EKS-ORN-00403
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00403
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20357.17.3E-10725289265
StatusUnreviewed
Ensembl ProteinENSONIP00000021446
UniProt AccessionI3KK00;
Protein Name
Protein Synonyms/Alias
Gene NameMAP4K4 (1 of 2)
Gene Synonyms/Alias
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000017004ENSONIP00000021446ENSONIT00000021465
ENSONIG00000017004ENSONIP00000021445ENSONIT00000021464
OrganismOreochromis niloticus
Functional Description
Protein Length1167
Protein Sequence
(FASTA)
MANDSPAKSL VDIDLASLRD PAGIFELVEV VGNGTYGQVY KGRHVKTGQL AAIKVMDVTE 60
DEEEEIKLEI NMLKKYSHHR NIATYYGAFI KKSPPGHDDQ LWLVMEFCGA GSITDLVKNT 120
KGNSLKEDWI AYISREILRG LAHLHAHHVI HRDIKGQNVL LTENAEVKLV DFGVSAQLDR 180
TVGRRNTFIG TPYWMAPEVI ACDENPDATY DYRSDLWSCG ITAIEMAEGA PPLCDMHPMR 240
ALFLIPRNPP PRLKSKKWSK KFFSFIESCL VKNYTQRPPT EQLLKHPFIR DQPNERQVRI 300
QLKDHIDRTK KKRGEKDETE YEYSGSEEEE EESSEQEGEP SSIVNVPGES TLRRDFIRLQ 360
QENKERSEAL RRQQLLQEQQ LREQEEYKRQ LLAERQKRIE QQKEQRRRLE EQQRREREMR 420
RQQEREQRRR EQEEKRRIEE MERRRKEEEE RRRAEEEKRR ADREQEYIRR QLEEEQRHLE 480
ILQQQLLHEQ AMLLADERYR KNIQGSPQSA QTKPQQPPVP PRSESSYPNG NSASEAMHRP 540
VEPQVRSHLA ALKSSSSVAS SNSSTATPPV VSRSHSCTEP LTPSFENLHL QNSHESRHHL 600
PSSSSPLSSS SSTPARTDPH PHPQPRQYEP APSAEVPPRV PVRTTSRSPV LPRRDSPHHL 660
GNAAHSSHAA QHNAASAAEP RLLWERVEKL VPRTTSNSGS GGSSSSSSSS NSSSQPGSHC 720
GSGERFRARS SSKSEGSPLQ RPENAGKKPE ERRDVLRPNR SADLTALAKE LRAVDDVRPL 780
NKVTDYPSSS SEESDTTDED DDEEVDQEAG EESTSGPEDS RAVSSRLSNG ETESVKTMIV 840
HEEGESDAGT TPCKDSTLIV RQSAGDNRKR TGPGPGQTQT PGMHAGFAPS PGSVSLQGLA 900
HHTPSPHHHH HHHHHHPIQH SDRNGFAGRI HHLPDLIQQS HHSSPSSSAS NSPSSSSLAS 960
PSSMSPQSPL DKLGILTESQ SSNNMQKHKS SSSFTPFIDP RLLQVSPSTG SALNNVGYGN 1020
DARLAEALRA DPSRKGSVVN VNPVNTRPQS DTPEIRKYKK RFNSEILCAA LWGVNLLVGT 1080
ESGLMLLDRS GQGKVYPLIN RRRFQQMDVL EGLNVLVTIS GKKNKLRVYY LSWLRNKILH 1140
NDPEVEKKQG WTTVGDLEGC VHYKVGT 1167
Nucleotide Sequence
(FASTA)
ATGGCGAACG ACTCTCCGGC TAAAAGTCTG GTGGACATAG ACCTGGCATC CCTGAGGGAT 60
CCTGCTGGGA TTTTCGAGCT GGTGGAAGTG GTCGGAAATG GTACATATGG ACAAGTCTAC 120
AAGGGTCGAC ATGTTAAGAC GGGACAGCTG GCGGCCATCA AGGTCATGGA CGTCACCGAG 180
GATGAAGAAG AGGAAATTAA GTTGGAAATC AACATGCTGA AGAAGTACTC CCATCACAGA 240
AACATAGCCA CCTACTACGG AGCCTTCATC AAGAAAAGTC CACCAGGCCA TGATGACCAG 300
CTCTGGCTGG TGATGGAGTT CTGTGGTGCC GGCTCCATCA CAGATCTGGT GAAGAACACC 360
AAGGGCAACT CCCTGAAGGA AGACTGGATC GCCTACATCT CCCGAGAGAT CCTCAGGGGA 420
TTAGCTCACC TGCATGCTCA TCATGTCATT CACCGCGACA TCAAAGGACA AAACGTGCTG 480
CTGACTGAAA ATGCTGAAGT CAAGCTGGTG GACTTTGGTG TGAGCGCTCA GCTGGACCGG 540
ACGGTAGGTC GAAGAAACAC CTTCATCGGG ACGCCATACT GGATGGCTCC AGAGGTCATC 600
GCTTGTGATG AAAACCCTGA TGCTACCTAC GATTACAGGA GTGATCTGTG GTCCTGTGGA 660
