EKS-ORN-00367
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00367
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR374.64.0E-112208499292
StatusUnreviewed
Ensembl ProteinENSONIP00000017402
UniProt AccessionI3K8F7;
Protein Name
Protein Synonyms/Alias
Gene NameTGFBR2 (2 of 2)
Gene Synonyms/Alias TGFBR2 (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000013839ENSONIP00000017402ENSONIT00000017417
OrganismOreochromis niloticus
Functional Description
Protein Length529
Protein Sequence
(FASTA)
QLHELCKFCD VEPTSCNGTG ICKTDCSISS ICEKPTEVCV SIWRRNETNL SIETLCHNPA 60
EPLYGITLDD YNSTTCVMKE KNTTTGLAHF CSCKGAECNE ELIFSQIFDY TEMSPGLFQV 120
NIQYINIYML PLLVMVIAFF GMFYWCRIHR QRRPNRQWES SFNFKRKPIA GGLDCSDACA 180
IMTDDDKSDS SSTHANSLNH NTEPLPIELD LLVGKGRFAQ VYKAKLKQTT WNQFETVAVK 240
IFPYEEYASW KNEKDIFSNT DLRHENILHF LTAEERKVEK QYWLITAFHP RGNLQEYLTH 300
HVISWQELQV LSSSLARGVA HLHSDRLPCG RPKVPIVHRD LKSSNILVKN DGTCCVCDFG 360
LGLCLDSSLS VDDLANSGQV GTARYMAPEV LEARLNLENI ESFKQTDIYS MALVLWEMTS 420
RCEAIGEVKD YEPAYGSKVR EHPCVESMKD NVLRDRGRPE IPDSWLRHQG MAVMCATIKE 480
CWDHDPEARL TAHCIAERIS ELEDEMGKLS SRSSSAEKIV EELKIPIEV 529
Nucleotide Sequence
(FASTA)
CAACTACATG AACTTTGTAA ATTCTGTGAT GTGGAGCCTA CCTCCTGCAA TGGCACAGGT 60
ATCTGCAAGA CCGACTGCAG CATCTCATCC ATATGTGAAA AACCAACTGA GGTCTGTGTT 120
TCTATCTGGA GAAGGAACGA AACAAACTTG TCCATCGAAA CACTCTGCCA CAACCCAGCA 180
GAGCCGTTGT ACGGCATTAC TCTGGATGAC TACAACAGCA CCACCTGTGT GATGAAGGAA 240
AAGAACACAA CAACGGGGTT GGCTCATTTC TGCTCCTGTA AAGGAGCAGA GTGCAACGAA 300
GAGCTAATAT TCTCCCAAAT ATTTGACTAC ACAGAGATGT CGCCTGGTCT CTTCCAAGTC 360
AATATTCAAT ATATTAACAT TTACATGCTG CCCCTGCTGG TGATGGTGAT CGCGTTTTTT 420
GGAATGTTCT ACTGGTGCAG AATCCATCGG CAGAGGCGTC CCAACCGCCA ATGGGAGAGC 480
AGCTTTAACT TTAAGCGCAA GCCGATAGCC GGTGGGCTGG ACTGCAGTGA CGCCTGCGCC 540
ATCATGACAG ATGATGATAA GTCAGACAGC AGCTCAACTC ATGCCAACAG CCTGAACCAC 600
AACACAGAGC CGCTGCCTAT AGAGCTGGAT CTGCTGGTGG GAAAGGGTCG CTTTGCTCAG 660
GTATACAAGG CTAAATTGAA GCAGACTACA TGGAATCAGT TTGAAACAGT AGCTGTAAAG 720
ATCTTCCCCT ATGAAGAGTA TGCATCCTGG AAGAACGAGA AGGACATTTT CTCCAACACA 780
GACCTCAGAC ATGAGAATAT CCTCCACTTC CTGACAGCTG AGGAGCGGAA GGTGGAGAAA 840
CAGTACTGGC TTATCACGGC CTTCCACCCC AGAGGAAACC TACAGGAGTA CCTGACGCAT 900
CACGTGATCA GCTGGCAGGA GCTGCAGGTG TTGAGCAGCT CTCTGGCACG AGGTGTCGCA 960
CATCTCCACA GTGATCGCCT CCCCTGTGGA CGCCCTAAGG TGCCGATAGT CCATCGAGAC 1020
CTAAAGAGCT CCAACATCTT GGTGAAGAAC GACGGGACGT GCTGTGTTTG TGACTTTGGC 1080
CTGGGACTCT GTCTGGACAG CAGCCTGTCA GTGGATGACC TTGCCAACAG TGGACAGGTG 1140
GGCACTGCGC GCTATATGGC ACCAGAGGTG CTGGAGGCCC GACTAAATCT GGAGAACATC 1200
GAGTCTTTCA AGCAGACTGA CATTTACTCC ATGGCTCTGG TCCTGTGGGA GATGACGTCA 1260
AGGTGTGAAG CTATTGGAGA GGTAAAGGAT TACGAGCCGG CGTATGGCTC TAAAGTGCGA 1320
GAGCACCCCT GTGTGGAGAG CATGAAGGAC AATGTGCTGA GAGACAGAGG GAGGCCTGAG 1380
ATCCCCGACA GCTGGCTCAG GCACCAGGGC ATGGCAGTGA TGTGCGCCAC CATTAAGGAA 1440
TGCTGGGACC ACGATCCCGA GGCCCGCCTC ACCGCACACT GCATTGCCGA ACGCATCTCT 1500
GAGCTGGAAG ACGAGATGGG CAAGCTGTCC AGCCGGAGCT CCTCGGCGGA GAAGATTGTA 1560
GAGGAACTGA AGATCCCAAT AGAGGTG 1587
Domain Profile
S: 2     klleligkGrygeVwkaklrg......eevAvKifstedeaswkrEkeiyqtvllrheni  55
