EKS-ORN-00338

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00338

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	421.5	1.6E-126	54	306	253

Status

Unreviewed

Ensembl Protein

ENSONIP00000018987

UniProt Accession

I3KCZ2;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK2

Gene Synonyms/Alias

PLK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000015086	ENSONIP00000018987	ENSONIT00000019004

Organism

Oreochromis niloticus

Functional Description

Protein Length

657

Protein Sequence
(FASTA)

MEVQRSVGPQ QTNGSAMCES TQRSCEPRRK KMDERSAPSE MARIITDPAT GKCYCRGKVL 60

GKGGFAKCYE MTDLSTSKVY AAKIIPHARV SKPHQREKID REIELHRLLH HKHIVHFYHH 120

FEDKENIYIL LEYCSRKSLA HILKVRKVLT EPEVRYYLRQ IVSGLKYLHE QEILHRDLKL 180

GNFFVNETME LKVGDFGLAA KLEPAGNRRK TICGTPNYLS PEVLNKQGHG CESDIWALGC 240

VMYTMLLGRP PFETTNLKET YRCIREARYS LPSSLSPQAK QLIASLLAKM PEDRPNLDHI 300

LRHDFFTQGF SPERLPASCC HSAPDFHVSS PAKSFFKKAA AALFGGKRDK VKYYETLNKL 360

TKEEEEIYKL QHDLERTAIS QQHSKKVSEN GSLLPPSAES PVAPATESQS PTTQDTIRLI 420

VRGSLGSCSS SSECLEDSTT GSVAETVASV LRGCLENMPK ASDIPQGSTS CSLQWVTKWV 480

DYSNKYGFGY QLSDHTVGVL FNNGTHMSLL PDRKTIHYYA ELGQRSVFPT CEVPEHFVGQ 540

VTVLKYFSHY MEENLMDGGD LGTITDSHMP RLYLLQWLKS DRALMMLFND GTFQVNFYHD 600

HTKIILCCQR DEYMLTYINE DRVSKTFKLS SLLKSGCSTD LRERMVYSLN MLLQRCS 657

Nucleotide Sequence
(FASTA)

