EKS-ORN-00517
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00517
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR464.14.3E-139570904335
StatusUnreviewed
Ensembl ProteinENSONIP00000022423
UniProt AccessionI3KMS8;
Protein Name
Protein Synonyms/Alias
Gene NameCSF1R (2 of 2)
Gene Synonyms/Alias CSF1R (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000017788ENSONIP00000022423ENSONIT00000022443
OrganismOreochromis niloticus
Functional Description
Protein Length946
Protein Sequence
(FASTA)
MCSCVFLFVS EPDPPSIRLN SDFLPSKSDR VLTAGTDFSL SCHGNGSVHW TSTAFPLVYR 60
GNLPDPVEVK RATRRHTGTY TCRYTNESLA HLNSWIHLYV TDPADPSKVF ETPQGNPSLK 120
EGEDFLFKCL LTDPLVTNLT LQSEDGRNLP TAMNVTFDPR RGALIRDLKT LFNGRYVCSG 180
WKDGRQFRSR PVNLLVFPVL HHPPSLSVSQ DEFVRLVGER FEVTCLCSNP THFYNVTWRD 240
PRKQKLEATQ SRYYSNGRLY INSTLSISEV TQTDSGQYMC TAVNEAGVAT ATIQLKVLGK 300
QKESLKPNLN SRDSVVYEGR DVALTFLLNA YPPITCQLWT TPTHLINNDS TVYQESYAAN 360
SYSSEATLLL HRVRPEDRGK YLFHFSNSFF SGSHTIDLKI YRFPATDVTL EDNTLMCNSS 420
GYPLPTILWF TCPGIQASCA HIATNEVSQA SVTSQDGEEV RSHFLLSADD DVTVECVASN 480
LMGESLRVFH HQFLFSTGIP TIFTPPLIGV LSATAVLFLL LLVVFYKCRQ KPKYEIRWKI 540
IESTDGNNYT FVDPTQLPYN QKWEFPRDKL RLGPILGSGA FGKVVEATAY GLETDNKITR 600
VAVKMLKPSA DSEEREALMS ELKILSHLGY HDNIVNLLGA CTRGGPMLMI TEYCSHGDLL 660
NFLRGHAQDI MASMVTVDEV HEEVFYKNMA DSGISCCSEY QEMQPILNPG QTYQGNLGSG 720
TETRPSHLQI ELNTAPSVLE HFRCDLDDLM SFSYQVSQGL DFLSTRNCIH RDVAARNVLL 780
TDRHVAKICD FGLARDIRND DSYIVQGNAR LPVKWMAPES IFQCIYTVQS DVWSYGVLLW 840
EIFSLGKSPY PNIAVDTNFY KMIKDGGHME QPDFAPAEMY QLMKLCWSLE PTHRPTFKTI 900
GQLISRLLPS TNDTSSRYSD QAVPHHLSSS SCVLSRLIGT STSAEK 946
Nucleotide Sequence
(FASTA)
ATGTGTTCAT GTGTCTTTCT ATTTGTTTCA GAACCTGATC CACCATCGAT CCGTCTAAAT 60
TCTGACTTCC TACCAAGTAA ATCTGATCGA GTTCTTACTG CCGGCACCGA CTTCAGCCTC 120
AGTTGCCATG GTAACGGGTC AGTTCACTGG ACCAGCACCG CATTTCCACT GGTGTATCGG 180
GGCAATCTAC CAGACCCTGT GGAGGTCAAA CGTGCTACAC GCAGGCACAC TGGAACATAC 240
ACCTGCAGAT ACACCAACGA GAGCCTGGCG CACCTGAACA GCTGGATCCA CCTGTATGTC 300
ACAGACCCAG CAGATCCCTC CAAAGTGTTT GAAACCCCTC AGGGCAACCC CAGTCTCAAG 360
GAGGGTGAGG ACTTCCTGTT CAAGTGTCTA CTGACTGACC CCTTGGTCAC AAATCTCACC 420
CTTCAATCAG AGGATGGGAG GAACCTGCCA ACCGCCATGA ACGTGACCTT TGATCCTCGA 480
AGAGGAGCCC TAATCCGAGA CCTGAAGACT TTGTTCAATG GACGCTACGT GTGTTCAGGC 540
TGGAAGGATG GCAGACAGTT CAGATCCAGG CCCGTGAACC TACTGGTGTT CCCTGTGTTG 600
CACCACCCCC CCTCCCTGTC TGTTAGTCAG GATGAATTTG TCCGTCTGGT AGGAGAGCGT 660
