EKS-ORN-00146

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00146

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NAK	356.1	1.6E-106	40	312	273

Status

Unreviewed

Ensembl Protein

ENSONIP00000021385

UniProt Accession

I3KJU0;

Protein Name

Protein Synonyms/Alias

Gene Name

GAK

Gene Synonyms/Alias

GAK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000016957	ENSONIP00000021385	ENSONIT00000021404

Organism

Oreochromis niloticus

Functional Description

Protein Length

1328

Protein Sequence
(FASTA)

MSLFQSALDF LAGPGSSGAA SRDQNDFVGQ VVELGDMKLR IKRVIAEGGF AFVYEAQDMS 60

SGKDYALKRL LSNEEEKNKE IIQEVCFMKK LSGHPNTVQF CSAASISKEE SDTGQAEFLI 120

LTELCKGQLV DFIKRVEQKA PLSCDTVLKI FYQACRAVQH MHKQKPPVIH RDLKIENLLI 180

SNQGTIKLCD FGSATTVSHY PDYSWSAQKR SMVEDEITRN TTPAYRTPEM IDLYSNFPIN 240

EKQDIWALGC ILYLLCFKQH PFEDGAKLQI VNGKYSMPQN DVKYTVYHDL IRSMLKVNPE 300

ERLSITELVN QLQEIAAARN VNPKSPITEL LEQNGGFGNN GAQPSMQIHN SHNNAAFFIG 360

VYDPDQSGSG LFDILKGGTE RFLTNIKDTS SKVIQSVASY AKGDLDISYI TSRIAVMSFP 420

AEGVESAIKN NIEDVRLFLD SRHAGHYAVY NLSKRSYRPS RFHNRVSECN WQLRRAPNLR 480

SLYSVCKNMH LWLKQDQRNI CVVHCLDGRA ASAVAVCSFL CFCRLFTTAE AAVYMFSMKR 540

CPPGISPSHK RYIEYMCDMM AEEPIIPHSK PVVIRSIIMT PVPLFNKQRN GCRPFCEVYV 600

GDERVLTTSQ EYDRMQDFKM EDGKAEIPLN VTVQGDVLVV IYHARSTLGG RLQAKMASMK 660

MFQIQFHTGF VPRNATTVKF AKYDLDACDI QEKYPDLFQV NLDIEVEPRE RPSTKTPPWE 720

GFQTKGLNPK ILFSSRDEQQ EILSKFGKPE LPRQPGSSAF YDSESPQPAQ TPDTSNATEP 780

ESPMSNDTNS SNFFQTLDWE DVRSAQDASD SQEGGYMNEQ EDLSDQSEGE SYSCSATSGE 840

PMSRDHSEPL FDSDFQTASP ATQEAPPEDT ADLLGLNSDP QPPTMSSTSS SAPPHGDQGG 900

MKAASSNSDL LTDLFAPPAG QTGAVQEDLF FSGPASGATP DQKHISCHFA CVAAMGDLFD 960

PFGMGSGSGV GSSVGSSRQA SGPDLFGDLL GSDSSATSGF GSAHSNATPA SNTSLFNLNK 1020

LVNDTPKMTS SASQPDLLGG WDSWAKGTTA GMSTTASKPS YTSTGRRNLS YRSFASGMPS 1080

MSKAKSQTFD PFADLGNLSS NLPGPSFGTK GPSSSSSSAK PQTQPWQSAR PTSAQNKPWI 1140

PGSGSGPKGS SASQPAGTQS SKPNYNLNFS SVIGGREERG VRGPGFGPKP KVKEDDFEDL 1200

LSTQGFASKP DKKGPRTIAE MRRQEITKDM DPLKLQILDW IEGKERNIRA LLSTLHTVLW 1260

EGEMRWKPVG MADLVSADQV KKYYRKAVLV VHPDKATGQP YEQYAKMIFM ELNDAWSEFE 1320

NQGSKALF 1328

Nucleotide Sequence
(FASTA)

