EKS-ORN-00388
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00388
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR484.01.3E-145712969258
StatusUnreviewed
Ensembl ProteinENSONIP00000021851
UniProt AccessionI3KL56;
Protein Name
Protein Synonyms/Alias
Gene NameEGFR (2 of 2)
Gene Synonyms/Alias EGFR (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000017327ENSONIP00000021851ENSONIT00000021870
OrganismOreochromis niloticus
Functional Description
Protein Length1192
Protein Sequence
(FASTA)
MKLLCGGGAA LLLLLLGRCC CTTPDRRVCQ GMSNHLSLLG TYEQHYDSMV RMYSNCSVVL 60
ENLEITYTQE HHDLSFLQSI QEVSGYVLIA MNDVATIPLV NLRLIRGQNL YEGRFALLVM 120
SNYHKNASSA TLNYTLHYLL TEILKGGVKV THNPLLCNIE TIDWWDIVDK AGNYSVVFTK 180
DDFPKKCQTC DPSCRNSSCW AAGQDHCQRF TKLLCAEQCS WRCRGPKPVD CCNEHCAAGC 240
TGPRATDCLA CRAFNDDGIC KDACPPLKRY DSKLHQVVEN PNAKFTFGAT CVKACPHNYV 300
VTEGSCVRSC SNRMYEVKEN GIQRCKDCDG PCPKACDGVG VGALINTIAI NATNIDLFKD 360
CTKINGDVVI VESSFTGDPH YNIPPMEPEK LENFKTVKEI TGYLMIQFWP KNLTSLSVFE 420
NLEIIRGRTT FSKHSLAVVK LKHLRWLGLR SLKEVSAGVV AVRNNPELCY VWKDQWSHLF 480
RSTDQTINLL DNSPPDVCER NNQTCDTECT DLGCWGPGPT MCLSCRQFNR KGCCVVSCNL 540
LQGEPREVEV NGSCIQCHPE CLLQTGSLTC SGPGPDKCSQ CAHVKDGPHC VPHCPHGVQG 600
EGGKLVWKYA DRMGQCQSCH QNCTEGCSGP GWSGCNGYSS VAHSTLAASV IGGLLLLVIV 660
SLIIFVLLRR MQIKRKRTVR RLLQERELVE PLTPSGQAPN QALLRILKET EFKKVRVLGS 720
GAFGTVYKGL WIPEGENVKI PVAIKVLREA TSPKANQEVL DEAYVMASVD HPHVCRLLGI 780
CLTSSVQLVT QLMPYGCLLD YVRHHRDSIG AQWLLNWCVQ IAKGMNYLEE RHLVHRDLAA 840
RNVLLKSPNH VKITDFGLAK LLTADEKEYH ADGGKVPIKW MALESILQWT YTHQSDVWSY 900
GVTVWEIMTF GSKPYDGIPA SEIATVLGRG ERLPQPPICT IDVYMIMVKC WMIDPSSRPR 960
FKELMVEFSK MASDPSRYLV IQGDLPSPSD SRFYSRLLST DDTEDVIDPD EYLLPYRGMG 1020
NHKDRPMVCY LYTLNISSVF YSNECALMKD NGHPAGENSL ALRYITDPTD SALEKDFIDH 1080
EYMNQSVSET SQSSRLSKVL NPNYEDLSLG WGAAPLPHPL EDLNTSQVPY GPEYLNASCK 1140
LRPLVTSHSL DNPDYQADFL PQTITDATLA ENHLFLPAAE NLEYLGVGGA LH 1192
Nucleotide Sequence
(FASTA)
ATGAAGCTTC TCTGCGGAGG AGGAGCGGCG CTGCTGCTGC TGCTGCTCGG CCGCTGCTGC 60
TGCACCACTC CCGACAGGAG AGTGTGTCAG GGAATGAGCA ACCACCTGTC GCTGTTGGGG 120
ACGTACGAGC AGCACTACGA CAGCATGGTG AGGATGTACT CCAACTGCTC CGTGGTGCTG 180
GAGAACCTGG AGATCACCTA CACGCAGGAG CACCACGACC TGTCCTTCCT GCAGTCCATC 240
CAGGAAGTAA GCGGTTATGT TCTGATCGCT ATGAACGACG TGGCGACCAT CCCATTGGTC 300
AACCTGAGAC TGATCCGGGG ACAGAACCTG TACGAAGGCC GGTTCGCTTT GCTGGTGATG 360
TCCAACTATC ACAAGAACGC CTCATCTGCA ACGCTCAACT ACACCCTTCA TTATCTCCTC 420
ACAGAGATCC TGAAAGGAGG TGTAAAGGTG ACCCACAATC CTTTGCTGTG CAACATAGAG 480
ACCATCGACT GGTGGGACAT CGTGGACAAG GCCGGCAATT ACAGCGTGGT GTTCACGAAG 540
GACGACTTTC CAAAGAAATG TCAGACGTGT GACCCCAGCT GTCGTAACAG CTCGTGCTGG 600
