EKS-ORN-00308

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00308

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	386.7	5.3E-116	49	300	252

Status

Unreviewed

Ensembl Protein

ENSONIP00000017035

UniProt Accession

I3K7E0;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK2

Gene Synonyms/Alias

MARK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000013549	ENSONIP00000017036	ENSONIT00000017051
ENSONIG00000013549	ENSONIP00000017035	ENSONIT00000017050

Organism

Oreochromis niloticus

Functional Description

Protein Length

790

Protein Sequence
(FASTA)

MSTRPPLVQV IENSTGQESK LSSGRSSTSR GRNSVATTTS DEQPHIGNYR LLKTIGKGNF 60

AKVKLARHVL TGKEVAVKII DKTQLNSSSL QKLFREVRIM KMLNHPNIVK LFEVIETEKT 120

LYLVMEYASG GEVFDYLVAH GRMKEKEARA KFRQIVSAVQ YCHQKCIVHR DLKAENLLLD 180

ADMNIKIADF GFSNEFTLGN KLDTFCGSPP YAAPELFQGK KYDGPEVDVW SLGVILYTLV 240

SGSLPFDGQN LKELRERVLR GKYRIPFYMS TDCENLLKKF LILNPSKRGS LEQIMRDRWM 300

NVGYEEEELK PYIEPQPDYK DPRRTDIMLQ MGFSQEEIQD SLVNQKYNDV MATYLLLDYR 360

NSELDEGGIK PRPGSDVQRS VSSNQKPQNR RTGDQGSSYS KRGGQTDNRS AGEDSGRKGS 420

SGSSTTKVPA SPLASSDRKK SATPSTNSIL STGTGRSRNS PLTDRATLDQ SIQNGKDSLN 480

TPGSRASTAS AAAVLSSSSS SSSRPRHHKS LSSSNHPCPS DLHAPRPSAP AQRAPGASPS 540

AHNISSAAVS DRTNFSRGVG IRSTFHAGQQ RSARDQQGSA YPGGPASPSL SHGNSQARRT 600

HGATGIFSKF TSKFVRKNLS FRFPRRGPYE GEGLDEGSRS VLTSTVDKSE KTSGGLSSSS 660

NNDENNSSPG SGNTGGTGTP PAISSQKDPV KPRSLRFTWS MKTTSSMEPT EMMREIRKVL 720

DSNSCEYELR ERYMLLCMSG KPAHDDFVQW EMEVCKLPRL SLNGVRFKRI SGTSIAFKNI 780

ASKIANELKL 790

Nucleotide Sequence
(FASTA)

