EKS-ORN-00184

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00184

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	535.3	3.0E-161	560	836	277

Status

Unreviewed

Ensembl Protein

ENSONIP00000021843

UniProt Accession

I3KL47;

Protein Name

Protein Synonyms/Alias

Gene Name

FGFR4

Gene Synonyms/Alias

FGFR4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000017319	ENSONIP00000021843	ENSONIT00000021862
ENSONIG00000017319	ENSONIP00000021842	ENSONIT00000021861

Organism

Oreochromis niloticus

Functional Description

Protein Length

904

Protein Sequence
(FASTA)

DLRVTRPLIV PGYPENTTAV VGGQAKLMCK VHRPATTKVQ WLKVNVSEPG QNQGGPPGLR 60

ALTPLQNISS KVNTLHLSNI TLEDAGEYIC MAENTHAGQT VQAMQSAWLE VLPDVLEDLS 120

EDTTEHLLLE PGNVLKLRCD MSTRPGMAVN WYKEGARVLP TPRIQMRGGI MEITDVTYED 180

SGVYVCVLRG SKEPVRNFTI TVADSLGSGD DDEDNDLEDS SAEIENDQVY IYRVPYWTHP 240

QRMEKKLYAV PAGNTVKFRC PAMGSPMPSI RWLKNGREFR GEHRIGGIKL RHQHWSLVME 300

SVVPSDRGNY TCVVENKYGS ISHSYVLDVL ETERSPHRPI LQAGLPANTT AVVGSDVQFH 360

CKVYSDAQPH IQWLKHIERN GRRYGPDGTP YVQVLKTGSL NMSEVEVLYL SKVTMEDAGE 420

YTCLAGNSIG YAHQSAWLTV ISVPAEEEAA DAMETMETKY SDIIIYACGF LALIMAIVIV 480

VLCRMQVNPR REPFDALPVQ KLSKFPLRRQ YSVESNSSGK SSASLMRVAR LSSSCSPMLA 540

GVMEFELPYD PDWEFPRENL TLGKPLGEGC FGQVVRAEAY GINKDCPEQA TTVAVKMLKD 600

DATDKDLADL ISEMELMKVM DKHKNIINLL GVCTQDGPLY VLVEYASKGS LREYLRARRP 660

PGMDYTFDVT KVPEEQLTFK DLLSCAYQVA RGMEYLASKR CIHRDLAARN VLVTEDNVMK 720

IADFGLARGV HQIDYYKKTT NGRLPVKWMA PEALFDRVYT HQSDVWSFGV LMWEIFTLGG 780

SPYPGIPVEE LFKLLKEGHR MDKPSNCTHE LYMMMRECWH AVPTQRPTFK QLVEELDRVL 840

LSISDEYLDL STPFEQYSPS CEDTSSSCSS DNDSVFTHDA LSTDPCLLGY QDVHSRIDMK 900

TALR 904

Nucleotide Sequence
(FASTA)

