EKS-ORN-00582

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00582

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	432.0	1.2E-129	55	343	289

Status

Unreviewed

Ensembl Protein

ENSONIP00000024429

UniProt Accession

I3KTI3;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK3

Gene Synonyms/Alias

MAPK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000019408	ENSONIP00000024429	ENSONIT00000024450

Organism

Oreochromis niloticus

Functional Description

Protein Length

394

Protein Sequence
(FASTA)

MADTSSTAAV AAEASDSAAA AAAAPVAPDA PPVAPVPRTP AESVKGQIFD VGPRYTNLSY 60

IGEGAYGMVC SALDNLTNQR VAIKKISPFE HQTYCQRTLR EIKILLRFHH ENIIGINDII 120

RAQQLDNMRD VYIVQTLMET DLYKLLKSQR LSNDHVCYFL YQILRGLKYI HSANVLHRDL 180

KPSNLLINTT CDLKICDFGL ARIADPEHDH TGFLTEYVAT RWYRAPEIML NSKGYSKSID 240

IWSVGCILAE MLSNKPIFPG KHYLDQLNHI LGILGSPSQE DLNCIINLKA RNYLQSLPEK 300

PKIPWEKLFY KADPKALDLL GRMLTFNPIK RITVEEALAH PYLEQYYDPS DEPVAEEPFT 360

FTMELDDLPK ERLKELIFEE TARFQDNYQP PVRS 394

Nucleotide Sequence
(FASTA)

ATGGCGGATA CGAGCAGCAC TGCGGCGGTC GCGGCCGAAG CCTCCGACAG CGCTGCTGCT 60

GCTGCTGCTG CGCCTGTTGC GCCCGATGCA CCGCCCGTAG CTCCGGTGCC CAGGACTCCA 120

GCCGAGTCCG TGAAGGGACA GATTTTTGAC GTGGGCCCCC GCTACACGAA CCTGTCGTAC 180

ATCGGGGAGG GTGCTTACGG AATGGTGTGC TCTGCTCTGG ACAACCTGAC AAACCAGCGC 240

GTAGCCATCA AGAAAATCAG CCCATTCGAG CACCAGACGT ACTGCCAGCG CACGCTGAGG 300

GAAATCAAGA TCCTGCTGCG TTTCCACCAT GAGAACATCA TCGGCATCAA CGACATCATC 360

AGGGCACAGC AGCTCGACAA CATGAGGGAT GTCTACATTG TGCAGACCCT GATGGAGACT 420

GACCTGTACA AGCTGCTGAA GAGCCAAAGG CTAAGCAACG ACCACGTCTG CTACTTCCTC 480

TACCAGATCC TGCGAGGCCT CAAGTACATT CACTCCGCCA ACGTGCTGCA CCGGGATCTC 540

AAGCCCTCCA ACCTGCTCAT CAACACCACC TGCGACCTCA AGATCTGTGA CTTTGGCCTG 600

GCGCGGATAG CTGACCCAGA GCACGACCAC ACTGGTTTTT TGACTGAGTA TGTGGCTACT 660

CGTTGGTACA GGGCTCCAGA AATCATGCTC AACTCCAAGG GCTACTCAAA GTCCATTGAC 720

ATCTGGTCGG TGGGCTGCAT CCTGGCTGAG ATGTTGTCCA ACAAACCCAT CTTCCCTGGG 780

AAACACTACT TGGACCAACT CAACCACATA CTCGGCATTC TTGGCTCTCC ATCTCAAGAA 840

GATCTGAACT GCATCATTAA CTTGAAGGCG AGGAACTACT TGCAGTCCCT GCCTGAAAAA 900

CCCAAGATCC CGTGGGAAAA GCTGTTCTAC AAGGCAGACC CTAAAGCTCT CGATCTGCTG 960

GGCCGCATGT TGACCTTTAA CCCCATCAAG CGCATCACCG TCGAGGAGGC CCTGGCTCAC 1020

CCTTACCTGG AGCAGTACTA CGATCCTTCA GATGAGCCTG TAGCAGAGGA GCCCTTCACT 1080

TTCACCATGG AACTGGACGA CCTTCCCAAA GAGAGGCTGA AGGAGCTGAT CTTTGAGGAA 1140

ACGGCTCGTT TCCAGGACAA CTACCAGCCG CCAGTTCGCT CCTGA 1185

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++l+++geGayg+v+sa d+ t++rvaikk+s pf+++t ++rtlRE+k+l +++heNi

Q: 55    YTNLSYIGEGAYGMVCSALDNLTNQRVAIKKIS-PFEHQTYCQRTLREIKILLRFHHENI  113

         78999***************************9.**************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i + d++++++ l++++dvY+v++lmetdL+k++ksq+ls++h+ ++lyqilrglky+Hs

Q: 114   IGINDIIRAQQ-LDNMRDVYIVQTLMETDLYKLLKSQRLSNDHVCYFLYQILRGLKYIHS  172

         **********9.************************************************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekk..lteyvatrwYraPeillsl  178

         anv+HrDlKPsNll+n++c+lki+dFGlar+ad+e++++  lteyvatrwYraPei+l++

Q: 173   ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTgfLTEYVATRWYRAPEIMLNS  232

         ***********************************99999********************

S: 179   keytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearn  238

         k y+k++DiWsvGCIlaE+l++kp+fpgk+++dql++il +lg+ps+e+l++i + +arn

Q: 233   KGYSKSIDIWSVGCILAEMLSNKPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARN  292

         ************************************************************

S: 239   yikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         y++slp+k+k ++e+lf ka+++aldLl ++L+++p kRi+veeaL+hpYl

Q: 293   YLQSLPEKPKIPWEKLFYKADPKALDLLGRMLTFNPIKRITVEEALAHPYL  343

         **************************************************7

Domain Sequence
(FASTA)

YTNLSYIGEG AYGMVCSALD NLTNQRVAIK KISPFEHQTY CQRTLREIKI LLRFHHENII 60

GINDIIRAQQ LDNMRDVYIV QTLMETDLYK LLKSQRLSND HVCYFLYQIL RGLKYIHSAN 120

VLHRDLKPSN LLINTTCDLK ICDFGLARIA DPEHDHTGFL TEYVATRWYR APEIMLNSKG 180

YSKSIDIWSV GCILAEMLSN KPIFPGKHYL DQLNHILGIL GSPSQEDLNC IINLKARNYL 240

QSLPEKPKIP WEKLFYKADP KALDLLGRML TFNPIKRITV EEALAHPYL 289

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Caenorhabditis elegans"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Gasterosteus aculeatus"; ?>Macropus eugenii"; ?>Oryzias latipes"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008349	; MAPK_ERK1/2.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01770

; ERK1ERK2MAPK.

Created Date

20-Feb-2013