EKS-ORN-00093

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00093

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	337.5	7.4E-101	26	335	310

Status

Unreviewed

Ensembl Protein

ENSONIP00000017757

UniProt Accession

I3K9G2;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK8

Gene Synonyms/Alias

CDK8;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000014123	ENSONIP00000017757	ENSONIT00000017772

Organism

Oreochromis niloticus

Functional Description

Protein Length

464

Protein Sequence
(FASTA)

MDYDFKVKLT GERERVEDLF EYEGCKVGRG TYGHVYKAKR KDGKDDKDYA LKQIEGTGIS 60

MSACREIALL RELKHPNVIS LQKVFLSHAD RKVWLLFDYA EHDLWHIIKF HRASKANKKP 120

LQLPRGMVKS LLYQILDGIH YLHANWVLHR DLKPANILVM GEGPERGRVK IADMGFARLF 180

NSPLKPLADL DPVVVTFWYR APELLLGARH YTKAIDIWAI GCIFAELLTS EPIFHCRQED 240

IKTSNPYHHD QLDRIFNVMG FPADKDWEDI KKMPEHSTLM KDFRRNTYTN CSLIKYMEKH 300

KVKPDSKAFH LLQKLLTMDP IRRITSEQAM QDPYFLEEPL PTSDVFAGCQ IPYPKREFLT 360

EEEPEDKADK KNQQQQQGNN HTNGAGHTGN PDNSHAQGPP LKKVRVVPPT TTSGGLIMTS 420

DYQRSNPHAA YQNPGPSTSL PQSSMGYSST SQQPPQYSHQ THRY 464

Nucleotide Sequence
(FASTA)

