EKS-ORN-00400
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00400
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20363.39.3E-10925289265
StatusUnreviewed
Ensembl ProteinENSONIP00000022276
UniProt AccessionI3KMD1;
Protein Name
Protein Synonyms/Alias
Gene NameTNIK (1 of 2)
Gene Synonyms/Alias TNIK (1 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000017666ENSONIP00000022276ENSONIT00000022295
OrganismOreochromis niloticus
Functional Description
Protein Length1362
Protein Sequence
(FASTA)
MASDSPARSL DEIDLSALRD PAGIFELVEL VGNGTYGQVY KGRHVKTGQL AAIKVMDVTG 60
DEEEEIKAEI NMLKKYSHHR NIATYYGAFI KKNPPGVDDQ LWLVMEFCGA GSVTDLIKNT 120
KGNSLKEEWI AYICREILRG LTHLHQHKVI HRDIKGQNVL LTENAEVKLV DFGVSAQLDR 180
TVGRRNTFIG TPYWMAPEVI ACDENPDATY DFKSDLWSLG ITAIEMAEGA PPLCDMHPMR 240
ALFLIPRNPA PRLKSKKWSK KFQSFIESCL VKSHSQRPST EQLLKHPFIR DLPNERQVRI 300
QLKDHIDRTK KRRGERDETE YEYSGSEEED EERDIGEPSS IINIPGESTL RRDFLRLQLA 360
NKERSELIRR QQLEQQQNEE HKRQLLAERQ KRIEEQKEQR RRLEEQQRRE RELRKQQERE 420
QRRRYEEMEQ LRREEERRHA EREQEYIRRQ LEEEQRQLEI LQQQLLQEQA LLLEYKRKQI 480
EEQRQAERLQ RQLQQERAYL VSLQQQQQEP PRPPQDKKQL YHYKDQAPSS NDKPTWAKEV 540
IERSVLHRTS SPALQHKVSN RISDPTLPPR SESFSSGGIQ QARTPPMHRS MEPQISRVAS 600
LVQEGLILSG SQSLYDPHGV SSSSALPSPS RPPMPRQNSD PTSDTPPPPP LSRLAPPLDK 660
LDRSSWLRQD DDMPPKVPQR TTSISPALVR KNSPGNGPGL GPRPGAHLIR ASNPDLRRPD 720
MYLDTPLKRT SSGSSSSSST PSSQYSTSLN ATQGGTTCLA SFSTTGNSAS KTEGHDAKDD 780
SREITRPSRP ASYKKAVDED LTALAKELRE LRQGEETSRP PVKVTDYSSS SEESHSSEDE 840
EGEGGANDGS VAVSDIPRIM PAASQSTNES FSATGEHNDT NEDTYANSSQ DSTLVMREKH 900
RERRRSSTAS NGFPGKLFSG SANLPDLVQQ STSPLVSPGD ASGVQVTVVV NWSYRNETEF 960
GMGGSGGSKA SFTPFVDPRV YGTSPTDEDD KTSASVCAAA LFADELLKQE QEQARLNEAR 1020
KISVVNVNPT NIRPHSDTPE IRKYKKRFNS EILCAALWGV NLLVGTENGL MLLDRSGQGK 1080
VYNLINRRRF QQMDVLEGLN VLVTISGKKN KLRVYYLSWL RNRILHNDPE VEKKQGWITV 1140
GDLEGCVHYK VVKYERIKFL VIALKNSVEI YAWAPKPYHK FMAFKSFTDL QHRPQLVDLT 1200
VEEGQRLKVI YGSSVGFHVI DVDSGNPYDI YIPAKIQGQV TPHAIVVLPK TDGMEMLLCY 1260
EDEGVYVNTY GRITKDVVLQ WGEMPTSVAY IHSNQIMGWG EKAIEIRSVE TGHLDGVFMH 1320
KRAQRLKFLT ERNDKVFFAS VRSGGSSQVF FMTLNRSSMM NW 1362
Nucleotide Sequence
(FASTA)
ATGGCGAGCG ACTCCCCGGC ACGGAGTCTG GACGAGATAG ACCTGTCTGC ACTACGGGAC 60
CCAGCCGGTA TCTTTGAGCT GGTCGAACTG GTTGGGAATG GCACCTATGG GCAGGTCTAC 120
AAGGGTCGCC ATGTCAAAAC TGGCCAGCTC GCTGCCATCA AGGTCATGGA TGTCACAGGC 180
GATGAGGAGG AGGAGATTAA AGCCGAGATC AACATGCTGA AGAAGTACAG CCACCACAGG 240
