EKS-ORN-00373

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00373

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/IRE	468.3	8.9E-141	565	826	262

Status

Unreviewed

Ensembl Protein

ENSONIP00000021652

UniProt Accession

I3KKK7;

Protein Name

Protein Synonyms/Alias

Gene Name

ERN1

Gene Synonyms/Alias

ERN1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000017169	ENSONIP00000021652	ENSONIT00000021671

Organism

Oreochromis niloticus

Functional Description

Protein Length

961

Protein Sequence
(FASTA)

LQPHAYIHAW FFLFIYFFKS RLHGLCSGST VSLPESLLFV STLDGNLHAV SKKSGSIKWT 60

LKEDPVLQVP THVAEPAFLP DPNDGSLYSL GGKNNEGLTK LPFTIPELVQ ASPCRSSDGI 120

LYMGKKQDLW YVVDLLTGEK QQTLTSSFAE MFCPSSSLLY LGRTEYTITM YDTKSRELRW 180

NATYSDYAST LPDDDTKYKM AHFVSNGDGL VVTVDSESGD VQWVQNYNSP VVAMYIWQRE 240

GLRKVPHTNV AVETLRYLTF MSGEVGRITQ WKYPFPKEKK PKNKFMATLY VGKYSSSLYA 300

SSSLVHDGVT VVPRGSTFPM LEGPDSQESE EDKECVITPS TSVKFNAALR SGYHTFCLSG 360

HHETPPEAHT KILEKFPDSF PRHQANVIPP TTDKKVEEKV NDSGMDDGPP SAVPETSIQE 420

PGTGGRAVRP EAPVDSMLKD MATIIFSTFL LAGWVAFVIT YPKSMHKQQQ LQHQEFQRQM 480

EERLEMLQRQ QPFPPADIGM GLTLESDYLE VAHIRSECSD HSSPNVTPRA SNHSNLSVSE 540

LGSSANEHED GEADSSIVRV GNITFHPKEV LGHGAEGTIV YKGQFDNRPV AVKRILPECF 600

SFADREVQLL RESDEHPNVI RYFCTERDRQ FQYIAIELCA ASLQEYVERK DFNRHGLEPV 660

MLLQQTMSGL AHLHSLNIVH RDLKPHNILV SMPNAHGRVR AMISDFGLCK KLAVGRHSFS 720

RRSGVPGTEG WIAPEVLSED CKDNPTCAVD IFSAGCVFYY VVSQGSHPFG KSLQRQANIL 780

LGSYSLDHLQ NDKHGDIVAR DLIEQMLSMD PHRRPSAESV LKHPFFWSLE KELQFFQDVS 840

DRIEKEPLDG PIVRQLERGG RAVVKADWRE HITVPLQTDL RKFRSYKGGS VRDLLRAMRN 900

KKHHYRELPA EVQETLGSIP DDFVSYFTSR FPHLLMHTYL AMRTCAPERP FLPYYCSAEQ 960

L 961

Nucleotide Sequence
(FASTA)

