EKS-ORN-00299

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00299

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	324.7	5.8E-97	166	418	253

Status

Unreviewed

Ensembl Protein

ENSONIP00000016682

UniProt Accession

I3K6D7;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K5

Gene Synonyms/Alias

MAP2K5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000013265	ENSONIP00000016682	ENSONIT00000016697

Organism

Oreochromis niloticus

Functional Description

Protein Length

449

Protein Sequence
(FASTA)

LLSLRLNTDS AMNTEAIVIR IKTPSGDMDS SVDCPSLLNF NDLLVAIRDV MPEATVTAFE 60

YEDEVGDRIT VRSDEELKAM LSYYCNTMNE QRMNGLLPDP LQIFPRAGKT PGIRNIHGLK 120

VNTRPNPAND CSHAVPDSIA NNSLKKSSAE LKRILTNGQI NAQDIHYQEQ LGHGNGGTVY 180

KAYHVHGKRV LAVKVIPLDI TVELQKQIMS ELEILYKCDS PYIITFFSAF FVENRISICT 240

EFMDGGSLDV YKRIPEHVLG RIAVAVVKGL TYLWSLKILH RDVKPSNMLV NTRGRVKLCD 300

FGVSTQLVNS IAKTYVGTNA YMAPERISGE QYGIHADVWS AGISFMELAL GMFPYPQIQK 360

NQGSLMPLQL LQCIVDEDPP VLPVSQFSEK FVHFITQCMR RNPKERPAPN NLMDHPFIIQ 420

YNDGNAEVVS MWVCRCLEER RAQLAQGRM 449

Nucleotide Sequence
(FASTA)

TTGCTCTCAC TGAGGTTAAA TACTGACAGC GCAATGAACA CCGAGGCTAT AGTGATCCGT 60

ATAAAAACGC CGTCAGGAGA CATGGACTCG TCCGTGGACT GTCCGTCTCT TCTGAACTTC 120

AATGACTTGC TCGTCGCAAT CAGAGATGTC ATGCCTGAAG CCACTGTCAC GGCCTTTGAA 180

TATGAAGATG AGGTGGGAGA CAGAATCACA GTAAGAAGTG ATGAAGAACT CAAAGCCATG 240

TTGTCATATT ACTGCAACAC AATGAATGAA CAACGCATGA ATGGACTGCT GCCGGACCCT 300

TTGCAGATTT TTCCAAGAGC CGGCAAGACT CCAGGGATCC GGAACATACA TGGCCTGAAG 360

GTTAATACAA GGCCTAACCC AGCAAATGAC TGCAGTCACG CTGTCCCAGA CTCTATAGCT 420

AACAACAGCT TAAAAAAGTC ATCTGCTGAG CTGAAGAGGA TCTTGACAAA TGGCCAGATA 480

AATGCCCAAG ATATCCACTA TCAGGAGCAA CTTGGCCATG GAAACGGAGG CACAGTTTAC 540

AAAGCATACC ACGTTCACGG CAAACGGGTT TTAGCTGTCA AGGTCATTCC CCTGGATATC 600

ACGGTGGAGT TACAGAAGCA AATCATGTCA GAATTAGAAA TTCTCTACAA GTGTGATTCT 660

CCCTACATCA TCACTTTCTT CAGTGCCTTT TTTGTAGAGA ACAGGATATC AATATGCACA 720

GAATTTATGG ACGGTGGCTC ACTGGACGTC TACAAAAGAA TTCCAGAGCA CGTGCTTGGG 780

AGGATTGCTG TGGCGGTAGT CAAAGGCCTG ACGTATCTGT GGAGCCTGAA GATACTTCAC 840

AGAGATGTCA AGCCTTCCAA TATGCTGGTG AACACCCGAG GACGAGTCAA GCTCTGTGAC 900

TTTGGTGTCA GCACACAGCT GGTGAATTCC ATTGCCAAAA CATACGTGGG AACTAATGCA 960

TACATGGCGC CGGAAAGGAT ATCAGGAGAA CAGTATGGGA TCCATGCAGA TGTCTGGAGT 1020

GCGGGCATCT CTTTCATGGA GCTGGCGCTT GGCATGTTCC CGTATCCACA GATTCAGAAA 1080

AACCAAGGAT CTTTAATGCC TCTCCAGTTA CTGCAATGCA TTGTTGATGA GGATCCTCCA 1140

GTTCTTCCTG TCAGCCAGTT TAGCGAAAAG TTTGTTCACT TCATCACTCA ATGCATGAGG 1200

CGGAACCCCA AGGAGAGACC TGCACCCAAT AACCTCATGG ATCATCCCTT CATCATACAG 1260

TATAACGATG GAAATGCGGA GGTGGTGTCG ATGTGGGTGT GCCGCTGTCT GGAGGAGAGG 1320

CGAGCTCAGC TGGCTCAGGG ACGCATGTGA 1350

Domain Profile

S: 2     ekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyiv  61

         +  e+lG+Gngg+V+k+ h + +++lavK i l+i+ e qkqi++ele+l k+ +spyi+

Q: 166   HYQEQLGHGNGGTVYKAYHVHGKRVLAVKVIPLDITVELQKQIMSELEILYKC-DSPYII  224

         56799************************************************.******

S: 62    kfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkek  121

         +f+ af+ e+++sic+e+mdg+sld v+k+       ipe+vlg+iavavvk+l+yl+ +

Q: 225   TFFSAFFVENRISICTEFMDGGSLD-VYKR-------IPEHVLGRIAVAVVKGLTYLW-S  275

         *************************.6775.......9********************.7

S: 122   lkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsv  181

         lki+HRDvKPsN+Lvn++G+vKlCDFGvs+qlv+siAk++vGt++YmaPEri+g ++Y +

Q: 276   LKILHRDVKPSNMLVNTRGRVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISG-EQYGI  334

         8*****************************************************.*****

S: 182   ksdvWslGltlvelatgrypyeklke......ilellkaivneeppklpeeefseefqef  235

         ++dvWs G++++ela g +py++ ++      +l+ll++iv+e+pp+lp ++fse+f++f

Q: 335   HADVWSAGISFMELALGMFPYPQIQKnqgslmPLQLLQCIVDEDPPVLPVSQFSEKFVHF  394

         ************************9999********************************

S: 236   vskClkkdekeRpklkellkhafi  259

         +++C+++++keRp  ++l++h+fi

Q: 395   ITQCMRRNPKERPAPNNLMDHPFI  418

         ***********************7

Domain Sequence
(FASTA)

HYQEQLGHGN GGTVYKAYHV HGKRVLAVKV IPLDITVELQ KQIMSELEIL YKCDSPYIIT 60

FFSAFFVENR ISICTEFMDG GSLDVYKRIP EHVLGRIAVA VVKGLTYLWS LKILHRDVKP 120

SNMLVNTRGR VKLCDFGVST QLVNSIAKTY VGTNAYMAPE RISGEQYGIH ADVWSAGISF 180

MELALGMFPY PQIQKNQGSL MPLQLLQCIV DEDPPVLPVS QFSEKFVHFI TQCMRRNPKE 240

RPAPNNLMDH PFI 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000270	; OPR_PB1.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00564	; PB1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013