EKS-ORN-00207
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00207
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKG473.51.9E-142464722259
StatusUnreviewed
Ensembl ProteinENSONIP00000017651
UniProt AccessionI3K956;
Protein NamecGMP-dependent protein kinase
Protein Synonyms/Alias
Gene NamePRKG2
Gene Synonyms/Alias PRKG2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000014042ENSONIP00000017651ENSONIT00000017666
OrganismOreochromis niloticus
Functional Description
Protein Length773
Protein Sequence
(FASTA)
MGNGSMKSKR YKHTDGCAHK DHGGGFKNST LDFLRARVEE LEREGKRKDE ELCVKEQQIK 60
GLQEQLAKHT RVLAEMSEEL QSKCIQLNKL QDVMKSGASA GLASRPPSVK VSSRGSPNLS 120
IRIKETLNRR KGAKAGVSAE PTSRTYDSSG LPKFSFEKAR VPKDASVKKL LTDALNKNQY 180
LKRLELQQIK DMVECMYEHT YQQGEYVIKQ GEPGNHLFVL ADGKLDVFQH NKLITSITVW 240
TAFGELAILY NCTRTASVRA VNKVRTWVLD REVFQNIMRR TAETRHEQYR NFLRSVSLLA 300
NLPEDKLSKI VDCLEVEYYD KGEYVIREGE EGSTFYIIAQ GKVKVTQTTE AHKLPQIINT 360
LQRGDYFGEK ALISDDVRSA NIIADENGVE CLVIDRETFD QTVGTFNELQ KYLQGYVATL 420
DRDDKKRHAK RSVSRHQSQP LSPDVIQLKE LVSKFSSSRP FDHLEVIATL GVGGFGRVEL 480
VKVKGEDITF ALKVIKKKHV VDNRQEEHIH SERRILAEAR SPFVVKLYRT FKDNKYVYML 540
LEACLGGEVW SLLRDRGSFD EPAAKFCVGC VTEAFEYLHR KGVLYRDLKP ENLILDSEGY 600
IKLVDFGFAK KIRCGQKTWT FCGTPEYVAP EIILNKGHNF SVDFWSLGIL VFELLTGSPP 660
FSGIDQMMTY TFILRGIEKM DFPKKITKRP EDLIRKLCRR NPSERLGNLK NGITDIKKHR 720
WFNGFNWEGL KARTLPSPLK RELTGPTDHS YFDSYPPDED SPPDELSGWD MDF 773
Nucleotide Sequence
(FASTA)
ATGGGGAACG GTTCAATGAA ATCAAAGCGC TACAAACACA CTGACGGCTG TGCGCACAAA 60
GATCATGGCG GTGGGTTCAA AAACTCGACC CTGGATTTCC TGAGGGCCCG GGTGGAGGAG 120
CTGGAGCGAG AGGGCAAGAG GAAGGATGAG GAGCTTTGTG TCAAAGAGCA GCAGATCAAA 180
GGTCTCCAGG AGCAGCTGGC CAAACACACG CGAGTGCTGG CCGAGATGAG CGAGGAGCTG 240
CAGAGTAAGT GCATCCAGCT CAACAAACTG CAGGACGTGA TGAAGAGCGG AGCATCGGCG 300
GGTCTTGCTT CGAGGCCTCC TTCAGTCAAA GTCAGCAGCA GAGGCAGCCC CAACCTCAGC 360
ATTCGCATCA AGGAAACCCT GAACAGAAGG AAAGGCGCCA AAGCCGGGGT ATCTGCCGAA 420
CCCACATCCA GAACATACGA CTCCAGCGGT CTGCCGAAGT TCTCCTTTGA GAAGGCTCGG 480
GTACCAAAGG ATGCAAGTGT GAAGAAGCTG CTGACAGATG CCCTCAACAA GAACCAATAC 540
CTGAAGAGGC TGGAGCTGCA GCAGATCAAA GACATGGTGG AGTGCATGTA TGAGCACACT 600
TACCAGCAGG GAGAGTACGT CATCAAGCAG GGAGAGCCTG GGAACCATCT GTTTGTCCTG 660
GCAGATGGGA AGCTGGATGT GTTTCAGCAT AACAAACTGA TCACGTCGAT AACGGTGTGG 720
ACTGCGTTTG GGGAGTTAGC CATTCTGTAC AACTGCACGC GGACCGCATC AGTGCGAGCT 780
