EKS-ORN-00247

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00247

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	391.2	2.8E-117	66	314	249

Status

Unreviewed

Ensembl Protein

ENSONIP00000019079

UniProt Accession

I3KD84;

Protein Name

Protein Synonyms/Alias

Gene Name

TESK2

Gene Synonyms/Alias

TESK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000015160	ENSONIP00000019079	ENSONIT00000019096

Organism

Oreochromis niloticus

Functional Description

Protein Length

573

Protein Sequence
(FASTA)

MERNKRNSIA GFPTRPEHLN ENRDDIGGVG VCEMGMAPPL QVSSPSSYRA LISAFSCLTR 60

LDDFSREWIG SGFFSDVFRV RHRASDQVMA LKMNKLSSNR ANMLREVQLM NRLNHPNILR 120

FKGVCVHEGQ LHALTEYING GNLEQLLDSN KHLSWPTRVK LACDIASGLA YLHSKGIFHR 180

DLTSKNCLIK SDDGMYTAVV GDFGLAEKIP TNLAEGEKLS VVGSPFWMAP EVLRDEPYNE 240

KADVFSYGII LCEIIARIQA DPDFLPRTEN FGLDYHTFQH MVGDCPPDFL QLAFNCCNMD 300

PKLRPSFSDL VRHLEEIFAH LKVEDMEHEC VPLTGDNDKK TIAKGEKIQG FKRGNPLGFQ 360

NDKIPPKSPR PRRNIWLSRS QSDIFSCKPG RKVNVQDPYY NPPTAKRASK ARKINPFTAR 420

EDLCGGKIKF YDVPSKSVFS LVFDLHSPPG SVFSNQPCAL GPGGAQQEAS YYWQQLPGRQ 480

CHSLPVSPQL PRSEIFFFTG TNSRSDTGQM GNDIRQKVAL SGWAKKYVVV EIPPYCRQRR 540

GEDDGEVEGR ESWSPMIPSS ERDSGEAMDC SSS 573

Nucleotide Sequence
(FASTA)

