EKS-ORN-00151

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00151

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	444.5	1.5E-133	1064	1324	261

Status

Unreviewed

Ensembl Protein

ENSONIP00000025556

UniProt Accession

I3KWR0;

Protein Name

Protein Synonyms/Alias

Gene Name

MST1R (1 of 2)

Gene Synonyms/Alias

MST1R (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000020282	ENSONIP00000025556	ENSONIT00000025577
ENSONIG00000020282	ENSONIP00000025557	ENSONIT00000025578

Organism

Oreochromis niloticus

Functional Description

Protein Length

1374

Protein Sequence
(FASTA)

MVHWTRQWWA CVWFQTVLAF ALANCASLAP NPVNFSVVYT MPFFQAGGPI QNIVNNSFYQ 60

EVYVASKNVI EAVNRSLEKV WELRTGPVGG SECHICNLCE IDKNHNFPED TDNQVLLLDT 120

LFMYLYSCGS SQYGVCYFHQ LNPNGEPPSL SKCLFRKGSN SAANCPDCVA SPLGTKVTMV 180

EEGQTVYFFV AASVNDSVTQ RYGRKSLSVR RPLATEDGFF SDVRGLTVLP SLRKTYHIEY 240

VYSFFTQEFV YFLSVQRESP DQESSPFQTR LGRLPRNEWE MKRYRELILE CRFEPKRRRR 300

NVASEPYKDI VYNVVQAAHF GKAGRELAEE LGAEEEDDIL YGVFAVTDDN GVTEHDSALC 360

AFPMDNVNKA IADGVDDCCE SGPEQLSRGL CHFQPCESCP HESMENNATC RDHPTMVSKP 420

YYRVDLFNRK MTNVLLTSLL VTTIENKTVA HIGTSTGRLL QLVLTRSSPV IFANYSLVEN 480

QRVSSIAAVH SSEYLLFVVG DKMIQVPQRG PGCQHFLTCA MCLTAPKFMG CGWCSGVCSW 540

ESECHNRWRN ESCPPGISGF FPRTAPPDGQ TELTLTGWEF QSPLRPAITS RTHQIRLGQT 600

SCTVIPAKSN ITHLVCKIRS GATELFKPVN ITVEVHEGKV EGRYSIEGKA EMPGFTFVVP 660

NITEIQPNYG PRVGGTLITV SGPHLDAGKT RRVTLNDVAC DIKRVTVPKG NVSSIICLSK 720

EISEVRDVPL SVFIDKSPVL TTKVFYYKEN PKITDVRPDC SFDRGSKIVI EGENLDSVYR 780

TIIHFKPNES HLKSVSTECL GKSLPTRMEC MTPVFHRDET VEGSLSFDMD GASSLWSKEF 840

SYHPYGEPIP FETEGHVLNL YPGFDEVSLH HQKLNLVSSC MTIIMTVAGV DCGAKVLDNE 900

ITCRIPKNMT IPSEGLPVKI SINGQVHNVG TVVRVSNHYM VGIVLGILAA LVAGAVLAFV 960

VMKHLRKKKK ASMVESHLTH SANRCGTNNV EMSPVGDYRR VVSLSPPTPL VGPVAFPSLT 1020

YAGGRIDPTL TPLLPTEKIP ITSFRPELLE EVKDVLIPAE MLVVQKHRII GKGHFGTVYH 1080

GYFTDSNNRE IHCAVKSLNR ITDVEEVEQF LKEGIIMKGF HHSNVLSLLG VLLPQEGLPL 1140

VVLPYMKHGD LRHFIRCEKR NPTVKDLIGF GLQVAKGMEY LAQKKFVHRD LAARNCMLDE 1200

SYTVKVADFG MARDVFDKEY YSVQDHRKAK LPVKWMAIES LQTQKFTSKS DVWSFGVLMW 1260

EMLTRGASPY PEVDPYDITH YLLKGRRLPQ PQYCPDPLYS IMLQCWDPDP ELRPSFATLV 1320

SAVSTILSGL EGEHYISLNV TYVNLDQPHP YPALTESADE YDSTDVEDSG SMSS 1374

Nucleotide Sequence
(FASTA)