TTTGAGGTTA CTTGTCTCTG CAGTAACCCC ACCCACTTCT ATAATGTTAC CTGGAGAGAC 720
CCAAGGAAGC AGAAACTGGA AGCCACTCAA AGTCGTTACT ATAGTAACGG GCGGCTGTAC 780
ATCAACAGCA CTCTGAGCAT ATCTGAGGTC ACCCAAACGG ACAGTGGACA GTACATGTGT 840
ACGGCAGTTA ACGAGGCCGG GGTTGCCACA GCAACCATCC AGCTCAAGGT GCTAGGTAAG 900
CAAAAGGAAA GTTTGAAGCC TAATCTTAAT AGTAGAGATA GTGTCGTTTA TGAAGGTCGT 960
GACGTGGCCC TCACCTTCCT GCTGAACGCC TATCCTCCAA TCACATGCCA GCTCTGGACC 1020
ACACCCACAC ACCTCATCAA CAATGACAGT ACGGTGTACC AGGAGAGCTA TGCTGCTAAC 1080
AGCTACAGCT CAGAGGCCAC CCTGCTGCTG CACCGCGTGC GTCCAGAGGA TCGGGGGAAA 1140
TACTTGTTTC ATTTCTCTAA CTCCTTTTTC AGCGGCTCAC ACACCATCGA CCTCAAGATC 1200
TACCGTTTTC CAGCTACTGA TGTCACTTTG GAGGACAATA CTCTGATGTG CAACAGCTCA 1260
GGATATCCAC TACCCACAAT TCTGTGGTTC ACCTGTCCTG GCATCCAGGC CTCGTGTGCA 1320
CACATTGCTA CCAATGAGGT TTCTCAGGCC AGTGTGACCT CACAGGATGG TGAGGAGGTG 1380
AGGTCCCACT TCCTCCTATC AGCTGATGAT GATGTCACTG TGGAGTGTGT TGCCTCCAAC 1440
CTCATGGGAG AGTCGCTACG GGTCTTCCAT CATCAGTTCC TGTTTTCTAC AGGGATTCCA 1500
ACCATCTTCA CTCCACCTCT GATTGGAGTT CTGAGTGCCA CCGCTGTCCT CTTCTTGCTC 1560
CTATTGGTCG TCTTCTACAA GTGCAGACAG AAACCCAAGT ATGAGATCCG CTGGAAGATC 1620
ATCGAAAGCA CTGATGGAAA CAACTACACC TTTGTTGACC CCACCCAGCT GCCATACAAC 1680
CAGAAGTGGG AGTTTCCCCG AGACAAACTG CGCCTCGGTC CCATCCTGGG CTCTGGGGCT 1740
TTCGGGAAGG TTGTTGAGGC CACAGCGTAC GGTTTGGAAA CTGACAACAA GATCACCAGA 1800
GTTGCTGTCA AGATGCTTAA ACCAAGCGCT GACTCGGAGG AACGGGAGGC TTTGATGTCT 1860
GAGCTTAAGA TTCTCAGCCA TCTCGGCTAC CATGACAACA TCGTTAACTT GCTGGGAGCC 1920
TGTACTCGTG GAGGCCCTAT GCTGATGATC ACAGAGTACT GTAGCCATGG TGACCTGCTC 1980
AACTTTCTGC GGGGTCATGC TCAGGACATC ATGGCGTCCA TGGTGACTGT GGATGAAGTA 2040
CACGAAGAGG TTTTCTATAA GAACATGGCT GACAGCGGGA TCTCATGCTG CTCGGAGTAT 2100
CAGGAGATGC AGCCAATTCT GAATCCCGGG CAAACATACC AGGGCAACCT GGGCAGCGGA 2160
ACGGAGACTA GACCGTCTCA TTTGCAAATC GAGCTCAACA CTGCCCCTAG CGTCCTGGAG 2220
CACTTCCGTT GTGATTTGGA TGACCTCATG AGTTTTTCCT ACCAGGTGTC CCAGGGTCTG 2280
GACTTCCTGT CCACCAGGAA TTGTATCCAC AGAGACGTAG CAGCGAGGAA TGTCCTGCTG 2340
ACTGATCGTC ATGTTGCAAA GATCTGCGAC TTCGGTTTGG CCCGAGACAT TCGCAATGAT 2400
GACAGTTACA TCGTTCAAGG AAATGCCCGC CTCCCGGTGA AGTGGATGGC TCCAGAGAGC 2460
ATCTTTCAGT GCATCTACAC GGTGCAGAGC GACGTCTGGT CCTATGGAGT CTTACTCTGG 2520
GAGATCTTCT CTCTGGGAAA GAGCCCATAC CCAAACATTG CCGTGGACAC CAACTTCTAC 2580
AAGATGATCA AAGATGGCGG CCACATGGAG CAGCCTGACT TCGCCCCAGC TGAGATGTAT 2640
CAGCTGATGA AGCTCTGCTG GAGCCTTGAG CCCACACACA GACCTACCTT CAAAACCATT 2700
