EKS-ORN-00046

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00046

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	322.8	2.4E-96	840	1110	271

Status

Unreviewed

Ensembl Protein

ENSONIP00000021375

UniProt Accession

I3KJT0;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

JAK2 (1 of 2)

Gene Synonyms/Alias

JAK2 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000016948	ENSONIP00000021375	ENSONIT00000021394

Organism

Oreochromis niloticus

Functional Description

Protein Length

1122

Protein Sequence
(FASTA)

MLLMASLPAM DTVTDTCPVV HQNGTAHRES ADTRPAAAVL RLHLYHTNQG VADGSFLSYP 60

PGDYVAEELC IEAAKACSIS PLYCSLFGLF REQDCLWFSP NHIFQLDETA SEDVFFRIRY 120

YFPGWYSGGA SRAYRYGVTK GSESPVIDDF VMSYLFFQWR NDYLNGLVKI SNSHETQEEC 180

LGLAVLDMTR TAKEKQLSPL DIYHSISYKS FLPKDMRAQI QDCNFLTRKR IRFRFKRFIQ 240

QFSQCRTTVR DLKLKYLISM ESLEKSFYTE TFQVKEPSGV QRIILVGADT GIQWCRELSK 300

DSEQELQTLC DFPDVTNISI KQANKDSTAE SRVVTINKQD GKNLELEFPS LLEALSFVSL 360

VDGYYRLTTD AHHYLCKEVA PPRLVEAISS HCHGPITMEF AVNWLQKSGN KRGLYILRCS 420

PKDFNKYFLT FPVEVYDAIE HKHCQITRSA SGEFNLSGTK RNFSSLQELL SCYQKETVRS 480

DSIIFQFSKC CPPKSKEKSC LLVCRSNKGS EVPLSPSLHR HNISQMVFHK IRKEDLEFME 540

SLGQGTFTKI FKGVRKELRD YGEHQTEVVM KVLDQSHRNF SESFFEAASM MSQLSHVHLI 600

LNYGVCVCGE ENIMVQEYVK FGSLDTYLKK NKNSINLLWK LEVAKQLAWA MNFLEEKHLV 660

HGNVCAKNVL LIREEDRRAG NPPFIKLSDP GISITVLPKE ILIERIPWVP PECIEDPAKL 720

SLAADKWSFG TTLWEICSGG DKPLATLDNS KKTLFYMDHH QLPAPKWTEL ANLISSCMDY 780

EPTFRPTFRA VIRDLHSLFT PDYELIVDSD ILPNRTVGSA WASGGFDNQD PAQFEERHLI 840

FLQQLGKGNF GSVEMCRYDP LQDNTGEVVA VKKLQHSTAE HMRDFEREIE ILKSLQHENI 900

VKYKGVCYSA GRRNLRLIME YLPFGSLRDY LIKNRERIDH QKLIHYTSQI CKGMEYLSSK 960

RYIHRDLATR NILVESELRV KIGDFGLTKV LPQDKDYYMV KDPGESPIFW YAPESLTESK 1020

FSVASDVWSF GVVLYELFTH SDKNCSPPAV FMAMMGNDKQ GQLIVYHLIE LLKSGSRLPQ 1080

PLRCPTEIHE IMEECWDKDP GLRPSFKELA LRIDLFRDSK EF 1122

Nucleotide Sequence
(FASTA)

