EKS-ORN-00541

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00541

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/WEE	356.0	1.5E-106	274	542	269

Status

Unreviewed

Ensembl Protein

ENSONIP00000019529

UniProt Accession

I3KEI4;

Protein Name

Protein Synonyms/Alias

Gene Name

WEE1

Gene Synonyms/Alias

WEE1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000015520	ENSONIP00000019529	ENSONIT00000019546

Organism

Oreochromis niloticus

Functional Description

Protein Length

619

Protein Sequence
(FASTA)

MSSYSRHRHG SPSPKSRPIR QKLQFTCSDG EDDLIEDINN STGGESGFTE MDSPMPVRRI 60

IADKCLDGSS SPLNQSGGDE DVELWDEEES FGSPTHLQSP SSVIFANCSP SPRKTSRLFG 120

GSPCRPGSPD DGGSSSPIPD CPDTPPHKTF KKLRLFDTPH TPKSLLSRAR SSGPGSSSRR 180

VSLFKKVDVS GKSLIDSGRR QQTPLVNFNP FTPDSLLIQS ATQQRINRKR AHWNDSCGED 240

MEASDGEGEE EVVPPSKRIT MMESNMTSRY ASEFLELEKI GCGEFGAVFK CVKRLDGCMY 300

AIKRSKKPLA GSVDEQNALR EVYAHAVLGQ HPHVVRYYSA WAEDDHMLIQ NEYCNGGTLS 360

DVITENYRRL SYLTELELKD LLVQVTQGLK YIHSTSLVHM DIKPSNIFIS RKSIVSCDEC 420

DEDEGLTPTV IYKIGDLGHV TRVNNPQVEE GDSRYLANEV LQEDYSNLTK ADIFALALTV 480

VNASGAEPLP TNGEKWHEIR RGKLPAIPQV LSPEFLSLLK LMIHPDPTRR PSTSDLMKHP 540

VLLTTARMSA DQLRVELNAE KFKNALLQKE LKKAQQARAA AEEKVLSTDR ILTRSTVQNS 600

RTTRLIGKKM SRSVSLTIY 619

Nucleotide Sequence
(FASTA)

