EKS-ORN-00243

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00243

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	451.9	8.4E-136	307	576	270

Status

Unreviewed

Ensembl Protein

ENSONIP00000016842

UniProt Accession

I3K6U7;

Protein Name

Protein Synonyms/Alias

Gene Name

LIMK2

Gene Synonyms/Alias

LIMK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000013399	ENSONIP00000016842	ENSONIT00000016857

Organism

Oreochromis niloticus

Functional Description

Protein Length

615

Protein Sequence
(FASTA)

ECCFFSCLLR CSVCCDHLTN WYYEKDGKLY CRNHYWEKFG ELCHGCSLLM TGPAMVAGEH 60

KYHPECFVCL SCKVVIEDRD TYALVERSKL YCGKCYKQKV LTPMLEKRSY DSVLDSLPHT 120

VTLISMPSAA NGKRGLSVSV LRDVNGSASV QVKEVRGMLI SPEVRNAIHV GDRILEINGL 180

PVATLMEQEV DDLIHRTSHT LHLLIEYDPV RHRLDRLRLE SPGNQLGVPA TSRMRMSSPS 240

DTVLERTDVV DDGTLKRRSL RRSNSICKSP GPTSPKDHPF ITRDIGRSES LRSSTSCSHR 300

IFRPCDLIHG EVLGKGFFGQ AIKVTHKATG EVMVMKELIR CDEETQKTFL KEVKVMRSLD 360

HPHVLKFIGV LYKDKRLNLI TEFIEGGTLK DFIRDMDPFP WEQRVSFAKG IASGMAYLHS 420

MSIIHRDLNT HNCLVKLDNT VVVADFGLSR LIVEEKVKPL PEKPTNKKRF RRIDRKKRYT 480

VVGNPYWMAP EMLNGKRYDE KVDIFSFGIV LCEIIGQVYA DPECLPRTLD FGLNVGKFVE 540

KFLPEDCPPA FFPLAVACCD LTPDNRPPFQ KLEDWFAALS LNQELGIPLP AELEELHQSL 600

SRLYWPKDGS PNQSS 615

Nucleotide Sequence
(FASTA)

