EKS-ORN-00518
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00518
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR461.33.0E-138574917344
StatusUnreviewed
Ensembl ProteinENSONIP00000022414
UniProt AccessionI3KMR9;
Protein Name
Protein Synonyms/Alias
Gene NamePDGFRB (2 of 2)
Gene Synonyms/Alias PDGFRB (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000017780ENSONIP00000022414ENSONIT00000022434
OrganismOreochromis niloticus
Functional Description
Protein Length950
Protein Sequence
(FASTA)
FSLQKVKKKS PLKLPLVTSG VFLVHPEGAV SLELLPSASE VLVPSNSNYT VECLGWSEVK 60
WHFPQEPPVD GVLVDNRGSR SILQLFNITW RNSGRYTCEE ASSDQSRNVD VFIPGQGPDE 120
WFVPMDLGVV MKEGEEGTIP CMVSNPKLNV SLYERPSRTL VSGMTYKPGR GFTGHLNDTS 180
YVCVATNGAQ ERESQTYYVF SIIVPKVMEV DLTVSSSVLK QGEVLTVNCT VKDTEMVFFS 240
WGFPRRQEIE PLTDFLPNQI RSFVNITAVT VADSGVYSCT VQETTQGQTV TDRGYVYLWP 300
SGETNVSSLL HHTLELSVEI DAHPAPTVIW TRQNQSVATE TTTINTTHLS DSRYVSTLTL 360
VRVQMDQTGS YTATISNDDD IREATFNLEV QDICRITSLS EVRSNAVLCV SEGAPPPSVT 420
WYTCSSSHRC NLLNGKWRSQ SKDSEGTTLQ ENITMVAERG ITQVHSMLTL QTLSSLSAVR 480
CEATNSAGRR GKDLRVLSSS LLSQVVVLAV VLVLVIIAVI FLIILIILWR KKPHYEVRWK 540
VIESVSPDGQ QYTYLDPTQL PYSPTWEIDR DHVNLGQVLG SGAFGRVVEA TISGLINSHS 600
TKAAVKMVKL TARSDAVQSL MSELKVLVHL GPHLNIVNLL GACTRGGPVY LITEFCCHGD 660
LVNYLQRNKH AFLQGDTQTK RPTHTHTLRF CPVLTHRLIH SDSDGGYMDM NKEESAQYVA 720
MKELSYADIE PAVYETPYTP TGDGCTQQEA STLLLSDSPL LSLNDLISFS YQIAQAMDFL 780
SSRKCVHRDL AARNVLVCEG KLVKVCDFGL ARDLLKDQDY IARGNSFLPL KWMSPESIFQ 840
NIYSSQSDVW SYGVLLWEIF SLGCSPYPDL PMTQEFYSAL KRGYRMSRPD HSPQDMYDLM 900
KRCWEEKPQS RPSFSSLLID MGNMLTDDYK QRYLQIAEDF LKGGNPAVHR 950
Nucleotide Sequence
(FASTA)
TTCAGCCTTC AGAAAGTTAA AAAAAAAAGC CCTTTAAAAC TTCCATTGGT GACATCAGGT 60
GTGTTCCTGG TTCATCCTGA AGGGGCGGTG TCTCTGGAGC TGCTGCCATC AGCCTCTGAA 120
GTTCTGGTCC CCTCCAACTC CAATTACACA GTGGAGTGTT TGGGGTGGAG TGAGGTCAAG 180
TGGCATTTTC CTCAGGAACC ACCAGTAGAC GGGGTCCTCG TGGACAATCG AGGCTCCAGG 240
AGCATCCTGC AGCTCTTTAA CATCACATGG AGGAATTCTG GGAGATACAC CTGTGAGGAG 300
GCATCATCTG ATCAGAGCAG AAATGTTGAT GTCTTTATAC CTGGACAAGG TCCCGATGAA 360
TGGTTTGTCC CAATGGATCT GGGTGTGGTG ATGAAGGAGG GAGAGGAAGG CACCATTCCC 420
TGCATGGTGT CCAACCCGAA GCTCAATGTC TCGCTGTACG AGCGCCCCAG CAGGACGCTG 480
GTCAGTGGGA TGACATATAA GCCAGGGCGT GGCTTCACGG GTCACCTCAA TGACACATCA 540
TACGTGTGCG TCGCCACGAA CGGAGCTCAG GAGAGGGAGT CGCAAACGTA CTACGTCTTC 600
AGCATCATAG TCCCAAAGGT CATGGAGGTG GACCTGACGG TGTCCAGCAG TGTGCTGAAG 660
