EKS-ORN-00564

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00564

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	355.0	3.2E-106	99	363	265

Status

Unreviewed

Ensembl Protein

ENSONIP00000024477

UniProt Accession

I3KTN0;

Protein Name

Protein Synonyms/Alias

Gene Name

CIT (2 of 2)

Gene Synonyms/Alias

CIT (2 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000019443	ENSONIP00000024477	ENSONIT00000024498
ENSONIG00000019443	ENSONIP00000024476	ENSONIT00000024497

Organism

Oreochromis niloticus

Functional Description

Protein Length

1661

Protein Sequence
(FASTA)

MLKFKYVSQG NLKTPSSSAD PITSRSSRLN QLFQGRLSLC GEQGGCTLGR EEFLDALLLL 60

YQECTSPELM KIHHVANFVN KFSEVVSELR ALQPGLQDFD LRAVVGRGRF AEVRVVREKA 120

TGGVCALKVM KKTVLRTQEN VIFHEEERRI LALNSSPWIP QLLYAFQDKD HVYLAMEYLP 180

GGDLMSLLNR YEDQFDESMA RFYLAELVEA IHAVHQLGYV HRDVKPENIL IDRTGHIKLA 240

DFGSAARLTA NKTVATPTVP VGTQDFLSPE VLTAMNGGSN STYGVECDWW SLGVIAYEMI 300

YARSPFSEAT STKTIYNILN FQRCLKFPEE PRTSKQFVDL VQSLLCGAKE RLGFQGLHCH 360

SFFSSVDWNN LRQVLPPFVP ALHAEDDTSN FEEPEQAAPW PASAAQQGAP PAGFQGQDLP 420

FLGWFFSRAL ILLAKTESVS AGLNSPAKTN SMEKKLHLKS KELQETQDKC HKMEQEISRF 480

QRKMTDLESV LHQKDVELKA SETQRSILEQ DLATYITECS SLKRSLEEAR VEVSREDDKA 540

MQLLHDIREQ SNKLQEIKEQ EYHAQLEEMQ VTIRQLEEDL SAARRRSDLY EAELRDSRQT 600

SEELKRKAVE YQQRIQKAKE QGKAEVEELL SKLEKTNSEQ QVKIQELQDK LSKAVKASTE 660

ATELLQNVRQ AKERLERDLE RLKGKTDSSD TLKRRLRETE EGRKTLENQV KRLEMVERRE 720

NKLKDDIQTK SQQIQQMAEK ILELEENLRD AQSTAQRMET QLVQKERLYE DKIKVLEAQM 780

KADLADKESL EARRAQQEEE SRENCKLISE QKATINAMDS KMKNLEQRIA ELSEANKLAA 840

NSSIYTQKNM KAQEEMISEL RQQKFYLESQ AGKLEAQNAK LEEHLEKMSQ QEQTKRTRLL 900

ELESRLREMG LEHEEEKLEI KRQVSELTLS LQERESQISS LQAARLALES QLQQAKTELE 960

ETTAEAEEEI TALRNHRDDI QRKFDALRDS CSVITDLEEQ LTQLSQENAE LNRQNFYLSK 1020

QLDEASDERE DRLQLSQEVD RLRREVADRE MHLNNQKQNI ETLKTTCSML EEQVVELESL 1080

NDELLEKERQ WEAWRAALED EKSQAERRSR DMQRLLDNEK QNRLRADQRS TESRQAVELA 1140

VKEHKAEILA LQQALKEQRL KAESLSDTLN DLEKKHAMLE MNARSLQQKL ETERELKQRL 1200

MEEQAKLQQQ MDLQKSHIFR LTQGLQDALD QTDMLKTERT DLEYQLENMQ AVYSHEKVKM 1260

EGTISQQTKL IDFLQAKMDQ PTKKKKGIFG RRREDVGTTT NGALAPQAQP AVPLQYSDMK 1320

LALEKERSRC AELEEALQKM RIELRSLREE AAHFKAQDHV APSTPAQARH QILMSAIVKS 1380

PEHQPNPSSL LNPSTRCKET STPEEFGHRV KERMHHNIPH RFTVGLNMRA AKCAVCLDTV 1440

HFGRQAATCL ECHTICHPKC SPCLPATCGL PAEYATHFSE ALCREKANSP ALQVKEASGH 1500

VRLEGWMKQP RNGKRGQQGW ERKYVVLDGT KVSIYDTEPR EDSVKAEEEF ELCLPDGEVT 1560

VHGAVGASEL INTAKSDIPY VLKLESHPHT TCWPGQSLYF MAPSFPDKQR WVAVLESVVG 1620

GSRGSREKVD SDAKLLGNSL LKLEGDDRLD INCTLPLTDQ V 1661

Nucleotide Sequence
(FASTA)

