EKS-ORN-00385
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00385
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR497.68.7E-150705961257
StatusUnreviewed
Ensembl ProteinENSONIP00000016825
UniProt AccessionI3K6T0;
Protein Name
Protein Synonyms/Alias
Gene NameERBB4 (1 of 2)
Gene Synonyms/Alias ERBB4 (1 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000013385ENSONIP00000016825ENSONIT00000016840
OrganismOreochromis niloticus
Functional Description
Protein Length1414
Protein Sequence
(FASTA)
MKFFPACVLV TLAVIGSCAA QSVCPGTENK LSTLSDLDQQ YRTLKKLYEN CEVVMGNLEI 60
TSIDRNRNLS FLKSIKEVTG YVLVALNQFD YLPLENLRII RGTKLYEGRY ALAIFLNYRR 120
DGLYGLRQLG LRNLTEILNG GVYVDQNKFL CHADTIHWRD IIKNPQAELL VVPSNNSNNG 180
CRRCHRSCNG RCWGHQEDQC QTLTKTVCAE QCDGRCFGPY VSDCCHRECA GGCSGPKDTD 240
CFACTNFNDS GACVTQCPQP FVYNPTSFQL EHNPRAKYTY GAFCVKKCPH NFVVDHSSCV 300
RACPSNKMEV EENRIKMCIP CTDICPKVCD GIGTGSLQSA QTVDASNIDK FVNCTKINGN 360
LIFLITGIKG DMYHGIGPLD PERLNVFRTV KEITGYLNIQ SWPENMTDLS VFSSLATIGG 420
RALYSGSGIS LLILKQRWIS SLQFQSLSEI SAGNVYIFNN SRLCFYNTIN WTSLFRTPSQ 480
KVLVRNNQDP KECIQQRMVC DRMCSDDGCW GPGPDQCLSC RYFKRGRTCV QSCNLFDGEE 540
REFANGSVCL ACDSQCEKMD GNTVTCLGPG PDQCVKCLHF KDGPNCVEKC PDGLQGANSF 600
IFKYAKANNE CHPCHANCTQ GCVGPRLQDC VGMMDRTPLI AAGVIGGLFI IVILALSVAV 660
YVRRKSIKKK RALRRFLETE LVEPLTPSGT APNQAQLRIL KETELKRVKI LGSGAFGTVY 720
KGIWVPEGET VKIPVAIKIL NETTGPKANV EFMDEALIMA SMEHPHLVRL LGVCLSPTIQ 780
LVTQLMPHGC LLDYVHEHKD NIGSQLLLNW CVQIAKGMMY LEERRLVHRD LAARNVLVKS 840
PNHIKITDFG LARLLDGDEK EYNADGGKMP IKWMALECIH YRKFTHQSDV WSYGVTIWEL 900
MTFGGKPYDG IPTREIPDIL EKGERLPQPP ICTIDVYMVM VKCWMIDADS RPKFKELAAE 960
FCRMARDPQR YLVIQGDDRM KLPSPSDSKF FQSLLDEEDL DDLMDAEEYL VPRGFNMATQ 1020
SCTTRPRVDP NRWRTLQKHV NQFGYRDGGL NPAEGPLAGA QACVNQDATG GPSPVLEEQR 1080
CNGSLHKKSL SQAGGEDSGG QRYSADPTIF LGERALRGDT DEDGYMTPMK DKSSSEYLNP 1140
IEENPFVTRR KNGEIHALDN PGYHSTPNSQ PKGEDEYINE PLYLNTFHTP AELGLEALRR 1200
NGLPLPTQPP SSISATTSGS HLPLTIQTSL PHYPLPTAQP SPSGIPCHHG PPTHILHAHH 1260
TVKPAGQPGN PGGGSVAQSQ IGTTAQAQVS QSGALSTSAT IGHGSLPAYQ SYATTHPASL 1320
LKHGGQTSGK ASGKKLKVTF DNPEYWQHSL PPKSSNQAAS DGAQGGSTNA KLFYKQNGHI 1380
RPAVAENPEY MSEFSLKSGT ILPPPPYRQR NTVV 1414
Nucleotide Sequence
(FASTA)
