EPS-ORN-00026

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ORN-00026

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	276.6	3.1E-82	23	290	268

Status

Unreviewed

Ensembl Protein

ENSONIP00000025345

UniProt Accession

I3KW49;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1A

Gene Synonyms/Alias

PPM1A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000020120	ENSONIP00000025346	ENSONIT00000025367
ENSONIG00000020120	ENSONIP00000025345	ENSONIT00000025366

Organism

Oreochromis niloticus

Functional Description

Protein Length

384

Protein Sequence
(FASTA)

MGAFLDKPKM EKYNSHGEGN NLRYGLSSMQ GWRVEMEDAH TAVIGLPHGL DLWSFFAVYD 60

GHAGSQVAKY CCEHLLEHIT SNSDFQSALQ DDPCVDSVKN GIRTGFLQID EHMRTISEKK 120

HGVDRSGSTA VGVMISPSHI YFINCGDSRG LLSRGGTVHF FTQDHKPSNP LEKERIQNAG 180

GSVMIQRVNG SLAVSRALGD FDYKCVHGKG PTEQLVSPEP EVYAIERSEG EDEFIILACD 240

GIWDVMANEE LCDFVRSRLE VTDDLEKVSN EIVDTCLYKG SRDNMSVVLV CFPGAPKVSS 300

EAVKREAELD KYLEARVEEI IKKHGDEGVP DLVHVMRTLA SESIPNLPPG GELASKRSVI 360

EAVYNKLIPY RSDDTDSAST DDMW 384

Nucleotide Sequence
(FASTA)

ATGGGTGCAT TTCTGGACAA ACCAAAGATG GAAAAGTATA ATTCCCATGG TGAAGGTAAC 60

AACCTGAGGT ATGGGCTGAG CAGCATGCAG GGTTGGCGGG TTGAGATGGA GGATGCACAC 120

ACAGCGGTAA TTGGTCTGCC TCATGGTCTT GACCTGTGGT CATTCTTCGC TGTTTATGAT 180

GGGCATGCTG GCTCTCAGGT GGCCAAGTAC TGCTGTGAGC ACCTGCTGGA GCACATCACC 240

AGCAACTCAG ACTTCCAGAG TGCTCTTCAG GATGACCCCT GTGTGGACAG CGTGAAGAAT 300

GGTATCCGCA CTGGGTTCTT GCAGATTGAC GAACACATGC GAACCATCTC TGAGAAGAAG 360

CACGGTGTGG ACCGAAGTGG CTCCACTGCA GTGGGGGTGA TGATTTCTCC AAGCCATATC 420

TACTTCATCA ACTGCGGCGA CTCGCGTGGG CTCCTCAGCC GGGGCGGCAC TGTGCACTTC 480

TTCACACAGG ATCACAAACC TAGCAACCCA CTGGAAAAGG AAAGGATCCA GAACGCCGGT 540

GGCTCAGTCA TGATCCAGCG AGTTAATGGG TCCCTAGCAG TGTCCCGTGC TCTGGGAGAC 600

TTCGACTACA AATGCGTGCA TGGAAAAGGC CCGACAGAGC AGCTTGTTTC TCCAGAGCCT 660

GAAGTTTATG CAATAGAGAG AAGCGAGGGG GAAGATGAAT TCATTATATT AGCTTGTGAT 720

GGCATCTGGG ATGTCATGGC CAATGAAGAA CTGTGTGACT TTGTGAGGTC AAGGCTAGAG 780

GTTACAGATG ATCTTGAAAA AGTCAGCAAT GAAATTGTTG ACACCTGCTT GTACAAGGGA 840

AGCCGGGACA ATATGAGTGT TGTGCTAGTC TGCTTTCCTG GAGCCCCAAA GGTATCTTCA 900

GAAGCAGTGA AACGAGAAGC TGAGCTGGAC AAATATCTGG AGGCCAGAGT AGAAGAGATA 960

ATCAAAAAGC ACGGGGATGA AGGTGTCCCG GATTTGGTCC ACGTGATGCG GACGTTAGCA 1020

TCTGAGAGCA TCCCTAACCT TCCTCCTGGT GGGGAGCTGG CGAGCAAACG AAGTGTTATT 1080

GAAGCAGTGT ACAACAAACT TATCCCCTAT CGAAGTGATG ACACAGACTC TGCATCCACA 1140

GATGACATGT GGTAA 1155

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++s++g+r emeda+t+   ++  p   d ++ff+vyDGh+gs+vak+c e+l e++

Q: 23    RYGLSSMQGWRVEMEDAHTA---VIGLPHGLDLWSFFAVYDGHAGSQVAKYCCEHLLEHI  79

         69****************97...5666666778***************************

S: 62    aeele.....sseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdsk  116

         + + +     + ++  + vk+ ++++Fl++de+++ ++ek++  d+sGstav ++i++s+

Q: 80    TSNSDfqsalQDDPCVDSVKNGIRTGFLQIDEHMRTISEKKHGVDRSGSTAVGVMISPSH  139

         ***99888877778888999****************************************

S: 117   lyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsR  176

         +y++n+GdSr +L+r+g+++  ++dHkps++ E+eRi++aggsv+ +   Rv+G+LavsR

Q: 140   IYFINCGDSRGLLSRGGTVHFFTQDHKPSNPLEKERIQNAGGSVMIQ---RVNGSLAVSR  196

         ***********************************************...**********

S: 177   alGdlylk.........pyvtpePevtshrltsede.fliLasDGlwdvvsneeavslvr  226

         alGd+++k         ++v+pePev+ +++++ ++ f+iLa+DG+wdv+ nee++++vr

Q: 197   ALGDFDYKcvhgkgpteQLVSPEPEVYAIERSEGEDeFIILACDGIWDVMANEELCDFVR  256

         *******************************765555***********************

S: 227   dvlekkeaeqeaakkLvklalargskdnvsaivv  260

         ++le +++++++++++v+++l +gs+dn+s+++v

Q: 257   SRLEVTDDLEKVSNEIVDTCLYKGSRDNMSVVLV  290

         *****************************99875

Domain Sequence
(FASTA)

RYGLSSMQGW RVEMEDAHTA VIGLPHGLDL WSFFAVYDGH AGSQVAKYCC EHLLEHITSN 60

SDFQSALQDD PCVDSVKNGI RTGFLQIDEH MRTISEKKHG VDRSGSTAVG VMISPSHIYF 120

INCGDSRGLL SRGGTVHFFT QDHKPSNPLE KERIQNAGGS VMIQRVNGSL AVSRALGDFD 180

YKCVHGKGPT EQLVSPEPEV YAIERSEGED EFIILACDGI WDVMANEELC DFVRSRLEVT 240

DDLEKVSNEI VDTCLYKGSR DNMSVVLV 268

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013