CAGGGCGAGG TCCTCACGGT AAACTGCACG GTTAAAGACA CAGAGATGGT CTTCTTCTCC 720
TGGGGCTTCC CCCGCAGACA GGAAATTGAG CCGCTGACGG ACTTCCTGCC CAATCAGATC 780
CGCTCCTTTG TTAACATCAC TGCAGTAACA GTGGCAGATT CAGGTGTTTA TAGCTGCACA 840
GTGCAGGAGA CGACACAGGG ACAAACTGTG ACAGACAGAG GTTACGTTTA CCTGTGGCCC 900
TCAGGTGAGA CCAATGTGTC GTCTCTCCTC CATCACACGC TGGAATTAAG TGTAGAGATT 960
GACGCCCACC CCGCCCCCAC TGTCATCTGG ACGAGACAGA ACCAATCTGT TGCCACAGAA 1020
ACCACCACTA TCAACACCAC ACACCTGTCA GACAGCCGGT ATGTGAGCAC ACTGACGCTG 1080
GTGCGCGTGC AGATGGATCA GACAGGAAGT TACACCGCAA CTATTTCCAA TGATGATGAC 1140
ATCAGAGAGG CTACCTTCAA CCTGGAGGTA CAAGACATCT GTAGGATCAC ATCCCTGTCA 1200
GAGGTCAGGA GTAACGCTGT GCTGTGTGTG AGTGAGGGAG CTCCACCCCC CTCTGTTACC 1260
TGGTACACCT GTTCCAGCTC ACACAGATGC AATCTTTTGA ATGGCAAGTG GAGGAGCCAA 1320
TCAAAAGACT CAGAGGGCAC GACGCTACAG GAGAACATTA CTATGGTGGC AGAGAGAGGC 1380
ATCACCCAGG TACACAGCAT GCTGACCCTC CAGACTCTCA GCTCTCTGTC GGCCGTGCGC 1440
TGTGAAGCCA CAAACTCAGC GGGCAGACGA GGGAAGGACC TGCGAGTCCT CTCCAGCTCT 1500
CTCCTGTCTC AGGTGGTGGT CTTAGCAGTA GTCCTGGTGT TGGTCATCAT TGCTGTCATC 1560
TTCCTCATCA TCCTCATTAT CCTGTGGAGG AAAAAACCTC ATTATGAAGT TCGTTGGAAG 1620
GTGATTGAGT CCGTGAGTCC TGATGGACAG CAGTACACCT ACCTCGACCC CACCCAACTG 1680
CCCTACAGCC CAACCTGGGA AATAGACAGA GACCATGTAA ATCTTGGTCA GGTGCTGGGT 1740
TCAGGGGCTT TCGGACGTGT TGTTGAGGCA ACCATCTCTG GTCTGATTAA TTCTCATTCT 1800
ACAAAGGCGG CCGTGAAGAT GGTCAAACTG ACTGCGAGGA GTGATGCAGT TCAGTCTCTG 1860
ATGTCAGAGT TGAAGGTTTT GGTTCATCTC GGTCCTCACC TGAACATTGT CAACCTGCTG 1920
GGAGCCTGCA CGAGAGGAGG TCCCGTCTAT CTGATCACTG AGTTTTGTTG TCATGGAGAC 1980
CTGGTGAACT ACCTGCAGAG GAATAAACAT GCCTTTCTAC AGGGAGACAC ACAGACCAAG 2040
AGACCCACAC ACACACACAC ACTCAGATTC TGTCCAGTGC TGACTCACCG GCTCATCCAC 2100
AGTGACAGTG ATGGAGGTTA CATGGACATG AACAAAGAGG AGAGCGCTCA GTACGTTGCC 2160
ATGAAGGAGC TCAGCTATGC CGACATCGAA CCCGCCGTAT ATGAGACACC GTACACGCCC 2220
ACAGGTGATG GCTGCACACA GCAGGAGGCA TCAACCCTGC TCCTCAGTGA CTCTCCTCTC 2280
CTCAGCCTCA ATGATCTCAT CAGTTTCTCT TACCAGATTG CTCAGGCCAT GGACTTCCTA 2340
TCATCTAGAA AGTGTGTGCA CAGAGACCTG GCTGCGAGGA ACGTTCTGGT GTGCGAGGGG 2400
AAGCTGGTGA AGGTCTGTGA CTTTGGTTTG GCCAGAGACC TGCTGAAGGA CCAGGATTAC 2460
ATCGCGAGGG GAAACAGCTT CCTGCCGCTG AAGTGGATGT CTCCAGAGAG CATCTTCCAG 2520
AACATTTACA GCTCGCAGAG CGACGTTTGG TCCTACGGAG TTCTGCTGTG GGAGATATTC 2580
TCTCTGGGCT GCAGCCCGTA CCCCGACCTC CCCATGACCC AGGAGTTCTA CTCTGCTCTG 2640
AAGAGAGGAT ACAGGATGAG TCGACCCGAC CACTCTCCTC AGGACATGTA CGACCTGATG 2700
AAACGCTGCT GGGAGGAGAA ACCTCAGTCC AGACCTTCAT TCTCCTCACT GCTCATCGAC 2760