ATGAAGTTCT TCCCAGCTTG CGTCCTCGTC ACTTTGGCGG TGATCGGATC CTGTGCGGCG 60
CAGTCAGTTT GTCCTGGTAC AGAGAACAAA TTGAGCACAC TGTCTGACCT GGACCAGCAG 120
TACCGCACCC TGAAGAAGCT CTACGAGAAC TGCGAAGTCG TCATGGGGAA TCTGGAGATT 180
ACCAGCATTG ATCGAAACCG CAACCTCTCC TTCCTCAAGT CTATCAAAGA AGTGACCGGT 240
TATGTGCTGG TGGCGCTCAA TCAGTTCGAC TACCTGCCAC TGGAGAACCT GCGGATCATC 300
CGAGGCACCA AACTTTACGA GGGTCGGTAC GCTCTGGCCA TCTTCCTGAA CTACAGACGG 360
GACGGTCTGT ACGGACTAAG GCAGCTGGGA TTACGTAACC TCACAGAGAT ACTGAATGGG 420
GGCGTTTATG TTGACCAGAA CAAATTCCTG TGTCACGCAG ACACCATCCA TTGGCGTGAC 480
ATTATCAAGA ACCCCCAAGC TGAGCTGCTG GTGGTGCCAT CCAACAACAG CAACAATGGA 540
TGCAGACGCT GTCATCGCTC ATGTAACGGA CGCTGCTGGG GCCATCAGGA GGACCAGTGT 600
CAAACTTTGA CAAAAACAGT GTGTGCAGAG CAGTGTGACG GTCGATGCTT CGGGCCTTAC 660
GTCAGCGACT GCTGCCATCG CGAATGCGCC GGCGGCTGCT CCGGCCCCAA GGACACGGAC 720
TGCTTCGCTT GCACCAATTT CAACGACAGC GGGGCCTGCG TGACACAGTG CCCTCAGCCC 780
TTTGTGTACA ACCCGACATC CTTCCAGTTA GAGCACAACC CCAGGGCGAA GTACACCTAC 840
GGAGCATTCT GTGTCAAGAA ATGTCCACAT AACTTTGTCG TGGACCACAG CTCCTGTGTG 900
AGAGCATGTC CCAGCAACAA GATGGAAGTG GAGGAGAACC GGATTAAAAT GTGCATCCCT 960
TGCACAGACA TCTGTCCAAA AGTGTGTGAC GGTATAGGGA CAGGAAGCCT GCAGTCAGCT 1020
CAAACAGTGG ACGCCAGCAA TATTGATAAA TTTGTCAACT GCACCAAAAT CAATGGCAAC 1080
CTCATCTTTC TCATTACTGG CATTAAAGGG GATATGTATC ATGGTATTGG ACCTTTGGAC 1140
CCTGAGCGCC TCAACGTGTT CCGCACCGTG AAAGAGATCA CAGGTTACCT CAACATCCAG 1200
TCCTGGCCTG AAAACATGAC AGATCTTAGT GTTTTTTCCA GCCTGGCTAC CATTGGAGGC 1260
AGAGCTCTTT ACAGTGGAAG TGGTATTTCT CTTTTGATCT TGAAGCAGCG TTGGATCTCC 1320
TCCCTCCAGT TCCAGTCGTT GAGTGAGATC AGCGCCGGGA ACGTGTACAT CTTCAACAAC 1380
AGCCGCCTCT GCTTCTATAA CACCATCAAC TGGACGTCGC TATTCAGGAC CCCGAGCCAA 1440
AAAGTCCTCG TCCGTAACAA CCAAGATCCA AAGGAGTGCA TCCAGCAACG AATGGTGTGT 1500
GACCGAATGT GTTCGGACGA TGGCTGTTGG GGACCAGGGC CAGACCAGTG CCTCTCCTGT 1560
CGATATTTCA AGCGAGGCCG TACCTGCGTT CAGTCCTGCA ACCTCTTTGA TGGGGAAGAG 1620
CGTGAATTTG CCAATGGATC CGTGTGCCTG GCGTGCGATA GCCAATGTGA GAAGATGGAT 1680
GGAAACACTG TGACATGTCT CGGTCCGGGC CCAGACCAGT GTGTAAAATG CCTCCACTTC 1740
AAAGACGGCC CTAACTGCGT AGAGAAGTGC CCCGACGGGC TGCAGGGAGC CAACAGTTTC 1800
ATCTTCAAAT ACGCCAAGGC CAACAACGAG TGTCATCCTT GCCATGCCAA TTGCACCCAG 1860
GGGTGCGTCG GGCCAAGACT CCAAGATTGT GTTGGGATGA TGGACAGGAC ACCCCTAATA 1920
