EKS-ORN-00075

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00075

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	443.5	3.8E-133	4	286	283

Status

Unreviewed

Ensembl Protein

ENSONIP00000024179

UniProt Accession

I3KST3;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK2

Gene Synonyms/Alias

CDK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000019208	ENSONIP00000024179	ENSONIT00000024200

Organism

Oreochromis niloticus

Functional Description

Protein Length

298

Protein Sequence
(FASTA)

MDSFQKVEKI GEGTYGVVYK AKNKVTGETV ALKKIRLDTE TEGVPSTAIR EISLLKELSH 60

PNIVKLRDVI HTENKLYLVF EFLHQDLKKF MDSSSVTGIP LPLVKSYLFQ LLQGLAFCHS 120

HRVLHRDLKP QNLLINAQGE IKLADFGLAR AFGVPVRAYT HEVVTLWYRA PEILLGCKYY 180

STAVDIWSLG CIFAEMVTRR ALFPGDSEID QLFRIFRTLG TPDETVWPGV TSMPDYKPTF 240

PKWARQDLSK VVPLLDEDGR ELLGEMLNYD PNKRLSAKNA LVHRFFRDVS MPLPHLRL 298

Nucleotide Sequence
(FASTA)

ATGGACTCCT TTCAGAAAGT AGAGAAAATT GGAGAGGGCA CGTATGGGGT GGTTTACAAA 60

GCCAAGAACA AAGTGACGGG AGAAACTGTC GCTCTGAAGA AAATCAGGCT GGACACGGAA 120

ACAGAGGGTG TACCAAGCAC AGCCATCCGG GAGATATCGC TTCTCAAAGA ACTCAGTCAC 180

CCAAATATTG TCAAATTACG CGATGTTATC CACACCGAGA ACAAGCTCTA TCTTGTTTTT 240

GAGTTTCTTC ACCAGGATTT AAAAAAGTTT ATGGACTCCT CCTCAGTCAC TGGTATCCCA 300

CTGCCTCTAG TAAAGAGCTA TCTTTTTCAG CTGCTGCAAG GCCTGGCTTT CTGCCACTCT 360

CACAGGGTTC TCCATCGAGA CCTGAAGCCC CAGAACCTCC TCATCAACGC CCAGGGTGAG 420

ATCAAGCTGG CTGACTTTGG CCTGGCAAGA GCCTTCGGAG TACCCGTCCG CGCATATACA 480

CATGAAGTGG TAACACTTTG GTACAGAGCC CCAGAAATTC TCCTGGGCTG CAAGTACTAC 540

TCCACAGCCG TTGACATCTG GAGTCTTGGA TGTATCTTTG CTGAAATGGT TACCAGGAGG 600

GCTTTGTTCC CCGGTGACTC GGAAATAGAT CAGTTATTCC GAATCTTTCG TACTCTGGGA 660

ACGCCTGACG AGACCGTCTG GCCCGGAGTC ACATCCATGC CTGACTACAA ACCAACCTTC 720

CCCAAGTGGG CTCGGCAGGA TTTATCAAAA GTGGTGCCTC TTCTTGACGA AGATGGAAGA 780

GAACTGCTCG GGGAAATGCT GAACTATGAT CCAAACAAAA GGCTGTCTGC CAAAAATGCT 840

CTTGTGCATC GATTTTTCCG TGATGTCTCC ATGCCACTTC CCCACCTCAG ACTCTGA 897

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         ++k+ekigeGtyg+vykak+k tge+vAlKkirl++e+egvp+ta+rEisllkel+h+ni

Q: 4     FQKVEKIGEGTYGVVYKAKNKVTGETVALKKIRLDTETEGVPSTAIREISLLKELSHPNI  63

         89**********************************************************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         vkL +v++ +++klyLvfefl+qdLkk++++++ ++++l  vks+l+qll+gla++Hs++

Q: 64    VKLRDVIH-TENKLYLVFEFLHQDLKKFMDSSSVTGIPLPLVKSYLFQLLQGLAFCHSHR  122

         ********.99*************************************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         +lHRDlKpqNlLi+++g++klaDfGlaraf++p+++yt+evvTlwYraPe+Llg+k+Yst

Q: 123   VLHRDLKPQNLLINAQGEIKLADFGLARAFGVPVRAYTHEVVTLWYRAPEILLGCKYYST  182

         ************************************************************

S: 181   avDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykksfpk  240

         avDiWs+gci+ae++tr++lf+g+seidql+rif++lgtp+e+vwp+v+++p+yk +fpk

Q: 183   AVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDETVWPGVTSMPDYKPTFPK  242

         ************************************************************

S: 241   kkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         +++++l+++v+ l+e++++ll ++l++dp+kR+sak+al h++f

Q: 243   WARQDLSKVVPLLDEDGRELLGEMLNYDPNKRLSAKNALVHRFF  286

         ******************************************98

Domain Sequence
(FASTA)

FQKVEKIGEG TYGVVYKAKN KVTGETVALK KIRLDTETEG VPSTAIREIS LLKELSHPNI 60

VKLRDVIHTE NKLYLVFEFL HQDLKKFMDS SSVTGIPLPL VKSYLFQLLQ GLAFCHSHRV 120

LHRDLKPQNL LINAQGEIKL ADFGLARAFG VPVRAYTHEV VTLWYRAPEI LLGCKYYSTA 180

VDIWSLGCIF AEMVTRRALF PGDSEIDQLF RIFRTLGTPD ETVWPGVTSM PDYKPTFPKW 240

ARQDLSKVVP LLDEDGRELL GEMLNYDPNK RLSAKNALVH RFF 283

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013