GGTCAGCTCA TCAGCAGACT CCTCCCCTCT ACCAATGATA CGTCATCACG TTACAGCGAC 2760
CAGGCTGTGC CTCATCATCT TTCTTCTTCT TCTTGTGTCC TCAGCCGACT TATAGGAACA 2820
TCGACGAGTG CAGAGAAG 2838
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG +lGsGafGkvveatayGl  ++   +vavkmlk++a+s+e+ealmselkilshlG
Q: 570   LRLGPILGSGAFGKVVEATAYGLETDNKITRVAVKMLKPSADSEEREALMSELKILSHLG  629
         689*********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
          h+nivnllGact+gGp+++iteyc +Gdlln+lr +++ ++ +++    e +ee+ +k+
Q: 630   YHDNIVNLLGACTRGGPMLMITEYCSHGDLLNFLRGHAQDIMASMVTV-DEVHEEVFYKN  688
         ****************************************99777776.56667777776
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadkla.sekkksalerevkaaleee  179
         +       s  s      +ey ++++ ++  ++ + +  +  e++ s l+ e ++a +  
Q: 689   M-----ADSGIS----CCSEYQEMQPILNPGQTYQGNLGSgTETRPSHLQIELNTAPSVL  739
         6.....233333....34678888887776666665544313344566666666666656
S: 180   dsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimk  239
         ++   +l+dl+sfsyqv++G++fl+++nc+hrd+aarnvllt+ +v+kicdfGlardi++
Q: 740   EHFRCDLDDLMSFSYQVSQGLDFLSTRNCIHRDVAARNVLLTDRHVAKICDFGLARDIRN  799
         66889*******************************************************
S: 240   dsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskf  299
         d +y+v+Gnarlpvkwmapesif+++ytv+sdvwsyG+llweifslG +pyp++ vd++f
Q: 800   DDSYIVQGNARLPVKWMAPESIFQCIYTVQSDVWSYGVLLWEIFSLGKSPYPNIAVDTNF  859
         ************************************************************
S: 300   yklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         yk+ik+G +m+qp++a++e+y++m+ cw  ep++rp+fk + +l+
Q: 860   YKMIKDGGHMEQPDFAPAEMYQLMKLCWSLEPTHRPTFKTIGQLI  904
         ****************************************99886
Domain Sequence
(FASTA)
LRLGPILGSG AFGKVVEATA YGLETDNKIT RVAVKMLKPS ADSEEREALM SELKILSHLG 60
YHDNIVNLLG ACTRGGPMLM ITEYCSHGDL LNFLRGHAQD IMASMVTVDE VHEEVFYKNM 120
ADSGISCCSE YQEMQPILNP GQTYQGNLGS GTETRPSHLQ IELNTAPSVL EHFRCDLDDL 180
MSFSYQVSQG LDFLSTRNCI HRDVAARNVL LTDRHVAKIC DFGLARDIRN DDSYIVQGNA 240
RLPVKWMAPE SIFQCIYTVQ SDVWSYGVLL WEIFSLGKSP YPNIAVDTNF YKMIKDGGHM 300
EQPDFAPAEM YQLMKLCWSL EPTHRPTFKT IGQLI 335
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Oryzias latipes"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-ORL-00493
EKS-TAR-00512
EKS-TEN-00514
EKS-XIM-00531
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013