GAGTGTTGTT TTTTTTCCTG TCTCCTTAGA TGTTCTGTCT GCTGTGACCA CCTGACTAAC 60

TGGTACTATG AGAAGGACGG CAAGCTGTAC TGTCGCAATC ACTACTGGGA AAAGTTTGGA 120

GAGCTCTGTC ATGGTTGCTC TCTGCTCATG ACCGGACCTG CGATGGTGGC TGGAGAACAT 180

AAGTACCATC CTGAGTGTTT TGTTTGCTTG AGCTGCAAGG TGGTCATTGA AGACCGGGAC 240

ACCTACGCTT TAGTCGAGAG GTCAAAACTA TATTGCGGAA AGTGCTACAA GCAGAAGGTT 300

CTCACACCCA TGTTGGAAAA ACGCTCGTAC GACTCGGTCC TGGACTCACT GCCCCACACG 360

GTGACCCTCA TCTCGATGCC TTCTGCAGCC AATGGGAAGA GAGGCCTCTC TGTGTCAGTG 420

CTGAGGGATG TCAATGGCTC AGCGAGTGTT CAGGTCAAAG AGGTCAGAGG GATGCTTATT 480

AGTCCAGAGG TTCGAAATGC CATCCATGTT GGAGACAGGA TTCTGGAGAT CAATGGCCTT 540

CCTGTGGCGA CTTTGATGGA GCAGGAGGTG GATGATCTTA TTCACCGTAC CAGTCACACG 600

CTGCACCTTC TAATAGAGTA CGACCCAGTC AGGCATCGTT TGGACCGGCT AAGGCTGGAA 660

TCACCGGGGA ACCAGCTAGG AGTCCCAGCC ACCTCCCGCA TGCGCATGTC CTCACCATCT 720

GACACGGTGC TGGAGAGAAC AGATGTGGTT GATGATGGCA CACTGAAAAG GAGGTCTTTG 780

AGGCGCAGTA ACAGTATATG CAAGTCACCG GGACCAACTT CTCCTAAAGA CCATCCATTT 840

ATTACACGAG ACATTGGGCG CTCGGAGTCC TTGAGATCCT CCACTAGCTG CTCTCACCGC 900

ATTTTTCGGC CATGTGACCT CATACACGGA GAGGTCTTAG GAAAAGGATT TTTTGGACAG 960

GCGATCAAGG TGACTCATAA AGCCACAGGA GAGGTGATGG TGATGAAGGA GCTGATCCGG 1020

TGTGATGAGG AGACCCAGAA AACTTTCCTT AAAGAGGTCA AAGTAATGCG AAGCCTTGAC 1080

CATCCCCACG TTTTGAAGTT TATCGGCGTG CTATACAAAG ACAAAAGGCT CAATTTGATT 1140

ACTGAGTTTA TTGAGGGCGG TACGCTGAAG GATTTCATCA GAGACATGGA CCCGTTTCCA 1200

TGGGAGCAGA GGGTGAGCTT TGCGAAGGGT ATCGCTTCTG GCATGGCCTA CCTCCACTCA 1260

ATGAGCATCA TCCACAGAGA CCTAAATACT CACAACTGTC TGGTTAAACT GGACAACACT 1320

GTAGTCGTTG CTGATTTCGG ACTGTCCCGA CTCATAGTAG AAGAGAAAGT TAAACCTCTA 1380

CCTGAAAAAC CTACCAATAA GAAACGTTTT AGACGGATTG ATCGAAAGAA GCGGTACACC 1440

GTTGTGGGGA ATCCTTATTG GATGGCTCCA GAGATGCTAA ATGGTAAACG TTACGATGAG 1500

AAGGTGGACA TTTTCTCTTT TGGAATTGTT CTCTGCGAGA TCATTGGACA AGTCTACGCA 1560

GACCCCGAGT GCCTCCCCAG GACTTTGGAC TTTGGCCTAA ATGTTGGCAA GTTTGTGGAG 1620

AAGTTTCTCC CTGAAGACTG CCCACCAGCT TTCTTTCCAC TGGCTGTAGC CTGCTGTGAC 1680

CTCACACCAG ACAACCGTCC ACCTTTTCAG AAGCTTGAGG ACTGGTTTGC AGCTCTGTCA 1740

CTCAATCAGG AGCTGGGAAT CCCCCTGCCT GCCGAACTGG AAGAACTGCA TCAGAGCCTG 1800

AGTCGACTTT ATTGGCCTAA AGACGGCTCT CCAAACCAGA GCTCC 1845

Domain Profile

S: 1     livgeklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlk  60

         li+ge+lGkGff++++kvth+a+Gevmv+kelir+dee++k++lkevk++r+l+hp+vlk

Q: 307   LIHGEVLGKGFFGQAIKVTHKATGEVMVMKELIRCDEETQKTFLKEVKVMRSLDHPHVLK  366

         689*********************************************************

S: 61    fiGvlvkdkklhllteyiegGtlkellkskeslpwtqrvrlakdiasGlsylhskgiihr  120

         fiGvl+kdk+l+l+te+iegGtlk+++++++++pw+qrv++ak+iasG++ylhs++iihr

Q: 367   FIGVLYKDKRLNLITEFIEGGTLKDFIRDMDPFPWEQRVSFAKGIASGMAYLHSMSIIHR  426

         ************************************************************

S: 121   dlnsknclvredksvvvadfGlarlvveerkks.....eklrslkkkdrkkrltvvGsPy  175

         dln++nclv+ d++vvvadfGl+rl+vee+ k+     +++++ ++ drkkr+tvvG+Py

Q: 427   DLNTHNCLVKLDNTVVVADFGLSRLIVEEKVKPlpekpTNKKRFRRIDRKKRYTVVGNPY  486

         ******************************99988888888889999*************

S: 176   wmaPevlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvaed  235

         wmaPe+l+gk ydekvd+fsfGivlceii++v+adP++lPrt dfgl+v +f+ek+ +ed

Q: 487   WMAPEMLNGKRYDEKVDIFSFGIVLCEIIGQVYADPECLPRTLDFGLNVGKFVEKFLPED  546

         ************************************************************

S: 236   cPeaflklavvccdldpesrpsfeelekkl  265

         cP+af++lav ccdl p++rp+f++le+++

Q: 547   CPPAFFPLAVACCDLTPDNRPPFQKLEDWF  576

         ***************************986

Domain Sequence
(FASTA)

LIHGEVLGKG FFGQAIKVTH KATGEVMVMK ELIRCDEETQ KTFLKEVKVM RSLDHPHVLK 60

FIGVLYKDKR LNLITEFIEG GTLKDFIRDM DPFPWEQRVS FAKGIASGMA YLHSMSIIHR 120

DLNTHNCLVK LDNTVVVADF GLSRLIVEEK VKPLPEKPTN KKRFRRIDRK KRYTVVGNPY 180

WMAPEMLNGK RYDEKVDIFS FGIVLCEIIG QVYADPECLP RTLDFGLNVG KFVEKFLPED 240

CPPAFFPLAV ACCDLTPDNR PPFQKLEDWF 270

Keyword

Complete proteome; LIM domain; Metal-binding; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0008270	; F:zinc ion binding

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001781	; Znf_LIM.

Pfam

PF00412	; LIM; 1.
PF00595	; PDZ; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00132	; LIM; 1.
SM00228	; PDZ; 1.

Prosites

PS00478	; LIM_DOMAIN_1; 1.
PS50023	; LIM_DOMAIN_2; 1.
PS50106	; PDZ; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013