GCAGCAGGAC AGGATCACTG TCAGAGATTC ACCAAGCTGC TGTGTGCAGA GCAGTGCAGC 660
TGGAGGTGTC GGGGGCCCAA ACCCGTCGAC TGCTGTAACG AGCACTGTGC TGCGGGCTGC 720
ACTGGACCTC GGGCCACCGA CTGCCTGGCC TGCAGGGCTT TCAATGATGA TGGAATCTGT 780
AAGGACGCGT GTCCACCTTT GAAACGCTAT GACTCCAAAC TTCATCAGGT GGTCGAAAAC 840
CCCAACGCCA AATTCACTTT CGGAGCGACC TGCGTCAAGG CCTGCCCACA TAACTACGTG 900
GTGACTGAAG GCTCGTGTGT TCGTTCCTGT AGCAACAGGA TGTACGAGGT GAAGGAGAAT 960
GGAATCCAAC GCTGCAAAGA CTGTGACGGA CCCTGTCCTA AAGCCTGTGA CGGGGTCGGG 1020
GTTGGCGCTC TGATCAACAC CATCGCTATC AACGCCACCA ACATTGACTT GTTTAAGGAC 1080
TGCACCAAAA TCAACGGCGA CGTCGTCATT GTTGAATCCT CCTTCACTGG GGATCCGCAT 1140
TACAACATCC CACCCATGGA GCCCGAGAAG CTGGAGAACT TCAAGACAGT GAAGGAAATC 1200
ACTGGTTACC TGATGATCCA GTTCTGGCCC AAGAATCTGA CATCTCTGTC TGTGTTTGAG 1260
AACCTGGAGA TCATCAGAGG AAGAACGACA TTCTCTAAAC ACAGTTTGGC CGTGGTGAAG 1320
TTGAAGCACC TGCGCTGGCT GGGTTTGCGC TCTCTGAAGG AGGTCAGTGC CGGCGTAGTG 1380
GCAGTGAGGA ATAACCCCGA GTTATGTTAT GTTTGGAAAG ACCAGTGGTC CCACCTATTC 1440
AGATCAACCG ACCAGACCAT TAACTTGTTG GACAACAGTC CCCCTGATGT GTGTGAGAGG 1500
AACAATCAAA CCTGTGACAC GGAGTGTACA GATTTGGGCT GCTGGGGCCC AGGGCCCACC 1560
ATGTGTTTGT CCTGCCGGCA ATTCAACCGC AAGGGCTGCT GTGTGGTGTC GTGCAACCTG 1620
CTGCAAGGTG AACCCAGAGA GGTGGAGGTA AATGGCAGCT GTATCCAGTG TCACCCAGAG 1680
TGTCTGCTGC AAACCGGGTC GCTGACCTGC TCCGGACCGG GCCCTGACAA GTGTTCCCAG 1740
TGTGCCCATG TTAAAGATGG CCCCCACTGC GTGCCACACT GCCCTCATGG TGTGCAGGGA 1800
GAGGGAGGCA AGCTGGTCTG GAAATATGCC GACAGAATGG GCCAGTGCCA GTCCTGCCAC 1860
CAGAACTGCA CCGAGGGGTG TTCTGGTCCT GGATGGTCTG GATGCAATGG ATACAGCTCT 1920
GTTGCACACT CTACACTGGC AGCCAGCGTG ATTGGAGGGC TCCTGCTTCT CGTCATTGTG 1980
TCACTGATCA TCTTTGTGTT GCTACGACGA ATGCAAATTA AGAGGAAGCG AACTGTACGC 2040
CGCCTGCTGC AGGAGAGAGA GCTGGTGGAG CCGCTGACCC CCAGTGGTCA GGCACCTAAC 2100
CAGGCACTGC TGAGGATCCT GAAGGAGACC GAGTTTAAGA AGGTCAGGGT GCTCGGCTCC 2160
GGCGCCTTTG GGACGGTGTA CAAGGGTTTG TGGATCCCTG AAGGCGAGAA CGTGAAGATC 2220
CCAGTAGCCA TCAAAGTTCT CAGAGAGGCC ACGTCACCGA AAGCCAACCA AGAAGTCCTG 2280
GATGAAGCGT ATGTGATGGC GAGTGTGGAT CACCCTCATG TGTGCCGCCT GCTGGGAATC 2340
TGCCTGACAT CATCGGTCCA GCTGGTTACT CAGCTGATGC CGTACGGCTG CTTGCTGGAC 2400
TATGTCCGGC ACCACAGGGA TAGCATTGGG GCGCAGTGGC TGCTCAACTG GTGTGTCCAG 2460
ATCGCTAAGG GGATGAACTA CCTGGAGGAG CGTCACCTGG TGCATCGTGA CCTGGCTGCA 2520
AGGAACGTCC TTTTGAAGAG TCCTAACCAC GTCAAGATCA CCGACTTCGG CCTCGCCAAG 2580
CTTCTGACGG CAGATGAGAA GGAATATCAC GCTGATGGAG GAAAGGTTCC CATTAAGTGG 2640
ATGGCATTAG AGTCGATCCT CCAGTGGACT TACACCCATC AGAGTGATGT CTGGAGTTAC 2700
GGTGTGACGG TGTGGGAGAT CATGACGTTC GGCTCCAAGC CATACGACGG CATCCCGGCC 2760
