSLASEPSDT IPFNCA 1006

Nucleotide Sequence
(FASTA)

GCAGCGCTGG GTGAGGTAAG GGAATGTGCC TTCATAGACC AGCAGCAGCA ATGGGAAGTG 60

GAACGAGTGG CGGGGGGTGA AGGCCGGGTC TCCCCAGAGA ACACCACTAT CCGATGTGCC 120

AAAGGCAGCC ACTGTTTTGG GCTGTGGGAG AAAACTCCTC CAGGAGAAGT GCGCCTGGTC 180

AAGCAAGGTT GCTGGACTCA CTTAGGCGAC AACCAGGCAT GCCGAGATGA CCGCTGTGTG 240

GTTACCAACT TGCCTCCACA GATACAGAAT GGGACTTACC ACTTCTGCTG CTGTGGCAGT 300

GACATGTGCA ATGTGAACTT CACAGAGGAC TTCCCGCTGC CAAGCCCCAC CACTGCGCAG 360

CCCATACATC CTCGCACACT GGGCTACAAA GAGACGGTAA TTATCGCCCT GGCAACAGTC 420

TCCGTGCTGG CTGTGGTAGC TGCAGCAGCC TTCTTTGGTT ACCGCATGAT GCATGGAGAT 480

GGCAAACAAG GCCTTCACAA TCTCAATATG ATGGAAGCTG CGGGCTCTGA AAGTTCTCTG 540

GACCTGGACA ATCTCAAACT ACTGGAGCTG ATTGGGCGTG GCAGATATGG AGCCGTGTAC 600

TGCGGCTCTC TGGATGAGCG GCCTGTCGCC GTAAAGGTGT TTACTGCAGC CAACAGACAG 660

AACTTCCTCA ACGAATGCTC TATCTACCGG CTGCCGCTGC TAGAGCATGA TAACATTGCT 720

CGGTTCGTGG CAGCCGATGA GCGGACGGGC CCAGAGGGAC GCACAGAGTA CCTACTGGTC 780

ATGGACTACT ACCCACATGG CTCTCTCAGT CGCTACCTGA GCATCCAGAC CAACGAATGG 840

GTGGGCAGCT GCCGACTGGC TCACTCTGTC ACCCGCGGCC TGGCCTACCT GCACACCGAG 900

CTCTTTAAAG GAGACTTGTA TAAGCCAGCG GTTTCACACA GGGACCTGAA CAGCCGAAAC 960

ATCCTCGTCA AAGCCGACGG CACATGTGTC ATTATCGACT TTGGCCTTTC CATGAAGCTG 1020

ACAGGGAACA GAGCAGCACG GCATGGGGAA GAGGAAAACG CCGCTATAAG TGAGGTGGGG 1080

ACTATCCGTT ACATGGCCCC CGAGGTACTT GAGGGCGCGG TGAACCTGAG GGACTGTGAG 1140

GCAGCACTGA AGCAGGTGGA CATGTATGCT CTAGGCCTAG TCTACTGGGA GACCTTCATG 1200

AGATGTACTG ACCTTTTCCC TGGAGAGTCT GTGCCAGAGT ACCAGATGGC CTTCCAGGCG 1260

GAGGCAGGGA ACCACCCAAC ATTTGAGGAC ATGCAAGTTC TGGTATCCAG GGAGAAGCAA 1320

AGGCCTAAAT TCCCTGAGGC CTGGAAAGAG AACAGTCTGG CGGTTCGATC TCTGAAAGAG 1380

ACAATGGAGG ACTGTTGGGA CCAGGACGCA GAGGCTCGCC TCACAGCTCA GTGCGCTGAG 1440

GAGCGTCTGG CGGAGCTGCT CCTCATATGG GACCGCTCCA AGTCTGTCAG CCCTACACTC 1500

AACCCCATGT CCACTACACT GCACAACGAG AGGCAAGTTT CAACAAATCG CATGACGCCA 1560

AAGTCCGGCC TGTACACAGA CCATTCGTCT ACGTACATTG AAGAGCATGA AGGTGTAGCC 1620

AAGAACACGC AGGTGGACGC AACTAGTTCT TTGACTGGTA GAGTTGTGGT TGGGACCGGA 1680

GAGAGGAACA GGAATTCCAT CAACCAGGAG CGTCAGCAGC AAGCAAACGC CCGTCTGCCC 1740

AGCCCAGAAA GCAGCACCAC CAGCATGGGC ATGAGAGGTA GCCCTTCAGC CTCCACTACG 1800

ACTACCACTA TCATCTCCGA GTCAGAGGGA CTTGCAGGGG CCACCACAGT GCCCGTGTGC 1860

CTACATCTAA CCCAAGAAGA CCTGGAAACC ACAAAGCTGG ACCCTAAAGA AGTAGACAAA 1920

AACCTGAAGG AGAGCTCTGA TGAGAACCTA ATGGAGCACT CCCAGAAGCA GTTCTGCTCA 1980

CCAGACCCAC TGAGTCCTGG CAGTTCCAGC CTGCTTTATC CCCTTATAAA GATGGCGAGT 2040

GAGGTCTCCG GCACATCAGA CACTGCTGCC ACAATGCCCA CTACCATCTT TCCCTTGCCC 2100

AAGCAGCAAA ACTTGCCCAA GAGGCCATCC AGTCTGCCCC TGCGCAACAA GCCTGTCAAG 2160

AAGGAATCCT CCTCCTCTTC ACTAAGGTTC AAGTTTGGGC GCTCAGGAAA GTCCAACCTG 2220

CGGCAGGTGG AGGGAACAAA GATGAACATT AGTACAGTTA CGGGCACAAA TTTGGCTGGA 2280

GAGGTTCACC GAGGCACAGG CACAAACAAC TTACCTGTTC GACGGGATAC ACATGCCAAC 2340