AACATAGCAA CCTATTATGG AGCCTTCATC AAGAAAAACC CTCCAGGAGT GGACGACCAG 300
CTCTGGTTGG TGATGGAGTT CTGCGGGGCC GGCTCGGTGA CGGATCTGAT CAAAAACACC 360
AAAGGGAACT CCCTCAAGGA GGAGTGGATT GCCTACATCT GCAGAGAGAT CCTCAGGGGT 420
CTGACCCACC TCCACCAGCA CAAGGTCATC CACAGAGATA TCAAAGGCCA GAACGTGCTG 480
CTGACGGAGA ACGCGGAGGT CAAACTCGTG GATTTTGGTG TGAGTGCTCA GCTGGACCGT 540
ACAGTGGGAC GGAGGAACAC GTTTATTGGG ACCCCGTACT GGATGGCCCC GGAGGTCATC 600
GCCTGTGATG AGAATCCTGA TGCCACGTAT GACTTCAAGA GTGATCTGTG GTCGCTCGGT 660
ATCACAGCCA TAGAGATGGC AGAGGGAGCG CCACCTCTGT GTGACATGCA TCCAATGAGG 720
GCGCTCTTCC TCATCCCCAG AAATCCTGCC CCGAGACTCA AATCAAAGAA GTGGTCGAAG 780
AAGTTCCAGT CGTTCATAGA GAGCTGCCTG GTGAAGAGTC ACAGCCAGAG GCCGAGCACC 840
GAGCAGCTTC TCAAGCACCC CTTCATCAGA GACCTCCCCA ACGAGCGGCA GGTCCGCATC 900
CAGCTGAAGG ACCACATCGA CCGCACCAAG AAGAGGAGGG GCGAGCGAGA TGAGACGGAG 960
TACGAGTACA GTGGGAGTGA GGAAGAGGAT GAAGAGAGGG ACATAGGAGA GCCCAGCTCC 1020
ATCATCAATA TTCCCGGTGA GTCCACGCTG AGGCGAGACT TCCTGCGTCT GCAGCTGGCC 1080
AATAAGGAGC GGTCGGAGCT GATCCGGCGT CAGCAGCTGG AGCAGCAGCA GAACGAGGAG 1140
CACAAGCGCC AGCTACTGGC CGAGAGACAA AAACGTATAG AAGAGCAGAA AGAGCAGCGG 1200
CGACGGCTAG AGGAGCAACA GCGTCGCGAG CGAGAACTGA GGAAGCAGCA GGAGCGAGAG 1260
CAGAGGAGGA GGTATGAAGA GATGGAGCAG CTCCGCCGCG AGGAGGAGAG GAGGCACGCA 1320
GAGAGAGAGC AGGAGTATAT CCGTAGACAG CTGGAGGAGG AGCAGAGGCA GCTGGAGATC 1380
CTGCAGCAGC AGCTCCTGCA GGAGCAGGCC CTACTGCTGG AGTACAAGAG GAAGCAGATC 1440
GAGGAGCAGC GGCAGGCCGA GCGGCTGCAG AGGCAGCTGC AGCAGGAGCG GGCGTACCTG 1500
GTGTCGCTGC AGCAGCAGCA GCAGGAGCCG CCGCGACCGC CGCAGGACAA GAAGCAGCTG 1560
TACCACTACA AGGATCAGGC GCCCAGCAGC AACGACAAGC CCACCTGGGC CAAAGAGGTC 1620
ATTGAACGCA GTGTTTTACA CAGAACGTCT TCTCCTGCAT TGCAGCATAA AGTCTCCAAC 1680
CGGATCTCAG ACCCAACCCT GCCACCACGC TCCGAGTCCT TCAGCAGCGG GGGCATCCAG 1740
CAGGCCCGGA CTCCGCCCAT GCACCGCTCC ATGGAGCCAC AGATCAGCAG AGTGGCCTCA 1800
TTAGTGCAGG AGGGGCTTAT CTTGTCAGGC TCCCAGTCCC TGTACGACCC CCACGGCGTG 1860
TCCTCCTCCT CGGCGTTGCC CTCCCCCTCC CGGCCTCCCA TGCCCCGGCA GAACTCTGAC 1920
CCCACCTCTG ACACCCCTCC TCCCCCGCCC CTGTCCCGCC TGGCGCCCCC CCTCGACAAG 1980
CTGGACCGCA GCTCCTGGCT GCGGCAGGAC GACGACATGC CCCCTAAGGT TCCTCAGAGG 2040
ACGACCTCCA TCTCTCCGGC TTTGGTCAGG AAGAACTCTC CTGGAAACGG GCCAGGCCTC 2100
GGCCCGCGGC CCGGCGCTCA CCTCATACGG GCCAGCAACC CTGACCTGCG GAGGCCTGAC 2160
ATGTACTTGG ACACTCCCCT GAAGAGAACG AGCAGCGGCA GCTCCTCCAG CTCCAGCACC 2220
CCCAGCTCCC AGTACTCGAC ATCGCTCAAC GCGACTCAAG GTGGTACAAC TTGCCTCGCC 2280