AGCGAGATCG CCACGGTGCT GGGGAGAGGC GAGCGGCTGC CTCAGCCCCC CATCTGCACC 2820
ATCGATGTCT ACATGATCAT GGTGAAATGC TGGATGATCG ACCCGTCGAG TCGGCCCAGG 2880
TTCAAAGAGC TGATGGTGGA GTTCTCCAAG ATGGCCAGCG ACCCGTCCAG ATACCTGGTC 2940
ATACAGGGGG ACCTGCCGAG TCCGTCAGAC AGCAGGTTTT ACTCTCGTCT GCTGAGCACC 3000
GACGACACCG AGGACGTCAT TGACCCGGAC GAATACCTGC TGCCCTACAG AGGCATGGGC 3060
AACCATAAGG ACCGGCCCAT GGTATGCTAT TTATATACTT TAAATATTTC CTCTGTGTTT 3120
TATTCTAATG AATGTGCTTT GATGAAAGAC AATGGTCATC CAGCCGGAGA GAACAGCCTC 3180
GCCCTGCGGT ACATCACCGA TCCCACTGAC AGCGCGCTGG AAAAGGACTT CATCGACCAC 3240
GAGTACATGA ACCAGAGTGT GAGTGAAACC AGCCAGAGCA GCCGGCTCTC CAAGGTTTTA 3300
AACCCTAATT ATGAGGACCT GAGCCTGGGC TGGGGTGCTG CCCCACTTCC CCACCCGCTG 3360
GAGGATCTGA ACACCTCCCA AGTACCCTAT GGACCCGAAT ACCTGAACGC CTCCTGCAAA 3420
CTGCGCCCTC TGGTGACCAG TCACAGCCTT GATAATCCAG ACTACCAGGC TGACTTCCTG 3480
CCTCAGACCA TTACAGATGC AACTTTAGCC GAGAACCATC TGTTCCTCCC AGCAGCGGAG 3540
AACCTCGAGT ATCTGGGTGT GGGCGGCGCT CTACAT 3576
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         +kk++vlGsGafGtvykG+wipegenvkipvaikvl+e+t++kan+e+ldea+v+as+dh
Q: 712   FKKVRVLGSGAFGTVYKGLWIPEGENVKIPVAIKVLREATSPKANQEVLDEAYVMASVDH  771
         599*********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+s++qlvtql+p+Gclldyvr+h+d++G+q llnwcvqiakGm+ylee+
Q: 772   PHVCRLLGICLTSSVQLVTQLMPYGCLLDYVRHHRDSIGAQWLLNWCVQIAKGMNYLEER  831
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         +lvhrdlaarnvl+kspnhvkitdfGlakll+adeke++a+ggkvpikw+alesil+ +y
Q: 832   HLVHRDLAARNVLLKSPNHVKITDFGLAKLLTADEKEYHADGGKVPIKWMALESILQWTY  891
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwe++tfG+kpydgipa+ei  +l +Gerl+qppictidvym++vkcw
Q: 892   THQSDVWSYGVTVWEIMTFGSKPYDGIPASEIATVLGRGERLPQPPICTIDVYMIMVKCW  951
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mid++srp+fkel+ efs
Q: 952   MIDPSSRPRFKELMVEFS  969
         ****************96
Domain Sequence
(FASTA)
FKKVRVLGSG AFGTVYKGLW IPEGENVKIP VAIKVLREAT SPKANQEVLD EAYVMASVDH 60
PHVCRLLGIC LTSSVQLVTQ LMPYGCLLDY VRHHRDSIGA QWLLNWCVQI AKGMNYLEER 120
HLVHRDLAAR NVLLKSPNHV KITDFGLAKL LTADEKEYHA DGGKVPIKWM ALESILQWTY 180
THQSDVWSYG VTVWEIMTFG SKPYDGIPAS EIATVLGRGE RLPQPPICTI DVYMIMVKCW 240
MIDPSSRPRF KELMVEFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Callithrix jacchus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>
EKS-ANC-00290
EKS-CAJ-00304
EKS-GAA-00371
EKS-GOG-00295
EKS-MEG-00239
EKS-MOD-00292
EKS-ORL-00359
EKS-PES-00265
EKS-TAG-00314
EKS-TAR-00392
EKS-TEN-00388
EKS-XET-00371
Gene Ontology
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 5.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013