CTACAACCGC ATGCATACAT ACATGCTTGG TTTTTTTTAT TTATTTATTT TTTTAAATCA 60

AGGCTCCATG GGCTTTGCAG TGGCAGCACA GTGTCGCTTC CTGAAAGCCT GCTCTTTGTG 120

TCCACCCTGG ATGGAAACCT GCATGCTGTT AGCAAGAAAT CAGGCTCTAT TAAATGGACT 180

CTAAAAGAAG ATCCAGTTCT TCAGGTCCCC ACGCATGTAG CAGAGCCGGC CTTTCTGCCC 240

GACCCAAATG ATGGCAGCCT GTACTCTCTA GGCGGGAAGA ACAATGAAGG CCTCACTAAA 300

TTACCCTTCA CCATCCCCGA GTTGGTCCAA GCTTCTCCCT GCCGCAGTTC TGATGGAATC 360

CTTTACATGG GTAAAAAGCA GGACTTGTGG TATGTGGTGG ATCTGTTGAC TGGTGAGAAA 420

CAGCAAACCC TGACCTCATC CTTTGCTGAG ATGTTCTGCC CCTCTTCATC TCTTCTCTAT 480

CTGGGACGCA CAGAGTATAC CATCACCATG TATGACACCA AGAGCAGAGA GCTGCGCTGG 540

AATGCAACCT ACTCCGACTA CGCCTCCACC CTCCCTGACG ATGACACCAA ATACAAGATG 600

GCTCATTTTG TGTCCAATGG TGACGGCCTT GTGGTGACCG TGGACAGCGA ATCTGGAGAT 660

GTCCAGTGGG TCCAGAACTA TAACTCTCCA GTGGTGGCCA TGTACATCTG GCAGCGCGAG 720

GGCCTCCGCA AAGTGCCCCA TACTAACGTG GCCGTGGAGA CCCTACGTTA CCTCACTTTC 780

ATGTCTGGAG AGGTTGGCCG CATCACACAG TGGAAATACC CATTTCCTAA GGAGAAGAAG 840

CCCAAGAACA AATTCATGGC TACTTTGTAT GTGGGCAAAT ACTCGTCCAG TCTGTATGCT 900

TCTTCCTCCC TGGTGCACGA TGGAGTTACT GTGGTGCCTC GTGGCAGCAC ATTCCCCATG 960

CTGGAAGGCC CGGATAGCCA GGAGTCGGAA GAAGACAAGG AGTGTGTCAT CACACCCAGC 1020

ACCAGCGTGA AGTTCAACGC TGCGCTCCGA AGTGGGTATC ACACCTTTTG TTTATCAGGT 1080

CACCATGAGA CGCCTCCAGA AGCTCACACT AAGATTCTTG AAAAATTCCC TGACAGCTTC 1140

CCACGCCATC AAGCCAACGT CATCCCACCA ACGACTGACA AGAAAGTAGA GGAGAAGGTT 1200

AATGACAGCG GTATGGATGA TGGGCCCCCT TCAGCTGTCC CTGAGACGTC TATCCAAGAA 1260

CCTGGGACTG GTGGCCGCGC TGTACGCCCA GAGGCCCCGG TGGATTCGAT GCTTAAAGAC 1320

ATGGCTACCA TCATCTTCTC CACATTCCTC CTGGCTGGCT GGGTTGCCTT TGTGATTACA 1380

TATCCCAAAA GTATGCACAA GCAGCAGCAG CTGCAGCACC AAGAGTTCCA GAGACAGATG 1440

GAGGAGAGGT TGGAGATGCT GCAGAGGCAG CAGCCTTTTC CACCTGCAGA CATAGGCATG 1500

GGTTTGACTC TAGAGAGCGA CTACCTGGAG GTGGCACACA TTCGCTCCGA ATGCTCAGAC 1560

CACAGCAGCC CCAATGTCAC CCCTCGTGCC TCCAACCACT CCAACTTGTC TGTGTCTGAG 1620

CTGGGGAGCT CAGCCAATGA GCACGAAGAT GGAGAGGCAG ACTCCAGTAT TGTCAGAGTG 1680

GGGAACATAA CTTTCCATCC CAAAGAGGTC CTGGGACATG GTGCTGAGGG GACTATTGTG 1740

TACAAGGGTC AGTTTGACAA CCGTCCAGTT GCAGTGAAGA GGATTCTCCC AGAGTGCTTC 1800

AGCTTTGCAG ACCGAGAAGT TCAGCTGCTG AGGGAGTCTG ATGAGCATCC AAATGTCATC 1860

CGTTACTTCT GCACGGAGAG GGACCGTCAG TTCCAGTACA TCGCCATTGA GCTTTGCGCT 1920

GCCTCCCTTC AGGAGTATGT GGAACGAAAG GATTTCAATC GTCATGGACT TGAGCCTGTT 1980

ATGCTTCTCC AGCAGACCAT GTCTGGACTG GCCCATCTGC ACTCCCTCAA CATCGTCCAC 2040

AGAGACCTGA AACCTCACAA TATTCTAGTG TCCATGCCCA ATGCACACGG TCGGGTCCGC 2100

GCCATGATTT CAGACTTCGG CCTGTGTAAG AAGCTCGCAG TGGGCCGCCA CAGTTTCAGT 2160

AGGAGGTCTG GGGTGCCCGG CACTGAAGGC TGGATCGCTC CAGAGGTCCT CAGCGAGGAC 2220

TGCAAAGACA ACCCGACCTG TGCAGTTGAT ATCTTCTCTG CTGGTTGTGT CTTCTACTAC 2280

GTTGTGTCCC AGGGAAGCCA CCCTTTTGGC AAATCACTGC AGAGGCAAGC AAACATCCTA 2340

CTGGGCTCGT ACAGCCTGGA CCATCTGCAG AATGACAAAC ATGGTGACAT TGTAGCCAGA 2400