ATGCTGAAGT TTAAATACGT GAGTCAGGGA AACCTGAAAA CACCGTCTTC CTCTGCTGAC 60

CCTATCACTA GCCGCAGCTC ACGACTCAAC CAGCTGTTTC AGGGACGACT GAGTCTGTGT 120

GGGGAGCAGG GAGGATGCAC TTTAGGTCGG GAAGAGTTTC TGGATGCTTT GCTGCTTCTC 180

TACCAAGAGT GCACTTCCCC AGAACTTATG AAGATACATC ATGTGGCAAA CTTCGTCAAT 240

AAATTTTCCG AAGTTGTCTC GGAGCTGCGG GCCCTACAGC CCGGGCTTCA AGACTTTGAC 300

CTGCGTGCAG TGGTGGGTCG GGGTCGTTTT GCTGAAGTCC GCGTTGTCCG AGAGAAGGCT 360

ACTGGAGGTG TTTGTGCACT TAAAGTCATG AAGAAGACAG TTTTACGCAC TCAAGAAAAT 420

GTGATTTTTC ATGAAGAGGA GCGGAGGATC TTGGCTCTGA ACAGTAGTCC CTGGATCCCA 480

CAGCTGCTGT ATGCCTTCCA GGATAAAGAT CATGTTTACC TGGCGATGGA GTACTTGCCA 540

GGCGGTGACC TGATGTCTCT CCTAAACCGA TATGAGGATC AGTTTGATGA GTCCATGGCT 600

CGATTTTATT TGGCTGAGCT GGTAGAGGCC ATTCATGCTG TCCACCAGTT GGGCTACGTC 660

CACAGAGATG TCAAACCAGA GAATATTCTC ATTGATCGGA CTGGTCATAT TAAGCTGGCT 720

GACTTTGGAT CAGCTGCCAG GCTGACTGCT AACAAAACGG TGGCCACTCC CACAGTGCCT 780

GTTGGAACCC AGGACTTTCT TTCCCCTGAA GTCCTGACAG CCATGAATGG GGGTTCTAAC 840

AGCACCTATG GAGTTGAGTG TGATTGGTGG TCCCTTGGGG TCATTGCCTA TGAGATGATT 900

TATGCCCGGT CACCTTTTTC TGAAGCCACT TCGACCAAGA CTATCTACAA CATCCTTAAC 960

TTCCAGCGTT GCTTAAAGTT TCCAGAGGAG CCACGTACCA GTAAGCAGTT TGTAGACTTG 1020

GTACAGAGCT TACTTTGTGG TGCAAAGGAG CGACTGGGTT TCCAGGGACT CCACTGTCAC 1080

TCTTTCTTCT CCAGTGTCGA CTGGAACAAC TTGCGACAAG TTCTCCCGCC TTTCGTTCCT 1140

GCATTGCATG CTGAAGATGA CACCTCTAAT TTTGAGGAGC CGGAGCAGGC AGCCCCCTGG 1200

CCAGCCTCAG CAGCCCAGCA AGGAGCTCCG CCGGCGGGCT TCCAGGGCCA GGATCTGCCT 1260

TTTCTAGGCT GGTTCTTCAG CAGAGCGTTG ATACTATTGG CCAAAACTGA GTCAGTGTCT 1320

GCAGGCCTCA ACTCTCCTGC TAAGACCAAC TCAATGGAAA AGAAACTGCA CCTTAAAAGC 1380

AAAGAACTAC AAGAAACTCA AGACAAATGT CACAAGATGG AGCAGGAAAT CTCCAGGTTC 1440

CAGCGTAAGA TGACTGACCT GGAGTCAGTG CTCCACCAGA AGGATGTGGA GCTGAAGGCC 1500

TCTGAGACTC AGCGGAGTAT CCTGGAGCAA GACCTTGCCA CCTACATTAC TGAGTGCAGC 1560

AGCCTAAAGC GAAGCTTGGA GGAGGCACGA GTGGAAGTCT CTAGAGAGGA CGACAAGGCC 1620

