EKS-ORN-00621

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00621

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TBCK	361.0	3.5E-108	18	273	256

Status

Unreviewed

Ensembl Protein

ENSONIP00000022085

UniProt Accession

I3KLU0;

Protein Name

Protein Synonyms/Alias

Gene Name

TBCK

Gene Synonyms/Alias

TBCK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000017514	ENSONIP00000022085	ENSONIT00000022104

Organism

Oreochromis niloticus

Functional Description

Protein Length

888

Protein Sequence
(FASTA)

MRSLKDAQLG AFTFFASALP HDVCGSNGLP LTPNSIKILG RFQILKTITH PRLCQYVDIS 60

RGKHERLIVV AEHYENSLSI FQKPENTPSA EKVLQIAYEV LEGLEFMNKH GLVHRALSPN 120

NVLMDCKGNV KLAKFGLYHM TDHGADVDFP IGYPSYLAPE VIAQGSFHPS DPSRDEAPLP 180

SGPKSDVWSL GILLFELCAG RRLLQNIDIS ERLKFILTLG CMDDIVTVLA EEHGCLDTIK 240

ELPDSVLELL RKCLTFLPSK RATPAELLRD PVFNGISCHY TPFQKPVSLF SSSLRCAHLV 300

LPDDISDLCK DDDEDYLSER AIDEVYYLWC LAGGDLEKEL TNQEIIQSKP PISTLPNFVL 360

EDGETFGQGR DRSFLLDDTT VTLSLCQLRN RLKDVAREAY YPLLEDEQSS LPQSNSSNEL 420

SAAVTLPLII RERDTEYQLI RIILFDRLLK AYPYKKTLVW KEARVDIPPL VRGLAWAGLL 480

GIEGDIQAKY EGIDKDTPIP TDRQIEVDIP RCHQYDELLS SPQGHIKFRR VLKAWVVSHP 540

DLVYWQGLDS LCAPFLYLNF NNEALAYACM SAFIPKYLYN FFLKDNSHVI QEYLTVFSQM 600

IAFHDPELSN HLNEIGFIPD LYAIPWFLTM FTHVFPLHKI FHLWDTLLLG NSSFPFCIGV 660

AILQQLRDRL LANGFNECIL LFSDLPEIDI ERCVRESISL FCWTPKSATY RQHAQPPKVA 720

GDNGFVKTST YYSSDYQDMP KTDLSREPLS LGDLKAEVSP RISAEDLIDL CELSLSGSSK 780

RNKTGKPKIV AVDIRTAEDF NRGHISGSIN IPFNTTFGPE NEVVQCPAAG GLQSYRGRVI 840

VVISHNMKSA AMFAAHLVKM SFPRVCILDG GINKLKPTGL LTVPSPQI 888

Nucleotide Sequence
(FASTA)

