EKS-ORN-00219
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00219
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC439.84.8E-132154420267
StatusUnreviewed
Ensembl ProteinENSONIP00000022598
UniProt AccessionI3KNA2;
Protein Name
Protein Synonyms/Alias
Gene NamePRKCZ
Gene Synonyms/Alias PRKCZ;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000017929ENSONIP00000022598ENSONIT00000022618
ENSONIG00000017929ENSONIP00000022597ENSONIT00000022617
OrganismOreochromis niloticus
Functional Description
Protein Length494
Protein Sequence
(FASTA)
VLTPLCAVES IYRRGARRWR KLYRVNGHLF QAKRFNRKAY CAHCSERIWG LGSQGYKCIN 60
CKLLVHKRCH RLIPQTCQRL MDPVMPSQKP PSDAQSAEVD LPLDDTEDTD GIPFLPHNCA 120
VNKAEDETED VKAVVDGIDG IKISQGLVLG LGDFDLIRVI GRGSYAKVLL VRLKKNEQMY 180
AMKVVKKELV HDDEDIDWVQ TEKHVFEQAS TNPFLVGLHS CFQTESRLFL VIEYVNGGDL 240
MFHMQRQRKL PEEHARFYAA EICIALNFLH EKGIIYRDLK LDNVLLDHEG HIKLTDYGMC 300
KEGIRPGDTT STFCGTPNYI APEILRGEDY GFSVDWWALG VLMFEMMAGR SPFDIITDNP 360
DMNTEEYLFQ VILEKPIRIP RSLSVKAAGV LKGFLNKDPK ERLGCQVQTG FTDIKSHTFF 420
RSIDWEQLEK KEVTPPFKPQ ISDEYGLENF DTQFTNEPVQ LTPDDEDVIK RIDQSEFEGF 480
EYINPLLLAT EESV 494
Nucleotide Sequence
(FASTA)
GTATTAACAC CTTTGTGTGC AGTAGAATCG ATCTACCGAC GGGGGGCCAG AAGATGGAGG 60
AAGCTCTACC GAGTGAACGG ACATCTCTTC CAGGCCAAAC GCTTTAACAG GAAAGCCTAC 120
TGTGCCCACT GTAGTGAAAG GATATGGGGG CTGGGCAGTC AGGGCTACAA GTGTATCAAC 180
TGCAAACTGC TGGTCCATAA GCGCTGTCAC AGACTCATCC CTCAGACCTG CCAAAGGCTT 240
ATGGATCCAG TCATGCCATC ACAGAAGCCC CCTTCAGATG CCCAGAGTGC CGAGGTGGAC 300
CTTCCGCTGG ATGACACAGA GGACACAGAT GGGATACCGT TTTTACCACA CAACTGTGCA 360
GTGAACAAAG CAGAAGACGA GACAGAGGAC GTCAAAGCAG TAGTTGATGG CATCGATGGC 420
ATTAAGATAT CCCAGGGACT GGTTCTCGGG CTGGGTGACT TTGACCTGAT TCGAGTAATA 480
GGACGTGGCA GCTATGCCAA AGTTCTGCTG GTGCGGCTAA AGAAGAATGA GCAGATGTAC 540
GCCATGAAGG TGGTGAAAAA GGAGCTGGTC CATGACGACG AGGATATTGA CTGGGTGCAG 600
ACAGAGAAGC ATGTTTTTGA GCAGGCTTCG ACCAATCCCT TCTTAGTCGG CCTCCACTCC 660
TGTTTCCAGA CAGAAAGTCG GTTATTTCTA GTGATCGAGT ATGTAAACGG TGGGGACTTG 720
ATGTTTCATA TGCAACGACA AAGGAAGCTC CCAGAAGAGC ACGCAAGATT CTACGCTGCT 780
GAAATCTGCA TCGCGTTGAA CTTCCTACAT GAAAAGGGCA TCATCTACCG TGATCTGAAG 840
CTGGACAACG TGCTCTTGGA CCACGAGGGA CACATCAAGC TCACAGACTA CGGCATGTGC 900
AAGGAGGGAA TCAGACCAGG TGATACCACC AGTACTTTCT GTGGCACTCC AAACTACATA 960
GCCCCTGAGA TCCTGAGAGG GGAAGACTAT GGCTTCAGTG TGGACTGGTG GGCTTTGGGC 1020
GTGCTGATGT TTGAGATGAT GGCTGGAAGG TCCCCGTTCG ACATCATCAC TGACAATCCT 1080
GACATGAACA CAGAGGAGTA CCTCTTTCAG GTTATTCTTG AGAAGCCCAT TCGGATCCCA 1140