ATGCAGCTGC TGCACGACAT ACGCGAACAG AGCAACAAAC TGCAAGAAAT TAAGGAGCAA 1680

GAGTACCATG CCCAGCTGGA GGAAATGCAG GTGACCATCA GGCAGCTGGA GGAGGATCTC 1740

TCCGCTGCCC GACGTCGCAG CGACCTCTAT GAAGCTGAAC TTAGAGACTC GAGACAAACA 1800

AGTGAGGAGC TCAAAAGAAA AGCTGTGGAA TACCAACAAA GGATCCAGAA GGCAAAAGAG 1860

CAGGGAAAAG CTGAAGTGGA GGAGCTTCTC TCCAAACTTG AAAAGACAAA CTCTGAGCAG 1920

CAGGTGAAGA TCCAGGAGCT CCAAGACAAA CTGTCCAAGG CAGTGAAAGC GAGCACAGAA 1980

GCCACAGAGC TGCTGCAGAA TGTTCGGCAG GCCAAAGAGC GGCTGGAACG AGATCTGGAG 2040

CGCCTGAAAG GCAAAACCGA CTCTAGTGAC ACTTTAAAAC GCCGTCTTAG GGAGACGGAG 2100

GAGGGCAGGA AGACACTTGA GAATCAGGTA AAAAGGCTGG AGATGGTTGA GCGTCGGGAA 2160

AACAAGCTGA AGGATGACAT TCAGACCAAA TCCCAACAGA TCCAGCAGAT GGCTGAAAAG 2220

ATCCTGGAAC TGGAGGAAAA CCTGAGGGAT GCCCAGTCAA CTGCACAGAG GATGGAAACG 2280

CAACTGGTTC AAAAGGAAAG GCTTTATGAA GACAAGATCA AAGTTCTTGA GGCCCAGATG 2340

AAAGCAGACC TGGCTGACAA AGAGAGCCTT GAGGCCAGAA GGGCGCAGCA GGAGGAGGAG 2400

TCAAGGGAGA ACTGTAAACT CATCAGTGAA CAGAAAGCAA CCATTAATGC TATGGATTCA 2460

AAGATGAAGA ACCTGGAGCA GCGCATCGCT GAGTTGTCAG AGGCTAACAA GCTGGCTGCT 2520

AACAGCAGCA TCTACACCCA GAAGAATATG AAAGCCCAGG AAGAAATGAT CTCAGAGCTT 2580

CGACAGCAAA AGTTTTATTT GGAGTCTCAG GCAGGCAAGC TTGAGGCCCA AAATGCCAAA 2640

CTAGAGGAAC ACCTGGAGAA GATGAGTCAA CAGGAGCAAA CCAAGAGAAC CCGGCTGCTG 2700

GAGCTGGAGA GCAGGCTGCG GGAGATGGGC CTAGAACATG AAGAGGAGAA ACTGGAGATC 2760

AAGAGGCAGG TGTCAGAGTT GACCCTGTCC CTGCAGGAGC GTGAGTCCCA AATCAGCAGC 2820

CTACAGGCTG CACGTCTTGC ATTGGAGAGT CAGCTGCAGC AAGCTAAGAC TGAGCTGGAA 2880

GAGACAACTG CAGAGGCTGA GGAGGAGATC ACGGCCCTCA GGAACCACAG GGATGATATT 2940

CAGCGAAAGT TTGATGCCTT AAGAGACAGT TGTTCAGTGA TCACTGACCT AGAGGAACAG 3000

CTGACACAGC TTAGTCAGGA GAACGCCGAG TTGAATCGCC AGAACTTCTA CCTGTCCAAA 3060

CAGCTTGATG AAGCATCAGA TGAGAGAGAG GATCGGCTGC AGCTCAGCCA GGAAGTGGAC 3120

CGCCTGAGGA GGGAGGTGGC TGACCGTGAG ATGCACCTCA ACAACCAGAA ACAGAACATT 3180

GAGACACTGA AGACCACATG CAGCATGTTG GAGGAGCAGG TGGTGGAGCT GGAGTCCCTA 3240

AACGACGAGT TGCTGGAAAA GGAGAGGCAG TGGGAGGCTT GGAGAGCAGC TCTGGAAGAT 3300