ATGGAACGGA ATAAACGCAA CTCCATTGCT GGGTTCCCTA CACGACCTGA ACACCTCAAT 60

GAGAACAGAG ATGATATCGG AGGGGTAGGA GTGTGTGAGA TGGGAATGGC TCCACCTTTG 120

CAGGTGTCTT CCCCATCATC CTACCGAGCC CTCATCAGTG CCTTCTCCTG TCTTACACGC 180

CTTGATGACT TCTCCCGCGA GTGGATTGGC TCAGGATTTT TCTCTGATGT ATTCAGGGTA 240

CGTCATCGAG CTTCAGACCA AGTTATGGCT CTAAAGATGA ACAAGCTCAG CAGTAACAGG 300

GCTAATATGT TGAGAGAAGT CCAGCTAATG AACCGGCTTA ATCATCCAAA CATACTCAGG 360

TTTAAAGGAG TTTGTGTCCA TGAGGGCCAG CTTCATGCTC TCACAGAGTA CATCAATGGT 420

GGGAACCTGG AGCAGCTTCT GGACAGCAAC AAACACCTGA GCTGGCCAAC CAGGGTGAAA 480

TTAGCCTGTG ATATCGCCAG CGGTCTGGCC TACTTGCACT CTAAAGGCAT ATTCCACCGG 540

GACCTCACCT CCAAGAACTG CCTGATAAAG AGTGATGACG GCATGTACAC AGCAGTGGTG 600

GGAGACTTTG GCCTGGCAGA AAAGATCCCT ACCAATCTCG CTGAAGGAGA GAAGCTTTCA 660

GTGGTTGGGT CTCCTTTCTG GATGGCTCCG GAGGTGCTGA GAGATGAACC CTACAATGAG 720

AAGGCCGACG TGTTCTCCTA TGGAATAATC CTGTGTGAAA TCATCGCAAG GATTCAGGCC 780

GACCCCGACT TCCTTCCCCG CACAGAGAAC TTCGGCCTGG ACTATCACAC GTTCCAGCAC 840

ATGGTTGGAG ACTGTCCGCC TGACTTCCTC CAGCTGGCCT TTAACTGCTG CAATATGGAT 900

CCTAAACTCC GTCCATCCTT CTCAGACCTC GTCAGGCATC TCGAGGAGAT TTTCGCACAC 960

CTTAAAGTTG AAGATATGGA GCATGAGTGT GTCCCGCTCA CTGGGGACAA TGACAAGAAA 1020

ACCATAGCCA AAGGTGAGAA GATTCAAGGC TTCAAGCGAG GTAATCCTCT TGGTTTCCAG 1080

AACGATAAAA TCCCTCCTAA ATCACCCCGC CCCAGACGAA ACATCTGGCT CAGCCGCAGC 1140

CAATCAGACA TCTTCTCCTG CAAGCCAGGA AGAAAAGTCA ACGTCCAGGA CCCTTACTAT 1200

AACCCCCCTA CTGCCAAGAG AGCCTCCAAA GCCCGCAAGA TCAACCCTTT TACAGCCCGA 1260

GAAGATCTGT GCGGTGGGAA GATTAAGTTT TACGACGTGC CCAGCAAGTC CGTCTTCTCC 1320

CTGGTGTTTG ACCTCCACTC GCCACCTGGA AGTGTGTTCA GTAACCAACC GTGTGCTCTC 1380

GGGCCCGGAG GAGCCCAACA GGAGGCGTCT TATTACTGGC AGCAGCTGCC GGGAAGACAG 1440

TGTCACTCCT TACCGGTATC GCCCCAGCTT CCTCGCTCTG AGATCTTTTT TTTTACAGGT 1500

ACTAACTCAC GATCTGATAC AGGCCAGATG GGAAATGACA TCCGGCAAAA GGTGGCGCTG 1560

AGCGGCTGGG CGAAGAAATA CGTTGTGGTT GAAATCCCAC CCTACTGCAG GCAGAGAAGA 1620

GGGGAGGATG ACGGGGAGGT AGAGGGAAGG GAGAGCTGGT CTCCGATGAT CCCCAGCAGT 1680

GAGAGAGACA GTGGAGAGGC CATGGACTGC TCGAGCAGC 1719

Domain Profile

S: 4     geklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlkfiG  63

          e +G+Gffs+vf+v+hras +vm+lk  ++++++nr+n+l+ev+l+++l+hpn+l+f G

Q: 66    REWIGSGFFSDVFRVRHRASDQVMALK--MNKLSSNRANMLREVQLMNRLNHPNILRFKG  123

         589************************..*******************************

S: 64    vlvkdkklhllteyiegGtlkellkskeslpwtqrvrlakdiasGlsylhskgiihrdln  123

         v+v++++lh+lteyi+gG+l++ll+s+++l+w+ rv+la diasGl+ylhskgi+hrdl+

Q: 124   VCVHEGQLHALTEYINGGNLEQLLDSNKHLSWPTRVKLACDIASGLAYLHSKGIFHRDLT  183

         ************************************************************

S: 124   sknclvre...dksvvvadfGlarlvveerkkseklrslkkkdrkkrltvvGsPywmaPe  180

         skncl++     +++vv+dfGla          ek+++   +   ++l+vvGsP+wmaPe

Q: 184   SKNCLIKSddgMYTAVVGDFGLA----------EKIPTNLAE--GEKLSVVGSPFWMAPE  231

         *******977669**********..........899985554..899*************

S: 181   vlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvaedcPeaf  240

         vl+++ y+ek+dvfs+Gi+lceiiar++adPd+lPrte+fgld+++f++ +v+ dcP++f

Q: 232   VLRDEPYNEKADVFSYGIILCEIIARIQADPDFLPRTENFGLDYHTFQH-MVG-DCPPDF  289

         *************************************************.999.******

S: 241   lklavvccdldpesrpsfeelekkl  265

         l+la++cc++dp+ rpsf++l ++l

Q: 290   LQLAFNCCNMDPKLRPSFSDLVRHL  314

         *******************998765

Domain Sequence
(FASTA)

REWIGSGFFS DVFRVRHRAS DQVMALKMNK LSSNRANMLR EVQLMNRLNH PNILRFKGVC 60

VHEGQLHALT EYINGGNLEQ LLDSNKHLSW PTRVKLACDI ASGLAYLHSK GIFHRDLTSK 120

NCLIKSDDGM YTAVVGDFGL AEKIPTNLAE GEKLSVVGSP FWMAPEVLRD EPYNEKADVF 180

SYGIILCEII ARIQADPDFL PRTENFGLDY HTFQHMVGDC PPDFLQLAFN CCNMDPKLRP 240

SFSDLVRHL 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013