ATGTCCCTAT TCCAGTCGGC ACTAGATTTC CTAGCCGGGC CCGGCTCCTC CGGAGCGGCC 60

AGTCGGGACC AAAATGATTT CGTCGGACAA GTCGTTGAAC TCGGTGACAT GAAGCTGAGG 120

ATCAAGAGGG TGATCGCTGA AGGTGGATTT GCTTTTGTAT ATGAAGCCCA GGACATGAGC 180

AGTGGTAAAG ACTACGCCCT CAAGAGGCTG CTGTCTAATG AAGAAGAGAA GAACAAAGAA 240

ATCATACAGG AAGTCTGCTT CATGAAAAAG CTGTCAGGTC ATCCAAATAC GGTTCAGTTC 300

TGCTCTGCGG CCTCCATCAG TAAAGAGGAG TCAGACACCG GGCAGGCTGA GTTTCTGATC 360

CTCACTGAGC TGTGTAAAGG TCAGCTGGTG GACTTTATAA AGAGGGTAGA GCAGAAGGCT 420

CCTCTATCAT GTGACACTGT GCTAAAAATC TTCTACCAGG CGTGCCGTGC TGTTCAGCAT 480

ATGCACAAAC AGAAGCCTCC CGTGATACAC AGAGACCTCA AGATTGAGAA CCTCTTGATT 540

AGTAACCAGG GCACCATCAA GCTGTGTGAC TTTGGCAGCG CCACCACAGT GTCACATTAT 600

CCAGACTACA GCTGGTCAGC ACAGAAGAGG TCAATGGTGG AGGATGAGAT AACAAGGAAC 660

ACCACTCCTG CGTACCGAAC GCCAGAGATG ATCGATCTCT ACTCCAACTT TCCCATCAAT 720

GAGAAGCAAG ACATCTGGGC TCTGGGATGC ATCCTCTACC TGTTGTGTTT TAAGCAGCAT 780

CCATTTGAGG ATGGAGCCAA GCTACAAATT GTCAACGGAA AATACTCCAT GCCTCAGAAC 840

GACGTGAAAT ACACTGTGTA TCACGACCTC ATACGTTCCA TGTTGAAGGT GAACCCAGAG 900

GAGCGTCTGT CTATTACAGA GTTGGTCAAC CAGCTCCAGG AGATAGCAGC AGCACGCAAC 960

GTCAACCCCA AGTCCCCCAT TACTGAGCTG CTGGAGCAGA ACGGAGGTTT TGGCAACAAT 1020

GGAGCACAGC CATCCATGCA GATCCACAAC AGCCATAACA ATGCAGCATT TTTTATAGGT 1080

GTATATGACC CCGATCAGTC TGGCAGTGGC CTGTTTGATA TTTTAAAGGG AGGAACAGAA 1140

CGCTTCCTGA CAAACATAAA GGATACTTCC TCCAAGGTCA TCCAGTCAGT AGCTAGCTAT 1200

GCCAAAGGGG ACCTGGATAT TTCTTACATC ACCTCCAGAA TTGCAGTCAT GTCTTTCCCA 1260

GCAGAAGGGG TGGAGTCTGC GATAAAGAAC AACATTGAGG ATGTCCGTCT GTTCCTTGAT 1320

TCACGTCATG CTGGCCACTA CGCTGTCTAC AACCTCTCCA AACGATCATA CAGGCCTTCT 1380

CGATTCCACA ACAGGGTTTC AGAGTGTAAT TGGCAGCTGC GCCGTGCCCC TAACCTCCGC 1440

AGTCTCTACA GCGTATGTAA GAACATGCAT CTATGGCTCA AACAGGACCA GAGGAACATC 1500

TGTGTGGTAC ACTGTCTGGA TGGCAGAGCA GCATCAGCAG TGGCAGTTTG CTCCTTCCTG 1560

TGTTTTTGCC GCCTTTTCAC CACTGCTGAG GCAGCAGTCT ACATGTTCTC AATGAAACGC 1620

TGTCCACCAG GCATATCACC TTCACACAAG AGGTATATAG AGTATATGTG TGACATGATG 1680

GCAGAGGAGC CCATCATCCC TCACAGCAAG CCTGTAGTTA TTCGCTCCAT CATCATGACA 1740

CCAGTGCCAC TGTTCAACAA GCAGCGTAAC GGGTGCCGGC CATTCTGCGA AGTCTACGTT 1800

GGGGACGAGA GGGTGCTCAC CACATCACAG GAGTATGACA GGATGCAGGA TTTTAAGATG 1860

GAAGATGGGA AAGCAGAGAT TCCTCTCAAT GTTACCGTTC AAGGAGACGT ACTGGTGGTG 1920