GAAAAAAGCC AAGCCGAGAG ACGCTCCAGG GACATGCAAA GACTGCTGGA CAATGAGAAG 3360

CAGAACAGGC TGCGTGCAGA CCAGCGCAGC ACTGAGTCTC GCCAGGCAGT AGAGCTGGCA 3420

GTCAAAGAGC ATAAGGCTGA GATCTTGGCC TTACAACAGG CTTTGAAGGA GCAAAGACTA 3480

AAGGCTGAAA GTCTATCTGA TACTCTCAAT GATCTGGAGA AGAAACATGC CATGCTGGAG 3540

ATGAATGCCC GTAGCTTACA GCAGAAACTG GAGACTGAGA GAGAACTGAA ACAAAGGCTG 3600

ATGGAAGAGC AAGCAAAACT CCAGCAGCAG ATGGACCTCC AGAAGAGCCA CATTTTCCGT 3660

TTGACCCAGG GCCTGCAGGA TGCTCTGGAC CAAACCGACA TGCTCAAGAC AGAGAGGACC 3720

GATCTGGAGT ACCAGCTGGA GAATATGCAG GCGGTATATT CCCACGAGAA GGTGAAGATG 3780

GAGGGGACAA TCTCCCAGCA GACTAAACTC ATTGACTTCC TCCAGGCCAA AATGGACCAA 3840

CCCACTAAAA AAAAGAAGGG TATATTTGGG CGGCGGCGGG AAGATGTAGG CACCACAACT 3900

AATGGGGCAT TAGCTCCACA GGCCCAGCCG GCAGTTCCAT TGCAGTACAG TGACATGAAA 3960

CTAGCTTTGG AGAAGGAGCG CTCAAGGTGT GCCGAGCTGG AAGAGGCTCT GCAGAAGATG 4020

AGGATAGAGC TGCGGTCCCT CAGAGAGGAG GCGGCTCATT TCAAAGCCCA GGACCATGTA 4080

GCTCCTTCCA CACCAGCCCA GGCTCGACAT CAAATCCTCA TGTCAGCCAT TGTCAAATCC 4140

CCAGAACATC AGCCCAACCC CAGCAGCCTG CTTAACCCCT CCACCCGCTG CAAGGAGACT 4200

TCTACACCTG AAGAGTTTGG TCATCGTGTG AAAGAAAGAA TGCATCACAA CATCCCTCAT 4260

CGTTTCACTG TGGGCCTCAA CATGAGGGCT GCCAAGTGTG CCGTCTGCCT GGACACTGTG 4320

CATTTTGGAC GGCAAGCTGC CACTTGTCTA GAGTGCCACA CTATTTGCCA TCCCAAATGC 4380

TCGCCGTGTC TTCCGGCCAC CTGTGGTCTG CCAGCTGAGT ATGCCACTCA CTTTTCAGAA 4440

GCTCTGTGCC GAGAAAAGGC AAACTCACCT GCACTGCAGG TCAAAGAGGC CAGTGGGCAT 4500

GTTCGCTTGG AAGGATGGAT GAAGCAGCCT AGAAATGGCA AGCGTGGGCA ACAAGGCTGG 4560

GAGAGGAAAT ATGTGGTTCT TGATGGGACC AAAGTGTCCA TCTATGATAC TGAGCCCAGA 4620

GAAGACTCTG TAAAGGCTGA GGAAGAGTTT GAGCTCTGTC TGCCTGATGG AGAGGTGACT 4680

GTCCATGGAG CTGTTGGAGC CTCTGAGCTC ATCAACACTG CCAAGTCAGA CATCCCGTAT 4740

GTGTTGAAGC TGGAATCGCA TCCGCACACC ACATGTTGGC CTGGCCAGTC CCTCTACTTC 4800

ATGGCTCCTA GCTTTCCTGA TAAGCAGCGC TGGGTGGCAG TACTGGAGTC TGTTGTGGGT 4860

GGTAGTCGTG GATCTAGAGA GAAAGTGGAT TCTGATGCTA AACTTCTGGG CAATTCTCTG 4920

