EKS-ORN-00379

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00379

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/BUB	322.1	2.9E-96	800	1060	261

Status

Unreviewed

Ensembl Protein

ENSONIP00000023631

UniProt Accession

I3KR85;

Protein Name

Protein Synonyms/Alias

Gene Name

BUB1

Gene Synonyms/Alias

BUB1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000018770	ENSONIP00000023630	ENSONIT00000023651
ENSONIG00000018770	ENSONIP00000023631	ENSONIT00000023652

Organism

Oreochromis niloticus

Functional Description

Protein Length

1094

Protein Sequence
(FASTA)

MDIASYLQRF ENSLTSYTGD DPLDPWIKFV EYLEQRLPAD GGRGMLLVFE RLVQRFLNEE 60

RYANDIRYVN YCIKCASYYL DPVSLYSQVF SRGVGTRTAA LYVAWAQHFE QRGLHEQADA 120

VYQKALENQA NPASTVLHEY KPTFVWRPDP SEIHSQSSDT EPLTSEVMFN TGSEITSNNE 180

PHTIDSEPEP TEMSKDHGQQ YCICDWRRPC QQWPTAHTSG TIPTSQGSGI QTVSEYTVED 240

LVCDESELCF EEARAQNYFR KLREQEENDK ADLSEFLILQ TSSQKVRQKH LDAVQAVLDV 300

HQRPKLEAQS KRASKKNKKK RQRRISLSCE SCKAALAASK NENRVHCVSL RVFSSLFQPP 360

AAETAAGVNP CLTQPSFKRP LPSNRLSSRR SLGLRLHSEP TFIQEAAATV PEPPRQHNID 420

TLSSVVSHHP PVPAERDVGL QKVSQGATAN LSHITPNNSL GFVQATPSRV LPSPTVNTRE 480

ALGVIMDMFQ APTFLEEPFS STSVLHAAEK ESEALFWTGE SNWIRSPMLK INVPPPPTMT 540

PFTIFQDDDN KENGSAAAPA DAEKPKGVRA LAEIPVSKAD KPNVSEFSHV KETPSDLIPD 600

ESTMWGARYN SLNSLAACPN STTDFAMLAQ FVSTPFTRKT FISSDFLEDR ENKCDDGEAD 660

EEAYLRRQTK KLSPILEQSP TDESTVGQTV PSSARQGTIV GEELAVAQHC LTASSITMVQ 720

PPPPAVLSFR DQTLCPADSS RTAGPGWELV SDPWDTELIS SLLSGLSPPL ATHPRCTAWQ 780

CNIPNITPKM TISMGKESLR VDCVLGEGAF ATVYQATNPA TLEKTVLKVQ KPANPWEFYI 840

NTQLDARLRP DVRHLYSSMH SAHLFHNGSV LLGELHSYGT LLNAVNMYRT LSDKVMPQPL 900

VMYFTVCILH MVELLHSIHI IHADIKPDNF LLGERFLENK RFDSESTDHG LVLVDLGQSI 960

DMELFPAGTA FTAKCLTSGF QCTEMLSGKL WNYQTDYFGI AGTVYCMLFG TYMQVTNEGG 1020

MWKTNGVFRR NPHSDLWLDL FHTLLNVPDC GSLPSLRSLR CRMNAVLQEN YGNKLPTLKS 1080

RLVVLLLENR KTVR 1094

Nucleotide Sequence
(FASTA)