ATCTATCATG CAAGATCTAC GCTGGGAGGA CGTCTGCAGG CAAAAATGGC GTCCATGAAA 1980

ATGTTCCAGA TCCAGTTCCA CACAGGCTTT GTACCAAGAA ATGCAACGAC TGTCAAGTTT 2040

GCCAAGTATG ATTTGGATGC CTGTGACATC CAGGAGAAGT ACCCAGACTT ATTCCAGGTC 2100

AACTTGGACA TTGAGGTTGA ACCCAGGGAG AGGCCCAGCA CCAAGACTCC TCCATGGGAG 2160

GGCTTTCAAA CCAAAGGCCT CAACCCCAAG ATCCTTTTCT CCTCTCGTGA TGAACAGCAA 2220

GAGATCCTCA GCAAATTTGG TAAGCCCGAG TTGCCTCGTC AGCCAGGTTC TTCGGCGTTT 2280

TATGACTCAG AGTCGCCCCA GCCAGCTCAA ACCCCAGACA CCTCCAATGC AACAGAACCA 2340

GAGTCCCCGA TGAGCAATGA TACTAATTCC AGCAACTTTT TCCAGACCCT AGACTGGGAA 2400

GATGTACGTA GCGCTCAGGA TGCCTCAGAC AGTCAAGAAG GAGGATATAT GAATGAACAG 2460

GAGGATCTGA GTGATCAGTC AGAAGGAGAG TCCTATTCTT GCTCTGCCAC CAGTGGAGAG 2520

CCAATGTCAC GTGACCACAG CGAGCCGCTG TTTGATTCTG ACTTTCAGAC GGCTTCTCCT 2580

GCAACACAGG AGGCTCCTCC TGAAGACACA GCTGACCTCT TGGGGTTGAA CTCTGACCCT 2640

CAACCTCCAA CCATGTCCTC AACTTCGTCC TCTGCTCCAC CACACGGAGA CCAGGGAGGA 2700

ATGAAAGCCG CCTCTAGCAA CAGCGACCTC CTCACTGACT TATTTGCACC TCCTGCTGGT 2760

CAGACTGGAG CAGTGCAGGA AGACTTGTTC TTCAGTGGGC CAGCCAGTGG AGCCACACCA 2820

GACCAAAAAC ATATTTCCTG TCACTTTGCC TGTGTTGCAG CCATGGGGGA TCTGTTTGAT 2880

CCGTTTGGGA TGGGGTCGGG TTCTGGTGTT GGCTCCAGCG TTGGTTCATC TCGACAAGCC 2940

TCTGGACCAG ACCTGTTTGG AGACTTGTTG GGTTCTGATA GTTCAGCAAC CAGTGGATTT 3000

GGTTCAGCTC ACAGTAACGC CACTCCTGCT TCCAACACCA GCCTCTTCAA CCTCAATAAG 3060

CTTGTAAATG ATACCCCTAA AATGACATCA TCAGCCAGCC AACCAGACCT GCTGGGTGGG 3120

TGGGACAGCT GGGCAAAAGG AACCACTGCT GGCATGAGCA CCACTGCCAG TAAACCAAGT 3180

TATACCAGCA CAGGTAGGAG AAACCTTTCT TACAGATCTT TTGCTTCTGG TATGCCATCC 3240

ATGTCAAAGG CCAAGTCTCA GACCTTTGAT CCTTTTGCTG ACCTAGGAAA CCTGAGCTCC 3300

AACTTGCCAG GACCATCCTT CGGCACAAAG GGTCCTTCTT CCTCTTCTTC CTCTGCTAAG 3360

CCTCAAACTC AGCCATGGCA GTCTGCAAGA CCCACCTCAG CCCAGAACAA ACCTTGGATT 3420

CCTGGATCTG GATCTGGCCC CAAAGGATCT TCAGCTTCTC AGCCTGCAGG AACACAGTCC 3480

TCTAAACCCA ACTACAACCT TAACTTCTCC AGTGTGATTG GTGGGAGAGA AGAGAGAGGA 3540

GTTCGTGGGC CTGGATTTGG CCCCAAGCCA AAGGTAAAGG AAGATGATTT CGAGGATCTG 3600

CTCTCAACTC AGGGTTTTGC TTCTAAACCT GACAAGAAGG GACCAAGGAC CATTGCTGAA 3660

ATGAGGAGAC AGGAGATCAC AAAAGACATG GATCCTCTCA AACTACAGAT CTTGGACTGG 3720

ATCGAAGGGA AGGAGCGAAA CATCCGCGCC CTGCTGTCAA CTCTACACAC AGTGTTGTGG 3780

GAGGGTGAAA TGCGCTGGAA GCCTGTGGGC ATGGCAGACC TGGTGTCAGC TGACCAGGTG 3840

AAGAAATACT ACAGGAAGGC TGTGCTGGTT GTCCATCCTG ATAAGGCAAC GGGCCAGCCT 3900