GATCTAATCG AGCAGATGCT GAGCATGGAT CCCCACCGGA GGCCTTCGGC TGAAAGCGTT 2460

CTTAAGCACC CTTTCTTCTG GAGCCTGGAG AAGGAGCTGC AGTTCTTTCA GGATGTGAGT 2520

GACAGAATAG AAAAGGAACC GCTGGACGGA CCAATTGTGA GACAGCTGGA GAGAGGGGGG 2580

AGGGCTGTTG TCAAGGCTGA CTGGAGAGAG CACATTACAG TGCCACTGCA GACTGATCTG 2640

AGGAAGTTTC GCTCCTATAA GGGCGGGTCA GTCAGAGACC TCCTGCGTGC AATGAGAAAC 2700

AAGAAACACC ATTATCGAGA GTTACCCGCT GAGGTCCAGG AGACTCTGGG CTCCATCCCC 2760

GATGACTTTG TCTCCTATTT CACCTCCCGC TTTCCCCACC TGCTGATGCA CACCTACCTA 2820

GCCATGCGGA CCTGCGCGCC TGAGAGACCA TTCCTGCCTT ACTACTGCTC TGCAGAACAG 2880

CTC 2883

Domain Profile

S: 1     fspkdvlGkGaeGtvvfrGsfegrevavkrllsefvdlakrevkllresdehpnviryfc  60

         f pk+vlG+GaeGt+v++G+f++r+vavkr+l+e++++a+rev+llresdehpnviryfc

Q: 565   FHPKEVLGHGAEGTIVYKGQFDNRPVAVKRILPECFSFADREVQLLRESDEHPNVIRYFC  624

         679*********************************************************

S: 61    tekdrqfryialelcaaslqdyvedkdlelqkelepisllkqiasGlahlhslkivhrdl  120

         te+drqf+yia+elcaaslq+yve kd++ +++lep+ ll+q++sGlahlhsl+ivhrdl

Q: 625   TERDRQFQYIAIELCAASLQEYVERKDFN-RHGLEPVMLLQQTMSGLAHLHSLNIVHRDL  683

         *****************************.99****************************

S: 121   kpqnilislpdakgklrvlisdfGlckkldvGkssfsrrsgvsGteGwiapelleeltke  180

         kp+nil+s+p+a+g++r++isdfGlckkl+vG++sfsrrsgv+GteGwiape+l+e++k+

Q: 684   KPHNILVSMPNAHGRVRAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEVLSEDCKD  743

         ************************************************************

S: 181   rltsavdifslGcvfyyvlskGkhpfGdslkrqanilsgelsldklkeekdeeviaedli  240

         ++t avdifs+Gcvfyyv+s+G+hpfG+sl+rqanil g++sld+l+++k+ +++a+dli

Q: 744   NPTCAVDIFSAGCVFYYVVSQGSHPFGKSLQRQANILLGSYSLDHLQNDKHGDIVARDLI  803

         ************************************************************

S: 241   skmidkdplkrpsakkvlkhplf  263

         ++m+++dp +rpsa+ vlkhp+f

Q: 804   EQMLSMDPHRRPSAESVLKHPFF  826

         **********************9

Domain Sequence
(FASTA)

FHPKEVLGHG AEGTIVYKGQ FDNRPVAVKR ILPECFSFAD REVQLLRESD EHPNVIRYFC 60

TERDRQFQYI AIELCAASLQ EYVERKDFNR HGLEPVMLLQ QTMSGLAHLH SLNIVHRDLK 120

PHNILVSMPN AHGRVRAMIS DFGLCKKLAV GRHSFSRRSG VPGTEGWIAP EVLSEDCKDN 180

PTCAVDIFSA GCVFYYVVSQ GSHPFGKSLQ RQANILLGSY SLDHLQNDKH GDIVARDLIE 240

QMLSMDPHRR PSAESVLKHP FF 262

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0016891	; F:endoribonuclease activity, producing 5'-phosphomonoesters
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006397	; P:mRNA processing

KEGG

InterPros

IPR010513	; KEN_RNase_activator.
IPR011009	; Kinase-like_dom.
IPR018391	; PQQ_beta_propeller_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR006567	; PUG-dom.
IPR011047	; Quinonprotein_ADH-like.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF06479	; Ribonuc_2-5A; 1.

SMARTs

SM00564	; PQQ; 5.
SM00580	; PUG; 1.

Prosites

PS51392	; KEN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013