GTGAACAAAG TGAGGACGTG GGTTTTGGAT CGGGAAGTTT TCCAGAACAT TATGAGGAGG 840
ACGGCCGAGA CACGACACGA ACAGTATCGC AACTTCCTCC GAAGTGTTTC ACTTTTGGCT 900
AATCTACCAG AGGACAAGCT AAGCAAAATA GTGGACTGCC TGGAGGTGGA ATACTATGAC 960
AAAGGCGAGT ACGTCATCCG GGAGGGAGAG GAGGGCAGCA CCTTTTACAT CATCGCACAA 1020
GGAAAGGTGA AAGTGACCCA GACCACCGAG GCCCACAAGC TGCCACAGAT CATCAACACA 1080
CTGCAGAGGG GAGACTACTT TGGAGAAAAA GCACTTATAA GTGACGACGT CAGGTCCGCC 1140
AATATCATTG CCGATGAGAA CGGGGTGGAG TGCCTTGTCA TCGACAGAGA GACATTTGAT 1200
CAGACAGTGG GCACCTTCAA TGAGCTGCAG AAGTACCTCC AAGGGTACGT GGCAACACTC 1260
GATCGCGACG ACAAGAAGAG ACATGCCAAG AGGTCTGTGT CACGCCACCA AAGTCAGCCT 1320
CTGTCTCCTG ACGTCATCCA GCTGAAGGAA CTGGTTTCCA AATTCTCTTC ATCCAGGCCC 1380
TTTGATCACC TGGAGGTCAT TGCTACCCTT GGGGTCGGCG GGTTCGGACG AGTAGAACTG 1440
GTGAAGGTGA AGGGTGAGGA TATCACCTTT GCACTCAAGG TCATCAAAAA GAAGCACGTG 1500
GTGGACAACA GGCAGGAAGA ACACATCCAC TCGGAGAGGA GGATCCTCGC AGAGGCTCGC 1560
TCGCCTTTCG TAGTCAAACT GTATCGCACA TTCAAGGATA ACAAATATGT GTACATGCTG 1620
CTGGAGGCCT GTCTGGGTGG AGAGGTCTGG AGTCTGCTCA GGGACAGGGG CAGCTTTGAT 1680
GAACCTGCTG CTAAATTCTG CGTGGGCTGT GTCACGGAGG CTTTCGAGTA CCTCCACCGG 1740
AAAGGTGTTC TCTACAGAGA CCTGAAGCCT GAGAACCTCA TTCTGGATTC TGAAGGATAC 1800
ATCAAACTGG TCGACTTTGG TTTTGCCAAG AAGATCAGAT GTGGCCAGAA GACTTGGACC 1860
TTCTGTGGCA CTCCAGAGTA TGTGGCACCG GAGATCATCC TCAACAAAGG CCACAACTTC 1920
AGTGTGGACT TCTGGTCTTT GGGCATCCTG GTGTTTGAGC TTCTTACCGG CAGTCCTCCG 1980
TTCTCAGGAA TTGACCAGAT GATGACGTAC ACTTTCATCT TGAGAGGCAT TGAGAAGATG 2040
GACTTCCCGA AGAAGATAAC AAAGAGACCG GAGGACCTCA TACGCAAGCT ATGCAGGCGG 2100
AACCCCTCAG AGCGACTGGG TAATCTCAAA AATGGAATAA CTGATATTAA GAAGCACAGG 2160
TGGTTTAATG GCTTCAACTG GGAGGGGCTG AAGGCAAGGA CGTTACCATC GCCACTGAAA 2220
AGAGAACTTA CAGGACCAAC AGATCACAGT TACTTCGACA GCTACCCTCC AGATGAGGAC 2280
AGTCCTCCTG ATGAGCTGTC TGGTTGGGAC ATGGACTTCT GA 2322
Domain Profile
S: 1     lkviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksd  60
         l+viatlgvggfgrvelvkvk  e  +falk++kkkh+vd++q+eh+ se+ril ea+s+
Q: 464   LEVIATLGVGGFGRVELVKVKG-EDITFALKVIKKKHVVDNRQEEHIHSERRILAEARSP  522
         689******************9.889**********************************
S: 61    fivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskn  120
         f+vklyrtfkd+kyvy+lleaclgge+w++lrdrgsfd+ +akf+v+cv+ea+eylh+k+
Q: 523   FVVKLYRTFKDNKYVYMLLEACLGGEVWSLLRDRGSFDEPAAKFCVGCVTEAFEYLHRKG  582
         ************************************************************
