EKS-ORN-00212
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00212
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC476.92.2E-143343601259
StatusUnreviewed
Ensembl ProteinENSONIP00000019772
UniProt AccessionI3KF77;
Protein NameProtein kinase C
Protein Synonyms/Alias
Gene NamePRKCB (1 of 2)
Gene Synonyms/Alias PRKCB (1 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000015710ENSONIP00000019772ENSONIT00000019789
ENSONIG00000015710ENSONIP00000019773ENSONIT00000019790
OrganismOreochromis niloticus
Functional Description
Protein Length680
Protein Sequence
(FASTA)
MADSAAANSD GEDGPRQPMR GFARQGALRQ KNVHEVKDHK FIARFFKQPT FCSHCTDFIW 60
GFGKQGFQCQ VCCFVVHKRC HEFVTFSCPG ADKGPASDDP RSKHKFKIHT YSSPTFCDHC 120
GSLLYGLIHQ GMRCDHCMMN IHKRCVANVP SLCGTDHTER RGRIQITAEV KTNVLTVTIK 180
EARNLVPMDP NGLSDPYVKL KLIPDPRSES KQKTKTIKCC LNPTWNETFK FHLKEYDKDR 240
RLSVEVWDWD LTSRNDFMGS LSFGISELQK LGVDGWFKLL SQEEGEYFNV PVPPEGEEGN 300
EELRQKFERA KIGPGKNTDG KSANAASRFD SNGNQDRMKL SDFNFLMVLG KGSFGKVMLA 360
ERKGTEDLYA IKILKKDVVI QDDDVECTMV EKRVLALSGK PPFLTQLHST FQTMDRLYFV 420
MEYINGGDLM YQIQQVGKFK EPHAVFYAAE IAIGLFFLHQ KGIIYRDLKL DNVMLDCEGH 480
IKIADFGMCK ENMNDGVTTK TFCGTPDYIA PEIIAYQPYG KSVDWWAFGV LLYEMLAGQP 540
PFDGEDEDEL FQSIMEHHVS YPKSMSKEAV AICKGLMTKH PAKRLGCGPE GERDIREHSF 600
FRYMDWEKLE NKEVQPPFKP RACGRDAENF DRFFTRHPPV LTPPDDEVIQ NLDQDEFQGF 660
SFINSEFTGN AAATTATEQA 680
Nucleotide Sequence
(FASTA)
ATGGCAGACT CGGCGGCGGC CAACAGTGAT GGGGAGGACG GACCCCGCCA GCCTATGAGG 60
GGGTTCGCGC GCCAGGGAGC TCTCCGGCAG AAGAACGTGC ACGAGGTGAA GGACCACAAA 120
TTCATCGCGC GCTTCTTCAA GCAGCCCACC TTCTGCAGCC ACTGCACCGA CTTCATCTGG 180
GGTTTTGGCA AGCAGGGATT TCAGTGTCAA GTGTGTTGTT TCGTGGTTCA CAAACGTTGC 240
CATGAGTTCG TCACTTTCTC CTGTCCAGGT GCTGATAAAG GGCCCGCGTC AGACGACCCG 300
AGGTCAAAGC ATAAGTTTAA GATCCACACC TACTCCAGCC CCACCTTCTG TGACCACTGT 360
GGCTCCCTAC TCTATGGCCT CATACACCAG GGCATGAGAT GTGACCACTG TATGATGAAC 420
ATCCATAAGC GATGTGTGGC CAACGTGCCG AGTCTGTGTG GCACAGACCA CACTGAGAGG 480
AGAGGTCGCA TCCAGATCAC CGCCGAGGTT AAGACCAATG TTCTCACTGT TACCATCAAA 540
GAGGCCAGGA ATCTGGTTCC CATGGACCCC AACGGTCTGT CAGACCCTTA TGTGAAGCTT 600
AAACTGATCC CGGATCCCCG CAGCGAGAGT AAACAGAAGA CCAAGACCAT AAAGTGCTGC 660
CTCAACCCCA CCTGGAACGA GACCTTTAAA TTCCACCTGA AAGAATACGA TAAGGACCGC 720
CGTCTGTCCG TGGAGGTGTG GGACTGGGAC CTGACCAGCC GCAATGACTT CATGGGATCA 780
CTGTCCTTTG GCATCTCGGA GCTCCAGAAA CTAGGGGTGG ATGGATGGTT TAAGCTGCTC 840
TCCCAAGAAG AAGGCGAGTA CTTCAATGTA CCTGTCCCTC CGGAGGGGGA GGAGGGCAAC 900
GAGGAGCTAC GGCAGAAATT TGAGAGGGCT AAAATTGGTC CTGGGAAGAA CACAGATGGG 960
AAGTCAGCCA ACGCCGCATC CCGGTTTGAC TCCAATGGCA ACCAAGACCG CATGAAGTTG 1020
TCTGACTTTA ACTTCCTCAT GGTGCTGGGC AAGGGCAGCT TTGGCAAGGT GATGCTGGCA 1080
GAGCGTAAAG GAACCGAGGA CCTGTACGCT ATAAAGATCC TGAAGAAGGA CGTCGTGATC 1140
CAAGATGACG ACGTAGAGTG CACCATGGTG GAGAAGAGAG TGCTAGCTTT ATCTGGAAAG 1200
CCCCCTTTCT TAACGCAGCT GCACTCTACC TTCCAGACTA TGGACCGTTT GTATTTTGTC 1260
ATGGAGTACA TAAACGGCGG AGATCTCATG TATCAGATAC AGCAGGTCGG CAAGTTCAAA 1320
GAACCTCACG CTGTATTCTA CGCTGCAGAG ATAGCGATTG GTCTGTTTTT CCTACATCAA 1380
AAGGGCATCA TCTACAGAGA TCTGAAGCTG GACAATGTAA TGCTGGACTG TGAGGGCCAC 1440
ATTAAAATCG CAGACTTTGG CATGTGTAAA GAGAATATGA ATGATGGAGT CACAACCAAG 1500
