EKS-ORN-00187

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00187

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/NDR	512.9	3.1E-154	89	382	294

Status

Unreviewed

Ensembl Protein

ENSONIP00000022612

UniProt Accession

I3KNB7;

Protein Name

Protein Synonyms/Alias

Gene Name

STK38

Gene Synonyms/Alias

STK38;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000017942	ENSONIP00000022612	ENSONIT00000022632

Organism

Oreochromis niloticus

Functional Description

Protein Length

467

Protein Sequence
(FASTA)

MAMTGQTSYP SMSNHTKERV TMAKVTLENF YSNLIAQHEE REMRQQKLEK VMDQEGLADE 60

EKRIRRSEHA RKETEFLRLK RTRLGLEDFE SLKVIGRGAF GEVRLVQKKD TGHVYAMKIL 120

RKADMLEKEQ VGHIRAERDI LVEADSLWVV KMFYSFQDKL NLYLIMEFLP GGDMMTLLMK 180

KDTLSEEATQ FYIAETVLAI DSIHQLGFIH RDIKPDNLLL DSRGHVKLSD FGLCTGLKRA 240

HRTEFYKNLN HSLPNDLTSQ NMNSKRKAET WKRNRRQLAF STVGTPDYIA PEVFMQNGYN 300

KLCDWWSLGV IMYEMLIGYP PFCSETPQET YRKVMNWRET LVFPPEVPIS EKAKDLILRF 360

CCEEEHRIGA SGVEEIKSNP FFEGVDYDHI RERPAAIPIN IRSIDDTSNF DEFPDSDILT 420

PTATQVSNQA EADLKNKDWV FINYTYKRFE GLTARGAIPS YMKSGKR 467

Nucleotide Sequence
(FASTA)

ATGGCAATGA CCGGCCAGAC CTCGTACCCT TCCATGAGTA ACCACACCAA AGAGAGGGTC 60

ACCATGGCCA AAGTGACCCT GGAGAACTTC TATAGTAACC TCATCGCTCA GCACGAGGAG 120

AGAGAGATGA GGCAGCAGAA GCTGGAGAAA GTTATGGATC AGGAGGGCTT GGCTGATGAA 180

GAGAAACGTA TCCGGCGCTC TGAGCATGCA AGGAAAGAGA CCGAATTTCT GCGTTTGAAA 240

CGTACTCGAC TGGGTCTGGA GGACTTTGAA TCCCTGAAGG TGATTGGCCG AGGAGCTTTC 300

GGAGAGGTAC GCTTGGTGCA GAAGAAAGAC ACCGGTCATG TTTATGCTAT GAAGATCCTC 360

CGCAAAGCTG ATATGCTTGA GAAAGAACAG GTTGGTCACA TCCGTGCTGA ACGAGACATT 420

CTGGTCGAGG CCGACAGTCT GTGGGTGGTC AAAATGTTCT ACAGCTTCCA GGATAAGCTG 480

AACCTTTACC TCATCATGGA GTTTCTACCT GGAGGCGACA TGATGACCCT GCTGATGAAG 540

AAGGACACTC TGTCAGAAGA AGCTACTCAG TTCTACATAG CAGAGACGGT GCTGGCCATT 600

GACTCCATCC ACCAGTTGGG CTTCATCCAC AGAGACATCA AACCAGACAA CCTGCTGCTG 660

GACTCCAGGG GTCACGTGAA GCTGTCTGAC TTTGGGCTGT GCACAGGCTT AAAGAGGGCT 720

CATCGGACTG AGTTCTACAA GAACCTGAAC CACAGCCTGC CCAATGACCT CACATCCCAG 780

AACATGAACT CTAAGAGGAA AGCAGAGACC TGGAAGAGGA ACAGGAGGCA GCTGGCATTC 840

TCCACAGTGG GAACACCAGA CTACATTGCT CCAGAGGTCT TCATGCAAAA TGGATACAAC 900

AAACTGTGTG ACTGGTGGAG CCTGGGTGTG ATCATGTATG AGATGCTGAT AGGTTATCCT 960

CCATTTTGCT CAGAGACGCC ACAAGAGACG TACAGAAAAG TGATGAACTG GAGAGAGACA 1020

CTCGTCTTTC CTCCAGAGGT GCCTATATCA GAGAAGGCCA AAGACCTCAT TCTCAGGTTC 1080

TGCTGTGAGG AGGAGCACAG GATTGGGGCT TCGGGCGTGG AGGAGATCAA GTCCAATCCT 1140

TTCTTTGAGG GTGTAGACTA TGACCATATC AGGGAGAGGC CTGCTGCCAT TCCCATAAAT 1200

ATCAGAAGCA TTGACGACAC CTCAAACTTT GACGAATTCC CTGATTCAGA TATCCTCACA 1260

CCTACAGCCA CTCAGGTGTC CAATCAGGCT GAGGCTGATC TGAAGAACAA GGACTGGGTC 1320

TTCATAAACT ACACCTACAA ACGTTTTGAA GGCCTGACGG CTCGAGGTGC TATCCCGTCC 1380

TACATGAAGT CGGGGAAAAG ATGA 1404

Domain Profile

S: 1     feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew  60

         fe+lkvig+GafGevrlv+kkdt++vya+kilrk+d+l+k+qv h++aerdil+eads w

Q: 89    FESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLW  148

         899*********************************************************

S: 61    vvklyysfqdkenlylvmeylPGGdlmtllikkeilkeelarfyiaelvlavesvhklGf  120

         vvk++ysfqdk nlyl+me+lPGGd+mtll+kk++l+ee+++fyiae+vla++s+h+lGf

Q: 149   VVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLSEEATQFYIAETVLAIDSIHQLGF  208

         ************************************************************

S: 121   ihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddleaseelkvler  180

         ihrd+kPdnll+d++Gh+kl+dfGlctGlk++hr+e+yk+l+++ ++dl      +++++

Q: 209   IHRDIKPDNLLLDSRGHVKLSDFGLCTGLKRAHRTEFYKNLNHSLPNDLTS----QNMNS  264

         *************************************************54....45555

S: 181   rkk....kknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyemlvGypPfla  236

         ++k    k+nrr+la+s+vGtpdyiapev++++gynklcdwWslGvi+yeml+GypPf++

Q: 265   KRKaetwKRNRRQLAFSTVGTPDYIAPEVFMQNGYNKLCDWWSLGVIMYEMLIGYPPFCS  324

         5444566*****************************************************

S: 237   etpqetykkvinwketlkfpeevelseeakdlierliadaekrlgkkGvdeikkhpff  294

         etpqety+kv+nw+etl fp+ev++se+akdli r++++ e+r+g++Gv+eik++pff

Q: 325   ETPQETYRKVMNWRETLVFPPEVPISEKAKDLILRFCCEEEHRIGASGVEEIKSNPFF  382

         *********************************************************9

Domain Sequence
(FASTA)

FESLKVIGRG AFGEVRLVQK KDTGHVYAMK ILRKADMLEK EQVGHIRAER DILVEADSLW 60

VVKMFYSFQD KLNLYLIMEF LPGGDMMTLL MKKDTLSEEA TQFYIAETVL AIDSIHQLGF 120

IHRDIKPDNL LLDSRGHVKL SDFGLCTGLK RAHRTEFYKN LNHSLPNDLT SQNMNSKRKA 180

ETWKRNRRQL AFSTVGTPDY IAPEVFMQNG YNKLCDWWSL GVIMYEMLIG YPPFCSETPQ 240

ETYRKVMNWR ETLVFPPEVP ISEKAKDLIL RFCCEEEHRI GASGVEEIKS NPFF 294

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013