GATCTTCGGG TCACTAGGCC TCTGATAGTT CCAGGTTACC CTGAAAACAC CACGGCAGTG 60

GTTGGTGGTC AGGCAAAGTT GATGTGTAAA GTCCACAGAC CAGCAACCAC AAAGGTGCAG 120

TGGCTTAAGG TGAATGTCAG CGAACCAGGT CAGAACCAGG GAGGACCCCC TGGCCTCAGG 180

GCTCTGACGC CCCTGCAGAA CATATCATCC AAGGTGAATA CTCTCCATCT GTCCAACATC 240

ACTTTGGAGG ATGCTGGCGA GTACATCTGC ATGGCTGAGA ACACCCATGC GGGACAGACA 300

GTGCAGGCCA TGCAGTCAGC ATGGCTGGAG GTCCTGCCTG ATGTTCTCGA GGACTTGAGT 360

GAGGACACCA CGGAGCATCT CCTGTTAGAG CCAGGCAACG TCCTAAAACT GCGCTGCGAC 420

ATGAGCACCC GGCCCGGCAT GGCTGTAAAC TGGTACAAGG AGGGTGCGCG TGTTCTGCCC 480

ACACCCCGGA TCCAGATGCG AGGCGGCATC ATGGAAATCA CAGACGTAAC ATATGAAGAT 540

TCAGGTGTTT ATGTTTGTGT TCTCCGGGGA TCCAAAGAGC CTGTGAGGAA CTTCACTATC 600

ACTGTGGCAG ACTCGCTGGG ATCTGGGGAC GACGATGAGG ACAACGACTT GGAGGATTCT 660

TCAGCTGAGA TTGAAAATGA CCAAGTATAC ATCTACAGAG TTCCATATTG GACACATCCC 720

CAGCGTATGG AGAAGAAACT CTATGCTGTT CCTGCAGGAA ACACAGTGAA GTTTCGTTGT 780

CCGGCCATGG GTAGCCCCAT GCCGAGCATC CGCTGGCTCA AAAATGGACG CGAATTTAGA 840

GGGGAGCATC GCATTGGAGG CATCAAGCTA CGACACCAGC ACTGGAGCCT GGTGATGGAG 900

AGTGTTGTGC CCTCAGACAG AGGAAACTAT ACCTGTGTGG TAGAGAACAA ATACGGCTCC 960

ATCAGTCACA GCTATGTTCT TGATGTTCTG GAAACAGAGC GTTCACCCCA CAGGCCCATC 1020

CTGCAGGCAG GTTTGCCAGC CAACACCACA GCAGTGGTAG GCAGTGATGT CCAGTTCCAC 1080

TGCAAGGTCT ACAGTGACGC CCAACCTCAC ATTCAGTGGC TCAAGCACAT CGAAAGGAAC 1140

GGCAGACGCT ATGGTCCTGA CGGGACCCCC TACGTTCAGG TCCTCAAGAC TGGAAGTCTG 1200

AACATGTCTG AGGTGGAGGT CCTTTACCTG TCCAAAGTTA CCATGGAGGA TGCTGGAGAG 1260

TACACCTGTC TGGCTGGAAA TTCAATTGGC TATGCCCACC AGTCTGCCTG GCTCACAGTC 1320

ATTTCAGTAC CTGCAGAGGA GGAAGCAGCA GATGCTATGG AAACAATGGA GACCAAATAT 1380

AGCGACATCA TTATCTATGC CTGTGGATTC CTGGCTCTGA TCATGGCCAT TGTCATCGTG 1440

GTGTTGTGCC GAATGCAGGT TAACCCCAGA AGGGAGCCAT TCGATGCACT CCCAGTGCAG 1500

AAGCTTTCCA AGTTCCCTCT TCGCAGACAG TACTCAGTGG AGTCCAACTC GTCAGGGAAG 1560

TCCAGCGCAT CTCTGATGAG GGTGGCTCGC CTCTCTTCCA GCTGTTCACC AATGTTGGCT 1620

GGAGTCATGG AGTTTGAGTT GCCCTATGAC CCAGACTGGG AGTTCCCCAG GGAGAATCTA 1680

ACATTGGGTA AACCTCTAGG AGAAGGCTGC TTTGGTCAGG TGGTCAGAGC TGAAGCCTAC 1740

GGCATCAACA AGGACTGTCC AGAACAAGCC ACTACTGTGG CAGTCAAGAT GCTCAAAGAT 1800

GACGCCACAG ACAAAGATCT GGCAGACCTC ATCTCAGAGA TGGAGCTGAT GAAGGTGATG 1860

GACAAGCACA AGAACATTAT CAACCTGCTG GGAGTCTGTA CACAGGATGG CCCTCTGTAT 1920

GTGCTGGTGG AGTATGCTTC CAAAGGAAGT CTGAGGGAGT ACCTGCGAGC CCGACGACCT 1980

CCAGGCATGG ATTACACCTT TGATGTGACT AAGGTGCCTG AAGAGCAGCT CACCTTTAAA 2040

GACCTGCTGT CCTGTGCCTA CCAGGTGGCC AGAGGGATGG AGTACCTGGC CTCTAAAAGA 2100

TGCATCCACA GAGATTTGGC AGCCAGGAAT GTTCTGGTGA CCGAGGACAA TGTGATGAAG 2160

ATTGCTGACT TTGGCCTGGC CAGAGGAGTC CACCAGATTG ACTACTACAA GAAAACCACC 2220

AATGGACGAC TGCCAGTGAA GTGGATGGCA CCAGAAGCTT TGTTTGACAG AGTCTACACA 2280

CACCAGAGTG ATGTGTGGTC ATTTGGTGTA TTGATGTGGG AAATTTTCAC ACTGGGCGGT 2340

TCACCGTACC CTGGTATCCC TGTTGAGGAA CTCTTTAAGC TGCTGAAGGA AGGACATCGC 2400

ATGGACAAAC CATCAAACTG CACACACGAA CTCTATATGA TGATGCGTGA ATGTTGGCAT 2460

GCTGTTCCCA CCCAGAGACC AACCTTCAAA CAGTTGGTTG AGGAACTGGA CAGAGTGCTG 2520

CTGTCCATTT CTGACGAGTA CTTGGATCTG TCAACGCCTT TTGAACAATA CTCCCCTTCG 2580

TGCGAGGACA CATCCAGCTC CTGCTCCTCT GACAACGACT CAGTTTTTAC CCATGATGCC 2640

TTATCCACCG ACCCCTGCCT CTTGGGCTAC CAGGACGTGC ACTCTCGGAT AGACATGAAG 2700

ACGGCTCTTC GATAG 2715

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+aea g++kd +++++tvavkmlk+datdkdladl+seme++k+

Q: 560   LTLGKPLGEGCFGQVVRAEAYGINKDCPEQATTVAVKMLKDDATDKDLADLISEMELMKV  619

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         + khkniinllG+ctq+Gplyv+veya+kG lre+lrarrp+g++++ d +k++eeqlt+

Q: 620   MDKHKNIINLLGVCTQDGPLYVLVEYASKGSLREYLRARRPPGMDYTFDVTKVPEEQLTF  679

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdl+s+ayqvarGmeylask+cihrdlaarnvlvtednv+kiadfGlar+vh+idyykkt

Q: 680   KDLLSCAYQVARGMEYLASKRCIHRDLAARNVLVTEDNVMKIADFGLARGVHQIDYYKKT  739

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllkeGh

Q: 740   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  799

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kp++ct+ely++mrecwha++++rptfkqlve+l

Q: 800   RMDKPSNCTHELYMMMRECWHAVPTQRPTFKQLVEEL  836

         ***********************************86

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVRAEA YGINKDCPEQ ATTVAVKMLK DDATDKDLAD LISEMELMKV 60

MDKHKNIINL LGVCTQDGPL YVLVEYASKG SLREYLRARR PPGMDYTFDV TKVPEEQLTF 120

KDLLSCAYQV ARGMEYLASK RCIHRDLAAR NVLVTEDNVM KIADFGLARG VHQIDYYKKT 180

TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH 240

RMDKPSNCTH ELYMMMRECW HAVPTQRPTF KQLVEEL 277

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Latimeria chalumnae"; ?>Monodelphis domestica"; ?>Myotis lucifugus"; ?>Oryzias latipes"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR013151	; Immunoglobulin.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07679	; I-set; 2.
PF00047	; ig; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 4.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 4.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013