ATGGTCCACT GGACCAGACA GTGGTGGGCA TGCGTCTGGT TCCAGACTGT GCTGGCCTTT 60

GCCCTGGCCA ACTGTGCGTC ATTGGCCCCC AACCCTGTCA ATTTCTCTGT TGTGTACACA 120

ATGCCTTTCT TCCAAGCTGG GGGTCCCATC CAAAACATAG TCAACAACTC ATTTTACCAA 180

GAAGTGTACG TGGCCTCTAA GAATGTGATC GAAGCTGTCA ACAGAAGCCT GGAGAAGGTG 240

TGGGAGCTCC GCACTGGGCC AGTGGGGGGC TCAGAGTGTC ACATATGCAA TTTGTGTGAG 300

ATTGACAAGA ATCACAACTT TCCAGAGGAC ACAGACAATC AGGTGTTGCT GTTGGATACA 360

CTCTTTATGT ATTTATATTC TTGTGGAAGT TCTCAGTACG GCGTATGCTA TTTCCACCAG 420

CTGAACCCAA ATGGAGAGCC ACCCTCTCTT TCAAAGTGTT TGTTCAGAAA GGGCTCAAAC 480

TCTGCTGCTA ACTGTCCTGA CTGTGTGGCT AGCCCTCTTG GTACGAAAGT CACAATGGTG 540

GAGGAGGGTC AGACTGTCTA TTTCTTTGTC GCGGCCAGTG TTAATGACAG TGTCACTCAG 600

CGTTATGGCA GGAAGTCTTT ATCAGTTCGC CGACCACTGG CCACAGAAGA TGGTTTCTTC 660

AGTGATGTGC GTGGTCTGAC TGTCCTTCCC AGCCTGCGGA AGACGTACCA TATTGAATAT 720

GTCTACAGCT TCTTCACTCA GGAGTTTGTG TACTTCCTTT CAGTCCAGAG AGAGAGCCCA 780

GATCAGGAAT CGTCACCTTT TCAGACTCGT CTGGGACGTC TCCCAAGGAA CGAATGGGAA 840

ATGAAGCGGT ATCGCGAGTT GATCTTGGAG TGTCGCTTTG AACCAAAGCG CAGGAGGAGG 900

AACGTAGCCA GTGAACCTTA TAAGGATATT GTGTACAACG TGGTCCAGGC AGCCCATTTT 960

GGCAAAGCAG GCAGGGAGCT GGCAGAGGAG TTAGGAGCGG AGGAGGAGGA TGACATCCTG 1020

TACGGTGTTT TTGCTGTCAC TGATGACAAC GGAGTCACGG AGCATGACTC TGCCCTGTGC 1080

GCCTTCCCCA TGGACAATGT GAACAAGGCA ATTGCTGATG GGGTGGATGA CTGCTGTGAG 1140

TCTGGACCTG AGCAGCTCTC TAGAGGGCTC TGCCATTTCC AACCCTGTGA GAGCTGTCCA 1200

CATGAGAGCA TGGAGAATAA TGCCACATGC AGAGACCATC CTACGATGGT GTCAAAGCCC 1260

TACTACAGAG TGGACCTGTT CAACAGGAAG ATGACAAACG TCCTGCTCAC ATCTCTCCTG 1320

GTCACAACTA TAGAGAACAA GACCGTGGCC CACATTGGTA CCTCAACCGG ACGCCTGCTT 1380

CAGCTTGTGC TGACAAGATC CAGCCCTGTC ATCTTTGCCA ATTACTCCTT GGTAGAAAAC 1440

CAGAGGGTCT CCTCCATTGC TGCTGTGCAT TCTTCAGAAT ATCTTCTCTT TGTGGTTGGA 1500

GACAAGATGA TCCAGGTGCC CCAAAGAGGA CCAGGCTGTC AACACTTCCT GACTTGTGCC 1560

ATGTGCCTGA CTGCCCCAAA ATTCATGGGC TGTGGCTGGT GCTCTGGAGT GTGCTCGTGG 1620

GAGAGCGAGT GCCACAATCG CTGGAGAAAC GAGTCCTGCC CACCTGGGAT CTCCGGATTC 1680

TTTCCACGGA CTGCTCCCCC TGATGGTCAA ACAGAGCTAA CGCTGACTGG GTGGGAGTTC 1740

CAGTCGCCTT TGAGACCCGC TATCACCTCC AGAACCCACC AGATCCGACT GGGACAGACG 1800

