EKS-ORN-00364

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00364

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	407.4	4.1E-122	192	480	289

Status

Unreviewed

Ensembl Protein

ENSONIP00000023305

UniProt Accession

I3KQB0;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2B (2 of 2)

Gene Synonyms/Alias

ACVR2B (2 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000018510	ENSONIP00000023305	ENSONIT00000023325

Organism

Oreochromis niloticus

Functional Description

Protein Length

514

Protein Sequence
(FASTA)

MSFSWLTCSL LLGTLCAGYS LGEAETRECV YYNDNWRSER TNQSGFERCE GEKDKRLHCY 60

ASWLNSSGTI KLVKKGCWLD DFNCYDRQEC VSMEENPQVF FCCCEGNYCN ERFTHLPDLI 120

GSGNRVKIQP PPRVPSLLSV LVYSLLPLCV LSLALVLALW MYRHRKPPYG HVDLSEDPGP 180

APPSPLVGLK PLQLLEIKAR GRFGCVWKAQ LMSEYVAVKI FPVQDKQSWQ NERDIFLTPG 240

MRHENILRYI AAEKHGTNME TELWLITEFH ERGSLTDHLK GNTVTWTELC HIAETMSRGL 300

AYLHEDIPSY KGEGPKPTIA HRDFKSKNVL LRDDLTAVIG DFGLAVRFEP GKPPGDTHGQ 360

VGTRRYMAPE VLEGAINFQR DSFLRIDMYA MGLVLWELVS RCSDTDGTVG EYMLPFEDEI 420

GQHPSLEDLQ DVVVHKKMRP VIKDSWLKHP GLSHMCETIE ECWDHDAEAR LSAGCVEERI 480

GQISRTIGST TSDSPISLVT SLINEDLPPK ESST 514

Nucleotide Sequence
(FASTA)