TACGAACAGT ACGCTAAGAT GATCTTTATG GAACTGAACG ACGCCTGGTC AGAGTTTGAG 3960

AACCAGGGAT CCAAAGCACT CTTCTAA 3987

Domain Profile

S: 2     riekvlaeGGfalvylaedastgekyalKrilvneeedleeikrEieimkklsghknivk  61

         ri++v+aeGGfa+vy a+d+s+g+ yalKr+l+neee+++ei++E+++mkklsgh+n v+

Q: 40    RIKRVIAEGGFAFVYEAQDMSSGKDYALKRLLSNEEEKNKEIIQEVCFMKKLSGHPNTVQ  99

         89**********************************************************

S: 62    lv..dssvkeekdngskevlllleyckkgslvdllnkrlekgelseaeilkilldvtrav  119

         ++  +s  kee+d+g++e+l+l+e+ck g+lvd++++ ++k  ls++++lki+++ +rav

Q: 100   FCsaASISKEESDTGQAEFLILTELCK-GQLVDFIKRVEQKAPLSCDTVLKIFYQACRAV  158

         **7667789999999************.8************99*****************

S: 120   aalHalsvpliHRDlkveNillsdegelvlcDlGSattaileve...skqelsalqeeie  176

         +++H++++p+iHRDlk+eN+l+s++g+++lcD+GSatt ++ ++   s+q++s++++ei+

Q: 159   QHMHKQKPPVIHRDLKIENLLISNQGTIKLCDFGSATTVSHYPDyswSAQKRSMVEDEIT  218

         *******************************************99999************

S: 177   knttlsyrsPElidlysnlvideksDiWaLGcllYklcffesPfeesvklailngkysiP  236

         +ntt+ yr+PE+idlysn++i+ek+DiWaLGc+lY lcf ++Pfe+++kl i+ngkys+P

Q: 219   RNTTPAYRTPEMIDLYSNFPINEKQDIWALGCILYLLCFKQHPFEDGAKLQIVNGKYSMP  278

         ************************************************************

S: 237   ensryseklkslikkmlevdpeeRptiaqvlell  270

         +n+  ++  ++li++ml+v+peeR++i++++++l

Q: 279   QNDVKYTVYHDLIRSMLKVNPEERLSITELVNQL  312

         ******************************9986

Domain Sequence
(FASTA)

RIKRVIAEGG FAFVYEAQDM SSGKDYALKR LLSNEEEKNK EIIQEVCFMK KLSGHPNTVQ 60

FCSAASISKE ESDTGQAEFL ILTELCKGQL VDFIKRVEQK APLSCDTVLK IFYQACRAVQ 120

HMHKQKPPVI HRDLKIENLL ISNQGTIKLC DFGSATTVSH YPDYSWSAQK RSMVEDEITR 180

NTTPAYRTPE MIDLYSNFPI NEKQDIWALG CILYLLCFKQ HPFEDGAKLQ IVNGKYSMPQ 240

NDVKYTVYHD LIRSMLKVNP EERLSITELV NQL 273

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR001623	; DnaJ_N.
IPR011009	; Kinase-like_dom.
IPR014019	; Phosphatase_tensin-typ.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR014020	; Tensin_phosphatase_C2-dom.

Pfam

PF00226	; DnaJ; 1.
PF00069	; Pkinase; 1.
PF10409	; PTEN_C2; 1.

SMARTs

SM00271

; DnaJ; 1.

Prosites

PS51182	; C2_TENSIN; 1.
PS50076	; DNAJ_2; 1.
PS51181	; PPASE_TENSIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013