EKS-ORN-00356

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00356

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	448.2	1.6E-134	236	523	288

Status

Unreviewed

Ensembl Protein

ENSONIP00000018799

UniProt Accession

I3KCF4;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR1B (1 of 2)

Gene Synonyms/Alias

BMPR1B (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000014932	ENSONIP00000018799	ENSONIT00000018816

Organism

Oreochromis niloticus

Functional Description

Protein Length

534

Protein Sequence
(FASTA)

LQVWLCYCKY LCYLIAHVQI LQAYSLGNIL DSMLLKASSK EAAESGKETF GSTAPASSSQ 60

RLLWCHCYHH CPEDSTNNTC RTDGFCFTMV EDEGGVPVQT AGCLGLVGSE FQCRDAGNSR 120

QRRSLECCTD EDYCNKNLHP TLPPLKPPLY VDGKIHHVAL LISVTVCTLI LAVIIIFCYV 180

RYKRQESRPR YSIGLEQDET YIPPGESLKD LIEQSQSSGS GSGLPLLVQR TIAKQIQMVK 240

QIGKGRYGEV WMGRWRGEKV AVKVFFTTEE ASWFRETEIY QTVLMRHENI LGFIAADIKG 300

TGSWTQLYLI TDYHENGSLY DYLKSTTLDN KAMLRLAYSS VSGLCHLHTE IFGTQGKPAI 360

AHRDLKSKNI LVKRNGTCCI ADLGLAVKFI SDTNEVDIPP NTRVGTKRYM PPEVLDETLN 420

RSHFQSYIMA DMYSFGLILW EIARRCISGG ILEEYQLPYH ELVPTDPSYE DMREVVCIKK 480

LRPSFPNRWT SDECLRQMGK LMTECWAHNP ACRLTALRVK KTLAKMSESQ DIKL 534

Nucleotide Sequence
(FASTA)

CTCCAAGTCT GGCTATGCTA CTGCAAATAC TTGTGTTATT TAATAGCACA TGTCCAAATT 60

CTGCAAGCCT ACTCTCTAGG CAACATATTG GACAGTATGC TGCTAAAAGC ATCCAGCAAG 120

GAGGCAGCAG AGAGTGGGAA GGAGACTTTT GGCAGCACAG CTCCTGCTTC ATCCTCCCAA 180

AGACTCCTGT GGTGTCACTG TTATCACCAC TGCCCAGAAG ATTCAACCAA TAACACGTGC 240

AGGACGGATG GCTTCTGTTT TACAATGGTG GAGGATGAGG GAGGGGTGCC GGTCCAGACG 300

GCAGGTTGCC TTGGGCTGGT CGGATCTGAA TTTCAGTGCA GAGACGCGGG GAACTCACGT 360

CAAAGGCGAT CACTAGAATG CTGTACAGAT GAAGATTACT GTAACAAAAA TCTGCATCCT 420

ACGCTGCCAC CACTCAAACC TCCTCTCTAC GTAGATGGGA AGATCCACCA TGTGGCCTTG 480

TTGATTTCAG TCACTGTATG CACCCTTATA TTGGCTGTCA TTATTATTTT CTGCTACGTC 540

AGGTATAAAC GACAGGAGTC TCGTCCTCGC TACAGCATTG GTCTAGAACA GGATGAGACA 600

TACATTCCCC CTGGAGAATC TCTGAAAGAC TTGATAGAGC AATCACAAAG CTCAGGCTCA 660

GGCTCAGGGC TCCCTCTATT GGTCCAGAGA ACGATAGCCA AGCAGATTCA GATGGTGAAG 720

CAGATAGGCA AGGGGAGATA CGGAGAGGTG TGGATGGGCA GGTGGAGGGG AGAAAAGGTG 780

GCTGTTAAAG TTTTCTTCAC CACTGAGGAA GCGAGTTGGT TCAGAGAGAC TGAAATCTAC 840

CAGACTGTCT TAATGAGACA TGAGAACATA CTGGGTTTTA TAGCTGCAGA TATTAAAGGA 900

ACTGGCTCTT GGACCCAACT CTACTTAATA ACTGACTACC ATGAAAATGG ATCATTGTAT 960

GACTACCTCA AATCGACCAC TCTAGACAAT AAAGCTATGC TGCGACTGGC CTACTCCTCT 1020

GTGTCAGGAC TCTGTCACCT CCACACAGAG ATCTTTGGCA CCCAGGGCAA ACCTGCCATT 1080

GCTCACAGGG ATCTGAAGAG TAAGAACATA CTTGTGAAAA GAAATGGGAC CTGCTGTATA 1140

GCTGACCTAG GACTGGCTGT CAAGTTTATC AGTGACACAA ATGAAGTAGA TATTCCCCCC 1200

AATACAAGAG TCGGTACAAA GCGCTACATG CCTCCAGAGG TTCTGGACGA GACTTTGAAC 1260

AGAAGTCACT TTCAGTCTTA CATCATGGCT GACATGTACA GTTTTGGGCT CATTCTCTGG 1320

GAGATTGCAC GTCGCTGCAT CTCAGGAGGA ATCCTTGAAG AGTACCAGTT ACCATATCAT 1380

GAGCTGGTTC CAACAGACCC TTCATATGAA GACATGAGAG AGGTGGTCTG CATCAAGAAG 1440

CTACGACCAT CCTTTCCTAA TCGATGGACC AGCGATGAGT GTTTGAGACA GATGGGGAAG 1500

CTGATGACAG AATGCTGGGC CCACAATCCA GCCTGCCGCC TCACAGCCCT ACGGGTCAAA 1560

AAGACACTTG CCAAAATGTC AGAATCACAG GATATCAAGC TGTGA 1605

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++++++igkGrygeVw++++rge+vAvK+f+t++easw+rE+eiyqtvl+rhenil+fia

Q: 236   IQMVKQIGKGRYGEVWMGRWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA  295

         799*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k ++s+t+l+l+t+yhe+gsL+dyLk++tld + +lrla+s +sGl+hLH+ei+gt+

Q: 296   ADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDNKAMLRLAYSSVSGLCHLHTEIFGTQ  355

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvk+++tcciaDlGLa+k+ ++++e+d+  n++vGtkRYm PE

Q: 356   G--KPAIAHRDLKSKNILVKRNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPE  413

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+ln ++f+++ +aD+Ys+gL+lWE+a+Rc + +++ eey+lp++e v++dPs+e+m

Q: 414   VLDETLNRSHFQSYIMADMYSFGLILWEIARRCIS-GGILEEYQLPYHELVPTDPSYEDM  472

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +evv+ kklrP++p++w+++e+l+++ kl++ecW+++p+ Rltalrvkk+l

Q: 473   REVVCIKKLRPSFPNRWTSDECLRQMGKLMTECWAHNPACRLTALRVKKTL  523

         *************************************************97

Domain Sequence
(FASTA)

IQMVKQIGKG RYGEVWMGRW RGEKVAVKVF FTTEEASWFR ETEIYQTVLM RHENILGFIA 60

ADIKGTGSWT QLYLITDYHE NGSLYDYLKS TTLDNKAMLR LAYSSVSGLC HLHTEIFGTQ 120

GKPAIAHRDL KSKNILVKRN GTCCIADLGL AVKFISDTNE VDIPPNTRVG TKRYMPPEVL 180

DETLNRSHFQ SYIMADMYSF GLILWEIARR CISGGILEEY QLPYHELVPT DPSYEDMREV 240

VCIKKLRPSF PNRWTSDECL RQMGKLMTEC WAHNPACRLT ALRVKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013