EKS-ORN-00392
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00392
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Alk517.21.1E-155447716270
StatusUnreviewed
Ensembl ProteinENSONIP00000024592
UniProt AccessionI3KTZ6;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameALK
Gene Synonyms/Alias ALK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000019537ENSONIP00000024592ENSONIT00000024613
OrganismOreochromis niloticus
Functional Description
Protein Length739
Protein Sequence
(FASTA)
MIFPTTDYSK KWIFHTCGAV GPEGPTPTQC LNSYRNSNVN VTVGTRGPFK GIQMWRVPET 60
GSYRVTVYGA AGGRSVLTTS RSHGAYMTGD LLLNKGELLY ILVGQRGEDA CPNGRAESDL 120
CCRTQSNGML NKICLEQSGP MVNKTQVKGG GGGGGGATYV FKVDREVYIP LIIAAGGGGR 180
GYSSQSETQQ EQMDYDPSQP GRNGKSHAAG GGGGWNDSAP VSQGGKPLVL GGQGGQACQK 240
FWQTRGGFGG GGGGCMSGGG GGGYRGGNTS ADNNPKHDGE DGSSFFKGEP FIHPLKGMEG 300
DGEVIISPVQ NCSHCESNEC HEIDIDSTIC FCDEGLTLAP DEVSCINTTE VSPQPPQPSL 360
SHLALGLSVG TSALIAALLL AVSGVMITVY RRKHTELQSI QLELQSPDCK LSKLRASTIM 420
TDYNPNYCFA GKTASVNDLK EVPRRNISLT RGLGHGAFGE VYEGLAVGIP GEPSPLQVAV 480
KTLPEVCSEQ DELDFLMEAL IISKFNHQNI VRCIGVSLQA MPRFILLELM AGGDLKTFLR 540
ETRPRLDQPS SLTMVDLLNV ARDIAKGCQY LEENQFIHRD IAARNCLLTC KGPGRVAKIG 600
DFGMARDIYR ASYYRKGGRA MLPVKWMPPE AFMEGIFTSK TDTWSFGVLL WEIFSLGYMP 660
YPSRSNQEVL EFVTNGGRMD PPKNCPGPVY RIMTQSWQHQ PEDRPNFSTI LERIDYCLQD 720
PDVVNVALPI EYGPVPEEE 739
Nucleotide Sequence
(FASTA)
ATGATCTTCC CCACCACAGA TTACTCCAAA AAATGGATTT TTCATACCTG TGGGGCTGTG 60
GGCCCTGAAG GTCCAACTCC CACTCAGTGC CTCAACTCCT ACAGGAACAG CAATGTCAAC 120
GTGACAGTTG GAACCCGGGG GCCATTCAAA GGCATTCAAA TGTGGCGGGT CCCAGAAACC 180
GGCTCCTACA GGGTCACAGT CTATGGCGCC GCTGGCGGGA GAAGTGTCTT GACCACGAGC 240
AGGTCACACG GTGCCTACAT GACAGGAGAC CTCCTGCTGA ACAAAGGAGA ACTGCTTTAC 300
ATCCTCGTGG GACAACGAGG AGAGGATGCC TGCCCCAACG GTCGTGCAGA AAGTGATTTG 360
TGCTGCAGAA CACAGTCTAA CGGCATGCTG AATAAGATAT GCCTGGAACA GAGCGGCCCA 420
ATGGTGAACA AAACACAAGT GAAAGGAGGG GGAGGAGGTG GTGGAGGGGC TACGTATGTA 480
TTCAAAGTGG ACAGAGAAGT GTACATCCCT CTCATCATCG CTGCTGGGGG AGGTGGCCGG 540
GGATACAGCA GCCAATCAGA GACCCAGCAG GAGCAAATGG ACTATGACCC TAGCCAACCT 600
GGACGCAATG GGAAGTCACA TGCTGCAGGT GGAGGAGGAG GTTGGAATGA CAGCGCTCCT 660
GTCAGCCAGG GCGGCAAACC GCTGGTGCTC GGGGGACAGG GAGGGCAAGC CTGTCAAAAG 720
TTCTGGCAGA CCCGTGGCGG CTTTGGAGGT GGCGGAGGTG GCTGTATGTC CGGCGGCGGC 780
GGCGGAGGCT ACAGAGGTGG TAACACCTCT GCAGATAACA ACCCTAAACA CGATGGTGAG 840
GATGGCTCGT CCTTCTTCAA GGGAGAACCC TTCATCCACC CCCTTAAAGG TATGGAGGGG 900
GATGGCGAGG TGATCATCAG CCCGGTGCAG AACTGCAGCC ACTGTGAGAG CAATGAATGC 960
CACGAGATAG ACATAGATTC CACAATCTGC TTCTGTGATG AAGGCCTCAC CCTGGCACCG 1020
GATGAAGTTT CCTGCATCAA CACCACAGAA GTGTCCCCGC AGCCTCCGCA GCCATCTCTC 1080
TCGCACCTGG CGCTCGGTCT GTCTGTGGGC ACCTCGGCGC TCATTGCTGC CCTCCTGCTG 1140
GCTGTGTCCG GAGTCATGAT AACAGTGTAT CGGCGTAAAC ACACAGAGCT GCAGTCCATT 1200
CAGCTGGAGC TGCAGAGTCC AGACTGCAAG CTCAGTAAGC TGCGGGCCTC CACCATCATG 1260
ACGGATTACA ACCCCAACTA CTGCTTCGCT GGCAAAACGG CCTCGGTCAA CGACCTGAAG 1320
GAAGTGCCAA GGCGAAACAT TTCTCTCACC AGGGGTCTAG GTCACGGTGC TTTTGGTGAG 1380
GTCTATGAAG GTCTTGCAGT GGGGATACCA GGTGAACCAA GTCCACTGCA AGTTGCAGTC 1440
AAGACTCTTC CGGAGGTTTG TTCTGAGCAG GATGAATTGG ACTTCCTCAT GGAGGCTCTA 1500
