EPS-ORN-00028

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ORN-00028

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	265.9	5.7E-79	23	288	266

Status

Unreviewed

Ensembl Protein

ENSONIP00000020015

UniProt Accession

I3KFW9;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1B

Gene Synonyms/Alias

PPM1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000015891	ENSONIP00000020014	ENSONIT00000020031
ENSONIG00000015891	ENSONIP00000020015	ENSONIT00000020032

Organism

Oreochromis niloticus

Functional Description

Protein Length

375

Protein Sequence
(FASTA)

MGAFLDKPKT EKHSAHGEGN GLRYGLSSMQ GWRVEMEDAH TAVVGLPHGL TDWSFFAVYD 60

GHAGSRVANY CSGHLLEHIL SGGAEFASGP SSVEGVKDGI RSGFLNIDEY MRSFSDLRQG 120

LDRSGSTAVC VLLSPTHLYF INCGDSRAVL SRDSKVGFST QDHKPCNPRE KERIQNAGGS 180

VMIQRVNGSL AVSRALGDYD YKCVDGKGPT EQLVSPEPEV CVLERVAEGD EFIVLACDGI 240

WDVMSNEELC EFVHSRLLVC DDLEKVCNSV VDTCLHKGSR DNMSVVLVCF SAAPKISEEA 300

VKKEEELDKY LETRVEELMG NCGEAGVPDL VSVLRSIASE NIPNLPPGGG LASKRSVIEA 360

VYNRLNPHRE EEGVS 375

Nucleotide Sequence
(FASTA)

ATGGGTGCAT TCCTGGACAA GCCGAAGACG GAGAAACACA GTGCCCACGG TGAGGGCAAT 60

GGGCTGCGTT ACGGCCTGAG CTCCATGCAA GGCTGGAGGG TGGAAATGGA GGACGCCCAC 120

ACAGCTGTGG TGGGCCTTCC CCATGGACTC ACCGACTGGT CTTTCTTTGC TGTCTACGAT 180

GGCCACGCTG GCTCCCGGGT GGCCAACTAC TGTTCTGGTC ACCTGCTGGA GCACATCTTG 240

TCAGGAGGGG CTGAATTTGC TTCAGGACCC AGCTCCGTGG AAGGCGTGAA AGACGGCATC 300

CGCTCTGGCT TCCTGAACAT TGACGAGTAT ATGCGCAGCT TCTCTGACCT GCGGCAGGGC 360

CTGGACCGCA GCGGATCAAC AGCAGTATGC GTGTTGCTCA GCCCGACCCA CCTCTACTTC 420

ATTAACTGCG GTGACTCACG GGCTGTGCTT AGTCGAGACA GCAAGGTGGG CTTCTCCACC 480

CAAGACCACA AGCCCTGCAA CCCACGTGAA AAAGAGCGCA TCCAGAATGC TGGCGGCTCA 540

GTCATGATCC AGAGGGTAAA CGGTTCCCTG GCTGTGTCCC GGGCTCTGGG GGACTACGAC 600

TACAAATGTG TGGATGGTAA GGGCCCCACG GAGCAGCTGG TGAGCCCCGA GCCAGAGGTA 660

TGTGTGTTGG AGCGGGTAGC CGAAGGAGAC GAGTTTATAG TCCTGGCGTG CGATGGGATC 720

TGGGATGTCA TGTCCAACGA GGAGCTGTGT GAGTTTGTCC ACTCACGACT TCTGGTGTGT 780

GACGACCTTG AAAAGGTCTG TAACTCAGTG GTGGACACCT GCTTGCATAA GGGGAGCAGG 840

GACAATATGA GTGTGGTGCT GGTGTGTTTC TCCGCGGCTC CCAAGATCTC AGAGGAGGCT 900

GTGAAGAAGG AAGAGGAATT GGATAAATAC TTGGAAACCC GTGTTGAGGA GCTTATGGGA 960

AACTGTGGAG AGGCTGGAGT CCCTGACCTG GTATCTGTCC TAAGGAGCAT TGCCTCAGAG 1020

AACATCCCCA ACCTTCCCCC TGGTGGAGGC CTGGCCAGCA AGCGGAGTGT GATCGAGGCG 1080

GTGTACAATA GGCTGAACCC TCACAGAGAA GAAGAAGGGG TGAGTTAA 1128

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++s++g+r emeda+t++ ++    + +  ++ff+vyDGh+gs+va++cs +l e++

Q: 23    RYGLSSMQGWRVEMEDAHTAVVGLPH--GLT-DWSFFAVYDGHAGSRVANYCSGHLLEHI  79

         69****************98444433..343.4***********************9999

S: 62    aeele...sseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdskly  118

                 s+ s+ + vk+ ++++Fl++de ++ +++ ++  d+sGstav++l+++++ly

Q: 80    LSGGAefaSGPSSVEGVKDGIRSGFLNIDEYMRSFSDLRQGLDRSGSTAVCVLLSPTHLY  139

         8765456688889999********************************************

S: 119   vanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsRal  178

         ++n+GdSravL+r+ k+   ++dHkp +++E+eRi++aggsv+ +   Rv+G+LavsRal

Q: 140   FINCGDSRAVLSRDSKVGFSTQDHKPCNPREKERIQNAGGSVMIQ---RVNGSLAVSRAL  196

         *********************************************...************

S: 179   Gdlylk.........pyvtpePevtshrl.tsedefliLasDGlwdvvsneeavslvrdv  228

         Gd+++k         ++v+pePev + ++  + def++La+DG+wdv+snee++++v+++

Q: 197   GDYDYKcvdgkgpteQLVSPEPEVCVLERvAEGDEFIVLACDGIWDVMSNEELCEFVHSR  256

         ***************************99788899*************************

S: 229   lekkeaeqeaakkLvklalargskdnvsaivv  260

         l   ++++++++++v+++l++gs+dn+s+++v

Q: 257   LLVCDDLEKVCNSVVDTCLHKGSRDNMSVVLV  288

         ***************************99875

Domain Sequence
(FASTA)

RYGLSSMQGW RVEMEDAHTA VVGLPHGLTD WSFFAVYDGH AGSRVANYCS GHLLEHILSG 60

GAEFASGPSS VEGVKDGIRS GFLNIDEYMR SFSDLRQGLD RSGSTAVCVL LSPTHLYFIN 120

CGDSRAVLSR DSKVGFSTQD HKPCNPREKE RIQNAGGSVM IQRVNGSLAV SRALGDYDYK 180

CVDGKGPTEQ LVSPEPEVCV LERVAEGDEF IVLACDGIWD VMSNEELCEF VHSRLLVCDD 240

LEKVCNSVVD TCLHKGSRDN MSVVLV 266

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013