ATGCGCTCCC TTAAAGACGC CCAGCTAGGA GCCTTTACCT TCTTTGCCTC AGCTCTTCCA 60

CATGATGTCT GTGGAAGCAA TGGACTCCCT CTGACTCCCA ACTCCATCAA AATCCTGGGA 120

CGTTTCCAGA TTCTCAAAAC CATCACTCAC CCCAGACTCT GCCAGTATGT GGACATTTCC 180

AGAGGGAAGC ACGAAAGGCT GATTGTTGTT GCCGAACACT ATGAGAACAG TTTAAGCATT 240

TTCCAAAAAC CAGAAAACAC ACCCAGTGCG GAAAAGGTGC TGCAAATAGC CTACGAGGTT 300

CTTGAAGGCC TGGAGTTTAT GAACAAACAT GGTTTGGTGC ACCGAGCCCT CAGCCCAAAC 360

AATGTGCTCA TGGACTGCAA GGGGAACGTC AAGCTGGCAA AGTTCGGCCT TTATCACATG 420

ACTGATCACG GGGCAGATGT GGATTTTCCC ATTGGGTACC CATCATACCT TGCTCCAGAG 480

GTGATCGCTC AGGGCTCCTT CCACCCCAGT GACCCTTCCC GTGATGAAGC TCCTCTGCCC 540

TCGGGACCAA AGTCTGATGT CTGGTCGCTC GGCATTTTGC TCTTTGAATT GTGTGCAGGC 600

AGAAGACTCC TGCAGAATAT TGATATAAGC GAGAGGCTGA AATTCATTTT AACCTTGGGT 660

TGCATGGATG ACATTGTCAC TGTCCTTGCA GAGGAACATG GTTGCTTGGA TACCATTAAG 720

GAGCTGCCTG ACAGTGTTCT TGAGTTATTA AGGAAGTGCT TGACCTTTCT TCCATCTAAA 780

AGGGCAACCC CTGCAGAACT ACTGCGAGAC CCTGTGTTTA ATGGCATCTC CTGCCACTAC 840

ACACCCTTCC AGAAGCCTGT CAGCCTGTTC TCCTCATCCC TGCGCTGTGC ACATCTGGTG 900

CTCCCAGATG ACATCAGTGA CCTTTGCAAA GACGACGATG AGGATTACCT GTCGGAGCGG 960

GCCATAGATG AGGTTTATTA TCTGTGGTGT CTGGCAGGTG GAGACCTAGA AAAGGAGCTC 1020

ACCAACCAGG AAATCATTCA GTCCAAACCA CCGATCTCCA CACTGCCCAA TTTCGTCTTG 1080

GAGGATGGGG AGACGTTTGG CCAGGGCAGG GATCGGAGTT TCTTGCTCGA TGACACGACA 1140

GTGACGCTGT CTCTGTGCCA ACTCAGAAAT AGGTTGAAAG ATGTAGCCAG AGAAGCCTAT 1200

TACCCTCTCC TCGAAGACGA ACAGTCGAGT TTGCCCCAGT CCAACAGCAG CAATGAACTG 1260

TCGGCCGCCG TCACGCTGCC ACTCATCATC CGTGAAAGAG ACACCGAATA CCAGCTGATC 1320

CGCATCATCC TCTTTGACAG ATTGCTCAAG GCCTACCCGT ACAAGAAGAC CCTAGTGTGG 1380

AAAGAAGCCA GAGTGGACAT TCCCCCGCTT GTACGAGGGC TGGCGTGGGC TGGCCTGCTG 1440

GGCATTGAGG GTGACATTCA AGCTAAATAT GAAGGTATAG ACAAGGATAC TCCCATACCA 1500

ACTGACAGAC AGATTGAGGT GGACATCCCA CGGTGCCACC AATATGATGA GCTGCTGTCA 1560

TCTCCTCAGG GCCACATCAA GTTCAGACGT GTGTTGAAAG CGTGGGTGGT GTCTCACCCT 1620

GACCTGGTCT ACTGGCAGGG TTTGGATTCG CTTTGTGCCC CCTTCCTATA TCTGAATTTC 1680

AACAATGAAG CTTTGGCATA TGCCTGCATG TCTGCCTTCA TCCCCAAGTA CTTGTACAAC 1740

TTCTTTCTGA AGGACAACTC TCATGTGATC CAAGAGTACT TGACTGTCTT CTCTCAAATG 1800

ATTGCCTTCC ATGACCCAGA GCTAAGCAAC CATCTAAATG AGATTGGCTT CATCCCAGAT 1860

CTTTATGCTA TTCCCTGGTT CCTAACAATG TTTACACATG TTTTTCCACT GCACAAGATC 1920

TTCCACCTGT GGGACACATT GCTCCTGGGT AACTCCTCAT TCCCATTCTG TATTGGCGTA 1980

GCTATATTGC AGCAACTCAG GGACCGCCTA TTGGCTAATG GCTTCAATGA ATGCATCCTG 2040

CTCTTCTCTG ACCTGCCAGA AATTGACATT GAGCGCTGTG TCCGTGAGTC CATCAGCCTG 2100

TTCTGCTGGA CCCCAAAGAG CGCAACATAC CGACAACATG CTCAGCCTCC AAAGGTTGCG 2160

GGCGACAATG GCTTTGTGAA AACGTCAACA TACTACTCAT CCGACTACCA GGACATGCCC 2220