ATCACAGCCA TTGAAATGGC TGAGGGAGCT CCTCCTCTGT GTGACATGCA TCCAATGAGA 720
GCCCTCTTCC TCATTCCCAG AAACCCACCT CCTCGACTCA AGTCCAAAAA ATGGTCAAAG 780
AAGTTCTTCA GCTTCATTGA GAGTTGCCTT GTGAAGAATT ACACCCAGCG CCCTCCCACT 840
GAGCAGCTGC TGAAACACCC CTTCATTCGG GACCAGCCCA ACGAGAGGCA GGTTCGCATC 900
CAGCTCAAAG ACCACATCGA CCGAACCAAG AAGAAGAGGG GCGAGAAAGA TGAGACAGAG 960
TATGAATACA GTGGCAGTGA AGAAGAGGAG GAAGAGTCAT CTGAGCAAGA AGGAGAGCCA 1020
AGTTCCATAG TCAACGTGCC GGGCGAGTCG ACCCTGCGTC GTGACTTCAT ACGTCTGCAG 1080
CAGGAGAACA AGGAGCGTTC GGAGGCCCTT CGCCGCCAAC AGCTCCTCCA GGAGCAGCAG 1140
CTCCGTGAGC AGGAGGAGTA CAAGCGCCAG CTGCTGGCTG AGAGGCAGAA ACGTATCGAG 1200
CAGCAGAAGG AGCAGCGGAG ACGGCTGGAG GAGCAACAAC GACGTGAGCG CGAGATGAGG 1260
AGGCAGCAGG AGCGTGAGCA GCGCCGGCGC GAGCAGGAGG AGAAGAGGCG CATCGAAGAG 1320
ATGGAACGAC GCCGCAAAGA AGAGGAGGAG CGCAGGAGGG CCGAGGAGGA AAAGAGGAGG 1380
GCTGACCGCG AGCAGGAGTA TATACGTCGA CAGCTGGAGG AGGAGCAGAG GCACCTGGAG 1440
ATCCTGCAAC AGCAGCTCCT CCATGAACAG GCCATGCTTC TGGCTGACGA GCGATATCGG 1500
AAGAACATCC AGGGTTCTCC CCAGTCAGCT CAGACCAAAC CACAGCAGCC TCCGGTGCCG 1560
CCACGATCTG AGTCTTCATA CCCCAATGGG AACTCTGCTT CTGAGGCCAT GCACCGGCCT 1620
GTGGAACCAC AGGTTCGTTC TCATCTGGCT GCTTTAAAGA GCAGCAGCAG CGTGGCCTCA 1680
TCAAACTCCT CCACTGCCAC TCCGCCTGTT GTGTCGCGAT CGCACTCCTG CACAGAGCCG 1740
CTCACTCCTA GCTTTGAAAA TCTCCACCTT CAAAACAGCC ACGAATCCCG CCATCACCTT 1800
CCATCATCAT CATCACCATT ATCATCCTCA TCATCAACGC CTGCTCGCAC TGACCCACAC 1860
CCCCATCCCC AGCCTAGGCA ATATGAACCA GCCCCTTCAG CGGAGGTCCC ACCGAGGGTT 1920
CCTGTCAGGA CTACATCAAG GTCCCCAGTG TTGCCGAGGC GAGATTCGCC TCATCACCTT 1980
GGCAACGCCG CACACAGCAG CCACGCAGCA CAACACAATG CTGCCAGTGC AGCGGAGCCT 2040
CGGCTGCTGT GGGAACGAGT GGAGAAACTG GTTCCCAGAA CGACCAGTAA TAGTGGCAGC 2100
GGAGGCTCCA GTTCCTCTAG CAGCTCCAGT AACTCCAGCT CTCAGCCCGG TTCTCACTGT 2160
GGCTCAGGAG AGAGGTTCAG GGCCCGCTCC TCTTCTAAAT CGGAGGGTTC ACCCCTCCAG 2220
CGGCCAGAGA ATGCTGGGAA AAAACCAGAG GAGAGGAGGG ACGTGCTCAG GCCGAACAGA 2280
TCAGCGGACC TGACGGCTCT GGCCAAAGAA CTGCGTGCAG TGGATGATGT TCGCCCCCTA 2340
AATAAGGTGA CAGATTACCC TTCATCCTCC AGTGAAGAAT CGGACACCAC TGACGAAGAT 2400
GACGATGAAG AGGTGGATCA GGAGGCAGGT GAAGAGTCGA CCTCTGGCCC GGAGGACTCC 2460
AGAGCTGTTT CTTCTCGGCT GAGTAACGGA GAAACGGAGT CAGTGAAAAC CATGATCGTC 2520
CACGAAGAGG GCGAGAGTGA TGCAGGCACA ACGCCATGCA AAGACAGCAC GCTGATTGTC 2580
AGACAGAGTG CAGGTGACAA CAGAAAGCGT ACGGGCCCTG GCCCAGGCCA AACGCAGACA 2640
CCTGGCATGC ATGCAGGCTT TGCCCCGAGC CCCGGCTCGG TGTCGCTCCA GGGCCTCGCT 2700
CACCACACCC CCAGCCCCCA CCACCACCAT CATCATCACC ATCATCACCC CATACAGCAT 2760
TCGGACAGGA ATGGCTTTGC TGGTCGCATC CACCATCTCC CAGACTTGAT CCAGCAGAGC 2820
CACCATTCCT CCCCCTCCTC CTCTGCATCC AACTCCCCTT CCTCTTCCAG CCTTGCCAGT 2880
CCCTCGTCTA TGTCCCCACA GAGTCCCTTG GACAAGCTTG GCATCCTCAC AGAGAGCCAG 2940
TCTAGTAACA ACATGCAGAA GCACAAGTCT TCTTCCTCCT TCACTCCGTT CATTGACCCA 3000