ATGTCTTTTT CATGGCTGAC TTGTTCACTT CTTCTGGGAA CTTTATGCGC AGGGTACAGT 60

CTTGGCGAAG CGGAGACCCG GGAGTGTGTG TACTACAACG ATAACTGGCG TTCGGAGAGG 120

ACCAACCAGA GCGGCTTCGA GCGTTGCGAG GGGGAAAAGG ACAAGCGACT GCACTGTTAT 180

GCCTCCTGGC TCAACTCCTC AGGGACCATC AAACTGGTGA AGAAAGGCTG CTGGCTGGAT 240

GACTTCAACT GCTATGACAG GCAAGAGTGC GTCTCCATGG AGGAAAACCC TCAGGTCTTC 300

TTCTGCTGCT GCGAGGGCAA CTACTGCAAT GAGCGATTCA CCCACCTTCC CGACTTGATT 360

GGTAGTGGCA ACCGAGTGAA AATCCAGCCT CCACCCCGAG TACCGTCCCT GCTCAGTGTG 420

CTGGTGTACT CCCTGCTGCC TCTCTGTGTG CTGTCCCTGG CCCTTGTTCT GGCCTTGTGG 480

ATGTACCGCC ACCGCAAACC TCCCTACGGC CATGTAGACC TGAGCGAGGA TCCAGGGCCG 540

GCTCCTCCAT CTCCCTTGGT GGGTCTGAAA CCATTGCAGC TTCTAGAAAT CAAAGCTAGG 600

GGGCGCTTTG GTTGTGTTTG GAAGGCCCAG TTAATGAGTG AATATGTTGC TGTTAAGATC 660

TTCCCAGTTC AGGATAAGCA GTCATGGCAA AATGAGCGCG ACATATTCTT GACTCCGGGG 720

ATGAGACATG AAAATATCTT GCGTTACATC GCTGCAGAGA AGCACGGAAC CAACATGGAG 780

ACGGAGCTGT GGCTTATCAC AGAGTTTCAT GAAAGGGGAT CCTTGACAGA CCACCTGAAG 840

GGCAACACTG TGACCTGGAC AGAGCTGTGT CACATAGCAG AGACCATGTC CCGCGGTTTG 900

GCTTACCTTC ATGAGGACAT TCCCAGTTAC AAGGGAGAGG GGCCTAAACC TACAATTGCA 960

CACAGGGACT TCAAGAGCAA GAATGTGTTA CTACGAGATG ACTTAACTGC AGTCATTGGT 1020

GACTTTGGGC TTGCTGTAAG ATTCGAGCCA GGAAAACCTC CTGGGGATAC TCATGGACAG 1080

GTGGGTACGA GGCGTTACAT GGCCCCAGAG GTGCTGGAGG GAGCCATCAA CTTTCAGCGA 1140

GACTCCTTCC TGAGGATAGA CATGTATGCT ATGGGCTTGG TGCTGTGGGA GCTGGTGTCT 1200

CGTTGCTCCG ACACAGATGG AACAGTTGGT GAGTACATGC TGCCATTTGA GGATGAAATA 1260

GGCCAGCATC CCTCCCTGGA GGATCTGCAG GATGTGGTGG TGCACAAGAA GATGCGTCCA 1320

GTCATCAAGG ACTCCTGGCT CAAGCATCCT GGTCTGAGCC ACATGTGTGA GACCATCGAG 1380

GAATGCTGGG ACCACGACGC AGAGGCTCGA CTGTCTGCAG GCTGCGTCGA GGAGCGCATC 1440

GGTCAGATCT CCAGGACGAT AGGCAGCACT ACCTCAGACA GCCCCATCTC TTTAGTCACG 1500

TCTCTCATCA ACGAGGACCT ACCTCCCAAA GAGTCCAGCA CCTGA 1545

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l+ e+vAvKif+ +d++sw++E++i+ t+ +rhenil++ia

Q: 192   LQLLEIKARGRFGCVWKAQLMSEYVAVKIFPVQDKQSWQNERDIFLTPGMRHENILRYIA  251

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ ++++tel+l+te+he+gsL+d+Lk +t++++el+++a+++++Gla+LHe+i+  k

Q: 252   AEKHGTNMETELWLITEFHERGSLTDHLKGNTVTWTELCHIAETMSRGLAYLHEDIPSYK  311

         ********************************************************9999

S: 121   g.kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaP  179

         g   Kp+iaHRD+kskN+l+++dlt++i+D+GLa+++e  k   d  ++ qvGt+RYmaP

Q: 312   GeGPKPTIAHRDFKSKNVLLRDDLTAVIGDFGLAVRFEPGKPPGD--THGQVGTRRYMAP  369

         989***************************************888..79***********

S: 180   EvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPslee  239

         Evle+a+n+++ ++f r+D+Y++gLvlWE++sRc+++d++v ey+lpfe+++g++Psle+

Q: 370   EVLEGAINFQR-DSFLRIDMYAMGLVLWELVSRCSDTDGTVGEYMLPFEDEIGQHPSLED  428

         **********9.9***********************************************

S: 240   mkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +++vvv+kk+rP i+++w k++ l+++++++eecWd+d+eaRl+a +v++r+

Q: 429   LQDVVVHKKMRPVIKDSWLKHPGLSHMCETIEECWDHDAEARLSAGCVEERI  480

         *************************************************985

Domain Sequence
(FASTA)

LQLLEIKARG RFGCVWKAQL MSEYVAVKIF PVQDKQSWQN ERDIFLTPGM RHENILRYIA 60

AEKHGTNMET ELWLITEFHE RGSLTDHLKG NTVTWTELCH IAETMSRGLA YLHEDIPSYK 120

GEGPKPTIAH RDFKSKNVLL RDDLTAVIGD FGLAVRFEPG KPPGDTHGQV GTRRYMAPEV 180

LEGAINFQRD SFLRIDMYAM GLVLWELVSR CSDTDGTVGE YMLPFEDEIG QHPSLEDLQD 240

VVVHKKMRPV IKDSWLKHPG LSHMCETIEE CWDHDAEARL SAGCVEERI 289

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013