AAGACAGACC TGTCTCGGGA GCCTCTGTCA CTGGGTGACC TGAAAGCAGA AGTATCTCCC 2280

AGGATCTCAG CGGAGGACTT AATTGACCTT TGTGAGCTGT CATTGTCCGG GTCCTCCAAA 2340

AGGAACAAAA CTGGCAAGCC CAAAATTGTT GCAGTCGATA TCCGCACTGC AGAAGACTTC 2400

AACAGAGGCC ACATTTCTGG AAGCATCAAC ATTCCCTTCA ACACGACTTT TGGTCCGGAA 2460

AATGAGGTGG TGCAGTGTCC TGCCGCAGGA GGCCTCCAGA GCTATAGAGG GCGTGTCATT 2520

GTGGTCATCA GCCACAACAT GAAGAGTGCA GCTATGTTTG CTGCACATCT AGTGAAGATG 2580

AGTTTTCCAC GTGTTTGTAT CCTGGACGGA GGGATCAACA AGCTGAAGCC CACCGGGCTC 2640

CTGACTGTCC CTTCCCCACA GATCTGA 2667

Domain Profile

S: 1     llaqdkdGsnGlplasnakkilGrfqiLkelqhdrLcqYldisrgkhervivvaehlels  60

         +l++d++GsnGlpl++n++kilGrfqiLk+++h+rLcqY+disrgkher+ivvaeh+e s

Q: 18    ALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLIVVAEHYENS  77

         589*********************************************************

S: 61    LeDllkerkpvseslvlriayevlsgldylnkhnivhralepksilldrkgqkvkLakyG  120

         L  + k ++  s  +vl+iayevl+gl+++nkh++vhral+p+++l+d kg+ vkLak+G

Q: 78    LSIFQKPENTPSAEKVLQIAYEVLEGLEFMNKHGLVHRALSPNNVLMDCKGN-VKLAKFG  136

         ****************************************************.*******

S: 121   LyhltayGkdvdfpigygsylaPerilqd.........edkllaatvksDvWsLglille  171

         Lyh+t++G+dvdfpigy+sylaPe+i+q+         ++ +l++++ksDvWsLg++l+e

Q: 137   LYHMTDHGADVDFPIGYPSYLAPEVIAQGsfhpsdpsrDEAPLPSGPKSDVWSLGILLFE  196

         *************************************999********************

S: 172   lilgikLfaeldlserlkillklstvdetliklaeekkcldiikklderleallkkCLtl  231

         l+ g++L +++d+serlk++l+l++ d+ + +laee++cld ik+l++ + +ll+kCLt+

Q: 197   LCAGRRLLQNIDISERLKFILTLGCMDDIVTVLAEEHGCLDTIKELPDSVLELLRKCLTF  256

         ************************************************************

S: 232   lpskRpspdellkekvf  248

         lpskR++p ell+++vf

Q: 257   LPSKRATPAELLRDPVF  273

         **************997

Domain Sequence
(FASTA)

ALPHDVCGSN GLPLTPNSIK ILGRFQILKT ITHPRLCQYV DISRGKHERL IVVAEHYENS 60

LSIFQKPENT PSAEKVLQIA YEVLEGLEFM NKHGLVHRAL SPNNVLMDCK GNVKLAKFGL 120

YHMTDHGADV DFPIGYPSYL APEVIAQGSF HPSDPSRDEA PLPSGPKSDV WSLGILLFEL 180

CAGRRLLQNI DISERLKFIL TLGCMDDIVT VLAEEHGCLD TIKELPDSVL ELLRKCLTFL 240

PSKRATPAEL LRDPVF 256

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0005097	; F:Rab GTPase activator activity
GO:0032851	; P:positive regulation of Rab GTPase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR000195	; Rab-GTPase-TBC_dom.
IPR001763	; Rhodanese-like_dom.

Pfam

PF00069	; Pkinase; 1.
PF00566	; RabGAP-TBC; 1.
PF00581	; Rhodanese; 1.

SMARTs

SM00450	; RHOD; 1.
SM00164	; TBC; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS50206	; RHODANESE_3; 1.
PS50086	; TBC_RABGAP; 1.

Prints

Created Date

20-Feb-2013