EKS-ORN-00341

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00341

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	365.1	2.6E-109	13	265	253

Status

Unreviewed

Ensembl Protein

ENSONIP00000025367

UniProt Accession

I3KW71;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK4

Gene Synonyms/Alias

PLK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000020136	ENSONIP00000025367	ENSONIT00000025388

Organism

Oreochromis niloticus

Functional Description

Protein Length

922

Protein Sequence
(FASTA)

MSVSIGDKIE DFKVLTLLGK GSFACVYRAK SVKTGLEVAI KTIDKKAMHK AGMVQRVRNE 60

VEIHCRLKHP SILELYNYFE DSNYVYLVLE MCHNGEMSRY LKERKMPFSE DEARHFMDQT 120

VKGMLYLHTH GILHRDLTLS NLLLTSNMNI KIADFGLATQ LKLPNEKHFT MCGTPNYISP 180

EVATRSAHGL ESDVWSLGCM FYAFLMGRPP FDTDTVKHTL SKVVLGDYEM PTHVSLEAQD 240

LIYQLLQKDP TQRPSLSAVL DHPFMTQSLL VRTKELGLGD DGSIDSGIAT ISTAYTSSTS 300

ASSGSRLQKR TKHMIGSALP NRMTPIPSLP RQPNSACFED GDQWQQQQHP LERFNREGRS 360

RAAHGGESAE PHSRYLRRAH SSDRPMSTST GSTHAELGRC HSEETLAGIG RPVFPVSSTP 420

HPFSEHGRLP SPPVKQPANS GYFSTETALP PNLQFQDLEG VSNWLNTEGS GQRSADGSAH 480

SSRGPLGVHN SWTDKPMSRG VNLHPNLHHQ LLSNSDSYRE NIPGLEFQPP PDRELKHSST 540

KPSTDKPKKT LRDVIPPLCA SRLKPIRQKT KNAVVSILDT GEVCMELLKC QSGQERVKEV 600

LRISCDGSMV TIYQPNGGKG FPVLDCPPAP PEDILICSYE DLPEKYWKKY QYASKFVQLV 660

KSKTPKVTLY TKYAKVMLME NSPNADLEVC FYDGAKTHKT SELVRVVEKS GKSYTVKGEA 720

GLSGLSPECR RYVELSDEGH AMCLSLEAAI TAEEQRSTKN VPFFPITIGR RPASSDAPGS 780

SSVPSHPVPP DTASPPKPPQ ITPSMISYDG SDFTTASLSK KSSPVRQDLI QSTGKVVKSI 840

FVPNVGWASQ LTSGEVWVQF NDGSQLVVQA GVSCITYTCP EGKITRYKEN EKLPEHVKEK 900

LHCLSTILGL LANPAAHHLQ SH 922

Nucleotide Sequence
(FASTA)

