EKS-ORN-00306

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00306

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	388.8	1.2E-116	59	310	252

Status

Unreviewed

Ensembl Protein

ENSONIP00000023250

UniProt Accession

I3KQ55;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK1

Gene Synonyms/Alias

MARK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000018468	ENSONIP00000023250	ENSONIT00000023270

Organism

Oreochromis niloticus

Functional Description

Protein Length

779

Protein Sequence
(FASTA)

MSTRTPLPTV NERDTENHSS VDGFVEPQAP PTKSASRHSL PRCRNSFTST EEHPHIGNYR 60

LLKTIGKGNF AKVKLARHVL TGREVAVKII DKTQLNPTSL QKLFREVRIM KILNHPNIVK 120

LFEVIETEKT LYLVMEYASG GEVFDYLVAH GRMKEKEARA KFRQIVSAVQ YCHQRRIVHR 180

DLKAENLLLD ADMNIKIADF GFSNEFTVGS KLDTFCGSPP YAAPELFQGK KYDGPEVDVW 240

SLGVILYTLV SGSLPFDGQN LKELRERVLR GKYRIPFYMS TDCENLLKKL LVLNPVKRGS 300

LEQIMKDHWM NVGHEEEELK PYIEPEADFS DSSRIELMVT MGFPKDEITD SLQSQKYDEV 360

MATYLLLGRK APEFEGSEPL ANSILGQRQR PTSDINNSSS ISPAHPKVTR SISTNQKQRR 420

YSDHVGPSVP PAVSYTKRGQ ALSVESDHRE EWDGARRLEL STSKGDVPAS PLGVQERKKT 480

TSAVGHKQTN GSMTRRNTYV CERSSTDRYS AIPNGKDSSL TEVSGSTPST AMSSTRPRHT 540

KSMSSSGHPS KSTLPPIDDN TELKASSSPR GPSTSPSAHS ISTPEKNRFP RGTTSRSTFH 600

GAQLRDRRSA TYNGPPASPT LSHDTGALAQ QRRGTSTGII SKITSKFVRR VPSEGEASAR 660

TETPRSASGD TKEDGGRDSK PRSLRFTWSM KTTSSMEPSE MMREIRKVLD ANSCDYEQRE 720

RFLLFCVHGD ARQDNLVQWE MEVCKLPRLS LNGVRFKRIS GTSIAFKNIA CKIANELKL 779

Nucleotide Sequence
(FASTA)