ATGCTGTTGA TGGCCTCCCT GCCAGCCATG GACACTGTGA CAGACACATG TCCAGTGGTG 60

CACCAAAATG GGACTGCCCA TCGGGAATCT GCAGACACAA GACCAGCTGC TGCTGTTCTA 120

AGGCTTCATT TATATCACAC CAACCAGGGA GTGGCCGACG GCAGCTTTCT AAGCTACCCA 180

CCTGGGGACT ATGTAGCTGA AGAGCTGTGC ATAGAGGCGG CAAAGGCATG CAGTATATCA 240

CCACTTTATT GCAGCCTTTT TGGGCTTTTC CGAGAGCAGG ATTGCTTGTG GTTTTCACCC 300

AATCACATCT TCCAGCTTGA TGAGACTGCC TCTGAAGATG TGTTTTTCAG AATACGGTAC 360

TACTTCCCTG GTTGGTATAG TGGTGGGGCA TCCAGGGCTT ATCGATATGG AGTCACAAAA 420

GGGTCAGAAA GCCCCGTCAT TGATGACTTC GTAATGTCGT ACCTCTTCTT TCAGTGGAGG 480

AATGACTATC TGAATGGCTT GGTGAAGATT TCCAACTCCC ATGAGACACA AGAAGAGTGC 540

CTTGGTTTGG CTGTGCTTGA CATGACAAGA ACAGCCAAAG AAAAGCAGCT GTCGCCTCTG 600

GACATATATC ACTCTATAAG CTACAAGTCC TTCTTGCCAA AGGACATGCG AGCTCAGATC 660

CAGGACTGCA ATTTCTTGAC ACGTAAACGC ATCCGCTTCC GCTTCAAGCG CTTCATCCAG 720

CAGTTCAGCC AGTGTCGGAC TACAGTTCGT GACCTTAAGC TTAAGTACCT CATCAGCATG 780

GAGTCTCTGG AGAAGTCCTT CTACACAGAG ACCTTCCAGG TCAAGGAGCC ATCAGGCGTC 840

CAGCGCATCA TCCTGGTTGG AGCAGATACT GGCATACAGT GGTGTCGGGA GTTGAGTAAG 900

GACTCAGAAC AGGAACTACA GACCTTGTGT GATTTCCCTG ATGTCACCAA CATCAGCATC 960

AAACAGGCCA ACAAAGACAG CACTGCAGAG AGTCGGGTGG TTACCATTAA CAAGCAAGAT 1020

GGCAAGAATC TGGAACTGGA ATTCCCCAGC CTGCTTGAAG CCCTCTCTTT TGTGTCTCTC 1080

GTTGATGGCT ACTATCGACT GACCACAGAT GCACATCATT ACCTTTGTAA AGAAGTGGCT 1140

CCCCCTAGGC TGGTTGAGGC CATATCTTCT CATTGCCACG GTCCAATCAC AATGGAGTTT 1200

GCAGTTAACT GGCTTCAGAA GTCTGGAAAC AAACGGGGAC TGTACATTTT GAGATGTAGC 1260

CCGAAAGATT TCAACAAATA CTTTTTGACT TTTCCCGTTG AGGTGTATGA TGCTATAGAA 1320

CACAAGCACT GCCAGATCAC CAGGTCTGCA AGTGGAGAGT TCAACCTCAG TGGAACCAAA 1380

AGAAACTTCA GCAGTCTGCA AGAACTGCTC AGCTGCTACC AGAAGGAAAC GGTGCGCTCA 1440

GACAGCATCA TTTTCCAATT CAGCAAGTGC TGCCCTCCTA AATCCAAAGA AAAGTCGTGC 1500

CTCCTCGTGT GCAGGAGCAA CAAAGGCTCG GAAGTGCCAC TGTCTCCATC ACTACATCGA 1560

CACAACATCA GTCAAATGGT GTTTCACAAG ATCAGGAAAG AAGATCTGGA ATTTATGGAG 1620

AGTCTCGGTC AAGGGACTTT TACGAAGATC TTTAAAGGGG TTCGAAAGGA GCTGAGAGAC 1680

TATGGAGAGC ACCAAACGGA AGTAGTCATG AAAGTGCTGG ACCAGTCCCA CAGGAACTTC 1740

TCTGAGTCAT TCTTTGAAGC CGCCAGCATG ATGAGCCAGT TGTCTCATGT ACACCTTATT 1800

CTAAACTACG GCGTTTGTGT CTGTGGAGAA GAGAACATCA TGGTTCAGGA GTATGTGAAA 1860

TTCGGCTCAC TGGACACCTA CTTGAAGAAA AACAAGAACT CGATTAACCT TCTGTGGAAG 1920

CTTGAAGTGG CGAAGCAGCT GGCCTGGGCC ATGAACTTCC TGGAAGAAAA ACATCTTGTT 1980

CATGGGAATG TGTGTGCAAA AAATGTTCTC CTGATCAGAG AAGAGGATCG AAGGGCTGGA 2040

AACCCACCTT TCATCAAACT AAGTGATCCT GGTATCAGCA TCACTGTCCT GCCCAAAGAA 2100

ATTCTGATTG AGAGGATTCC TTGGGTGCCC CCTGAATGTA TTGAGGACCC TGCCAAACTG 2160

AGTCTGGCTG CTGACAAGTG GAGTTTTGGC ACTACACTGT GGGAAATCTG TAGTGGTGGC 2220

GATAAACCTT TAGCAACACT AGACAACTCA AAGAAAACCC TGTTTTACAT GGATCACCAC 2280

CAGCTTCCTG CACCAAAGTG GACTGAACTG GCTAATCTGA TTTCTAGCTG CATGGACTAT 2340

GAGCCCACAT TCAGGCCTAC GTTTCGTGCT GTTATCCGTG ACCTCCACAG CCTCTTCACA 2400

CCAGACTATG AGTTGATTGT GGACAGTGAC ATCCTGCCAA ATAGGACAGT GGGCTCTGCG 2460

TGGGCATCTG GTGGGTTTGA CAATCAGGAT CCAGCTCAGT TTGAAGAGAG ACACCTCATA 2520

TTCTTACAGC AGCTGGGCAA GGGAAACTTT GGCAGTGTGG AGATGTGTCG GTATGACCCA 2580

