EKS-ORN-00592

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00592

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	403.5	6.1E-121	69	361	293

Status

Unreviewed

Ensembl Protein

ENSONIP00000025301

UniProt Accession

I3KW05;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK7

Gene Synonyms/Alias

MAPK7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000020084	ENSONIP00000025301	ENSONIT00000025322

Organism

Oreochromis niloticus

Functional Description

Protein Length

820

Protein Sequence
(FASTA)

MSLKEGGESK NGQPVASPEK MATDKSRENQ NPRGVEVPGS NADTSTAAKN LALLKAHSLD 60

VKFDVGEEYD IIETIGTGAY GVVSSARRRD NGQQVAIKKI SNAFEVVTNA KRTLRELKIL 120

KHFKHDNIIA IKDILQPNLP HSAFKSVYVV LDLMESDLHQ IIHSAQTLTP EHTRYFLYQL 180

LRGLKYVHSA NVIHRDLKPS NLLVNENCEL KIGDFGMARG LSSHPEESHS FMTEYVATRW 240

YRAPELLLSL NHYSLAIDLW SVGCIFAEML GRKQLFPGKH YVHQLQLILN VLGTPPEGLI 300

GAIRADRVRA YVQSLPSRSP IPLAKLYPQA EPEALDLLAA MLRFDPRQRI SVTEALEHSY 360

LAKYHDPDDE PICVPAFDFE FDKLQMNKEQ IKEAILIEIQ DFHRNKQSSR QRLQFRPLNL 420

PLLAKSESGP VDVDMPSANS ENGQPETIDL TTPVSSQDGP SETSLSKNAR PAPCAAEGTR 480

KEGAISEDTK AALKAALLKS ALRNRARGGK PSSLSSVPES RRPVTAQERQ REREEKRRKR 540

QERARERERK MREKEKREGK QGDSLGGVLL TDNDKSLLQR WTKMMDSRNE KSQPSNNNGA 600

KNKDCNVQRV KPNQLGLFQP PSTQQPSLVF SMSQTKPPAA TAPASESNPA RPSTSVTAAR 660

PGGFFVESSA TEHQRYKQEC GYQGAESLGV PSQPKSSLGF TDTGQQGPSI APDIHMVTLQ 720

LSKSQVEDLL PPAFSVTPKG SGAGYGLGFD LDDLLNQSLT DLQHCDRESA SIYDSAPLSA 780

SLLSDWSEVH RMTPADLESL QQELQLGSPM ILSDTIPPDA 820

Nucleotide Sequence
(FASTA)