CGACTTCTCC AGGTCTCTCC ATCCACCGGC AGTGCCCTCA ACAATGTCGG CTATGGGAAC 3060
GATGCCCGGC TGGCAGAGGC ACTGAGAGCA GATCCATCCC GGAAGGGCTC CGTGGTCAAC 3120
GTCAATCCGG TCAACACCCG CCCTCAGAGT GACACCCCAG AGATCCGCAA ATACAAGAAG 3180
AGGTTCAACT CTGAGATTCT TTGCGCTGCA CTCTGGGGAG TGAACTTACT GGTGGGAACA 3240
GAAAGTGGCC TGATGCTGTT GGATCGCAGT GGTCAGGGGA AAGTTTACCC TCTGATTAAC 3300
CGCCGGCGCT TCCAGCAGAT GGACGTCCTG GAAGGACTCA ATGTCTTGGT CACTATATCA 3360
GGTAAGAAGA ACAAGCTCCG TGTATACTAC CTGTCCTGGC TGAGGAATAA GATTCTGCAT 3420
AATGACCCAG AGGTTGAGAA GAAACAGGGC TGGACAACCG TAGGAGACTT GGAGGGATGC 3480
GTCCACTACA AAGTTGGTAC GTAA 3504
Domain Profile
S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkh.pniv  59
         +el+e++g+G++g+vy++r++ktg+l+aik++++++ +++ee++ ei++lkk++h +ni 
Q: 25    FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEEEEIKLEINMLKKYSHhRNIA  83
         899********************************8.999*************998****
S: 60    eylesflk......eeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLey  113
         +y+++f+k      +++lwlvme++ +Gs++dlvk+++ ++lkE++iayi re+l++L++
Q: 84    TYYGAFIKksppghDDQLWLVMEFCGAGSITDLVKNTKGNSLKEDWIAYISREILRGLAH  143
         *************9**********************************************
S: 114   lHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe  173
         lH+++viHrdik++n+Llte++eVkL+dfgv+aql++t+ +r+t++gtpywmAPEvia++
Q: 144   LHAHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACD  203
         ************************************************************
S: 174   ...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskef  230
            + +Yd+++D+ws+GItaie+aeg+pP++d++p++al++i++n+pp+lksk k+sk+f
Q: 204   enpDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSK-KWSKKF  262
         999999********************************************888.******
S: 231   kefvekclqknpekRpsasellkhkFl  257
          +f+e+cl kn+ +Rp +++llkh+F+
Q: 263   FSFIESCLVKNYTQRPPTEQLLKHPFI  289
         **************************7
Domain Sequence
(FASTA)
FELVEVVGNG TYGQVYKGRH VKTGQLAAIK VMDVTEDEEE EIKLEINMLK KYSHHRNIAT 60
YYGAFIKKSP PGHDDQLWLV MEFCGAGSIT DLVKNTKGNS LKEDWIAYIS REILRGLAHL 120
HAHHVIHRDI KGQNVLLTEN AEVKLVDFGV SAQLDRTVGR RNTFIGTPYW MAPEVIACDE 180
NPDATYDYRS DLWSCGITAI EMAEGAPPLC DMHPMRALFL IPRNPPPRLK SKKWSKKFFS 240
FIESCLVKNY TQRPPTEQLL KHPFI 265
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Gorilla gorilla"; ?>Ornithorhynchus anatinus"; ?>
EKS-GOG-00307
EKS-ORA-00280
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005083; F:small GTPase regulator activity
KEGG
InterPros
IPR001180; Citron.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00780; CNH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00036; CNH; 1.
Prosites
PS50219; CNH; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013