ATGTCGAGCT ACAGCCGCCA TCGGCACGGA TCTCCTTCTC CAAAAAGTCG GCCAATCCGT 60

CAGAAATTAC AGTTCACATG CAGCGACGGA GAGGACGATC TCATCGAGGA CATCAACAAC 120

AGCACAGGGG GAGAGTCTGG CTTCACGGAG ATGGATTCCC CGATGCCAGT ACGAAGGATC 180

ATCGCCGACA AATGCCTGGA CGGGAGCAGC AGCCCCCTGA ATCAGTCCGG TGGGGATGAA 240

GACGTGGAGC TATGGGACGA GGAGGAGAGT TTTGGATCCC CAACTCACCT GCAGTCACCC 300

AGCAGTGTTA TATTTGCCAA CTGCTCGCCA TCCCCTCGGA AAACCTCTCG GCTGTTTGGA 360

GGGTCTCCCT GTCGTCCCGG ATCTCCGGAC GACGGGGGAT CCAGCTCCCC GATCCCGGAC 420

TGTCCAGACA CACCTCCGCA CAAAACCTTC AAGAAACTGC GGCTTTTTGA CACACCGCAC 480

ACACCAAAGA GTTTACTGTC CAGAGCTAGA AGCTCAGGCC CAGGGTCCTC CAGCAGGAGA 540

GTTTCCTTAT TCAAGAAAGT GGACGTTTCA GGAAAGTCAC TTATTGACAG TGGCAGGAGA 600

CAGCAGACTC CCCTGGTCAA CTTTAACCCC TTCACCCCTG ACTCCCTCCT CATTCAGTCT 660

GCCACGCAGC AGAGAATCAA CAGAAAGCGA GCACACTGGA ATGACTCCTG TGGAGAAGAC 720

ATGGAAGCAA GTGACGGTGA AGGAGAGGAG GAAGTGGTGC CACCATCTAA GAGGATCACA 780

ATGATGGAAA GCAACATGAC GTCCCGGTAT GCTTCAGAGT TCCTTGAGTT GGAGAAAATC 840

GGCTGCGGGG AGTTCGGTGC TGTGTTTAAG TGCGTGAAAA GGCTTGACGG CTGCATGTAT 900

GCTATCAAGA GGTCAAAGAA ACCTCTGGCA GGATCAGTAG ACGAGCAAAA TGCCTTACGG 960

GAGGTGTATG CTCATGCCGT GCTGGGCCAA CATCCCCACG TGGTACGCTA CTACTCAGCC 1020

TGGGCTGAAG ACGACCACAT GCTCATCCAG AATGAGTACT GCAACGGCGG CACGCTGTCC 1080

GACGTCATCA CAGAGAACTA CAGACGGCTC AGCTACCTGA CGGAGCTTGA GCTGAAAGAT 1140

CTGCTTGTGC AGGTCACACA GGGACTAAAG TACATCCACT CAACCTCTCT GGTGCACATG 1200

GATATCAAAC CAAGCAACAT CTTTATTTCA CGGAAATCCA TAGTGAGCTG TGATGAATGT 1260

GATGAGGATG AAGGACTGAC TCCTACTGTT ATCTACAAAA TTGGTGATCT CGGTCATGTG 1320

ACAAGAGTGA ACAATCCACA GGTTGAAGAG GGCGACAGCA GATACCTGGC TAATGAAGTC 1380

TTACAAGAGG ACTACAGTAA CCTGACAAAA GCAGACATCT TTGCTTTGGC CCTGACTGTT 1440

GTCAACGCGT CAGGGGCCGA ACCTCTACCC ACCAACGGAG AGAAGTGGCA TGAGATCAGA 1500

CGGGGCAAAC TCCCTGCCAT TCCTCAAGTG CTTTCTCCAG AGTTTCTCAG TCTTCTAAAG 1560

CTTATGATCC ACCCTGATCC AACAAGGCGC CCATCAACCT CTGACCTCAT GAAACACCCG 1620

GTACTTCTGA CCACTGCCAG AATGAGTGCT GATCAGCTCA GAGTGGAGCT CAACGCAGAG 1680

AAGTTTAAGA ACGCCCTGCT TCAAAAAGAG CTGAAGAAAG CCCAGCAGGC TAGAGCGGCA 1740

GCTGAGGAGA AAGTTTTATC CACGGACAGG ATCTTAACCC GCTCCACAGT CCAGAACTCC 1800

AGAACCACCA GGCTTATTGG GAAAAAAATG AGCCGATCGG TCAGCCTCAC AATCTACTGA 1860

Domain Profile

S: 1     FeevekiGkGefgevfkvvkredgklyAikkskkplkglskekkalrEvtahavlgqhen  60

         F e+ekiG Gefg vfk+vkr+dg++yAik+skkpl+g+++e++alrEv+ahavlgqh++

Q: 274   FLELEKIGCGEFGAVFKCVKRLDGCMYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHPH  333

         7899********************************************************

S: 61    vvryisaWeeddslyiqtElCeggsLeaalqeceakkkaleeaelkkilldlllglrylH  120

         vvry+saW+edd+++iq+E+C+gg L+++++e+++  ++l+e elk++l+++++gl+y+H

Q: 334   VVRYYSAWAEDDHMLIQNEYCNGGTLSDVITENYRRLSYLTELELKDLLVQVTQGLKYIH  393

         ************************************************************

S: 121   ssslvHlDikpenifi.................tkevtlklgDlGlvtelnsedkskveE  163

         s+slvH+Dikp+nifi                 t +v++k+gDlG+vt++   ++++veE

Q: 394   STSLVHMDIKPSNIFIsrksivscdecdedeglTPTVIYKIGDLGHVTRV---NNPQVEE  450

         **************************************************...9******

S: 164   GDsrylakEilqeeyskl.kaDiFslgltilevaanvelPsnGeaWhklRkgklpdeilk  222

         GDsryla+E+lqe+ys+l kaDiF+l+lt+++++++++lP+nGe+Wh++R+gklp  i +

Q: 451   GDSRYLANEVLQEDYSNLtKADIFALALTVVNASGAEPLPTNGEKWHEIRRGKLP-AIPQ  509

         *******************************************************.****

S: 223   elsedlrellklmlepdperRptaeellkhevl  255

         +ls ++ +llklm++pdp+rRp++++l+kh+vl

Q: 510   VLSPEFLSLLKLMIHPDPTRRPSTSDLMKHPVL  542

         ******************************986

Domain Sequence
(FASTA)

FLELEKIGCG EFGAVFKCVK RLDGCMYAIK RSKKPLAGSV DEQNALREVY AHAVLGQHPH 60

VVRYYSAWAE DDHMLIQNEY CNGGTLSDVI TENYRRLSYL TELELKDLLV QVTQGLKYIH 120

STSLVHMDIK PSNIFISRKS IVSCDECDED EGLTPTVIYK IGDLGHVTRV NNPQVEEGDS 180

RYLANEVLQE DYSNLTKADI FALALTVVNA SGAEPLPTNG EKWHEIRRGK LPAIPQVLSP 240

EFLSLLKLMI HPDPTRRPST SDLMKHPVL 269

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007067	; P:mitosis

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017164	; Wee1-like_protein_kinase.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013