ATGAGTGTTT CGATCGGCGA TAAAATTGAG GACTTCAAGG TCCTCACTCT GCTCGGGAAG 60

GGCTCCTTTG CGTGTGTTTA CCGGGCCAAA TCGGTGAAGA CTGGTCTGGA GGTTGCCATC 120

AAAACGATTG ACAAAAAAGC AATGCACAAA GCTGGCATGG TCCAACGTGT GAGGAACGAG 180

GTGGAGATTC ACTGCCGACT GAAGCATCCT TCCATACTGG AGCTTTACAA CTACTTTGAG 240

GACAGCAACT ATGTGTATTT GGTGTTGGAG ATGTGCCACA ATGGAGAGAT GAGTCGGTAC 300

CTCAAAGAGC GAAAGATGCC TTTCTCTGAA GATGAAGCGA GACATTTCAT GGACCAAACA 360

GTGAAAGGGA TGCTTTATTT ACATACTCAT GGGATCTTGC ACCGAGACCT GACTTTGTCC 420

AACCTTCTGC TGACCAGCAA CATGAACATT AAGATAGCAG ACTTTGGCCT GGCCACTCAG 480

CTCAAACTCC CAAACGAAAA GCACTTCACC ATGTGTGGCA CACCAAATTA CATCTCCCCA 540

GAGGTGGCCA CTCGCAGCGC CCACGGGCTG GAATCAGATG TTTGGTCACT GGGATGCATG 600

TTCTATGCTT TCCTGATGGG TCGCCCTCCA TTTGACACAG ACACAGTGAA GCACACTTTG 660

TCCAAAGTGG TTCTCGGGGA CTATGAGATG CCTACCCACG TTTCTCTGGA GGCTCAGGAC 720

CTGATTTATC AGCTGCTGCA GAAAGACCCC ACCCAGCGGC CCAGCCTCTC TGCAGTACTG 780

GACCACCCAT TCATGACCCA GAGCCTGCTG GTCAGGACCA AAGAGCTGGG GCTTGGGGAT 840

GACGGATCCA TTGACAGTGG CATTGCCACC ATCTCTACAG CCTACACCTC CTCCACCTCT 900

GCCAGCAGCG GCAGTCGCCT CCAGAAGCGA ACCAAGCACA TGATAGGCTC TGCTCTGCCT 960

AATCGCATGA CACCCATCCC AAGCCTTCCA CGCCAGCCCA ACAGTGCCTG TTTTGAGGAC 1020

GGAGACCAGT GGCAGCAGCA GCAGCATCCG CTGGAGCGGT TCAACAGAGA GGGCAGGAGC 1080

AGGGCGGCTC ACGGTGGAGA AAGCGCAGAG CCTCATTCTC GCTACCTGAG GAGGGCTCAC 1140

TCTTCAGACC GTCCCATGTC CACTTCAACA GGTTCAACTC ATGCTGAGCT GGGGCGATGC 1200

CACTCAGAGG AGACTCTGGC TGGTATTGGA CGCCCAGTCT TCCCCGTGTC CTCCACTCCA 1260

CACCCGTTTT CAGAGCACGG AAGACTCCCG TCTCCACCTG TCAAGCAGCC AGCAAATTCT 1320

GGGTATTTTT CCACAGAGAC CGCACTTCCA CCAAACTTGC AATTTCAGGA CTTAGAGGGA 1380

GTTTCTAATT GGCTCAACAC TGAAGGCTCT GGACAGAGGT CCGCAGATGG CAGCGCCCAC 1440

AGCAGTAGAG GACCTTTAGG TGTTCACAAC TCCTGGACAG ATAAGCCCAT GAGCCGAGGC 1500

GTGAACCTTC ACCCCAACCT GCACCACCAG CTTCTTTCCA ACTCCGACTC ATACAGGGAG 1560

AACATCCCCG GATTAGAGTT CCAACCTCCT CCTGACAGAG AGTTAAAGCA CTCTTCAACC 1620

AAACCCAGTA CAGATAAGCC GAAGAAAACG CTGAGAGACG TAATCCCGCC TCTGTGTGCC 1680

TCCCGACTGA AGCCGATCAG ACAGAAGACC AAAAATGCTG TTGTGAGCAT TTTGGACACG 1740

GGTGAAGTTT GTATGGAGCT GTTAAAATGT CAGAGTGGTC AAGAAAGAGT CAAAGAAGTC 1800

CTCCGGATTT CCTGTGATGG CTCAATGGTG ACGATATACC AGCCTAATGG TGGAAAAGGT 1860

TTTCCTGTGC TGGACTGCCC GCCAGCTCCT CCAGAAGATA TTCTCATTTG TAGCTACGAG 1920

GATCTTCCAG AGAAATACTG GAAAAAGTAC CAGTATGCCT CCAAGTTTGT TCAGCTTGTT 1980

AAATCCAAGA CTCCTAAAGT GACCCTTTAC ACCAAGTATG CCAAGGTCAT GCTGATGGAG 2040

