EKS-ORN-00560

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00560

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	491.7	6.7E-148	74	340	267

Status

Unreviewed

Ensembl Protein

ENSONIP00000023954

UniProt Accession

I3KS57;

Protein Name

Protein Synonyms/Alias

Gene Name

CDC42BPB

Gene Synonyms/Alias

CDC42BPB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000019024	ENSONIP00000023953	ENSONIT00000023974
ENSONIG00000019024	ENSONIP00000023954	ENSONIT00000023975

Organism

Oreochromis niloticus

Functional Description

Protein Length

1687

Protein Sequence
(FASTA)

MSAQERLKRL EKLLLEQRAA GCLSVEALLD LLLCFYTECS QSPLKREKHV TDFLEWVKPF 60

TTTVKDMRLH KDDFEILKVI GRGAFGEVAV VKMKHTEQVY AMKILNKWEM LKRAETACFR 120

EERDVLVKGD SQWITNLHYA FQDDNYLYLV MDYYVGGDLL TLLSKFEDRL PEDMAKFYVA 180

EMVLAIHSIH QQHYIHRDIK PDNVLLDVNG HIRLADFGSC LRMMEDGTVQ SSVAVGTPDY 240

ISPEILQAME DGMGRYGPEC DWWSLGVCMY EMLYGETPFY AESLVETYGK IMNHEERFQF 300

PSHVTDVSED AKDLIQRLLC SRERRLGLNG ISDFKSHPFF NAIDWDNIRS TGAPYIPEVS 360

SPTDTSNFDV DDDVLKNPDI GPPVSHTGFT GQHLPFVGFT YTTDSCFSDR SSVSRAGLRV 420

QIETDGGAGG EEVEVFEKRI RRLEQEKQEL NRKLQESTQA LQAPARGGTL SRDKEIKKLN 480

EEIERLKKKL ADSDRLEHQL EEAVSLRQDY ESSASKMRSL EKQVKSLRQE KDEVHKQLAD 540

ALERLRSQTK ELKEAHSQRK LALQEFSELS ERMAELRSSK QRLTRQLRDK EEEMEALLQK 600

MDGTRQEIRK MEKSRKELEA QLDEAQTEAS KERKLREHSE VYSKQLEAEL QSLKSQQGRG 660

VAAGGAEFHQ ELSRLKAELD KKVVFYEEEL LRRDSAHSSE IKNLRKDLQE SEGAQLTANK 720

ELLQLRDKLD KAKRDRQVEM EEALTALKEK HEREKNLLTE ENRKLTTETD KLCSFVDNLT 780

AQNRQLEDEL QDLASKKESV AHWEAQITEI IQWVSDEKDA RGYLQALATK MTEELETLRS 840

SSLGTRPLDP LWKVRRSQKL DMSARLELQS ALDAEIRAKQ LVQEELRKVK ASNINLESKL 900

KETEERSKEM VEQMETLKKE MEETRSRSDK GLKLPDFQDP IFEYFNTSPL APDLTFRPSD 960

IDATPAKSDT TPPSPSTGSE NEEIKAVPSS PSPIYQSTAL TTPKPKAHQL SIKTFSSPPQ 1020

CTHCTSLMVG LIRQGYACEV CSFICHVSCK DHAPLVCPIP AEQAKRPQGI DVQRGIGTAY 1080

KGYVRIPKPS GVKKGWQRAF AVVSDCKLFL YDIPEGKSTQ PGVAAGLVLD LRDEDLSVSS 1140

VLASDVIHAT RKDIPCIFRV TSSQLISQLS SVSLLVLAES EVEKRKWVRI LEGMQSIVTK 1200

NLLKSQQVHV LHEAYDASLP IIKTTLSAAV LDRERIALGT EEGLFVVEVT RDVIVRAADS 1260

KKISQIELIP KEKIIALLCG RNRQVHLHPW GVLEGAESSF DAKLADTKGC QAMAAGVLRP 1320

GGPPCLLAAV KRQVQCYEIT PGKPHHKKLW EVQAPGLVQW LGMLRDRLCI GYPSGFALLA 1380

LQGESSPISL VSPADPSLSF LAQQPLDALH ALEVGSSELL LCFSQLGVYV DGQGRRSRTQ 1440

ELMWPATPLA FCSNSSHLTV YSEYGVDVFD IHTTEWVQTI SLRKIRPLNV EGTLNLLSSE 1500

PPRLIYFSNT SSEGDLTIPE TSDHSRKLMV RTRSKRKFLF KVPEEERLQQ RREMLRDPEL 1560

RSKMISNPTN FNHVAHMGPG DGMQVLMDLP LSVMPSSHDD SIKDKPRPLS SISRQQRSKT 1620

HITRTASDFG GGASSRSICD PDEMDREPDS DSTKHSTPSN SSNPSSPPSP NSPHRSQLTL 1680

DGLDSEA 1687

Nucleotide Sequence
(FASTA)