ATCATCAGTA AGTTCAACCA CCAGAACATT GTGCGCTGTA TAGGAGTAAG TCTGCAGGCT 1560
ATGCCCCGGT TCATCCTGCT CGAGCTGATG GCTGGAGGGG ACCTCAAGAC TTTCCTGAGG 1620
GAGACCAGAC CCCGGCTGGA TCAACCATCC AGCCTAACCA TGGTGGACCT CCTCAATGTG 1680
GCCAGAGACA TCGCTAAGGG CTGCCAGTAT CTTGAGGAGA ACCAGTTTAT ACACAGGGAC 1740
ATTGCAGCAC GGAATTGCCT TCTGACCTGC AAAGGACCGG GACGGGTGGC TAAGATCGGA 1800
GATTTTGGGA TGGCTCGAGA CATTTACAGG GCGAGCTATT ACAGGAAGGG TGGGCGTGCC 1860
ATGTTGCCGG TGAAATGGAT GCCACCTGAA GCTTTCATGG AGGGCATCTT CACATCTAAA 1920
ACAGACACGT GGTCATTTGG GGTTCTGCTG TGGGAGATCT TCTCGCTGGG CTACATGCCA 1980
TATCCGAGCC GCAGTAACCA AGAAGTGCTG GAGTTTGTAA CAAATGGGGG AAGAATGGAC 2040
CCGCCTAAAA ACTGTCCCGG ACCAGTGTAC CGTATAATGA CTCAGAGTTG GCAGCACCAG 2100
CCTGAAGACA GGCCCAACTT CTCAACCATC CTGGAGAGAA TCGACTACTG CTTACAGGAC 2160
CCCGATGTGG TGAACGTGGC TCTGCCTATC GAGTATGGGC CAGTACCCGA GGAGGAG 2217
Domain Profile
S: 1     ielvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfn  60
         i l+r+lG+GafGevyegl  g+pg++s+l+vavktlpe++seqdeldfl+ealiiskfn
Q: 447   ISLTRGLGHGAFGEVYEGLAVGIPGEPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFN  506
         6789********************************************************
S: 61    henivrliGvsleklprlillellaGGdlksflresrpkpeqlsslamkdllkvaldvak  120
         h+nivr+iGvsl+++pr+illel+aGGdlk+flre+rp+ +q+ssl+m dll+va+d+ak
Q: 507   HQNIVRCIGVSLQAMPRFILLELMAGGDLKTFLRETRPRLDQPSSLTMVDLLNVARDIAK  566
         ************************************************************
S: 121   GckyleenkfihrdiaarnillsskGpsrvakiadfGmardiyraeyyrkggrallpvkw  180
         Gc+yleen+fihrdiaarn+ll++kGp+rvaki+dfGmardiyra+yyrkggra+lpvkw
Q: 567   GCQYLEENQFIHRDIAARNCLLTCKGPGRVAKIGDFGMARDIYRASYYRKGGRAMLPVKW  626
         ************************************************************
S: 181   mppeafleGiftsktdvwsfGvllwevfslGvvpypgksnqevlelvveGgrldspkeip  240
         mppeaf+eGiftsktd+wsfGvllwe+fslG++pyp++snqevle+v++Ggr+d+pk++p
Q: 627   MPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSRSNQEVLEFVTNGGRMDPPKNCP  686
         ************************************************************
S: 241   gsvyrimtdcwkhepedrpkfvsilerlqa  270
         g+vyrimt+ w+h+pedrp+f +iler+++
Q: 687   GPVYRIMTQSWQHQPEDRPNFSTILERIDY  716
         ***************************986
Domain Sequence
(FASTA)
ISLTRGLGHG AFGEVYEGLA VGIPGEPSPL QVAVKTLPEV CSEQDELDFL MEALIISKFN 60
HQNIVRCIGV SLQAMPRFIL LELMAGGDLK TFLRETRPRL DQPSSLTMVD LLNVARDIAK 120
GCQYLEENQF IHRDIAARNC LLTCKGPGRV AKIGDFGMAR DIYRASYYRK GGRAMLPVKW 180
MPPEAFMEGI FTSKTDTWSF GVLLWEIFSL GYMPYPSRSN QEVLEFVTNG GRMDPPKNCP 240
GPVYRIMTQS WQHQPEDRPN FSTILERIDY 270
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gasterosteus aculeatus"; ?>Oryctolagus cuniculus"; ?>Pelodiscus sinensis"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00050
EKS-BOT-00308
EKS-CAE-00256
EKS-DRM-00153
EKS-EQC-00292
EKS-GAA-00374
EKS-ORC-00284
EKS-PES-00268
EKS-SUS-00272
EKS-TAR-00395
EKS-TEN-00398
EKS-XIM-00390
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0000187; P:activation of MAPK activity
GO:0048666; P:neuron development
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR026830; ALK.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013