EKS-ORN-00369
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00369
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR365.82.0E-109233526294
StatusUnreviewed
Ensembl ProteinENSONIP00000024765
UniProt AccessionI3KUG9;
Protein Name
Protein Synonyms/Alias
Gene NameTGFBR2 (1 of 2)
Gene Synonyms/Alias TGFBR2 (1 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000019673ENSONIP00000024765ENSONIT00000024786
OrganismOreochromis niloticus
Functional Description
Protein Length556
Protein Sequence
(FASTA)
VGSCLTTLWD LHLVAWTPSC SDDYQTHRHS SHNPVCLTDT EASGMKLNKL CKFCDIQPTN 60
CSGKGNCKVE CGITSICPQK EDVCVSIWRK KDGNVTFDTV CHNPAEKLYG LVLKDYNNSE 120
CEMKELSGMG SKFFICSCSE DECNERVFFD PTLGPTEPQV MAVILVSLVP LLVMATVVIT 180
FFYFYRVCRQ RNAHCRRKKG SPLEIDPLVI IEEDSSSTHA NSLNHNTELL PIELDVQVGK 240
GRFAEVYKAK LKQGSSVSVE QNFETVAIKI FSNEEYPSWK NEKDIFSDAD LTHENVLHFL 300
TAEDRKEQRQ YWLITAYHPR GNLQEYLTHN IISWHDLWLL GGSLARGVAH LHSDRTPCGR 360
SKVPIAHRDI KSSNILVKND LTCCLCDFGL ALRLDNSLSV DELANSGQVG TARYMAPEVL 420
ESRINLENIE SFKQADVYSM ALVLWEIISR CSAIGDVKAY EPPFGNLREH PCVESMKDSV 480
LRDRGRPEIP NSWTNHSGIQ MLCASIEDCW DHDPEARLTA HCVAERFNGM EYLDKLSDCS 540
DSEEKIPEEI FVVDEK 556
Nucleotide Sequence
(FASTA)
GTTGGGAGCT GCCTCACAAC GCTGTGGGAT CTCCACCTTG TGGCTTGGAC CCCATCATGC 60
AGTGATGATT ATCAAACCCA CAGGCACTCC TCACACAATC CTGTGTGTCT CACTGATACA 120
GAGGCCTCTG GAATGAAGCT AAATAAGCTG TGCAAGTTTT GTGATATACA GCCAACTAAC 180
TGCTCGGGTA AAGGGAACTG TAAGGTGGAG TGTGGCATTA CATCTATTTG CCCCCAAAAA 240
GAAGACGTGT GTGTCAGTAT TTGGAGGAAG AAAGATGGCA ACGTCACCTT TGATACAGTA 300
TGCCACAACC CAGCTGAAAA ACTGTACGGC CTAGTCTTGA AGGACTACAA CAACAGCGAG 360
TGTGAAATGA AAGAGCTGAG TGGCATGGGC TCAAAGTTCT TCATCTGTTC ATGCTCTGAG 420
GATGAATGCA ATGAGCGCGT CTTTTTTGAC CCAACTTTAG GGCCCACAGA ACCACAGGTG 480
ATGGCTGTTA TCTTAGTAAG CCTGGTGCCT CTCCTGGTTA TGGCTACCGT GGTGATCACT 540
TTCTTCTACT TCTACCGCGT GTGCCGCCAG CGCAATGCCC ACTGCAGACG CAAGAAAGGT 600
TCTCCGCTGG AAATCGACCC ACTCGTCATT ATAGAAGAAG ACAGCAGCTC CACGCACGCC 660
AACAGCCTCA ATCACAACAC TGAGCTGCTG CCCATCGAGC TGGACGTGCA GGTTGGAAAA 720
GGGCGCTTTG CAGAAGTTTA CAAAGCCAAG CTGAAGCAGG GCTCCTCTGT TAGCGTGGAG 780
CAGAACTTTG AGACTGTAGC AATTAAAATT TTCTCAAACG AGGAGTATCC ATCCTGGAAG 840
AACGAGAAGG ACATTTTCTC AGATGCGGAT TTGACGCATG AGAATGTGCT TCACTTCCTG 900
ACAGCAGAGG ACAGGAAGGA GCAGAGACAG TACTGGCTGA TCACAGCTTA TCATCCACGA 960
GGGAATCTCC AGGAGTACCT GACTCATAAT ATTATCAGCT GGCATGACCT GTGGCTGCTC 1020
GGGGGTTCGC TAGCCCGTGG AGTGGCACAC CTTCACAGCG ACCGCACCCC CTGCGGTCGC 1080
TCCAAGGTGC CTATCGCACA CAGGGACATT AAGAGCTCCA ACATACTGGT GAAAAATGAC 1140
TTGACCTGCT GCCTGTGTGA TTTTGGCCTT GCACTTCGGC TGGACAACTC TCTGTCTGTG 1200
GATGAGCTGG CCAACAGTGG GCAGGTGGGC ACTGCCAGGT ACATGGCCCC CGAGGTGTTG 1260
GAGTCCAGAA TCAACCTAGA AAACATTGAG TCTTTCAAAC AAGCCGATGT TTATTCCATG 1320
GCTCTCGTAC TGTGGGAGAT CATCTCAAGG TGTAGTGCAA TTGGAGACGT GAAAGCATAC 1380
GAGCCACCGT TTGGAAACCT GAGGGAACAC CCGTGTGTAG AGAGCATGAA GGACAGCGTC 1440
CTCAGGGACA GAGGAAGACC TGAGATCCCC AACAGCTGGA CCAACCACTC GGGCATCCAG 1500