GCAGCCATTA ACGGCACCGT CAATGGTCAC GTCAGTGCTG GGATCTCATC CATAGTAACA 2400

GGTGGAGCAA CAGGTTTTGG AGGCTCCAAC ATAACTCACA ATGGATCTGG AGCTCTGAGG 2460

TCAGATGACA GCCGGCTGTC CCTCGGCGTC ATCACAGCCA GCCCCGATGA ACACGAGCCT 2520

CTTTTGAGCC AAGAACGAGA GCAGCCCGAT CAAAGAGACG CGTCCACGAA CGTGACCGCT 2580

CTCCGCTCGG CCCGACCCAA CACCAACAAC AACAACAGCA ACACGGGTCA TGGCCAGGGG 2640

GATGGCGACA GCGGCGGAGA AAGTGATGAA GGAGAGCCGG AGCCCAGAGC CCGTAGGCCA 2700

GAGAGACCTA ACTCTCTAGA TCTGTCCTTC ACAACACAGG ACCTGGCCTC ACTAGGAGAT 2760

GGTTTAGTCC AGCCAGATGG AGCATTGGGG ACTGGAGATA AGATCAAGAA GCGCGTCAAA 2820

ACCCCTTATT CTCTGAAAAA GTGGCGACCC ACCACATGGG TCATCTCTAC AGATACCCGG 2880

GGGCCAGAAG TTAACAACAA TGGCTCTACC CGAGGTCAAA GTCACAGTCA GAACCGGCCC 2940

AAGTCCAGTT CAGCCATCTA CCTGCGGGGG GGCAGCTTGG CCAGCGAACC CAGTGACACC 3000

ATACCTTTTA ATTGTGCA 3018

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         lkllelig+Gryg+V+ ++l+++ vAvK+f++++++++ +E  iy+++ll+h+ni +f+a

Q: 185   LKLLELIGRGRYGAVYCGSLDERPVAVKVFTAANRQNFLNECSIYRLPLLEHDNIARFVA  244

         6899********************************************************

S: 61    adk.keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgt  119

         ad+ +  + +te+llv++y+++gsLs yL+ +t ++  ++rla+s+++Gla+LH+e+++

Q: 245   ADErTGPEGRTEYLLVMDYYPHGSLSRYLSIQTNEWVGSCRLAHSVTRGLAYLHTELFKG  304

         ***88899************************************************8755

S: 120   kgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekee....ldlaansqvGtkR  175

          + +Kpa++HRDl+s+Nilvk d+tc+i D+GL++kl+ ++ +    +++aa+s+vGt R

Q: 305   -DLYKPAVSHRDLNSRNILVKADGTCVIIDFGLSMKLTGNRAArhgeEENAAISEVGTIR  363

         .57*********************************9988877677688899********

S: 176   YmaPEvleealnlkdfe.afkraDvYslgLvlWEvasRcee..vdeeveeyklpfeevvg  232

         YmaPEvle+a+nl+d+e a+k++D+Y+lgLv+WE ++Rc++  ++e+v+ey+++f+++ g

Q: 364   YMAPEVLEGAVNLRDCEaALKQVDMYALGLVYWETFMRCTDlfPGESVPEYQMAFQAEAG  423

         *****************99*****************************************

S: 233   sdPsleemkevvvekklrPkipeawkkke.alkelsklleecWdadpeaRltalrvkkrl  291

         ++P++e+m+ +v ++k+rPk+peawk+++ a+++l++++e+cWd+d+eaRlta++ ++rl

Q: 424   NHPTFEDMQVLVSREKQRPKFPEAWKENSlAVRSLKETMEDCWDQDAEARLTAQCAEERL  483

         ***************************9999*************************9986

Domain Sequence
(FASTA)

LKLLELIGRG RYGAVYCGSL DERPVAVKVF TAANRQNFLN ECSIYRLPLL EHDNIARFVA 60

ADERTGPEGR TEYLLVMDYY PHGSLSRYLS IQTNEWVGSC RLAHSVTRGL AYLHTELFKG 120

DLYKPAVSHR DLNSRNILVK ADGTCVIIDF GLSMKLTGNR AARHGEEENA AISEVGTIRY 180

MAPEVLEGAV NLRDCEAALK QVDMYALGLV YWETFMRCTD LFPGESVPEY QMAFQAEAGN 240

HPTFEDMQVL VSREKQRPKF PEAWKENSLA VRSLKETMED CWDQDAEARL TAQCAEERL 299

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR015770	; BMPRII.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013