AGGTCTCTGT CGGTGAAAGC TGCCGGCGTG CTCAAGGGCT TTCTAAACAA GGATCCCAAG 1200
GAGCGGCTGG GTTGCCAGGT CCAGACAGGC TTCACAGACA TCAAGTCCCA CACGTTTTTC 1260
CGCAGTATAG ACTGGGAACA GCTTGAGAAG AAAGAAGTGA CGCCGCCCTT CAAACCTCAA 1320
ATCTCTGATG AATACGGCCT AGAAAACTTT GACACGCAGT TTACTAATGA ACCAGTGCAG 1380
CTAACACCAG ATGATGAGGA TGTCATCAAG AGAATAGACC AGTCCGAGTT TGAGGGATTT 1440
GAATATATCA ACCCCCTGCT GCTAGCCACA GAAGAGTCTG TATGA 1485
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f+l++v+G+Gs++kvll++lkk++++ya+kv+kk++v++d+d++++++ek+v+++as +p
Q: 154   FDLIRVIGRGSYAKVLLVRLKKNEQMYAMKVVKKELVHDDEDIDWVQTEKHVFEQASTNP  213
         89**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         flv l+scfqte+rlf+v+eyvnGGdlmfh+q++rkl+ee+arfyaaei++al+flhekg
Q: 214   FLVGLHSCFQTESRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHEKG  273
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldnvlld+eGhikl+d+G+cke+i  g+ttstfcGtP+yiaPeil++e+yg+s
Q: 274   IIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFS  333
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfe.......gededelfesilekevlyPkslskeaveilkg  233
         vdwwalGvl++em+ag+sPf+       +++e++lf++ilek +++P+sls++a+ +lkg
Q: 334   VDWWALGVLMFEMMAGRSPFDiitdnpdMNTEEYLFQVILEKPIRIPRSLSVKAAGVLKG  393
         **************************999*******************************
S: 234   lltkdpekrlGvk.eegeedikehaff  259
         +l+kdp++rlG++ ++g +dik+h+ff
Q: 394   FLNKDPKERLGCQvQTGFTDIKSHTFF  420
         ************88************9
Domain Sequence
(FASTA)
FDLIRVIGRG SYAKVLLVRL KKNEQMYAMK VVKKELVHDD EDIDWVQTEK HVFEQASTNP 60
FLVGLHSCFQ TESRLFLVIE YVNGGDLMFH MQRQRKLPEE HARFYAAEIC IALNFLHEKG 120
IIYRDLKLDN VLLDHEGHIK LTDYGMCKEG IRPGDTTSTF CGTPNYIAPE ILRGEDYGFS 180
VDWWALGVLM FEMMAGRSPF DIITDNPDMN TEEYLFQVIL EKPIRIPRSL SVKAAGVLKG 240
FLNKDPKERL GCQVQTGFTD IKSHTFF 267
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Ochotona princeps"; ?>Oryzias latipes"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00165
EKS-DAR-00466
EKS-DIO-00088
EKS-GAA-00210
EKS-ICT-00168
EKS-LAC-00182
EKS-LOA-00172
EKS-OCP-00108
EKS-ORL-00205
EKS-SAH-00165
EKS-TAG-00202
EKS-TEN-00219
EKS-XET-00161
EKS-XIM-00213
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0008270; F:zinc ion binding
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR000270; OPR_PB1.
IPR012233; PKC_zeta.
IPR017892; Pkinase_C.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 1.
PF00564; PB1; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013