GCAGCTGGAG TCATCGGCGG CCTATTCATC ATCGTCATTC TGGCGCTCAG CGTGGCCGTT 1980
TATGTTCGCC GCAAAAGCAT CAAAAAGAAA AGGGCCTTGC GGCGTTTCTT GGAGACAGAG 2040
CTGGTGGAGC CCCTGACCCC CAGTGGAACT GCTCCAAACC AGGCCCAGCT GCGGATCCTG 2100
AAAGAGACAG AGCTGAAGAG GGTGAAGATT TTGGGTTCGG GAGCTTTCGG AACAGTCTAC 2160
AAGGGCATCT GGGTCCCAGA AGGTGAGACG GTGAAGATCC CCGTGGCTAT TAAAATCCTC 2220
AATGAGACCA CCGGTCCTAA AGCCAACGTG GAGTTCATGG ACGAGGCCCT GATCATGGCC 2280
AGCATGGAGC ACCCCCACCT GGTGCGTCTC CTCGGTGTCT GCCTGAGCCC CACCATCCAG 2340
CTGGTCACCC AGCTCATGCC CCACGGCTGC CTCCTCGACT ATGTGCACGA GCACAAGGAC 2400
AACATTGGAT CGCAGCTGCT GCTCAACTGG TGTGTCCAAA TTGCAAAGGG AATGATGTAC 2460
CTGGAGGAGA GGAGGCTGGT CCACAGGGAC CTGGCAGCTC GGAACGTGCT GGTAAAGTCT 2520
CCCAATCACA TCAAGATCAC CGACTTCGGC CTGGCCCGAC TGCTGGACGG CGATGAGAAA 2580
GAATACAACG CAGACGGGGG AAAGATGCCC ATTAAATGGA TGGCTCTGGA GTGCATCCAC 2640
TACAGGAAGT TCACCCATCA GAGTGACGTG TGGAGCTACG GAGTGACCAT CTGGGAGCTG 2700
ATGACATTCG GAGGCAAGCC TTACGATGGG ATCCCCACGC GAGAAATCCC AGACATCCTG 2760
GAAAAAGGCG AGCGCCTGCC CCAGCCGCCA ATTTGCACCA TAGACGTCTA CATGGTCATG 2820
GTCAAATGCT GGATGATTGA TGCAGACAGC AGGCCAAAGT TCAAGGAGCT GGCCGCCGAG 2880
TTCTGCAGAA TGGCCCGTGA CCCACAGCGA TATCTGGTGA TTCAGGGAGA CGACCGCATG 2940
AAGCTTCCCA GTCCCAGTGA CAGCAAGTTC TTCCAGAGCC TGCTGGACGA AGAGGACCTT 3000
GATGACTTGA TGGATGCCGA GGAGTATCTG GTGCCTCGAG GTTTCAACAT GGCCACTCAG 3060
TCGTGCACGA CCAGGCCTCG TGTTGACCCC AACAGGTGGA GAACTTTACA AAAACATGTG 3120
AATCAGTTTG GCTATCGAGA TGGTGGTCTA AATCCTGCAG AAGGACCCTT GGCAGGCGCA 3180
CAAGCTTGTG TGAACCAGGA TGCCACAGGT GGCCCGAGCC CAGTCCTGGA GGAGCAGCGT 3240
TGTAATGGAA GCCTCCATAA GAAGAGCCTG AGCCAGGCTG GAGGGGAAGA CAGTGGGGGT 3300
CAGAGGTACA GTGCTGACCC AACCATCTTT CTGGGGGAGA GAGCACTGAG AGGGGACACT 3360
GATGAGGACG GATACATGAC GCCAATGAAG GACAAGAGCT CCTCAGAATA TCTGAATCCC 3420
ATCGAAGAGA ACCCGTTTGT CACACGACGT AAAAACGGCG AGATCCACGC CCTGGATAAC 3480
CCAGGCTACC ACAGCACACC CAACAGTCAG CCCAAAGGAG AGGACGAGTA CATCAATGAG 3540
CCCCTCTACC TCAACACCTT CCATACCCCC GCTGAGTTGG GCCTGGAAGC CCTGAGGAGA 3600
AATGGTCTGC CCCTACCCAC TCAGCCTCCT TCTTCTATCT CAGCCACAAC CTCAGGCTCC 3660
CATCTTCCGC TTACCATCCA GACTAGCCTG CCCCACTACC CTCTCCCCAC AGCCCAACCA 3720
TCTCCATCTG GCATTCCTTG CCACCATGGT CCACCGACTC ACATCCTCCA TGCCCACCAC 3780