TCGTTTTCCA CTACAGGTAA TTCAGCCTCT AAGACTGAAG GCCACGACGC CAAAGACGAC 2340
AGCAGAGAGA TAACCCGACC CAGCAGGCCT GCAAGCTATA AGAAAGCTGT AGACGAGGAT 2400
CTGACGGCTC TGGCCAAAGA GCTGAGAGAG CTGCGGCAGG GCGAGGAAAC CAGCCGCCCG 2460
CCGGTCAAAG TGACTGACTA CTCGTCGTCC AGTGAGGAGT CCCACAGCAG CGAGGATGAA 2520
GAGGGAGAGG GCGGGGCTAA CGATGGATCC GTGGCTGTCA GTGATATTCC ACGCATCATG 2580
CCCGCTGCGA GTCAGAGCAC CAACGAGTCC TTCAGCGCGA CGGGAGAGCA CAACGACACC 2640
AACGAGGACA CGTATGCAAA CAGCTCCCAG GACAGCACCC TGGTGATGCG TGAGAAACAC 2700
AGGGAACGGA GGCGGAGCTC AACCGCCAGC AACGGTTTCC CCGGCAAACT GTTCTCTGGC 2760
AGCGCCAATC TCCCCGATTT GGTGCAGCAA AGCACCTCCC CCCTGGTCTC CCCAGGGGAT 2820
GCCTCTGGGG TCCAAGTGAC TGTTGTTGTG AATTGGAGCT ATAGGAATGA AACTGAATTT 2880
GGCATGGGAG GCAGCGGAGG CTCCAAGGCC TCCTTCACGC CATTTGTTGA TCCGAGGGTG 2940
TACGGGACCT CCCCGACCGA TGAAGATGAT AAAACCTCAG CCTCAGTTTG TGCTGCAGCG 3000
CTGTTTGCTG ATGAGTTGCT GAAGCAGGAG CAAGAGCAGG CGAGGCTCAA CGAGGCCCGC 3060
AAGATCTCCG TGGTCAACGT CAACCCCACT AACATCAGGC CACACAGCGA CACGCCCGAG 3120
ATCCGTAAAT ACAAGAAACG CTTCAACTCT GAGATCCTCT GTGCGGCTCT CTGGGGAGTG 3180
AACCTGCTGG TGGGGACGGA GAACGGCCTG ATGCTGCTGG ATCGAAGTGG TCAAGGCAAA 3240
GTTTACAACC TGATCAATCG AAGGCGCTTC CAACAGATGG ACGTCCTGGA GGGACTCAAC 3300
GTCCTGGTCA CCATCTCAGG GAAGAAGAAC AAGCTGCGGG TTTACTACCT GTCCTGGCTG 3360
AGGAACAGGA TATTACACAA TGACCCTGAA GTGGAGAAGA AACAGGGTTG GATTACAGTC 3420
GGGGACCTGG AGGGCTGCGT GCATTACAAA GTCGTGAAGT ACGAGAGGAT TAAATTCTTG 3480
GTGATTGCTC TAAAGAACTC AGTCGAGATC TATGCCTGGG CACCTAAACC TTACCACAAG 3540
TTTATGGCTT TCAAGTCTTT CACTGACCTG CAGCATCGCC CCCAGCTGGT GGACTTGACT 3600
GTAGAGGAAG GGCAGAGGTT AAAGGTCATC TATGGCTCTA GTGTTGGCTT CCATGTAATT 3660
GATGTGGATT CTGGAAATCC CTACGACATC TACATCCCCG CCAAGATTCA GGGTCAGGTG 3720
ACCCCGCACG CCATCGTGGT TCTGCCCAAG ACGGACGGCA TGGAGATGCT GCTGTGCTAC 3780
GAGGACGAGG GCGTCTACGT CAACACCTAC GGACGCATCA CCAAAGATGT GGTGCTGCAG 3840
TGGGGCGAGA TGCCCACCTC CGTCGCCTAC ATCCACTCCA ACCAGATCAT GGGCTGGGGA 3900
GAGAAGGCCA TTGAGATCCG GTCCGTGGAG ACGGGACACC TCGACGGAGT TTTCATGCAC 3960
AAGCGAGCTC AGCGACTGAA GTTCCTGACG GAGAGGAACG ACAAAGTCTT CTTCGCCTCG 4020
GTGCGTTCTG GAGGCAGCAG TCAAGTCTTC TTCATGACCC TCAACAGAAG CTCCATGATG 4080
AACTGGTAA 4089
Domain Profile
S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkh.pniv  59
         +el+e +g+G++g+vy++r++ktg+l+aik+++++  +++ee++ ei++lkk++h +ni 
Q: 25    FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG-DEEEEIKAEINMLKKYSHhRNIA  83