ATGTCGGCGC AGGAGCGGTT GAAGCGGCTG GAGAAGCTGC TGCTGGAGCA GCGGGCGGCC 60

GGCTGCCTGA GCGTGGAGGC GCTGCTAGAC CTGCTGCTCT GCTTCTACAC CGAGTGCTCC 120

CAGTCCCCGC TCAAGAGGGA GAAGCACGTC ACCGACTTCC TGGAGTGGGT GAAGCCATTC 180

ACAACCACGG TGAAGGACAT GCGGCTGCAC AAAGACGACT TCGAGATCCT GAAGGTGATT 240

GGACGAGGAG CTTTTGGAGA GGTTGCCGTG GTGAAAATGA AGCACACGGA GCAAGTTTAT 300

GCTATGAAGA TCCTCAATAA GTGGGAGATG CTAAAGCGAG CAGAGACGGC ATGTTTCCGT 360

GAAGAGCGTG ACGTCCTGGT GAAAGGAGAC AGTCAGTGGA TCACCAACCT GCACTACGCC 420

TTCCAGGACG ACAACTATTT GTACTTGGTG ATGGATTACT ACGTGGGTGG CGACCTGCTG 480

ACGCTGCTCA GTAAGTTTGA GGATCGACTT CCTGAGGATA TGGCCAAGTT CTACGTGGCT 540

GAGATGGTAC TTGCCATCCA CTCCATCCAT CAGCAGCACT ACATCCACAG AGACATCAAA 600

CCTGACAACG TCCTGCTCGA CGTCAATGGC CATATTCGCC TCGCAGACTT CGGATCCTGT 660

CTCCGCATGA TGGAGGACGG CACGGTTCAG TCCTCGGTGG CAGTTGGCAC GCCAGACTAC 720

ATCTCCCCAG AGATCCTGCA GGCAATGGAG GACGGGATGG GCCGCTATGG CCCAGAGTGC 780

GACTGGTGGT CGCTGGGTGT GTGCATGTAC GAGATGCTGT ACGGCGAGAC ACCGTTCTAC 840

GCTGAGTCGC TGGTTGAAAC CTATGGCAAG ATCATGAATC ATGAGGAGCG TTTCCAGTTC 900

CCTTCCCATG TGACCGATGT GTCTGAAGAT GCCAAGGATC TGATCCAGCG CTTGCTCTGT 960

TCCAGGGAAC GTCGCCTCGG ACTTAATGGG ATCTCCGACT TTAAAAGCCA CCCTTTCTTC 1020

AACGCGATCG ACTGGGACAA CATCCGGTCC ACCGGGGCCC CCTACATCCC CGAGGTGTCG 1080

TCACCCACCG ACACCTCCAA CTTTGACGTA GATGATGATG TCCTGAAGAA CCCGGACATT 1140

GGACCTCCAG TGTCTCACAC TGGTTTTACA GGGCAGCACC TCCCCTTCGT TGGATTCACC 1200

TACACCACCG ACAGCTGCTT CTCCGACCGC AGCTCTGTCA GCAGGGCGGG GTTGCGTGTC 1260

CAGATCGAAA CAGACGGCGG AGCGGGAGGG GAGGAGGTGG AGGTTTTTGA GAAGAGGATT 1320

CGTCGACTGG AGCAGGAGAA ACAGGAACTG AACCGCAAAC TGCAGGAGTC GACTCAGGCC 1380

CTGCAGGCTC CAGCTCGAGG AGGAACTCTG AGTCGAGACA AAGAGATCAA GAAGCTCAAC 1440

GAGGAGATTG AACGACTCAA GAAGAAGCTG GCAGACTCTG ACAGGCTGGA GCACCAGCTG 1500

GAGGAGGCGG TCTCTCTCAG ACAGGACTAT GAAAGCTCCG CCTCCAAAAT GAGGAGCCTG 1560

GAGAAGCAGG TGAAAAGCCT GCGACAGGAG AAGGATGAGG TCCACAAGCA GTTGGCTGAC 1620

GCCCTGGAAC GCCTGAGGAG TCAGACGAAG GAGCTGAAGG AGGCGCACTC GCAGAGGAAG 1680

