EKS-ORN-00391

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00391

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	394.1	3.3E-118	712	968	257

Status

Unreviewed

Ensembl Protein

ENSONIP00000023986

UniProt Accession

I3KS89;

Protein Name

Protein Synonyms/Alias

Gene Name

ERBB3 (1 of 2)

Gene Synonyms/Alias

ERBB3 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000019052	ENSONIP00000023986	ENSONIT00000024007
ENSONIG00000019052	ENSONIP00000023985	ENSONIT00000024006

Organism

Oreochromis niloticus

Functional Description

Protein Length

1326

Protein Sequence
(FASTA)

VAVLGFLELF GFFLSFLFFS SSLTICDGTK NSLSTTGNSE IQYNLMKTRY NNCDIVMGNL 60

EITMMDHTRD FSFLESIKEV TGYILFAVNE FSRLPLDHLR IIRGSTLYED QYALAVMVNY 120

QRDGEHGLQE LGLTHLTEIF RGGVKIIQNK YLSYAPQVNW LDIVKDGSAQ IMIEDNGPEI 180

FISEPCHKAC GDVPCWGPGN DTCQILTKTV CAPQCSGRCF GRNPSECCHV ECAGGCTGPK 240

DTDCFACRNF NNSGSCVPQC PQTVIYNKLT YRMEPNPNAK YQYGSICVTQ CPKNFVVDGS 300

SCVSNCPSNK MEVEKNGVKT CEPCKGLCPK VCHGTSWTDS NRETVDARNI ESFINCTKIQ 360

GSLNFLVTGI EGDPFNDVPP LDPEKLKIFN TVEEITDFLN IQSWPASMSD LSVFSNLQTI 420

RGRKLYKSYA LLVVKINSLT SLGLRSLQNI NDGAVYIKGN KNLCYHDTVN WTRLLGSRPQ 480

KRSKLLDVTD NQKKDECVKE NHVCHPLCSS DGCWGPGPDQ CVSCKKYSRG GTCVPDCMFL 540

TGKQREFATK SGECLPCHPE CKVQEGKETC TGPGANKCLA CASLKDGPHC VSMCPEGVMG 600

QEGTIFKYPD KEGNCKPCHN NCTQRCTGPG IGDCTISSRY ISGQMTTAIV LGVIALIFAS 660

FSIFVLSILY RRSLAIRRKR AMRRYMMNSE SFEPLEDKGT KYEPRTLKPS ELRKIRLLGN 720

GVFGSVHKGV WIPEGDTVKL PVAIKTIDDR SGRRTFSDVT DHMRMMASLN HINVVRTLGI 780

CPGNSLQLVT PLNRQGSLLA HVKKNKGKLS PQRLLNWCVQ IAKGMNYLEE NRMVHRNLAA 840

RNVLLNDNFT AQVSDYGIAD LLYSDDKKYY CNEPKTPIRW MALESILFRR YTHQSDVWSY 900

GVTIWEMMSY GAEPYSTMRP QEVPDLLEKG ERLPQPQICT IDVYMVMVKC WMIDENVRPT 960

FKELASEFTR MARDPPRYLV IKEDCSQQDS SPDEPVQRSA DLDDLDDVDV NLGDPLADEK 1020

EDDLSPANYY MAKSLNRYSR MDTHKAILNP SSGTGYLPMT SGVDNHTQAM WQSRSRLNSA 1080

RTVSESSEGC GTGMEMEMGE DFPLAGSLKR RRHREDSAYV SQRDSMSGGP PETPSPEMEE 1140

EDQNGYVLPG GSPERARAAP GRMGKSRSSE LLDDPDDEEY EYMNKQVCLT PVSLSEVEYE 1200

YMDIRGGEKL EGPPVRDPPP PPAPVRMSSK VEEEEDEYVE DSNYHYTNRQ PKLRQALQDK 1260

KELNVEGTEA DEYEDMDCFS APPPGGNGVV YQNLQRVTES AVGDRSFDNP GYWHSRMFLK 1320

PSAVPT 1326

Nucleotide Sequence
(FASTA)