CTGAAGCTGG AGGGTGACGA CCGTTTGGAC ATCAACTGCA CTCTGCCTCT CACTGACCAG 4980

GTATAA 4986

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         f+++ v+GrG f+ev+vvrekat+ v a+k++kk+ l +++++ f +eer +l+ + s+w

Q: 99    FDLRAVVGRGRFAEVRVVREKATGGVCALKVMKKTVLRTQENVIFHEEERRILALNSSPW  158

         78999*******************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         i ql yafqd++++yl meyl+GGdl++ll++yed+++e++arfylaelv a+++vh+lg

Q: 159   IPQLLYAFQDKDHVYLAMEYLPGGDLMSLLNRYEDQFDESMARFYLAELVEAIHAVHQLG  218

         ************************************************************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvks.svavGtpdyispevlkalee.  178

         yvhrd+kp+nil+d++GhikladfGs+++l++++tv++ +v+vGt d++spevl+a++

Q: 219   YVHRDVKPENILIDRTGHIKLADFGSAARLTANKTVATpTVPVGTQDFLSPEVLTAMNGg  278

         ***********************************9873789***************996

S: 179   gkgeygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpedekvseeak  238

         ++++yg ecdwwslGvi+ye+++ ++pf + ++++t  +iln++++lkfpe+ + s+++

Q: 279   SNSTYGVECDWWSLGVIAYEMIYARSPFSEATSTKTIYNILNFQRCLKFPEEPRTSKQFV  338

         889*********************************************************

S: 239   dlikklltsreerlgregiedlkkhpff  266

         dl+++ll+ ++erlg++g+   ++h+ff

Q: 339   DLVQSLLCGAKERLGFQGL---HCHSFF  363

         ******************9...899998

Domain Sequence
(FASTA)

FDLRAVVGRG RFAEVRVVRE KATGGVCALK VMKKTVLRTQ ENVIFHEEER RILALNSSPW 60

IPQLLYAFQD KDHVYLAMEY LPGGDLMSLL NRYEDQFDES MARFYLAELV EAIHAVHQLG 120

YVHRDVKPEN ILIDRTGHIK LADFGSAARL TANKTVATPT VPVGTQDFLS PEVLTAMNGG 180

SNSTYGVECD WWSLGVIAYE MIYARSPFSE ATSTKTIYNI LNFQRCLKFP EEPRTSKQFV 240

DLVQSLLCGA KERLGFQGLH CHSFF 265

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR017405	; Citron_Rho-interacting_kinase.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00109	; C1; 1.
SM00036	; CNH; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013