ATGGATATCG CCTCGTATTT ACAGCGTTTT GAAAACAGTT TGACCTCATA CACAGGGGAC 60

GACCCACTGG ACCCCTGGAT CAAGTTTGTG GAGTACCTGG AGCAGAGGCT ACCTGCAGAT 120

GGTGGCAGAG GGATGTTGTT GGTGTTTGAG CGTCTTGTCC AGAGATTTTT GAATGAAGAG 180

CGATATGCGA ATGACATCAG ATATGTGAAC TACTGCATCA AATGTGCAAG TTATTACTTG 240

GATCCTGTTT CACTGTACAG TCAGGTCTTC AGTAGGGGCG TCGGCACTAG GACGGCTGCC 300

CTGTATGTGG CCTGGGCTCA GCACTTTGAA CAGAGAGGAC TGCATGAACA GGCTGATGCA 360

GTGTACCAGA AAGCGCTGGA GAACCAAGCT AATCCAGCCA GCACTGTTCT CCATGAATAC 420

AAGCCTACGT TTGTGTGGAG GCCTGATCCG TCCGAAATTC ATAGCCAGTC CTCTGACACG 480

GAGCCATTAA CCTCCGAAGT TATGTTTAAC ACTGGTTCGG AGATAACATC AAATAATGAG 540

CCACATACGA TCGACTCCGA GCCAGAGCCT ACTGAAATGT CGAAAGACCA TGGGCAGCAA 600

TACTGCATTT GTGACTGGAG GCGACCATGC CAGCAGTGGC CTACAGCTCA TACTTCCGGG 660

ACGATCCCCA CCAGTCAAGG CTCCGGCATT CAGACCGTGT CTGAGTACAC GGTGGAAGAT 720

CTTGTCTGCG ACGAATCTGA GCTATGCTTC GAGGAGGCCC GAGCTCAGAA TTACTTCCGC 780

AAGCTCCGTG AGCAGGAAGA GAACGACAAG GCAGACTTAA GTGAGTTTTT AATACTGCAG 840

ACTTCATCTC AAAAGGTGAG ACAAAAGCAC CTCGATGCAG TGCAGGCTGT GCTGGATGTG 900

CATCAGAGGC CTAAACTTGA GGCTCAAAGC AAACGTGCCA GCAAAAAAAA CAAAAAAAAA 960

AGACAAAGAA GGATTAGTCT GAGCTGCGAA TCATGCAAAG CTGCTCTAGC AGCATCCAAG 1020

AATGAAAACA GGGTTCACTG CGTCAGTCTG AGAGTGTTTT CTTCTTTATT TCAGCCGCCT 1080

GCAGCAGAAA CGGCTGCCGG TGTGAACCCA TGTCTTACCC AACCCTCCTT CAAGCGACCT 1140

CTGCCCTCAA ACCGTCTGAG CAGCCGGCGC TCTCTTGGCT TGAGATTACA CTCCGAGCCG 1200

ACCTTCATCC AAGAGGCCGC CGCCACCGTT CCCGAACCTC CTCGCCAGCA TAACATTGAC 1260

ACGCTAAGTT CGGTGGTATC CCATCATCCC CCTGTCCCGG CTGAGCGGGA CGTGGGTTTG 1320

CAGAAAGTGT CACAGGGAGC CACAGCTAAC CTGTCTCACA TCACTCCTAA TAACTCGCTC 1380

GGCTTTGTTC AGGCCACGCC ATCGCGGGTG CTGCCGTCAC CTACTGTCAA CACACGGGAG 1440

GCGCTGGGCG TGATCATGGA CATGTTCCAG GCTCCGACCT TCCTTGAGGA ACCGTTCAGC 1500

AGCACATCAG TGCTCCACGC TGCCGAGAAG GAGTCTGAAG CCCTATTCTG GACAGGCGAA 1560

TCTAACTGGA TCCGGTCACC AATGCTTAAA ATTAATGTTC CTCCTCCTCC CACCATGACT 1620

CCGTTCACCA TCTTTCAGGA TGACGACAAC AAAGAAAACG GCAGTGCCGC TGCTCCTGCT 1680

GATGCTGAGA AGCCTAAAGG AGTCAGAGCT CTGGCTGAAA TCCCAGTGTC GAAGGCAGAC 1740

AAACCCAACG TGAGTGAATT TTCTCACGTT AAGGAGACTC CTTCAGATCT GATCCCAGAT 1800

GAGAGCACCA TGTGGGGAGC TCGCTACAAC TCGCTCAACT CGCTCGCCGC CTGTCCCAAC 1860

AGCACCACAG ACTTCGCCAT GCTGGCTCAG TTCGTCTCCA CGCCATTCAC TCGCAAAACC 1920

TTTATCAGCA GCGATTTCCT CGAGGACCGA GAGAATAAAT GTGATGACGG TGAAGCTGAT 1980

GAAGAAGCTT ATCTGAGGCG TCAGACCAAA AAGCTGAGTC CCATCCTGGA GCAGAGTCCG 2040

ACCGACGAGA GCACCGTCGG CCAGACGGTG CCCTCCTCCG CCAGGCAGGG CACCATCGTT 2100

GGAGAGGAGC TGGCCGTGGC CCAGCACTGC CTTACTGCGT CCTCCATCAC CATGGTGCAG 2160

CCTCCTCCTC CCGCCGTGCT GTCCTTCAGG GACCAGACAC TCTGTCCCGC CGACTCCTCC 2220

AGGACAGCGG GGCCTGGCTG GGAGCTGGTG TCGGATCCCT GGGACACCGA ACTGATCTCC 2280

AGCCTGCTGT CTGGACTCAG CCCGCCTCTC GCCACCCACC CGCGCTGCAC CGCCTGGCAG 2340

TGCAACATAC CGAACATCAC TCCAAAAATG ACCATCAGCA TGGGAAAGGA GTCCCTCCGA 2400

GTGGACTGTG TTCTTGGAGA GGGAGCCTTT GCGACAGTTT ACCAGGCCAC GAACCCCGCG 2460

ACCTTAGAGA AGACCGTTTT AAAGGTTCAG AAGCCGGCCA ATCCCTGGGA GTTTTACATC 2520