         899********************************8.999*************998****
S: 60    eylesflk......eeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLey  113
         +y+++f+k      +++lwlvme++ +Gs++dl+k+++ ++lkEe+iayi+re+l++L++
Q: 84    TYYGAFIKknppgvDDQLWLVMEFCGAGSVTDLIKNTKGNSLKEEWIAYICREILRGLTH  143
         ********9***************************************************
S: 114   lHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe  173
         lH++kviHrdik++n+Llte++eVkL+dfgv+aql++t+ +r+t++gtpywmAPEvia++
Q: 144   LHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACD  203
         ************************************************************
S: 174   ...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskef  230
            + +Yd k+D+wslGItaie+aeg+pP++d++p++al++i++n++p+lksk k+sk+f
Q: 204   enpDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSK-KWSKKF  262
         999999********************************************888.******
S: 231   kefvekclqknpekRpsasellkhkFl  257
         ++f+e+cl k+ ++Rps+++llkh+F+
Q: 263   QSFIESCLVKSHSQRPSTEQLLKHPFI  289
         **************************7
Domain Sequence
(FASTA)
FELVELVGNG TYGQVYKGRH VKTGQLAAIK VMDVTGDEEE EIKAEINMLK KYSHHRNIAT 60
YYGAFIKKNP PGVDDQLWLV MEFCGAGSVT DLIKNTKGNS LKEEWIAYIC REILRGLTHL 120
HQHKVIHRDI KGQNVLLTEN AEVKLVDFGV SAQLDRTVGR RNTFIGTPYW MAPEVIACDE 180
NPDATYDFKS DLWSLGITAI EMAEGAPPLC DMHPMRALFL IPRNPAPRLK SKKWSKKFQS 240
FIESCLVKSH SQRPSTEQLL KHPFI 265
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00288
EKS-ANC-00307
EKS-BOT-00325
EKS-CAJ-00314
EKS-CAF-00329
EKS-CAP-00343
EKS-DAR-00667
EKS-EQC-00300
EKS-FEC-00295
EKS-GAG-00270
EKS-GAA-00385
EKS-GOG-00305
EKS-HOS-00315
EKS-ICT-00307
EKS-LAC-00328
EKS-LOA-00329
EKS-MAM-00312
EKS-MOD-00303
EKS-MUM-00340
EKS-MUP-00305
EKS-MYL-00320
EKS-NOL-00284
EKS-ORA-00286
EKS-ORC-00291
EKS-ORL-00382
EKS-OTG-00324
EKS-PAT-00292
EKS-PES-00274
EKS-PEM-00170
EKS-POA-00300
EKS-RAN-00324
EKS-SUS-00290
EKS-TAG-00323
EKS-TAR-00403
EKS-TEN-00401
EKS-XET-00385
EKS-XIM-00416
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005083; F:small GTPase regulator activity
KEGG
InterPros
IPR001180; Citron.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00780; CNH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00036; CNH; 1.
SM00220; S_TKc; 1.
Prosites
PS50219; CNH; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013