GTGGCGGTCC TAGGCTTTTT GGAGCTTTTT GGCTTTTTTT TGTCTTTTCT TTTTTTTTCT 60

TCTTCTTTGA CCATTTGTGA TGGCACCAAG AACTCTCTGA GTACAACTGG AAATTCAGAG 120

ATCCAGTACA ACTTGATGAA GACGAGGTAC AATAACTGCG ACATTGTGAT GGGCAACCTC 180

GAGATTACCA TGATGGACCA CACCAGAGAC TTCAGCTTTC TGGAGTCTAT CAAGGAGGTG 240

ACAGGGTACA TCCTTTTTGC TGTCAATGAG TTCAGCCGCC TCCCACTGGA CCACCTGCGC 300

ATCATCAGAG GCAGCACACT GTATGAGGAC CAGTATGCCT TGGCTGTCAT GGTCAACTAT 360

CAGAGGGATG GAGAGCATGG CCTTCAAGAA CTGGGTCTGA CTCACCTCAC AGAGATCTTC 420

AGGGGAGGAG TGAAGATCAT CCAGAATAAG TATCTGAGCT ACGCCCCGCA GGTGAACTGG 480

CTGGACATAG TGAAGGATGG ATCAGCCCAA ATTATGATAG AGGACAATGG GCCTGAAATT 540

TTTATCTCAG AGCCTTGTCA CAAAGCCTGT GGAGACGTGC CATGCTGGGG CCCAGGAAAT 600

GACACATGCC AGATCTTGAC AAAGACCGTG TGCGCCCCTC AGTGTAGTGG CCGCTGCTTT 660

GGTAGAAACC CGAGCGAGTG CTGCCACGTT GAGTGTGCTG GAGGTTGCAC TGGGCCCAAG 720

GATACAGACT GCTTTGCCTG CAGGAACTTC AACAACTCAG GCTCCTGCGT GCCTCAGTGC 780

CCACAGACTG TGATCTACAA CAAGCTTACA TACAGAATGG AGCCCAACCC CAATGCCAAG 840

TACCAGTACG GCTCTATTTG TGTGACCCAA TGCCCCAAAA ACTTTGTGGT GGATGGCAGT 900

TCATGTGTGA GCAACTGCCC ATCTAATAAA ATGGAAGTGG AGAAAAATGG TGTGAAAACA 960

TGTGAGCCCT GCAAAGGCCT CTGCCCTAAA GTTTGCCATG GCACAAGCTG GACTGATTCA 1020

AACAGGGAAA CGGTCGATGC TCGCAACATA GAAAGTTTCA TAAACTGCAC TAAGATCCAG 1080

GGAAGTCTTA ACTTCCTGGT GACGGGAATA GAAGGTGATC CCTTCAACGA CGTACCACCC 1140

CTTGATCCAG AAAAACTGAA AATCTTCAAC ACGGTGGAGG AGATTACAGA CTTCCTCAAT 1200

ATCCAGTCGT GGCCTGCAAG CATGTCTGAC CTGTCAGTCT TCTCCAACCT CCAAACAATT 1260

CGGGGAAGAA AACTTTACAA GAGCTATGCA CTCCTGGTGG TTAAGATCAA TTCTCTGACC 1320

TCGCTGGGGT TGCGCTCGCT GCAAAACATA AATGATGGTG CCGTGTACAT TAAAGGAAAC 1380

AAGAATCTCT GCTATCATGA TACTGTCAAC TGGACACGGC TCTTAGGCTC CCGTCCACAG 1440

AAACGTTCAA AGCTCTTAGA CGTCACCGAC AACCAAAAGA AGGATGAATG TGTTAAAGAA 1500

AATCATGTGT GTCACCCGCT GTGCTCCTCT GATGGCTGCT GGGGTCCGGG CCCAGACCAG 1560

TGTGTCAGCT GTAAGAAATA CAGCAGGGGA GGAACCTGTG TACCAGACTG CATGTTCTTA 1620

ACTGGGAAGC AGAGGGAGTT TGCTACTAAG TCAGGGGAGT GTCTGCCCTG TCACCCTGAG 1680

TGTAAGGTCC AGGAGGGGAA GGAGACGTGC ACAGGCCCGG GAGCAAATAA ATGTCTAGCT 1740

TGTGCCAGCC TGAAGGATGG CCCACACTGT GTCTCCATGT GTCCTGAGGG TGTTATGGGG 1800