AACACCCAGC TCGACGCTCG GCTGCGGCCT GATGTCCGTC ACCTCTACAG CAGCATGCAC 2580

TCAGCTCACC TCTTCCACAA CGGGAGCGTG CTGCTCGGCG AGCTTCACAG CTACGGCACC 2640

CTGCTGAACG CTGTGAACAT GTACAGAACC CTCAGTGACA AAGTGATGCC TCAGCCCCTC 2700

GTCATGTACT TCACCGTCTG CATCCTGCAC ATGGTGGAAC TGCTGCACAG CATCCACATC 2760

ATCCACGCCG ACATCAAACC TGACAACTTC CTGCTGGGAG AGAGGTTCCT GGAGAACAAG 2820

CGTTTTGATT CAGAGAGCAC GGACCACGGC CTGGTCCTTG TCGACCTCGG ACAGAGCATC 2880

GACATGGAGC TCTTCCCAGC AGGCACTGCG TTCACTGCCA AGTGCCTGAC GTCAGGCTTC 2940

CAGTGCACAG AGATGCTGAG CGGAAAACTA TGGAACTACC AGACCGACTA CTTTGGGATC 3000

GCGGGGACCG TGTACTGCAT GCTGTTTGGG ACGTACATGC AGGTGACTAA CGAAGGAGGC 3060

ATGTGGAAGA CAAACGGCGT TTTTAGAAGG AACCCTCACA GCGACCTGTG GCTGGACTTG 3120

TTCCACACAC TGCTGAATGT TCCAGACTGC GGCTCGCTGC CGAGCCTGCG GAGCCTCCGC 3180

TGCCGGATGA ACGCCGTTCT GCAGGAGAAC TACGGCAACA AACTACCCAC GCTCAAGAGC 3240

CGGCTGGTGG TGCTGCTGCT GGAGAACCGC AAGACGGTGC GG 3282

Domain Profile

S: 2     eiekeigeGayakvykaehdsksgelvalKvekpansWefYIclqlkeRlkeeellksii  61

          ++  +geGa+a+vy+a+ +  + e+++lKv+kpan+WefYI++ql  Rl+ +++ + +

Q: 800   RVDCVLGEGAFATVYQAT-NPATLEKTVLKVQKPANPWEFYINTQLDARLR-PDVRHLYS  857

         57889*************.899*****************************.77******

S: 62    eissallfqdasllvleyasygtlldlinkvkevtnkvmdeelvvllivqllkiveklHe  121

         ++ sa+lf+++s+l+ e++sygtll+++n +++ ++kvm++ lv++++v +l++ve lH+

Q: 858   SMHSAHLFHNGSVLLGELHSYGTLLNAVNMYRTLSDKVMPQPLVMYFTVCILHMVELLHS  917

         ************************************************************

S: 122   veIiHgDlkPdnfllgnrimdkad..kdkeekglkliDfgrsiDmkllpdgtkfkgkakt  179

         ++IiH+D+kPdnfllg+r+ +++   +++ ++gl l+D+g+siDm+l+p gt+f++k+ t

Q: 918   IHIIHADIKPDNFLLGERFLENKRfdSESTDHGLVLVDLGQSIDMELFPAGTAFTAKCLT  977

         *******************99987225667789***************************

S: 180   dafeciemlagkswsYqvDlfglaavihvllfgkyleviqeggswklkqkikrllkkelw  239

         ++f+c+eml+gk w+Yq+D+fg+a++++++lfg+y++v++egg wk +  ++r+++++lw

Q: 978   SGFQCTEMLSGKLWNYQTDYFGIAGTVYCMLFGTYMQVTNEGGMWKTNGVFRRNPHSDLW  1037

         ************************************************************

S: 240   ekiferlLNisdastlpsleelv  262

          ++f++lLN++d+ +lpsl  l+

Q: 1038  LDLFHTLLNVPDCGSLPSLRSLR  1060

         *******************9998

Domain Sequence
(FASTA)

RVDCVLGEGA FATVYQATNP ATLEKTVLKV QKPANPWEFY INTQLDARLR PDVRHLYSSM 60

HSAHLFHNGS VLLGELHSYG TLLNAVNMYR TLSDKVMPQP LVMYFTVCIL HMVELLHSIH 120

IIHADIKPDN FLLGERFLEN KRFDSESTDH GLVLVDLGQS IDMELFPAGT AFTAKCLTSG 180

FQCTEMLSGK LWNYQTDYFG IAGTVYCMLF GTYMQVTNEG GMWKTNGVFR RNPHSDLWLD 240

LFHTLLNVPD CGSLPSLRSL R 261

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR013212	; Mad3_BUB1_I.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR015661	; Ser/Thr_kinase_Bub1.

Pfam

PF08311	; Mad3_BUB1_I; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00777

; Mad3_BUB1_I; 1.

Prosites

PS51489	; BUB1_N; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013