ACCGTCAAAC CTGCAGGGCA ACCTGGCAAT CCAGGTGGCG GCTCTGTTGC TCAGAGCCAA 3840
ATAGGAACTA CTGCTCAAGC TCAGGTGAGC CAGTCGGGTG CCCTGTCCAC TTCAGCCACC 3900
ATCGGGCATG GCAGCCTGCC AGCCTACCAG AGCTACGCCA CCACACACCC TGCCAGTTTG 3960
CTGAAGCATG GAGGGCAGAC ATCAGGTAAA GCCAGCGGGA AGAAGCTAAA GGTGACCTTT 4020
GACAATCCAG AATACTGGCA GCACAGCTTG CCTCCCAAAT CATCTAACCA GGCAGCCTCA 4080
GATGGTGCCC AGGGAGGTTC CACCAACGCC AAGCTCTTCT ATAAGCAGAA TGGACACATA 4140
CGGCCGGCAG TAGCTGAAAA CCCTGAATAC ATGTCTGAGT TTTCCCTGAA ATCTGGAACC 4200
ATCTTGCCAC CTCCACCTTA CCGGCAACGA AACACTGTGG TCTAG 4245
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         lk++k+lGsGafGtvykGiw+pege+vkipvaik+l+e+tg+kan e++deal++as++h
Q: 705   LKRVKILGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMEH  764
         699*********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++lvrllg+cls t+qlvtql+p+Gclldyv+ehkd++Gsq llnwcvqiakGm+ylee+
Q: 765   PHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEER  824
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvkspnh+kitdfGla+ll+ deke++a+ggk+pikw+ale+i++rk+
Q: 825   RLVHRDLAARNVLVKSPNHIKITDFGLARLLDGDEKEYNADGGKMPIKWMALECIHYRKF  884
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvt+wel+tfG kpydgip++eipd+lekGerl+qppictidvymv+vkcw
Q: 885   THQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDILEKGERLPQPPICTIDVYMVMVKCW  944
         ************************************************************
S: 241   midaesrpkfkelaeef  257
         mida+srpkfkela+ef
Q: 945   MIDADSRPKFKELAAEF  961
         ***************99
Domain Sequence
(FASTA)
LKRVKILGSG AFGTVYKGIW VPEGETVKIP VAIKILNETT GPKANVEFMD EALIMASMEH 60
PHLVRLLGVC LSPTIQLVTQ LMPHGCLLDY VHEHKDNIGS QLLLNWCVQI AKGMMYLEER 120
RLVHRDLAAR NVLVKSPNHI KITDFGLARL LDGDEKEYNA DGGKMPIKWM ALECIHYRKF 180
THQSDVWSYG VTIWELMTFG GKPYDGIPTR EIPDILEKGE RLPQPPICTI DVYMVMVKCW 240
MIDADSRPKF KELAAEF 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ciona intestinalis"; ?>Drosophila melanogaster"; ?>Gasterosteus aculeatus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-CII-00175
EKS-DRM-00152
EKS-GAA-00369
EKS-ORA-00263
EKS-ORL-00356
EKS-TEN-00384
EKS-XIM-00381
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 5.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013