ATGGACTATG ATTTTAAAGT GAAGCTGACC GGCGAAAGAG AGCGTGTCGA GGACCTGTTT 60

GAGTACGAAG GATGCAAAGT GGGTAGAGGC ACCTACGGCC ATGTATACAA GGCGAAGAGA 120

AAAGATGGGA AGGATGATAA GGACTACGCC CTCAAGCAGA TTGAAGGCAC TGGCATCTCC 180

ATGTCAGCCT GCAGAGAGAT TGCACTGCTG CGGGAGCTGA AGCACCCCAA TGTCATCTCA 240

CTGCAGAAGG TTTTCCTGTC ACATGCTGAC CGTAAAGTAT GGCTGCTCTT TGACTATGCT 300

GAACATGATC TCTGGCACAT TATTAAGTTC CACAGAGCAT CTAAGGCCAA CAAGAAGCCG 360

CTTCAGTTGC CTAGAGGAAT GGTGAAGTCT CTGCTCTATC AGATTCTGGA TGGCATCCAT 420

TACCTTCACG CTAACTGGGT CCTTCATAGA GATCTTAAAC CAGCGAACAT TTTAGTGATG 480

GGGGAAGGGC CAGAGAGGGG TAGAGTAAAG ATTGCGGACA TGGGGTTTGC TCGTCTCTTC 540

AATTCACCGC TGAAGCCTTT AGCCGATCTC GACCCTGTGG TGGTCACCTT CTGGTACAGA 600

GCACCTGAAC TGCTCCTGGG AGCTCGGCAC TACACCAAAG CCATCGACAT CTGGGCGATT 660

GGCTGCATTT TTGCGGAGCT GCTGACGTCT GAGCCCATAT TCCACTGTCG CCAGGAGGAT 720

ATCAAGACCA GTAACCCTTA CCATCATGAC CAGCTGGACC GCATCTTTAA TGTCATGGGC 780

TTCCCTGCCG ATAAAGACTG GGAGGACATC AAAAAGATGC CAGAACACTC CACGCTGATG 840

AAAGACTTTA GGAGGAACAC ATACACAAAC TGCAGCCTTA TAAAGTACAT GGAAAAACAT 900

AAAGTTAAAC CAGACAGCAA AGCATTCCAC TTGCTGCAAA AGCTATTGAC CATGGACCCC 960

ATCCGTAGAA TCACATCCGA GCAGGCCATG CAGGACCCCT ACTTTTTAGA GGAGCCTTTA 1020

CCCACCTCTG ATGTGTTTGC AGGCTGCCAG ATTCCCTACC CCAAGAGGGA GTTTCTGACA 1080

GAGGAGGAGC CAGAGGACAA GGCAGACAAA AAAAACCAGC AGCAGCAACA GGGAAATAAC 1140

CACACAAATG GAGCGGGGCA CACAGGCAAC CCAGACAACA GCCACGCCCA GGGCCCGCCT 1200

CTAAAGAAAG TGCGAGTTGT CCCGCCCACC ACTACCTCAG GTGGCCTCAT TATGACCTCA 1260

GACTACCAGC GCTCCAATCC ACATGCTGCC TACCAGAACC CTGGACCAAG CACATCACTG 1320

CCCCAGAGCA GCATGGGATA TTCCTCTACC TCCCAACAGC CGCCCCAGTA CTCCCACCAG 1380

ACCCACCGCT ACTGA 1395

Domain Profile

S: 6     kigeGtygkvykakdke..tgevvAlKkirlekekegvpitalrEisllkelkhknivkL  63

         k+g+Gtyg+vykak+k+  +++ +AlK+i    e +g++++a+rEi+ll+elkh+n+++L

Q: 26    KVGRGTYGHVYKAKRKDgkDDKDYALKQI----EGTGISMSACREIALLRELKHPNVISL  81

         79************986447778******....999************************

S: 64    levva.kdkkklyLvfefleqdLkkllkkkkkk.......klsleevkslllqlleglay  115

         ++v+  ++++k++L+f+++e+dL++++k ++++       +l++ +vksll+q+l+g++y

Q: 82    QKVFLsHADRKVWLLFDYAEHDLWHIIKFHRASkankkplQLPRGMVKSLLYQILDGIHY  141

         ****94555*********************9999999*9*********************

S: 116   lHsnkilHRDlKpqNlLiske....gklklaDfGlarafssplk...tytkevvTlwYra  168

         lH+n++lHRDlKp+N+L++ e    g++k+aD+G+ar f+splk   +++++vvT+wYra

Q: 142   LHANWVLHRDLKPANILVMGEgperGRVKIADMGFARLFNSPLKplaDLDPVVVTFWYRA  201

         *******************9988889*************99999665699**********

S: 169   PelLlgakeYstavDiWsvgcilaelltrkplfqgkse.........idqlerifkllgt  219

         PelLlga++Y++a+DiW++gci+aellt++p+f++++e         +dql+rif+++g

Q: 202   PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEdiktsnpyhHDQLDRIFNVMGF  261

         ************************************************************

S: 220   psekvwpevsklpeyk...ksfpkkkkk..klkekvkklk....ekaldllekllaldpk  270

         p +k+w++++k+pe++   k+f++++++  +l ++++k k    +ka++ll+kll++dp

Q: 262   PADKDWEDIKKMPEHStlmKDFRRNTYTncSLIKYMEKHKvkpdSKAFHLLQKLLTMDPI  321

         ***************96644777777764455666644333354679*************

S: 271   kRisakealqhkyf  284

         +Ri++++a+q++yf

Q: 322   RRITSEQAMQDPYF  335

         *************9

Domain Sequence
(FASTA)

KVGRGTYGHV YKAKRKDGKD DKDYALKQIE GTGISMSACR EIALLRELKH PNVISLQKVF 60

LSHADRKVWL LFDYAEHDLW HIIKFHRASK ANKKPLQLPR GMVKSLLYQI LDGIHYLHAN 120

WVLHRDLKPA NILVMGEGPE RGRVKIADMG FARLFNSPLK PLADLDPVVV TFWYRAPELL 180

LGARHYTKAI DIWAIGCIFA ELLTSEPIFH CRQEDIKTSN PYHHDQLDRI FNVMGFPADK 240

DWEDIKKMPE HSTLMKDFRR NTYTNCSLIK YMEKHKVKPD SKAFHLLQKL LTMDPIRRIT 300

SEQAMQDPYF 310

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013