ATGTCAACAA GGCCCCCACT GGTTCAAGTC ATTGAAAATT CGACCGGGCA GGAGTCCAAG 60

TTATCATCTG GCCGCTCCAG TACGTCGCGA GGTCGAAACT CCGTGGCCAC GACCACATCA 120

GACGAGCAGC CGCACATCGG TAACTATCGG TTACTGAAAA CCATTGGCAA AGGCAACTTT 180

GCCAAGGTCA AACTGGCACG ACACGTCCTC ACCGGAAAAG AGGTGGCTGT AAAGATCATA 240

GATAAGACAC AGCTCAACTC CTCCAGTTTG CAAAAGCTCT TCCGGGAGGT GAGGATCATG 300

AAGATGTTGA ATCATCCCAA CATAGTCAAG CTCTTTGAGG TGATAGAAAC AGAGAAGACT 360

TTGTACCTGG TAATGGAGTA CGCTAGTGGA GGAGAGGTCT TTGATTACTT GGTGGCTCAT 420

GGCAGGATGA AGGAGAAGGA AGCCCGTGCC AAATTCAGAC AGATTGTGTC AGCTGTGCAG 480

TATTGCCATC AGAAGTGTAT AGTACACAGA GACCTCAAGG CAGAGAACTT GCTGCTGGAC 540

GCAGACATGA ACATCAAAAT AGCCGACTTT GGCTTCAGTA ATGAATTTAC TCTGGGGAAC 600

AAGCTGGACA CATTCTGTGG CTCCCCGCCC TACGCAGCTC CAGAGCTCTT CCAGGGCAAA 660

AAGTACGACG GGCCTGAGGT GGATGTCTGG AGCCTCGGAG TGATCCTCTA CACACTGGTC 720

AGCGGCTCGC TGCCCTTCGA TGGACAAAAC CTCAAGGAAC TGAGAGAGCG TGTGCTGCGT 780

GGTAAATACA GGATTCCTTT CTATATGTCC ACCGACTGTG AGAACCTGCT CAAAAAGTTC 840

CTCATCCTGA ACCCTTCAAA AAGAGGCAGC CTCGAGCAGA TAATGAGAGA CCGGTGGATG 900

AATGTGGGCT ATGAGGAAGA GGAACTCAAA CCCTACATCG AACCTCAGCC AGATTATAAG 960

GACCCCAGGA GGACAGACAT CATGCTGCAG ATGGGATTCT CTCAGGAGGA GATCCAGGAC 1020

TCGCTGGTAA ACCAGAAGTA CAACGACGTG ATGGCCACAT ACCTGCTTCT GGACTATAGG 1080

AACTCTGAGC TTGATGAAGG TGGCATCAAA CCTCGGCCCG GAAGTGATGT ACAGCGCAGT 1140

GTGTCATCCA ACCAGAAGCC TCAGAACCGC CGAACCGGCG ACCAGGGCTC CTCCTATTCT 1200

AAAAGGGGAG GTCAGACAGA CAACCGGTCA GCAGGGGAGG ATTCTGGGAG GAAGGGTTCA 1260

TCAGGCAGCT CCACCACCAA GGTGCCGGCC AGTCCTCTGG CCTCGTCCGA CCGCAAGAAG 1320

AGTGCCACAC CCTCCACCAA TAGCATCCTG TCCACCGGTA CCGGCCGCAG TCGGAATTCT 1380

CCTCTGACCG ACAGAGCCAC TCTCGACCAG AGCATCCAGA ACGGCAAAGA CAGCCTAAAC 1440

ACTCCGGGTT CCCGCGCCTC CACTGCCTCA GCCGCTGCCG TCCTCTCCTC CTCCTCCTCC 1500

TCATCCTCGC GTCCCCGCCA CCACAAGTCC CTGTCCTCCT CCAATCATCC ATGCCCCTCT 1560

GACCTGCACG CACCACGGCC CAGTGCCCCG GCGCAGCGGG CACCCGGCGC CTCCCCTTCT 1620

GCCCACAACA TCAGCAGCGC CGCCGTGTCA GACCGTACCA ATTTCTCCAG AGGGGTGGGC 1680

ATCCGCAGCA CGTTCCACGC AGGTCAGCAG CGGAGTGCCC GGGACCAGCA GGGCTCCGCC 1740

TACCCCGGCG GGCCTGCTTC TCCATCACTG TCGCATGGCA ACAGCCAGGC CCGAAGAACA 1800

CATGGCGCCA CGGGGATTTT CAGCAAGTTC ACATCCAAGT TTGTACGCAA AAATCTCTCG 1860

TTCAGGTTTC CGAGAAGGGG TCCATATGAG GGAGAGGGTC TTGATGAGGG GAGCAGGTCT 1920

GTGCTGACCA GTACTGTAGA CAAGTCCGAG AAGACGTCCG GTGGTTTGTC CTCCTCTTCT 1980

AACAACGATG AGAACAACTC GTCCCCAGGA TCTGGAAACA CTGGTGGCAC TGGCACCCCT 2040

CCCGCCATCT CCAGCCAGAA GGACCCTGTC AAGCCGCGCT CGCTGCGCTT CACCTGGTCC 2100

ATGAAGACCA CGTCGTCCAT GGAGCCCACG GAGATGATGC GCGAGATCCG CAAGGTGCTC 2160

GACTCCAACA GCTGCGAGTA CGAGCTGCGC GAGCGCTACA TGCTGCTGTG CATGTCCGGG 2220

AAACCGGCGC ACGACGATTT CGTCCAGTGG GAAATGGAGG TGTGCAAGCT GCCGCGACTC 2280

TCCCTCAACG GCGTGCGCTT CAAGCGGATC TCGGGCACGT CCATCGCCTT CAAGAACATT 2340

GCCTCAAAGA TCGCCAACGA GCTCAAACTG TGA 2373

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+llkt+G+g+f+kVkla+h +t+++vavKii+k++l+++sl+k++rE++i+k+l+hpni

Q: 49    YRLLKTIGKGNFAKVKLARHVLTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKMLNHPNI  108

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lylv+eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k iv

Q: 109   VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIV  168

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 169   HRDLKAENLLLDADMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVD  228

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+k+L  +p+kR

Q: 229   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKR  288

         ************************************************************

S: 241   atieeilkhewl  252

          ++e+i++++w+

Q: 289   GSLEQIMRDRWM  300

         ***********8

Domain Sequence
(FASTA)

YRLLKTIGKG NFAKVKLARH VLTGKEVAVK IIDKTQLNSS SLQKLFREVR IMKMLNHPNI 60

VKLFEVIETE KTLYLVMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKCIV 120

HRDLKAENLL LDADMNIKIA DFGFSNEFTL GNKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK KFLILNPSKR 240

GSLEQIMRDR WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013