ATGTCACTTA AGGAGGGCGG AGAGAGTAAA AATGGTCAAC CTGTGGCATC CCCTGAAAAA 60

ATGGCCACAG ACAAAAGCAG AGAAAACCAG AACCCACGGG GAGTCGAGGT ACCGGGCAGC 120

AACGCGGACA CCAGCACGGC AGCTAAAAAC TTGGCTTTGC TTAAAGCACA CTCTTTAGAT 180

GTGAAGTTTG ATGTCGGAGA GGAGTACGAC ATCATAGAAA CCATTGGCAC TGGGGCCTAT 240

GGTGTTGTTT CCTCTGCCAG GAGGAGGGAC AATGGCCAGC AGGTGGCAAT AAAGAAGATA 300

TCCAATGCAT TTGAAGTGGT GACAAATGCC AAACGCACAC TGAGAGAACT GAAGATTCTT 360

AAACACTTCA AACATGACAA CATTATCGCT ATCAAAGACA TCCTGCAGCC AAACCTCCCT 420

CATTCTGCCT TCAAGTCTGT GTATGTGGTG CTGGATCTCA TGGAGAGTGA CCTGCACCAG 480

ATTATCCATT CTGCCCAGAC GCTGACCCCA GAGCACACGC GCTACTTTCT GTACCAGCTC 540

CTTCGTGGCC TTAAGTATGT GCACTCTGCC AACGTCATCC ACCGTGACCT CAAACCTTCC 600

AACTTGCTGG TGAACGAAAA CTGTGAGCTA AAAATCGGTG ACTTCGGCAT GGCAAGGGGT 660

CTCAGTTCAC ACCCTGAGGA GTCTCATTCC TTCATGACTG AATATGTGGC GACTCGATGG 720

TACCGTGCTC CTGAACTCCT GCTGTCTCTG AATCACTATA GCTTGGCCAT TGACTTGTGG 780

TCCGTGGGCT GCATCTTTGC TGAGATGTTG GGCCGTAAGC AGCTGTTTCC TGGAAAGCAC 840

TATGTACACC AGCTCCAGCT TATTTTGAAT GTGTTAGGCA CTCCTCCCGA GGGTCTAATT 900

GGTGCTATTA GGGCTGACAG GGTCCGCGCA TATGTTCAGA GTCTTCCATC ACGATCTCCC 960

ATACCTTTGG CCAAACTATA TCCACAAGCT GAACCAGAAG CTTTAGACCT GCTGGCGGCC 1020

ATGCTGCGCT TTGACCCTCG CCAGCGAATA AGCGTGACAG AAGCTCTGGA GCATTCTTAC 1080

CTGGCTAAAT ACCATGACCC AGATGACGAG CCAATTTGCG TGCCAGCTTT TGACTTTGAG 1140

TTTGATAAGC TTCAGATGAA CAAGGAACAA ATTAAAGAGG CAATTCTTAT AGAGATCCAG 1200

GACTTTCACA GAAACAAACA AAGCTCTCGT CAGAGGCTGC AGTTCAGGCC TTTGAATTTA 1260

CCTCTCCTCG CTAAAAGTGA AAGTGGCCCG GTTGATGTGG ACATGCCAAG TGCCAACTCG 1320

GAAAACGGTC AGCCAGAAAC TATAGATTTA ACAACACCGG TGTCTAGTCA GGACGGTCCA 1380

TCAGAGACGT CCCTGTCCAA GAACGCCAGA CCTGCTCCAT GTGCAGCAGA GGGAACCAGA 1440

AAAGAAGGTG CTATTTCAGA AGATACTAAA GCTGCACTTA AAGCAGCTTT ATTGAAATCA 1500

GCTCTCAGAA ATAGAGCCAG GGGTGGTAAG CCGTCCTCCC TGTCTTCTGT TCCGGAGTCG 1560

CGTCGGCCTG TCACAGCCCA GGAGCGTCAA CGAGAAAGAG AGGAGAAAAG AAGGAAGAGG 1620

CAGGAGCGCG CGCGAGAGAG GGAGAGGAAA ATGAGAGAAA AAGAAAAAAG AGAGGGAAAA 1680

CAAGGGGATT CGCTGGGCGG GGTTCTGCTG ACTGACAACG ATAAAAGTCT TCTGCAGCGC 1740

TGGACAAAGA TGATGGACAG CCGCAATGAG AAGTCTCAGC CTTCTAATAA CAACGGTGCA 1800

AAGAATAAGG ACTGCAATGT ACAGAGAGTT AAACCTAACC AGCTGGGCTT GTTTCAGCCT 1860

CCCAGCACCC AGCAACCATC GTTAGTTTTC TCCATGAGCC AGACGAAGCC TCCAGCAGCC 1920

ACAGCTCCAG CCTCAGAATC AAACCCAGCT CGACCCTCAA CCTCAGTCAC AGCTGCTCGC 1980

CCTGGAGGGT TTTTTGTCGA AAGCTCCGCC ACTGAGCACC AGAGATACAA ACAGGAATGT 2040

GGATATCAGG GGGCAGAGTC TTTAGGAGTC CCCTCTCAGC CAAAGTCCAG CTTGGGATTC 2100

ACAGATACTG GACAGCAAGG ACCCTCCATT GCCCCTGATA TTCATATGGT GACACTCCAG 2160

CTCTCAAAGT CCCAGGTAGA GGACCTTTTA CCCCCTGCAT TCTCAGTCAC CCCTAAGGGC 2220

AGCGGGGCTG GCTACGGCTT GGGCTTTGAC CTGGATGACC TTCTCAACCA GTCTCTTACA 2280

GACTTGCAAC ACTGTGACAG AGAAAGTGCA AGTATTTACG ACTCAGCCCC CCTCTCGGCT 2340

TCCCTGTTAT CTGATTGGAG CGAAGTCCAC CGCATGACTC CAGCTGACCT GGAGTCTCTG 2400

CAGCAGGAGT TACAGCTCGG CTCTCCCATG ATTCTCTCTG ATACCATCCC TCCTGACGCC 2460

TGA 2463

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y+ ++++g+Gaygvv sa +++++++vaikk+s++f+  t+akrtlRElk+lk++kh+Ni

Q: 69    YDIIETIGTGAYGVVSSARRRDNGQQVAIKKISNAFEVVTNAKRTLRELKILKHFKHDNI  128

         677899******************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksq.klsdehiklllyqilrglkylH  119

         i + d+++p+   +++k+vY+v +lme+dL+++i+s  +l+ eh +++lyq+lrglky+H

Q: 129   IAIKDILQPNLPHSAFKSVYVVLDLMESDLHQIIHSAqTLTPEHTRYFLYQLLRGLKYVH  188

         ***********************************998**********************

S: 120   sanviHrDlKPsNllvnedcelkildFGlarsadkekekk...lteyvatrwYraPeill  176

         sanviHrDlKPsNllvne+celki dFG+ar  +++ e++   +teyvatrwYraPe+ll

Q: 189   SANVIHRDLKPSNLLVNENCELKIGDFGMARGLSSHPEEShsfMTEYVATRWYRAPELLL  248

         *******************************977766555579*****************

S: 177   slkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseea  236

         sl++y+ a+D+WsvGCI+aE+l +k+lfpgk++++ql++il+vlgtp e  + +i+ +++

Q: 249   SLNHYSLAIDLWSVGCIFAEMLGRKQLFPGKHYVHQLQLILNVLGTPPEGLIGAIRADRV  308

         ************************************************************

S: 237   rnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         r+y++slp+++  ++++l+p+a++ealdLl  +L +dp++Risv+eaLeh Yl

Q: 309   RAYVQSLPSRSPIPLAKLYPQAEPEALDLLAAMLRFDPRQRISVTEALEHSYL  361

         ****************************************************7

Domain Sequence
(FASTA)

YDIIETIGTG AYGVVSSARR RDNGQQVAIK KISNAFEVVT NAKRTLRELK ILKHFKHDNI 60

IAIKDILQPN LPHSAFKSVY VVLDLMESDL HQIIHSAQTL TPEHTRYFLY QLLRGLKYVH 120

SANVIHRDLK PSNLLVNENC ELKIGDFGMA RGLSSHPEES HSFMTEYVAT RWYRAPELLL 180

SLNHYSLAID LWSVGCIFAE MLGRKQLFPG KHYVHQLQLI LNVLGTPPEG LIGAIRADRV 240

RAYVQSLPSR SPIPLAKLYP QAEPEALDLL AAMLRFDPRQ RISVTEALEH SYL 293

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013