CTGCAGGACA ACACCGGAGA GGTCGTGGCC GTGAAGAAAC TTCAGCACAG CACCGCAGAG 2640

CACATGCGAG ACTTTGAGCG GGAGATCGAG ATCCTAAAAT CTCTTCAGCA TGAGAACATT 2700

GTCAAGTACA AGGGTGTTTG CTACAGTGCA GGTCGACGAA ACCTCCGTCT CATCATGGAA 2760

TATCTTCCCT TTGGAAGTCT GCGAGATTAC CTCATAAAAA ACCGAGAGCG AATCGACCAT 2820

CAGAAGCTCA TCCATTACAC TTCCCAGATC TGCAAGGGTA TGGAGTACCT ATCAAGTAAG 2880

CGGTATATCC ATAGAGACCT GGCAACACGA AATATCCTAG TGGAGAGCGA ACTCAGAGTA 2940

AAAATCGGGG ATTTCGGCCT CACCAAAGTT CTGCCTCAAG ACAAAGACTA CTACATGGTC 3000

AAAGATCCGG GAGAGAGCCC CATATTCTGG TATGCCCCCG AGTCTTTGAC TGAAAGCAAG 3060

TTCTCTGTGG CCTCGGATGT CTGGAGCTTT GGAGTTGTAC TTTATGAGCT CTTCACCCAC 3120

AGTGACAAGA ACTGCAGTCC TCCAGCAGTT TTCATGGCCA TGATGGGGAA TGACAAGCAA 3180

GGACAGCTGA TTGTCTATCA CCTCATTGAG CTCCTCAAAT CAGGCAGCAG GCTGCCTCAA 3240

CCCCTGAGAT GTCCTACAGA GATACATGAA ATCATGGAGG AGTGCTGGGA CAAAGACCCT 3300

GGTTTGCGCC CTTCTTTCAA GGAGCTGGCC CTGCGCATCG ACCTGTTCAG GGACAGTAAA 3360

GAGTTTTAA 3369

Domain Profile

S: 2     kqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlsheh  61

          ++++Lgkg+f++v+++r+d+ +d+t+e va+k L++s+ +++rdf+re+eil++l+he+

Q: 840   IFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTAEHMRDFEREIEILKSLQHEN  899

         6789********************************************************

S: 62    ivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLed  119

         ivk+kgvc++ g++  rl+mey++ GsL++yL k++e++++++l+++++q++k+meYL++

Q: 900   IVKYKGVCYSAGRRnlRLIMEYLPFGSLRDYLIKNRERIDHQKLIHYTSQICKGMEYLSS  959

         *********999888*********************************************

S: 120   kklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwlap  178

         k+++hrd+a+rn+Lve+e +      vk++d+gl+k+++qd +Yy+v+++++s+i+w+ap

Q: 960   KRYIHRDLATRNILVESELR------VKIGDFGLTKVLPQDkDYYMVKDPGESPIFWYAP  1013

         ********************......**********************************

S: 179   eclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle........rklell  225

         e+l+e+k +s+asdvWsFgv+lyel+t  +k++sp    + +++++        +++ell

Q: 1014  ESLTESK-FSVASDVWSFGVVLYELFThSDKNCSPpavfMAMMGNDkqgqlivyHLIELL  1072

         *******.*******************9**********988888888999**********

S: 226   eekerlpkpk.cpaelaelmtnclsyepsqrpsFrail  262

         +++ rlp+p  cp+e++e+m++c++++p  rpsF++++

Q: 1073  KSGSRLPQPLrCPTEIHEIMEECWDKDPGLRPSFKELA  1110

         ***********************************985

Domain Sequence
(FASTA)

IFLQQLGKGN FGSVEMCRYD PLQDNTGEVV AVKKLQHSTA EHMRDFEREI EILKSLQHEN 60

IVKYKGVCYS AGRRNLRLIM EYLPFGSLRD YLIKNRERID HQKLIHYTSQ ICKGMEYLSS 120

KRYIHRDLAT RNILVESELR VKIGDFGLTK VLPQDKDYYM VKDPGESPIF WYAPESLTES 180

KFSVASDVWS FGVVLYELFT HSDKNCSPPA VFMAMMGNDK QGQLIVYHLI ELLKSGSRLP 240

QPLRCPTEIH EIMEECWDKD PGLRPSFKEL A 271

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020693	; Tyr_kinase_non-rcpt_Jak2.

Pfam

PF07714	; Pkinase_Tyr; 2.
PF00017	; SH2; 1.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.

Prints

PR01823	; JANUSKINASE.
PR01825	; JANUSKINASE2.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013