CTGGCACTGC AGGAGTTCTC TGAGCTGTCA GAGAGGATGG CTGAGCTGCG CTCCTCAAAG 1740

CAGCGCCTGA CCCGCCAGCT CCGTGACAAG GAGGAGGAGA TGGAAGCGCT GCTGCAGAAG 1800

ATGGACGGCA CGAGGCAGGA AATCCGCAAG ATGGAGAAGA GCCGCAAGGA GCTGGAGGCT 1860

CAGCTGGATG AGGCGCAGAC AGAGGCATCA AAGGAGAGGA AGCTGAGGGA GCACAGCGAG 1920

GTTTACTCCA AACAGCTGGA GGCGGAGCTA CAGAGTCTAA AGTCTCAGCA GGGCCGTGGA 1980

GTAGCAGCGG GAGGAGCGGA GTTTCACCAG GAACTATCCC GTCTAAAGGC AGAGCTGGAC 2040

AAGAAGGTGG TGTTCTACGA GGAGGAGCTC CTGAGGAGGG ACTCGGCCCA CTCCTCTGAG 2100

ATAAAAAACC TCCGCAAAGA CCTGCAGGAG TCTGAGGGGG CGCAGCTCAC CGCCAACAAG 2160

GAGCTGCTGC AGCTCCGAGA CAAGCTAGAC AAGGCCAAGA GGGACAGGCA AGTTGAGATG 2220

GAAGAAGCTC TCACTGCTCT CAAGGAGAAA CATGAGCGAG AGAAGAACCT GCTGACAGAA 2280

GAAAACCGAA AACTGACGAC AGAGACCGAC AAGCTGTGCT CGTTCGTGGA TAACTTGACG 2340

GCTCAGAATC GGCAACTAGA AGACGAGCTG CAGGACCTGG CGTCCAAGAA GGAGAGCGTG 2400

GCTCACTGGG AGGCTCAGAT CACCGAGATC ATCCAGTGGG TCAGCGACGA GAAGGACGCT 2460

CGAGGTTATC TGCAGGCTCT GGCCACCAAG ATGACGGAGG AGCTGGAAAC TCTACGCAGC 2520

TCCAGCTTGG GAACCAGACC TCTGGACCCC CTGTGGAAGG TGCGCCGCAG TCAGAAGTTG 2580

GACATGTCTG CTCGCCTCGA GCTGCAGTCA GCTCTGGATG CTGAAATCAG AGCCAAACAG 2640

CTGGTCCAGG AGGAGCTGCG CAAAGTCAAA GCCTCAAACA TCAACCTGGA AAGTAAGCTT 2700

AAGGAGACAG AGGAAAGGAG CAAGGAAATG GTGGAGCAGA TGGAGACCCT AAAAAAGGAG 2760

ATGGAGGAGA CCCGTTCACG TTCCGACAAA GGTCTGAAGC TCCCGGACTT CCAGGACCCT 2820

ATCTTTGAAT ACTTCAACAC GTCTCCTCTA GCTCCAGACC TCACCTTCAG ACCCTCAGAC 2880

ATAGACGCCA CCCCTGCAAA ATCAGACACT ACGCCCCCAT CACCCTCCAC AGGCTCCGAA 2940

AACGAGGAAA TTAAAGCAGT CCCTTCGAGC CCCTCTCCCA TCTATCAGAG CACAGCGCTG 3000

ACCACACCAA AGCCCAAAGC TCACCAGCTG AGCATCAAGA CATTCTCCAG CCCGCCTCAG 3060

TGCACGCACT GCACCTCCCT GATGGTGGGA CTAATCCGGC AGGGATACGC CTGCGAAGTG 3120

TGCTCCTTCA TCTGTCACGT TTCCTGTAAA GACCACGCCC CTCTTGTCTG CCCAATCCCA 3180

GCAGAGCAGG CCAAGAGGCC ACAGGGCATT GACGTCCAGA GGGGAATCGG CACTGCATAT 3240

AAGGGCTACG TCAGGATTCC GAAGCCCAGT GGCGTGAAAA AGGGCTGGCA GCGAGCATTC 3300

GCCGTGGTCT CTGACTGCAA ACTCTTTCTC TACGACATCC CAGAGGGAAA ATCCACGCAG 3360

