EKS-ORN-00296

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00296

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	377.0	6.3E-113	70	363	294

Status

Unreviewed

Ensembl Protein

ENSONIP00000019419

UniProt Accession

I3KE74;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K1

Gene Synonyms/Alias

MAP2K1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000015432	ENSONIP00000019419	ENSONIT00000019436

Organism

Oreochromis niloticus

Functional Description

Protein Length

395

Protein Sequence
(FASTA)

MQKRRKPEPI QLNPIPDGNT INGSGATETN LEALQKKLEE LELDEQQRKR LEAFLTQKQK 60

VGELKDDDFE KICELGAGNG GVVFKVSHRP SGLIMARKLI HLEIKPAIRN QIIRELQVLH 120

ECNSPYIVGF YGAFYSDGEI SICMEHMDGG SLDQSLKKAG KIPEQILGKV SIAVIKGLSY 180

LREKHKIMHR DVKPSNILVN SRGEIKLCDF GVSGQLIDSM ANSFVGTRSY MSPERLQGTH 240

YSVQSDIWSM GLSLVEMAIG RFPIPPPDAK ELEQIFGFPV EGEAASSDSS PKPRPPGRPG 300

SSYGPDSRPP MAIFELLDYI VNEPPPKLPA VFSSEFQDFV NKCLIKNPAE RADLKQLMVH 360

PFIKNSEAEE VDFAGWLCTT IGLSQPLTPT HGTTM 395

Nucleotide Sequence
(FASTA)

ATGCAGAAGA GAAGGAAGCC TGAGCCGATC CAACTCAACC CCATCCCTGA TGGAAACACT 60

ATCAACGGCA GCGGAGCCAC AGAAACTAAC TTGGAGGCAC TGCAGAAAAA ACTAGAGGAG 120

CTCGAGTTGG ATGAGCAGCA GCGGAAACGC TTGGAGGCCT TTCTGACACA GAAGCAGAAG 180

GTGGGAGAGC TGAAGGACGA TGACTTTGAG AAGATCTGCG AGCTCGGTGC CGGCAACGGA 240

GGAGTTGTCT TTAAGGTCTC CCACCGACCC TCGGGTCTGA TTATGGCAAG GAAGCTGATC 300

CACCTTGAGA TTAAACCAGC CATCAGGAAC CAGATCATTA GGGAGCTGCA GGTGCTACAT 360

GAGTGCAACT CCCCATATAT TGTGGGCTTC TACGGGGCTT TTTACAGCGA TGGAGAAATC 420

AGCATCTGCA TGGAGCATAT GGATGGTGGC TCCCTGGACC AATCACTGAA GAAAGCAGGC 480

AAGATCCCAG AGCAGATCCT TGGCAAAGTC AGCATTGCTG TAATTAAAGG TCTTTCCTAC 540

CTGAGGGAGA AGCACAAGAT CATGCACAGA GATGTCAAGC CTTCTAACAT CCTAGTGAAT 600

TCCCGTGGTG AGATCAAGCT GTGTGACTTT GGAGTGAGCG GACAGCTGAT AGACTCCATG 660

GCCAACTCCT TTGTGGGCAC TCGGTCGTAC ATGTCGCCCG AGCGCTTACA AGGCACCCAC 720

TATTCTGTTC AGTCGGACAT CTGGAGCATG GGTCTGTCAC TGGTTGAAAT GGCCATTGGA 780

CGCTTTCCTA TTCCACCACC TGATGCTAAG GAGCTCGAAC AGATTTTCGG CTTCCCAGTG 840

GAAGGGGAGG CAGCCTCCAG TGATTCCTCC CCAAAGCCGC GGCCCCCTGG GCGACCCGGC 900

AGCTCATACG GCCCAGACAG CAGACCTCCA ATGGCTATTT TTGAGCTTCT TGATTACATT 960

GTTAATGAGC CTCCACCAAA ACTGCCTGCT GTATTTAGTT CTGAATTCCA AGACTTTGTT 1020

AATAAATGCT TGATTAAAAA CCCAGCAGAG AGAGCAGACT TGAAACAGTT GATGGTGCAT 1080

CCTTTCATCA AAAACTCTGA AGCAGAGGAA GTTGACTTTG CTGGCTGGCT GTGCACCACC 1140

ATTGGACTCA GTCAGCCTTT GACACCAACT CACGGTACCA CAATGTGA 1188

Domain Profile

S: 2     ekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyiv  61

         ek+ elGaGnggvV kv+h++sg i+a+K i+leik+++++qi+rel+vl+++ nspyiv

Q: 70    EKICELGAGNGGVVFKVSHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHEC-NSPYIV  128

         7899*************************************************.******

S: 62    kfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkek  121

         +fyGaf+s+g++sicme+mdg+sld+ lkk    +++ipe++lgk+++av+k+l+yl+ek

Q: 129   GFYGAFYSDGEISICMEHMDGGSLDQSLKK----AGKIPEQILGKVSIAVIKGLSYLREK  184

         **************************9988....8*************************

S: 122   lkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsv  181

         +ki+HRDvKPsNiLvns+Ge+KlCDFGvsgql+ds+A+s+vGt+sYm+PEr++g ++Ysv

Q: 185   HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG-THYSV  243

         ******************************************************.*****

S: 182   ksdvWslGltlvelatgrypyeklke..................................  207

         +sd+Ws+Gl+lve+a+gr+p++++++

Q: 244   QSDIWSMGLSLVEMAIGRFPIPPPDAkeleqifgfpvegeaassdsspkprppgrpgssy  303

         ***********************9999*********************************

S: 208   .........ilellkaivneeppklpeeefseefqefvskClkkdekeRpklkellkhaf  258

                  i+ell++ivne+ppklp+  fs+efq+fv+kCl+k+++eR++lk+l+ h+f

Q: 304   gpdsrppmaIFELLDYIVNEPPPKLPA-VFSSEFQDFVNKCLIKNPAERADLKQLMVHPF  362

         *************************96.8*******************************

S: 259   i  259

Q: 363   I  363

Domain Sequence
(FASTA)

EKICELGAGN GGVVFKVSHR PSGLIMARKL IHLEIKPAIR NQIIRELQVL HECNSPYIVG 60

FYGAFYSDGE ISICMEHMDG GSLDQSLKKA GKIPEQILGK VSIAVIKGLS YLREKHKIMH 120

RDVKPSNILV NSRGEIKLCD FGVSGQLIDS MANSFVGTRS YMSPERLQGT HYSVQSDIWS 180

MGLSLVEMAI GRFPIPPPDA KELEQIFGFP VEGEAASSDS SPKPRPPGRP GSSYGPDSRP 240

PMAIFELLDY IVNEPPPKLP AVFSSEFQDF VNKCLIKNPA ERADLKQLMV HPFI 294

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013