ACCTTCTGTG GCACACCGGA TTACATTGCT CCTGAGATTA TAGCCTACCA GCCTTACGGG 1560
AAATCTGTGG ACTGGTGGGC CTTTGGCGTC TTGCTCTACG AGATGCTGGC TGGACAGCCT 1620
CCATTTGACG GAGAGGATGA AGATGAGTTA TTTCAGTCAA TCATGGAGCA CCACGTCTCC 1680
TATCCCAAGT CAATGTCCAA GGAGGCTGTC GCTATCTGTA AAGGGCTGAT GACAAAGCAT 1740
CCAGCAAAAC GCCTGGGCTG TGGTCCAGAG GGGGAGAGAG ACATCAGAGA GCACAGCTTC 1800
TTCCGCTACA TGGACTGGGA GAAACTGGAG AACAAGGAGG TGCAACCACC CTTCAAACCG 1860
AGAGCTTGTG GACGAGATGC CGAAAACTTT GACCGTTTTT TCACACGCCA CCCGCCGGTG 1920
CTGACCCCTC CCGATGATGA AGTGATTCAG AATCTGGACC AAGACGAGTT CCAGGGATTC 1980
TCCTTTATCA ACTCAGAGTT CACAGGAAAT GCTGCTGCCA CCACTGCCAC CGAGCAGGCT 2040
TGA 2043
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f++l+vlGkGsfgkv+lae+k+t++lyaik+lkkdvv+qdddve+t+vekrvlal+ k+p
Q: 343   FNFLMVLGKGSFGKVMLAERKGTEDLYAIKILKKDVVIQDDDVECTMVEKRVLALSGKPP  402
         99**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         fl+ql+s+fqt+drl+fv+ey+nGGdlm++iq+++k+ke++a+fyaaei+++l+flh+kg
Q: 403   FLTQLHSTFQTMDRLYFVMEYINGGDLMYQIQQVGKFKEPHAVFYAAEIAIGLFFLHQKG  462
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldnv+ld+eGhik+adfG+cke++ +g tt+tfcGtPdyiaPei+++++ygks
Q: 463   IIYRDLKLDNVMLDCEGHIKIADFGMCKENMNDGVTTKTFCGTPDYIAPEIIAYQPYGKS  522
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdwwa+Gvllyemlagq+Pf+gededelf+si+e++v+yPks+skeav+i+kgl+tk+p+
Q: 523   VDWWAFGVLLYEMLAGQPPFDGEDEDELFQSIMEHHVSYPKSMSKEAVAICKGLMTKHPA  582
         ************************************************************
S: 241   krlGvkeegeedikehaff  259
         krlG+ +ege+di+eh+ff
Q: 583   KRLGCGPEGERDIREHSFF  601
         ******************9
Domain Sequence
(FASTA)
FNFLMVLGKG SFGKVMLAER KGTEDLYAIK ILKKDVVIQD DDVECTMVEK RVLALSGKPP 60
FLTQLHSTFQ TMDRLYFVME YINGGDLMYQ IQQVGKFKEP HAVFYAAEIA IGLFFLHQKG 120
IIYRDLKLDN VMLDCEGHIK IADFGMCKEN MNDGVTTKTF CGTPDYIAPE IIAYQPYGKS 180
VDWWAFGVLL YEMLAGQPPF DGEDEDELFQ SIMEHHVSYP KSMSKEAVAI CKGLMTKHPA 240
KRLGCGPEGE RDIREHSFF 259
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00161
EKS-CAE-00131
EKS-CAJ-00176
EKS-CAF-00175
EKS-CAP-00168
EKS-CIS-00205
EKS-DAR-00459
EKS-EQC-00169
EKS-FEC-00158
EKS-GAM-00087
EKS-GAG-00145
EKS-GAA-00204
EKS-HOS-00174
EKS-ICT-00163
EKS-LAC-00180
EKS-LOA-00168
EKS-MAM-00166
EKS-MOD-00168
EKS-MUM-00173
EKS-MUP-00173
EKS-MYL-00177
EKS-NOL-00161
EKS-OCP-00107
EKS-OTG-00174
EKS-PAT-00159
EKS-POA-00165
EKS-RAN-00164
EKS-SAH-00162
EKS-SUS-00147
EKS-TAR-00219
EKS-TUT-00154
EKS-XET-00157
EKS-XIM-00206
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0004697; F:protein kinase C activity
GO:0008270; F:zinc ion binding
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020477; C2_dom.
IPR018029; C2_membr_targeting.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR014375; Protein_kinase_C_a/b/g.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 2.
PF00168; C2; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 2.
SM00239; C2; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50004; C2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 2.
PS50081; ZF_DAG_PE_2; 2.
Prints
PR00360; C2DOMAIN.
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013