CCTGGGGTGG CAGCCGGTCT GGTCCTCGAC CTCAGGGATG AAGATTTGTC CGTTAGTTCG 3420

GTCTTGGCTT CCGATGTGAT CCACGCAACC AGGAAGGACA TCCCCTGCAT CTTCAGAGTG 3480

ACATCATCGC AGCTGATCTC GCAGCTGTCT TCAGTGTCTC TGCTTGTCCT GGCAGAGAGC 3540

GAGGTAGAAA AGAGAAAATG GGTCCGGATT CTGGAAGGTA TGCAGAGCAT CGTGACCAAG 3600

AACCTGCTGA AGAGCCAGCA GGTCCACGTC CTGCACGAGG CCTACGATGC CTCGCTGCCC 3660

ATCATCAAGA CCACGCTGTC CGCCGCTGTG CTCGATCGTG AGAGGATCGC CCTGGGAACA 3720

GAAGAAGGAC TGTTTGTGGT TGAAGTCACG AGAGACGTGA TTGTGAGAGC CGCAGACAGT 3780

AAGAAGATCT CTCAGATTGA ATTGATCCCA AAGGAGAAGA TCATTGCGCT CCTCTGTGGT 3840

CGCAACCGTC AAGTTCACCT TCACCCCTGG GGGGTGCTGG AGGGAGCGGA GTCCAGCTTC 3900

GATGCCAAGC TGGCAGACAC CAAAGGCTGC CAGGCTATGG CTGCCGGCGT TCTCCGCCCA 3960

GGAGGCCCCC CCTGCCTGCT GGCTGCCGTC AAACGTCAGG TTCAGTGCTA CGAGATCACT 4020

CCGGGAAAGC CCCACCACAA GAAGCTGTGG GAGGTGCAGG CCCCAGGTTT GGTTCAGTGG 4080

TTGGGGATGC TCAGGGACCG GCTGTGCATC GGTTACCCGT CAGGCTTCGC TCTGCTGGCC 4140

TTGCAGGGGG AGTCGTCGCC CATAAGCCTG GTGAGCCCGG CAGACCCATC GCTGTCCTTC 4200

CTGGCGCAGC AGCCACTGGA CGCTCTGCAT GCCCTGGAGG TCGGATCCAG CGAGCTGCTG 4260

CTCTGCTTCA GCCAGCTCGG TGTCTATGTG GATGGACAGG GACGTCGGTC CCGGACCCAG 4320

GAGCTCATGT GGCCCGCCAC ACCGCTTGCT TTCTGCTCTA ACTCATCTCA CCTGACGGTC 4380

TACAGCGAGT ATGGGGTCGA TGTCTTTGAT ATTCACACTA CTGAGTGGGT CCAAACAATC 4440

TCCCTGCGCA AGATTCGACC TCTGAATGTT GAAGGAACGT TAAACCTGCT GAGCTCAGAA 4500

CCTCCTCGTC TGATTTACTT CAGCAACACC TCCTCAGAGG GCGATCTCAC CATCCCGGAG 4560

ACGTCCGATC ACAGCAGGAA GTTGATGGTT CGAACTCGCA GCAAGAGAAA GTTTCTCTTC 4620

AAGGTTCCCG AGGAGGAGCG ACTCCAGCAG AGGAGGGAGA TGCTGAGGGA TCCGGAGCTT 4680

CGCTCTAAGA TGATTTCTAA CCCCACCAAC TTTAACCACG TGGCTCACAT GGGACCAGGA 4740

GACGGCATGC AGGTCCTCAT GGACCTTCCT CTGAGTGTGA TGCCCTCCTC TCATGACGAC 4800

TCCATTAAAG ATAAGCCCCG CCCCCTCTCC AGTATCTCAC GGCAACAGAG GAGCAAGACG 4860

CACATCACAC GCACAGCTTC AGATTTTGGG GGAGGAGCTT CGTCCCGCAG CATCTGTGAC 4920

CCGGACGAGA TGGACCGAGA GCCTGACTCT GACTCCACCA AACACTCGAC GCCCTCCAAC 4980

AGCTCCAACC CCAGCAGCCC CCCCAGCCCC AACTCCCCCC ACCGCAGCCA GCTCACCCTC 5040