ATGGGCAATA TGCTGACTGA CGACTATAAA CAGCGTTACC TGCAGATTGC CGAAGACTTC 2820
CTGAAGGGAG GAAATCCAGC TGTGCACCGA 2850
Domain Profile
S: 2     elGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlGe  61
         +lG+vlGsGafG+vveat  Gl++s++  k avkm+k tars+  ++lmselk+l hlG+
Q: 574   NLGQVLGSGAFGRVVEATISGLINSHS-TKAAVKMVKLTARSDAVQSLMSELKVLVHLGP  632
         69*********************9976.599*****************************
S: 62    henivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldskal  121
         h+nivnllGact+gGp+y+ite+cc+Gdl+nyl+r++++fl+  +++k+++++++  +  
Q: 633   HLNIVNLLGACTRGGPVYLITEFCCHGDLVNYLQRNKHAFLQGDTQTKRPTHTHTLRF--  690
         *****************************************99988877766555544..
S: 122   ladkslrsksslssesseeyvdlkkd............vsdvssskadklasekkksale  169
              + ++  + s+s++ y+d++k+            ++d++++ +++++  + +  ++
Q: 691   ---CPVLTHRLIHSDSDGGYMDMNKEesaqyvamkelsYADIEPAVYETPYTPTGDGCTQ  747
         ...34555666666788888888887788888888888****************999999
S: 170   revkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkic  229
         +e+ + l  + s  l+l+dl+sfsyq+a+ m+fl+s++cvhrdlaarnvl++eGk+vk+c
Q: 748   QEASTLLLSD-SPLLSLNDLISFSYQIAQAMDFLSSRKCVHRDLAARNVLVCEGKLVKVC  806
         9988777766.9************************************************
S: 230   dfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstp  289
         dfGlard++kd +y+++Gn++lp+kwm+pesif+++y+ +sdvwsyG+llweifslG +p
Q: 807   DFGLARDLLKDQDYIARGNSFLPLKWMSPESIFQNIYSSQSDVWSYGVLLWEIFSLGCSP  866
         ************************************************************
S: 290   ypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkql  340
         yp+l++ ++fy ++k+Gyrm++p+++++++y++m++cwe++p+ rpsf+ l
Q: 867   YPDLPMTQEFYSALKRGYRMSRPDHSPQDMYDLMKRCWEEKPQSRPSFSSL  917
         ************************************************987
Domain Sequence
(FASTA)
NLGQVLGSGA FGRVVEATIS GLINSHSTKA AVKMVKLTAR SDAVQSLMSE LKVLVHLGPH 60
LNIVNLLGAC TRGGPVYLIT EFCCHGDLVN YLQRNKHAFL QGDTQTKRPT HTHTLRFCPV 120
LTHRLIHSDS DGGYMDMNKE ESAQYVAMKE LSYADIEPAV YETPYTPTGD GCTQQEASTL 180
LLSDSPLLSL NDLISFSYQI AQAMDFLSSR KCVHRDLAAR NVLVCEGKLV KVCDFGLARD 240
LLKDQDYIAR GNSFLPLKWM SPESIFQNIY SSQSDVWSYG VLLWEIFSLG CSPYPDLPMT 300
QEFYSALKRG YRMSRPDHSP QDMYDLMKRC WEEKPQSRPS FSSL 344
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-TAR-00513
EKS-TEN-00515
EKS-XIM-00508
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013