EKS-ORN-00134
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00134
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec401.71.4E-120240487248
StatusUnreviewed
Ensembl ProteinENSONIP00000022178
UniProt AccessionI3KM34;
Protein Name
Protein Synonyms/Alias
Gene NameITK
Gene Synonyms/Alias ITK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000017591ENSONIP00000022179ENSONIT00000022198
ENSONIG00000017591ENSONIP00000022178ENSONIT00000022197
OrganismOreochromis niloticus
Functional Description
Protein Length493
Protein Sequence
(FASTA)
MDGKWRCCQQ TEKLASGCNV YDPVGYASKK PLPSLPEPEM ELEDSGQQKV IALQNYTPQG 60
DNDLPLQKDQ EYLLVKNSHS IWWLVQDERG NSGFVPSTFV AEKSINNFER FEWYNKNISR 120
AQAEELLMKE GKEGAFMVRD SRQAGVYTVS VFTKAPGSNG EKNPRVKHYQ IRQTETSPAS 180
FYLAEKYLFS TIPELIYYHQ HNAAGLITRL RHPVSQGGRC SQDATDITKD QWEVDPAELI 240
LGQEIGSGQF GLVLEGSWRD RKVAVKMVRE ECMSDEEFKE EARIMMRLSH SKLVQLYGVC 300
TQHSPICLVF EYMDNGCLTD YLRERKGSLS QDILLGMCLD VSEGMAYLEM SNFIHRDLAA 360
RNCLVSKNNE VKVSDFGMTR FVLDDQYTSS QCSKFPVKWS APEVIRYCKF STKSDVWSFG 420
VLMWEVYNEG RLPYENRTNA EVVDSLNAGL RLLKPRLAPD SVHLLMEWCW KEKPDDRPTF 480
GLLFHELASL SDA 493
Nucleotide Sequence
(FASTA)
ATGGATGGAA AATGGAGATG CTGCCAGCAA ACAGAGAAAC TGGCGAGTGG GTGCAACGTG 60
TACGACCCAG TGGGCTATGC CTCTAAAAAG CCGCTTCCCA GCCTCCCGGA GCCAGAGATG 120
GAGCTGGAAG ATTCGGGGCA ACAGAAGGTC ATTGCTTTGC AAAACTACAC GCCACAGGGG 180
GACAATGACT TACCTCTTCA GAAAGATCAG GAGTATCTCC TGGTTAAGAA TTCCCATTCC 240
ATCTGGTGGC TTGTACAGGA TGAAAGAGGG AACTCGGGTT TTGTGCCCAG TACGTTCGTA 300
GCTGAAAAAT CCATCAACAA CTTTGAAAGA TTTGAATGGT ACAACAAAAA CATTAGCAGA 360
GCGCAAGCAG AAGAATTGTT AATGAAAGAG GGTAAGGAAG GTGCATTCAT GGTGCGGGAC 420
TCAAGACAGG CGGGAGTGTA CACGGTGTCT GTTTTCACCA AAGCACCAGG GTCTAACGGG 480
GAGAAGAATC CGAGAGTGAA GCATTACCAA ATCAGACAGA CCGAAACAAG CCCAGCTTCT 540
TTTTACCTGG CAGAGAAGTA CCTGTTTAGC ACCATTCCTG AGCTCATATA TTACCACCAG 600
CACAATGCTG CAGGGCTAAT AACACGGCTG AGACACCCCG TCTCTCAAGG TGGACGCTGC 660
TCCCAGGATG CTACTGATAT CACAAAAGAT CAATGGGAAG TGGACCCTGC GGAGCTGATA 720
CTGGGTCAGG AGATAGGCAG CGGCCAGTTT GGACTGGTGC TGGAAGGCAG CTGGAGGGAT 780
CGCAAGGTGG CGGTGAAGAT GGTAAGAGAA GAGTGCATGT CAGACGAAGA ATTTAAAGAA 840
GAGGCACGGA TTATGATGAG ACTCTCTCAC TCTAAGCTGG TACAGCTGTA TGGCGTGTGC 900
ACACAGCATT CTCCCATCTG CCTCGTGTTT GAGTACATGG ACAACGGCTG TCTAACGGAC 960
TACCTGCGAG AAAGGAAAGG CTCCTTGTCT CAGGATATAT TGTTGGGGAT GTGTCTGGAT 1020
GTCAGCGAAG GGATGGCTTA CCTAGAGATG TCCAACTTCA TCCACAGAGA TCTAGCTGCC 1080
AGGAACTGTC TCGTCTCAAA GAACAACGAG GTGAAGGTAT CGGACTTTGG AATGACCAGA 1140