GACGGCCTGG ACTCCGAAGC CTGA 5064

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         feilkviGrGafgevavv++k+te+vyamkil+k+e+lkrae+a+freerdvlvk+ds+w

Q: 74    FEILKVIGRGAFGEVAVVKMKHTEQVYAMKILNKWEMLKRAETACFREERDVLVKGDSQW  133

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         i++l+yafqd++ylylvm+y+vGGdlltllsk+ed+lpe++a+fy+ae+vla++s+h+ +

Q: 134   ITNLHYAFQDDNYLYLVMDYYVGGDLLTLLSKFEDRLPEDMAKFYVAEMVLAIHSIHQQH  193

         ************************************************************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         y+hrdikpdn+lld++Ghi+ladfGscl+++edgtv+ssvavGtpdyispe+l+a+e+g+

Q: 194   YIHRDIKPDNVLLDVNGHIRLADFGSCLRMMEDGTVQSSVAVGTPDYISPEILQAMEDGM  253

         ************************************************************

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpede.kvseeakd  239

         g+yg+ecdwwslGv++ye+l+getpfyaeslvety+ki+nh+e+++fp+++ +vse+akd

Q: 254   GRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVtDVSEDAKD  313

         **************************************************99********

S: 240   likklltsreerlgregiedlkkhpff  266

         li++ll+sre+rlg +gi+d+k+hpff

Q: 314   LIQRLLCSRERRLGLNGISDFKSHPFF  340

         **************************9

Domain Sequence
(FASTA)

FEILKVIGRG AFGEVAVVKM KHTEQVYAMK ILNKWEMLKR AETACFREER DVLVKGDSQW 60

ITNLHYAFQD DNYLYLVMDY YVGGDLLTLL SKFEDRLPED MAKFYVAEMV LAIHSIHQQH 120

YIHRDIKPDN VLLDVNGHIR LADFGSCLRM MEDGTVQSSV AVGTPDYISP EILQAMEDGM 180

GRYGPECDWW SLGVCMYEML YGETPFYAES LVETYGKIMN HEERFQFPSH VTDVSEDAKD 240

LIQRLLCSRE RRLGLNGISD FKSHPFF 267

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR000095	; PAK_box_Rho-bd.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR026611	; Ser/Thr_kinase_MRCK.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 1.
PF08826	; DMPK_coil; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00036	; CNH; 1.
SM00285	; PBD; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50108	; CRIB; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013