ATGTTGTGTG CCTCCATTGA GGACTGCTGG GACCACGACC CGGAGGCCCG TCTCACCGCC 1560
CATTGTGTTG CTGAGCGCTT CAATGGCATG GAGTACCTGG ACAAGCTGTC AGATTGCTCT 1620
GACTCAGAGG AGAAAATCCC TGAAGAAATC TTTGTAGTGG ATGAAAAGTA A 1671
Domain Profile
S: 2     klleligkGrygeVwkaklrg..........eevAvKifstedeaswkrEkeiyqtvllr  51
         +l  ++gkGr++eV+kakl++          e+vA+Kifs+e+  swk+Ek+i++   l 
Q: 233   ELDVQVGKGRFAEVYKAKLKQgssvsveqnfETVAIKIFSNEEYPSWKNEKDIFSDADLT  292
         67779***************99**************************************
S: 52    henilqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlah  111
         hen+l+f++a+ ++e  + +++l+t+yh++g+L++yL+++++++++l  l  sla+G+ah
Q: 293   HENVLHFLTAEDRKE--QRQYWLITAYHPRGNLQEYLTHNIISWHDLWLLGGSLARGVAH  350
         **********99774..58*****************************************
S: 112   LHeeivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqv  171
         LH++ ++ +g++K  iaHRD+ks Nilvk+dltcc++D+GLal+l+++ ++ +la++ qv
Q: 351   LHSD-RTPCGRSKVPIAHRDIKSSNILVKNDLTCCLCDFGLALRLDNSLSVDELANSGQV  409
         ****.678899*************************************************
S: 172   GtkRYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevv  231
         Gt RYmaPEvle+++nl+++e+fk+aDvYs++LvlWE++sRc++  + v+ y++pf   +
Q: 410   GTARYMAPEVLESRINLENIESFKQADVYSMALVLWEIISRCSA-IGDVKAYEPPF-GNL  467
         ********************************************.999********.779
S: 232   gsdPsleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290
         +++P++e+mk+ v++++ rP+ip++w++++ +++l+  +e+cWd+dpeaRlta++v++r
Q: 468   REHPCVESMKDSVLRDRGRPEIPNSWTNHSGIQMLCASIEDCWDHDPEARLTAHCVAER  526
         ********************************************************987
Domain Sequence
(FASTA)
ELDVQVGKGR FAEVYKAKLK QGSSVSVEQN FETVAIKIFS NEEYPSWKNE KDIFSDADLT 60
HENVLHFLTA EDRKEQRQYW LITAYHPRGN LQEYLTHNII SWHDLWLLGG SLARGVAHLH 120
SDRTPCGRSK VPIAHRDIKS SNILVKNDLT CCLCDFGLAL RLDNSLSVDE LANSGQVGTA 180
RYMAPEVLES RINLENIESF KQADVYSMAL VLWEIISRCS AIGDVKAYEP PFGNLREHPC 240
VESMKDSVLR DRGRPEIPNS WTNHSGIQML CASIEDCWDH DPEARLTAHC VAER 294
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Gasterosteus aculeatus"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-GAA-00350
EKS-TAR-00370
EKS-TEN-00365
EKS-XIM-00361
Gene Ontology
GO:0016021; C:integral to membrane
GO:0043235; C:receptor complex
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004702; F:receptor signaling protein serine/threonine kinase activity
GO:0005026; F:transforming growth factor beta receptor activity, type II
GO:0023014; P:signal transduction by phosphorylation
GO:0007179; P:transforming growth factor beta receptor signaling pathway
KEGG
InterPros
IPR000333; Activin_II/TGFBeta-II_recpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
IPR017194; Transform_growth_fac-b_typ-2.
IPR015013; Transforming_GF_b_rcpt_2_ecto.
Pfam
PF08917; ecTbetaR2; 1.
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR00653; ACTIVIN2R.
Created Date20-Feb-2013