TTTGTTCTTG ATGATCAGTA CACGAGCTCA CAGTGCTCCA AGTTCCCTGT CAAGTGGTCA 1200
GCCCCAGAGG TCATCAGATA CTGCAAATTC AGCACCAAGT CTGACGTCTG GTCGTTCGGT 1260
GTGCTCATGT GGGAGGTGTA CAACGAAGGC CGACTCCCCT ATGAGAACCG CACTAATGCA 1320
GAAGTGGTGG ACTCCCTGAA CGCAGGCCTG AGGCTCCTGA AGCCGCGCTT GGCCCCGGAC 1380
TCTGTCCACC TACTCATGGA GTGGTGTTGG AAGGAGAAAC CAGACGATCG CCCAACATTT 1440
GGGCTCCTCT TTCACGAGCT GGCCTCCCTT TCAGACGCCT GA 1482
Domain Profile
S: 2     tllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqlyg  61
         +l +e+gsgqfg+v  g wr + +va+k+++e +ms+e+f eea++mm+lsh+klvqlyg
Q: 240   ILGQEIGSGQFGLVLEGSWRDR-KVAVKMVREECMSDEEFKEEARIMMRLSHSKLVQLYG  298
         5669****************75.8************************************
S: 62    vclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrdl  121
         vc+++ pi++v+ey++ngcl +ylre+k++l++++ll mc dv+egm+yle ++fihrdl
Q: 299   VCTQHSPICLVFEYMDNGCLTDYLRERKGSLSQDILLGMCLDVSEGMAYLEMSNFIHRDL  358
         ************************************************************
S: 122   aarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvwa  181
         aarnclv++++ vkvsdfg++r+vlddqy+ss+ +kfpvkws+pev++y k+s+ksdvw+
Q: 359   AARNCLVSKNNEVKVSDFGMTRFVLDDQYTSSQCSKFPVKWSAPEVIRYCKFSTKSDVWS  418
         ************************************************************
S: 182   fgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeerp  241
         fgvlmwev+ eg+lpye+++n+evv++++ glrl +p+la+++v+ +m+ cwkekp++rp
Q: 419   FGVLMWEVYNEGRLPYENRTNAEVVDSLNAGLRLLKPRLAPDSVHLLMEWCWKEKPDDRP  478
         ************************************************************
S: 242   tfkellsal  250
         tf  l+++l
Q: 479   TFGLLFHEL  487
         **9998876
Domain Sequence
(FASTA)
ILGQEIGSGQ FGLVLEGSWR DRKVAVKMVR EECMSDEEFK EEARIMMRLS HSKLVQLYGV 60
CTQHSPICLV FEYMDNGCLT DYLRERKGSL SQDILLGMCL DVSEGMAYLE MSNFIHRDLA 120
ARNCLVSKNN EVKVSDFGMT RFVLDDQYTS SQCSKFPVKW SAPEVIRYCK FSTKSDVWSF 180
GVLMWEVYNE GRLPYENRTN AEVVDSLNAG LRLLKPRLAP DSVHLLMEWC WKEKPDDRPT 240
FGLLFHEL 248
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Danio rerio"; ?>Gasterosteus aculeatus"; ?>Oryzias latipes"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-DAR-00357
EKS-GAA-00128
EKS-ORL-00125
EKS-TAR-00137
EKS-TEN-00127
EKS-XIM-00131
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004713; F:protein tyrosine kinase activity
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00402; TECBTKDOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013