         +l  l+gkGr+++V+kakl++      e+vAvKif++e+ aswk+Ek+i++++ lrheni
Q: 208   ELDLLVGKGRFAQVYKAKLKQttwnqfETVAVKIFPYEEYASWKNEKDIFSNTDLRHENI  267
         66778***************9999999*********************************
S: 56    lqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHee  115
         l+f++a++++  ++++++l+t++h++g+L++yL++++++++el  l +sla+G+ahLH++
Q: 268   LHFLTAEERK--VEKQYWLITAFHPRGNLQEYLTHHVISWQELQVLSSSLARGVAHLHSD  325
         *******977..779*********************************************
S: 116   ivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkR  175
          +  +g+ K  i+HRDlks Nilvk+d+tcc++D+GL l l+++ ++ dla++ qvGt R
Q: 326   -RLPCGRPKVPIVHRDLKSSNILVKNDGTCCVCDFGLGLCLDSSLSVDDLANSGQVGTAR  384
         .577899*****************************************************
S: 176   YmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdP  235
         YmaPEvle +lnl+++e+fk++D+Ys++LvlWE++sRce+  +ev++y++++ ++v+++P
Q: 385   YMAPEVLEARLNLENIESFKQTDIYSMALVLWEMTSRCEA-IGEVKDYEPAYGSKVREHP  443
         ****************************************.999****************
S: 236   sleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291
         ++e+mk+ v++++ rP+ip++w +++ +++++ +++ecWd+dpeaRlta+++++r+
Q: 444   CVESMKDNVLRDRGRPEIPDSWLRHQGMAVMCATIKECWDHDPEARLTAHCIAERI  499
         ****************************************************9985
Domain Sequence
(FASTA)
ELDLLVGKGR FAQVYKAKLK QTTWNQFETV AVKIFPYEEY ASWKNEKDIF SNTDLRHENI 60
LHFLTAEERK VEKQYWLITA FHPRGNLQEY LTHHVISWQE LQVLSSSLAR GVAHLHSDRL 120
PCGRPKVPIV HRDLKSSNIL VKNDGTCCVC DFGLGLCLDS SLSVDDLANS GQVGTARYMA 180
PEVLEARLNL ENIESFKQTD IYSMALVLWE MTSRCEAIGE VKDYEPAYGS KVREHPCVES 240
MKDNVLRDRG RPEIPDSWLR HQGMAVMCAT IKECWDHDPE ARLTAHCIAE RI 292
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00266
EKS-ANC-00272
EKS-BOT-00284
EKS-CAJ-00290
EKS-CAF-00290
EKS-CAP-00319
EKS-DAR-00626
EKS-EQC-00276
EKS-ERE-00022
EKS-FEC-00270
EKS-GAM-00178
EKS-GAG-00237
EKS-GAA-00348
EKS-GOG-00283
EKS-HOS-00290
EKS-ICT-00268
EKS-LAC-00295
EKS-LOA-00294
EKS-MAM-00286
EKS-MEG-00224
EKS-MOD-00279
EKS-MUM-00315
EKS-MUP-00279
EKS-MYL-00286
EKS-NOL-00262
EKS-OCP-00027
EKS-ORA-00245
EKS-ORC-00266
EKS-OTG-00289
EKS-PAT-00268
EKS-PES-00253
EKS-PEM-00154
EKS-POA-00275
EKS-RAN-00300
EKS-SAH-00266
EKS-SUS-00252
EKS-TAG-00296
EKS-TAR-00368
EKS-TAS-00020
EKS-TEN-00368
EKS-TUT-00042
EKS-XET-00356
EKS-XIM-00362
Gene Ontology
GO:0016021; C:integral to membrane
GO:0043235; C:receptor complex
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004702; F:receptor signaling protein serine/threonine kinase activity
GO:0005026; F:transforming growth factor beta receptor activity, type II
GO:0023014; P:signal transduction by phosphorylation
GO:0007179; P:transforming growth factor beta receptor signaling pathway
KEGG
InterPros
IPR000333; Activin_II/TGFBeta-II_recpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
IPR017194; Transform_growth_fac-b_typ-2.
IPR015013; Transforming_GF_b_rcpt_2_ecto.
Pfam
PF08917; ecTbetaR2; 1.
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR00653; ACTIVIN2R.
Created Date20-Feb-2013