AACTCTCCTA ACGCGGACCT GGAAGTTTGC TTTTATGATG GCGCAAAGAC CCACAAGACG 2100

TCCGAACTTG TGCGAGTGGT GGAGAAGAGC GGGAAGTCGT ACACTGTGAA GGGCGAGGCG 2160

GGGCTGAGCG GCCTGAGCCC GGAGTGCCGG AGGTATGTGG AGCTGTCGGA CGAGGGCCAC 2220

GCCATGTGTT TATCTCTCGA GGCGGCCATC ACTGCAGAGG AGCAGCGCAG CACCAAGAAC 2280

GTCCCTTTCT TCCCCATAAC GATTGGCAGG AGACCCGCCA GCTCAGACGC TCCAGGCTCA 2340

TCGTCTGTGC CCTCGCACCC GGTTCCTCCA GATACAGCAT CGCCTCCTAA ACCTCCACAA 2400

ATCACTCCTT CGATGATTTC CTACGACGGG TCTGACTTCA CCACAGCCAG CCTGAGTAAG 2460

AAAAGCTCCC CAGTGCGACA GGACCTCATT CAGAGCACAG GAAAGGTGGT CAAGTCGATA 2520

TTTGTGCCAA ATGTTGGATG GGCATCCCAG CTGACGAGCG GAGAGGTATG GGTGCAGTTC 2580

AACGATGGTT CTCAGCTGGT GGTTCAGGCA GGAGTTTCCT GCATCACCTA CACGTGTCCA 2640

GAAGGGAAGA TCACCAGGTA TAAGGAGAAC GAGAAGTTGC CTGAGCACGT TAAGGAAAAG 2700

CTTCACTGTC TCTCGACCAT TCTCGGCCTG TTGGCGAACC CGGCAGCGCA TCACCTGCAG 2760

TCCCATTAA 2769

Domain Profile

S: 2     ergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkni  61

         ++  llGkG+fa +y++k+++t+ ++a+k+++k++++k+ + ++v++e+eih++lkh++i

Q: 13    KVLTLLGKGSFACVYRAKSVKTGLEVAIKTIDKKAMHKAGMVQRVRNEVEIHCRLKHPSI  72

         67789*******************************************************

S: 62    vklyeffedkenvylvlelcsrrslaellkrr.kaltepevryylrqivsglkylhekri  120

         ++ly++fed+++vylvle+c+++++ ++lk+r  +++e e+r+++ q v+g++ylh++ i

Q: 73    LELYNYFEDSNYVYLVLEMCHNGEMSRYLKERkMPFSEDEARHFMDQTVKGMLYLHTHGI  132

         *******************************9558*************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         lhrdl+l+nl+l++++++ki+dfGlat+l+ ++e++ t+cGtPnyi+Pev+++++h+le+

Q: 133   LHRDLTLSNLLLTSNMNIKIADFGLATQLKLPNEKHFTMCGTPNYISPEVATRSAHGLES  192

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         d+WslGc++y++l+G+PPf+t+++k+t++k++  +y++P+++s ea++li +ll+k+P++

Q: 193   DVWSLGCMFYAFLMGRPPFDTDTVKHTLSKVVLGDYEMPTHVSLEAQDLIYQLLQKDPTQ  252

         ************************************************************

S: 241   rpsleevlkdefl  253

         rpsl++vl+++f+

Q: 253   RPSLSAVLDHPFM  265

         ***********98

Domain Sequence
(FASTA)

KVLTLLGKGS FACVYRAKSV KTGLEVAIKT IDKKAMHKAG MVQRVRNEVE IHCRLKHPSI 60

LELYNYFEDS NYVYLVLEMC HNGEMSRYLK ERKMPFSEDE ARHFMDQTVK GMLYLHTHGI 120

LHRDLTLSNL LLTSNMNIKI ADFGLATQLK LPNEKHFTMC GTPNYISPEV ATRSAHGLES 180

DVWSLGCMFY AFLMGRPPFD TDTVKHTLSK VVLGDYEMPT HVSLEAQDLI YQLLQKDPTQ 240

RPSLSAVLDH PFM 253

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013