ATGTCGACCA GAACGCCATT GCCCACAGTG AACGAGCGTG ACACCGAGAA CCACTCTTCG 60

GTGGACGGCT TTGTTGAACC CCAAGCCCCC CCAACAAAGT CCGCGAGTCG TCACAGCCTG 120

CCACGATGCC GCAACTCTTT CACCTCCACA GAGGAGCACC CTCACATCGG CAATTACCGC 180

CTCCTCAAGA CCATTGGGAA GGGGAATTTT GCCAAAGTGA AGCTGGCACG ACATGTCCTG 240

ACTGGACGAG AGGTGGCGGT GAAGATAATA GACAAAACCC AGCTGAATCC AACCAGCCTA 300

CAGAAGCTCT TCAGGGAAGT CAGAATAATG AAGATTCTGA ATCATCCAAA TATAGTGAAA 360

TTGTTTGAGG TGATTGAAAC GGAGAAGACT CTTTATTTGG TGATGGAGTA TGCCAGTGGT 420

GGTGAAGTGT TTGACTATCT AGTGGCTCAT GGCAGAATGA AGGAGAAGGA GGCCAGAGCC 480

AAGTTCAGAC AGATTGTGTC TGCAGTGCAG TATTGTCACC AGAGGAGGAT AGTACACAGA 540

GATCTAAAGG CAGAGAACCT GTTGTTAGAT GCAGATATGA ACATCAAGAT AGCTGATTTT 600

GGCTTCAGCA ATGAGTTCAC TGTGGGCAGC AAACTGGATA CTTTCTGTGG CTCTCCGCCA 660

TACGCTGCTC CCGAACTCTT CCAGGGGAAG AAGTACGATG GTCCAGAGGT GGATGTTTGG 720

AGTCTAGGGG TTATCCTCTA CACACTGGTC AGCGGCTCAC TGCCCTTTGA TGGGCAGAAC 780

CTAAAGGAGC TGAGAGAGAG AGTCCTGCGA GGAAAGTACC GTATTCCCTT CTACATGTCC 840

ACAGACTGTG AAAACCTGCT AAAGAAACTG CTCGTGCTCA ACCCCGTGAA ACGAGGCAGT 900

TTGGAGCAAA TCATGAAAGA CCACTGGATG AATGTAGGTC ACGAGGAGGA GGAGCTTAAA 960

CCTTACATCG AGCCTGAGGC GGACTTCAGT GATTCATCCA GAATAGAGCT CATGGTGACG 1020

ATGGGTTTCC CTAAAGATGA GATCACCGAT TCCCTGCAGA GTCAAAAATA TGACGAAGTC 1080

ATGGCCACTT ACCTGCTCCT GGGAAGAAAA GCCCCGGAGT TCGAAGGGAG CGAGCCTCTG 1140

GCTAACAGCA TCCTGGGTCA GCGACAGCGG CCGACCAGTG ACATCAACAA CAGCTCCAGC 1200

ATTTCTCCCG CCCATCCCAA GGTCACGCGC AGCATCTCGA CCAATCAGAA GCAGCGCCGC 1260

TACAGTGATC ATGTGGGTCC ATCTGTGCCG CCGGCGGTAT CGTATACAAA GCGTGGCCAG 1320

GCTTTGAGCG TGGAAAGTGA CCACAGGGAG GAGTGGGACG GAGCGCGCCG GCTAGAGCTC 1380

AGCACTTCAA AAGGAGATGT ACCCGCCTCG CCCCTGGGGG TGCAGGAGAG GAAGAAAACC 1440

ACAAGTGCTG TGGGGCACAA ACAGACCAAC GGGTCTATGA CTCGCAGGAA CACATACGTG 1500

TGTGAACGAT CCTCCACTGA CCGCTATTCA GCTATTCCCA ATGGCAAAGA CAGCAGTTTA 1560

ACCGAGGTGT CAGGGAGTAC CCCGTCGACT GCAATGAGCT CCACACGACC TCGTCACACC 1620

AAGTCTATGT CATCATCAGG GCATCCTTCA AAGAGCACAC TGCCCCCCAT CGATGACAAC 1680

ACTGAGCTTA AAGCCAGCTC GTCTCCACGC GGCCCCTCCA CCTCTCCGTC TGCACACAGT 1740

ATTAGCACCC CAGAGAAGAA CCGTTTCCCC CGTGGTACCA CCAGTCGCAG CACTTTTCAC 1800

GGAGCCCAGC TCAGAGACCG CCGCAGCGCC ACCTACAACG GACCTCCAGC TTCACCCACA 1860

TTGTCTCATG ATACGGGGGC TCTTGCTCAA CAACGCAGGG GCACCTCTAC AGGGATCATT 1920

AGCAAGATCA CCTCCAAGTT TGTCCGCAGG GTGCCTAGTG AGGGCGAGGC CAGTGCCAGG 1980

ACAGAAACAC CAAGGAGTGC GTCTGGCGAC ACTAAGGAGG ACGGCGGTCG GGATTCAAAG 2040

CCACGCTCCC TGCGTTTCAC CTGGAGCATG AAGACCACCT CCTCCATGGA GCCCTCCGAG 2100

ATGATGAGGG AGATCAGAAA AGTCCTGGAC GCCAACAGCT GCGACTACGA GCAGCGCGAG 2160

CGCTTCCTCC TTTTCTGTGT CCACGGCGAC GCTCGCCAGG ACAATCTGGT CCAGTGGGAG 2220

ATGGAGGTGT GCAAGCTGCC CCGCCTTTCG CTCAATGGCG TGCGCTTCAA GAGGATATCG 2280

GGCACGTCCA TCGCCTTTAA GAACATCGCC TGCAAAATTG CCAACGAGCT CAAACTGTGA 2340

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+llkt+G+g+f+kVkla+h +t+++vavKii+k++l+ +sl+k++rE++i+k+l+hpni

Q: 59    YRLLKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI  118

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lylv+eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+++iv

Q: 119   VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQRRIV  178

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 179   HRDLKAENLLLDADMNIKIADFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVD  238

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+klLv +p kR

Q: 239   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPVKR  298

         ************************************************************

S: 241   atieeilkhewl  252

          ++e+i+k++w+

Q: 299   GSLEQIMKDHWM  310

         ***********8

Domain Sequence
(FASTA)

YRLLKTIGKG NFAKVKLARH VLTGREVAVK IIDKTQLNPT SLQKLFREVR IMKILNHPNI 60

VKLFEVIETE KTLYLVMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQRRIV 120

HRDLKAENLL LDADMNIKIA DFGFSNEFTV GSKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK KLLVLNPVKR 240

GSLEQIMKDH WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR000449	; UBA/transl_elong_EF1B_N.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.
PF00627	; UBA; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013