ATGGAAGTAC AGAGAAGCGT CGGGCCCCAA CAGACAAACG GCAGCGCCAT GTGTGAATCC 60

ACGCAGAGGT CCTGCGAGCC TCGCCGAAAG AAAATGGATG AGCGCAGTGC ACCCTCAGAA 120

ATGGCCAGGA TAATCACTGA TCCTGCCACG GGGAAGTGCT ACTGCCGTGG AAAAGTTTTG 180

GGAAAGGGAG GATTTGCTAA ATGTTATGAG ATGACCGACC TCTCCACCAG CAAAGTTTAC 240

GCAGCCAAAA TCATCCCTCA TGCGCGCGTC TCCAAACCTC ACCAACGGGA GAAGATTGAC 300

AGAGAAATTG AGCTGCACAG ATTACTGCAC CATAAACACA TCGTGCACTT TTATCACCAT 360

TTTGAGGACA AGGAGAACAT CTACATCCTG CTGGAGTACT GCAGCAGAAA ATCATTAGCC 420

CATATCCTGA AGGTCCGCAA AGTGCTTACT GAGCCAGAGG TGCGTTATTA CCTGAGACAG 480

ATTGTGTCTG GACTGAAGTA CCTGCATGAA CAAGAAATCC TTCACAGAGA CCTGAAACTT 540

GGTAACTTTT TTGTGAACGA GACGATGGAG CTGAAGGTCG GGGACTTTGG TCTGGCTGCC 600

AAGTTGGAGC CAGCGGGAAA CAGGAGGAAG ACGATCTGCG GGACTCCCAA CTACCTGTCC 660

CCTGAGGTTC TCAACAAGCA GGGCCACGGC TGTGAATCAG ACATCTGGGC CTTAGGCTGT 720

GTAATGTACA CTATGCTGCT GGGCAGACCT CCTTTCGAAA CCACCAACCT GAAGGAGACA 780

TACAGGTGTA TTAGAGAAGC CCGCTACTCC CTCCCCTCGT CCCTGTCACC ACAGGCTAAG 840

CAGCTAATCG CCAGCCTGCT TGCCAAGATG CCAGAGGACA GGCCCAACCT GGACCACATT 900

CTGAGGCATG ACTTCTTCAC ACAGGGCTTC AGTCCAGAAC GTCTGCCTGC TAGCTGCTGC 960

CATTCAGCAC CAGATTTCCA CGTCTCTAGC CCTGCCAAGA GTTTCTTCAA GAAAGCTGCT 1020

GCTGCGCTGT TTGGTGGGAA GAGGGACAAG GTCAAGTACT ACGAGACTCT GAATAAGTTA 1080

ACCAAAGAGG AAGAGGAGAT CTACAAGTTG CAGCATGACT TGGAGAGAAC TGCCATCAGC 1140

CAACAGCACA GCAAAAAGGT GTCTGAGAAT GGAAGTCTAC TTCCGCCATC TGCCGAGAGC 1200

CCCGTTGCCC CGGCAACAGA GAGCCAGTCC CCGACGACGC AAGACACCAT CCGTCTGATC 1260

GTCAGGGGGA GTCTGGGAAG CTGCAGCAGC AGTAGTGAAT GCCTGGAAGA CAGCACGACA 1320

GGGAGTGTGG CTGAGACTGT TGCAAGTGTG CTGAGGGGGT GTCTGGAGAA TATGCCTAAA 1380

GCCAGTGACA TTCCTCAGGG CTCAACCAGC TGCAGTCTTC AATGGGTGAC CAAATGGGTG 1440

GATTACTCCA ACAAGTACGG TTTTGGATAC CAGTTATCTG ATCACACCGT GGGAGTTCTC 1500

TTCAACAATG GCACTCACAT GAGCCTCCTA CCCGACCGAA AGACCATCCA TTACTACGCA 1560

GAGCTGGGCC AGCGCTCCGT CTTTCCCACC TGTGAGGTTC CTGAACACTT TGTTGGGCAG 1620

GTCACTGTGC TTAAGTACTT CTCCCATTAC ATGGAGGAAA ATCTTATGGA TGGCGGGGAC 1680

CTTGGCACTA TAACAGACTC ACACATGCCC AGACTTTACC TGCTGCAGTG GCTCAAGTCA 1740

GACCGCGCCC TCATGATGCT GTTTAATGAC GGCACTTTCC AGGTCAACTT TTACCACGAT 1800

CACACCAAGA TCATCCTGTG TTGCCAGAGG GACGAGTACA TGCTGACATA CATTAACGAA 1860

GACCGCGTCT CCAAAACCTT CAAACTTAGC TCCCTGTTGA AGTCTGGCTG CTCTACTGAC 1920

CTGCGGGAGC GCATGGTGTA TTCCCTCAAC ATGCTTCTGC AGAGATGCAG CTAA 1974

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y+rgk+lGkGgfakcye++dl+t++v+a+k++p++++ k++qrek+++eie+hr l+hk+

Q: 54    YCRGKVLGKGGFAKCYEMTDLSTSKVYAAKIIPHARVSKPHQREKIDREIELHRLLHHKH  113

         99**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         iv++y++fedken+y++le+csr+sla++lk rk+ltepevryylrqivsglkylhe++i

Q: 114   IVHFYHHFEDKENIYILLEYCSRKSLAHILKVRKVLTEPEVRYYLRQIVSGLKYLHEQEI  173

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         lhrdlklgn+f+ne++e+k+gdfGla++le++++r+kt+cGtPny++Pevl+k+gh++e+

Q: 174   LHRDLKLGNFFVNETMELKVGDFGLAAKLEPAGNRRKTICGTPNYLSPEVLNKQGHGCES  233

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         diW+lGc++yt+l+G+PPfet++lkety++i++a+yslPssls++ak+lia+ll+k Pe+

Q: 234   DIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYSLPSSLSPQAKQLIASLLAKMPED  293

         ************************************************************

S: 241   rpsleevlkdefl  253

         rp+l+++l+++f+

Q: 294   RPNLDHILRHDFF  306

         ************8

Domain Sequence
(FASTA)

YCRGKVLGKG GFAKCYEMTD LSTSKVYAAK IIPHARVSKP HQREKIDREI ELHRLLHHKH 60

IVHFYHHFED KENIYILLEY CSRKSLAHIL KVRKVLTEPE VRYYLRQIVS GLKYLHEQEI 120

LHRDLKLGNF FVNETMELKV GDFGLAAKLE PAGNRRKTIC GTPNYLSPEV LNKQGHGCES 180

DIWALGCVMY TMLLGRPPFE TTNLKETYRC IREARYSLPS SLSPQAKQLI ASLLAKMPED 240

RPNLDHILRH DFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013