S: 121   iiyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsv  180
         ++yrdlkpenl+ld+egy+klvdfgfakk++ g+ktwtfcgtpeyvapeiilnkgh++sv
Q: 583   VLYRDLKPENLILDSEGYIKLVDFGFAKKIRCGQKTWTFCGTPEYVAPEIILNKGHNFSV  642
         ************************************************************
S: 181   dywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnp  240
         d+w+lgilv+elltg+ppfsg+d+++ty+ il+gi+k+++p+kitk++edli+klcr np
Q: 643   DFWSLGILVFELLTGSPPFSGIDQMMTYTFILRGIEKMDFPKKITKRPEDLIRKLCRRNP  702
         ************************************************************
S: 241   aerlgylkggikdikkhkwf  260
         +erlg+lk+gi+dikkh+wf
Q: 703   SERLGNLKNGITDIKKHRWF  722
         *******************9
Domain Sequence
(FASTA)
LEVIATLGVG GFGRVELVKV KGEDITFALK VIKKKHVVDN RQEEHIHSER RILAEARSPF 60
VVKLYRTFKD NKYVYMLLEA CLGGEVWSLL RDRGSFDEPA AKFCVGCVTE AFEYLHRKGV 120
LYRDLKPENL ILDSEGYIKL VDFGFAKKIR CGQKTWTFCG TPEYVAPEII LNKGHNFSVD 180
FWSLGILVFE LLTGSPPFSG IDQMMTYTFI LRGIEKMDFP KKITKRPEDL IRKLCRRNPS 240
ERLGNLKNGI TDIKKHRWF 259
KeywordATP-binding; cGMP; cGMP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00158
EKS-ANC-00160
EKS-BOT-00166
EKS-CAF-00173
EKS-CAP-00165
EKS-DAR-00456
EKS-EQC-00165
EKS-FEC-00155
EKS-GAM-00085
EKS-GAG-00142
EKS-GAA-00197
EKS-GOG-00165
EKS-ICT-00161
EKS-LAC-00176
EKS-LOA-00165
EKS-MAM-00164
EKS-MEG-00131
EKS-MOD-00165
EKS-MUM-00171
EKS-MUP-00170
EKS-MYL-00174
EKS-NOL-00159
EKS-ORC-00153
EKS-ORL-00192
EKS-OTG-00172
EKS-PAT-00157
EKS-PEM-00088
EKS-POA-00162
EKS-PTV-00148
EKS-RAN-00162
EKS-SAH-00159
EKS-SUS-00145
EKS-TAG-00195
EKS-TAR-00214
EKS-VIP-00079
EKS-XET-00154
EKS-XIM-00202
Gene Ontology
GO:0005524; F:ATP binding
GO:0030553; F:cGMP binding
GO:0004692; F:cGMP-dependent protein kinase activity
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR016232; cGMP-dependent_protein_kinase.
IPR002374; cGMP_dep_kinase.
IPR018490; cNMP-bd-like.
IPR018488; cNMP-bd_CS.
IPR000595; cNMP-bd_dom.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR014710; RmlC-like_jellyroll.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00027; cNMP_binding; 2.
PF00069; Pkinase; 1.
SMARTs
SM00100; cNMP; 2.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00888; CNMP_BINDING_1; 2.
PS00889; CNMP_BINDING_2; 2.
PS50042; CNMP_BINDING_3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR00104; CGMPKINASE.
Created Date20-Feb-2013