CAAGAGGGAA CCATCTTTAA ATATCCAGAC AAGGAGGGCA ACTGTAAACC TTGCCACAAC 1860

AACTGTACCC AGAGGTGCAC TGGTCCAGGA ATCGGGGACT GTACAATATC ATCTCGGTAC 1920

ATTTCAGGGC AAATGACCAC GGCCATCGTA CTGGGAGTGA TTGCCCTCAT CTTTGCTTCC 1980

TTCTCCATTT TCGTGCTGAG TATTCTCTAC CGCCGAAGTC TCGCTATTCG TCGCAAGCGA 2040

GCCATGAGAA GATACATGAT GAATAGCGAA AGTTTTGAGC CCCTGGAAGA TAAAGGGACA 2100

AAATATGAAC CTCGGACCCT TAAACCTTCG GAGCTGCGTA AGATCAGGCT GCTGGGTAAC 2160

GGAGTGTTTG GATCAGTCCA TAAGGGCGTT TGGATTCCTG AAGGCGACAC AGTGAAGCTT 2220

CCTGTGGCCA TTAAGACAAT TGATGACCGC AGTGGTCGTC GGACCTTCTC TGACGTGACC 2280

GATCACATGA GGATGATGGC AAGTCTGAAC CACATTAACG TTGTCAGGAC CCTGGGTATC 2340

TGTCCCGGTA ACAGCCTGCA GCTTGTTACC CCGCTCAACA GGCAAGGCTC GCTGCTGGCA 2400

CATGTAAAGA AAAATAAGGG CAAGCTCAGC CCACAGAGGC TGCTCAACTG GTGTGTTCAA 2460

ATTGCAAAGG GTATGAATTA CCTGGAAGAG AACAGGATGG TTCACAGGAA CCTGGCTGCC 2520

AGAAATGTAC TCCTGAATGA TAATTTCACT GCCCAGGTTT CAGACTATGG CATTGCAGAC 2580

CTGCTCTACT CTGATGACAA GAAGTACTAT TGCAACGAGC CCAAGACACC AATCAGGTGG 2640

ATGGCCCTGG AGAGCATCTT GTTTCGCAGA TACACTCATC AGAGCGATGT TTGGAGTTAT 2700

GGTGTGACAA TATGGGAAAT GATGTCTTAT GGAGCAGAGC CGTATTCAAC GATGCGACCA 2760

CAGGAGGTTC CCGATCTGCT GGAAAAGGGC GAGCGTTTGC CCCAGCCTCA AATTTGCACC 2820

ATAGATGTCT ATATGGTCAT GGTTAAGTGT TGGATGATTG ATGAGAATGT CCGTCCAACA 2880

TTCAAGGAGC TGGCGAGTGA ATTTACCAGA ATGGCCAGAG ACCCACCTCG CTACTTGGTG 2940

ATCAAAGAGG ACTGTAGCCA ACAGGACTCA TCCCCAGATG AACCCGTCCA ACGAAGTGCA 3000

GACCTGGATG ACTTGGATGA TGTAGATGTC AACCTTGGGG ACCCGTTGGC AGATGAGAAA 3060

GAAGATGACT TGTCTCCAGC CAACTACTAC ATGGCAAAAA GTCTCAATCG TTACTCTAGG 3120

ATGGACACTC ACAAAGCGAT TCTTAATCCA TCCAGCGGAA CTGGATACCT GCCCATGACC 3180

TCAGGTGTTG ACAACCATAC ACAGGCGATG TGGCAGTCAC GCTCTCGGCT AAATTCTGCC 3240

CGTACTGTGT CCGAGAGCTC GGAAGGCTGC GGCACAGGAA TGGAGATGGA GATGGGCGAG 3300

GACTTCCCCT TAGCAGGGAG CCTGAAAAGA AGACGTCATC GTGAGGACAG CGCTTACGTG 3360

TCGCAGAGAG ACAGCATGTC CGGCGGGCCA CCTGAGACTC CCTCACCAGA GATGGAAGAA 3420

GAAGATCAAA ATGGATATGT GCTTCCTGGA GGGAGCCCGG AGAGAGCGCG AGCTGCTCCT 3480

GGGAGGATGG GAAAGTCTCG TTCGTCAGAG CTCCTGGACG ACCCAGATGA TGAAGAATAC 3540

GAGTACATGA ACAAGCAGGT GTGTTTAACA CCTGTATCAC TCAGTGAAGT TGAGTATGAA 3600

TACATGGACA TCAGAGGCGG CGAAAAGCTG GAAGGCCCAC CAGTACGTGA CCCTCCTCCT 3660

CCTCCAGCTC CTGTGAGGAT GAGCAGCAAG GTGGAGGAGG AGGAGGATGA ATACGTGGAG 3720

GACAGTAACT ATCATTACAC AAACAGGCAG CCAAAGCTAC GACAGGCTCT TCAAGACAAG 3780

AAAGAGCTGA ATGTAGAGGG GACAGAGGCA GATGAATACG AGGATATGGA CTGCTTTTCT 3840

GCCCCACCAC CTGGTGGAAA TGGTGTGGTG TATCAAAACT TACAGAGGGT CACGGAGTCT 3900

GCTGTCGGTG ACAGATCTTT CGACAACCCA GGGTACTGGC ACAGCAGGAT GTTTCTTAAG 3960

CCCAGTGCTG TGCCGACATG A 3981

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         l+k++ lG G+fG+v+kG+wipeg++vk+pvaik +++++g++++++++d++ ++asl+h

Q: 712   LRKIRLLGNGVFGSVHKGVWIPEGDTVKLPVAIKTIDDRSGRRTFSDVTDHMRMMASLNH  771

         699*********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

          n+vr lg+c  ++lqlvt l   G+ll +v+++k+kl +q llnwcvqiakGm+ylee+

Q: 772   INVVRTLGICPGNSLQLVTPLNRQGSLLAHVKKNKGKLSPQRLLNWCVQIAKGMNYLEEN  831

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         r+vhr+laarnvl++     +++d+G+a+ll +d+k++  ++ k+pi+w+alesil+r+y

Q: 832   RMVHRNLAARNVLLNDNFTAQVSDYGIADLLYSDDKKYYCNEPKTPIRWMALESILFRRY  891

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvt+we++++Ga+py +++ +e+pdllekGerl+qp+ictidvymv+vkcw

Q: 892   THQSDVWSYGVTIWEMMSYGAEPYSTMRPQEVPDLLEKGERLPQPQICTIDVYMVMVKCW  951

         ************************************************************

S: 241   midaesrpkfkelaeef  257

         mid+++rp+fkela+ef

Q: 952   MIDENVRPTFKELASEF  968

         ***************99

Domain Sequence
(FASTA)

LRKIRLLGNG VFGSVHKGVW IPEGDTVKLP VAIKTIDDRS GRRTFSDVTD HMRMMASLNH 60

INVVRTLGIC PGNSLQLVTP LNRQGSLLAH VKKNKGKLSP QRLLNWCVQI AKGMNYLEEN 120

RMVHRNLAAR NVLLNDNFTA QVSDYGIADL LYSDDKKYYC NEPKTPIRWM ALESILFRRY 180

THQSDVWSYG VTIWEMMSYG AEPYSTMRPQ EVPDLLEKGE RLPQPQICTI DVYMVMVKCW 240

MIDENVRPTF KELASEF 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Danio rerio"; ?>Gasterosteus aculeatus"; ?>Latimeria chalumnae"; ?>Oryzias latipes"; ?>Pteropus vampyrus"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 4.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013