TCCTGCACTG TGATTCCAGC CAAAAGCAAC ATCACGCACT TGGTGTGTAA GATTCGCTCT 1860

GGGGCCACTG AGCTGTTCAA ACCAGTCAAC ATTACAGTGG AAGTGCATGA GGGCAAAGTG 1920

GAGGGACGCT ACTCTATTGA AGGGAAGGCA GAAATGCCAG GATTCACGTT TGTGGTTCCC 1980

AACATCACAG AAATCCAGCC CAACTACGGC CCTCGTGTTG GGGGCACACT TATCACAGTG 2040

AGTGGGCCTC ACTTGGATGC TGGAAAGACC AGGAGAGTCA CTCTTAACGA TGTGGCCTGC 2100

GACATAAAAA GGGTCACAGT GCCTAAAGGC AACGTGTCTT CCATCATTTG TTTGTCCAAA 2160

GAAATCTCAG AGGTGAGAGA TGTTCCTCTG AGTGTGTTCA TTGACAAGTC TCCTGTTCTC 2220

ACAACAAAGG TGTTTTACTA CAAGGAAAAC CCAAAGATAA CAGACGTCCG GCCTGACTGT 2280

AGCTTTGACA GAGGTTCAAA GATTGTCATT GAAGGGGAGA ACCTGGATTC TGTTTACCGC 2340

ACCATCATCC ACTTTAAACC CAATGAGAGC CACCTGAAAT CTGTGTCAAC GGAGTGCCTC 2400

GGCAAGTCTT TACCCACACG GATGGAATGC ATGACCCCTG TTTTCCACAG GGATGAAACT 2460

GTGGAAGGAT CGCTATCTTT TGATATGGAT GGAGCATCAA GCCTGTGGAG CAAAGAGTTC 2520

TCCTATCACC CCTACGGCGA GCCCATACCT TTTGAAACAG AAGGACATGT TCTAAATTTG 2580

TACCCTGGGT TTGATGAGGT GTCACTACAT CACCAAAAGC TGAACCTGGT GAGCTCCTGC 2640

ATGACCATCA TTATGACGGT GGCAGGTGTT GATTGTGGTG CTAAAGTCCT GGATAATGAG 2700

ATAACCTGCA GGATCCCCAA AAACATGACC ATTCCTAGTG AGGGACTACC AGTGAAGATC 2760

TCCATCAACG GACAGGTTCA CAACGTTGGC ACAGTGGTGA GGGTCAGCAA CCATTACATG 2820

GTGGGCATTG TTTTGGGGAT CCTGGCAGCT CTGGTGGCCG GGGCAGTGCT GGCCTTTGTT 2880

GTCATGAAAC ACTTAAGGAA GAAGAAGAAA GCCTCCATGG TAGAGTCACA TTTAACCCAC 2940

AGCGCCAACC GCTGTGGTAC AAATAATGTG GAGATGTCAC CTGTTGGAGA CTACAGAAGA 3000

GTAGTATCGC TGAGTCCTCC CACCCCCTTG GTTGGGCCGG TAGCATTCCC CAGCCTGACC 3060

TATGCTGGAG GTCGCATAGA TCCGACCCTC ACTCCCCTCC TTCCTACAGA AAAGATCCCT 3120

ATCACCAGTT TTAGGCCAGA GCTGCTGGAA GAGGTGAAAG ATGTTCTTAT TCCTGCAGAG 3180

ATGCTTGTTG TCCAGAAACA TCGGATTATC GGAAAAGGTC ATTTTGGAAC CGTCTATCAC 3240

GGCTACTTCA CAGACTCCAA CAACAGAGAA ATCCACTGTG CTGTCAAGTC TTTGAATAGA 3300

ATAACAGATG TGGAAGAGGT GGAGCAGTTT CTGAAGGAAG GCATCATAAT GAAGGGCTTC 3360

CATCACAGCA ACGTGCTTTC TCTGTTGGGC GTCCTCCTGC CACAGGAAGG GCTCCCTCTT 3420

GTGGTTCTGC CATACATGAA ACACGGGGAC TTGCGGCATT TCATACGCTG CGAGAAGAGG 3480

AACCCCACTG TAAAGGATCT GATTGGCTTT GGGCTGCAAG TTGCCAAGGG GATGGAGTAT 3540

TTGGCCCAGA AGAAGTTTGT GCACAGAGAT CTCGCTGCAC GCAACTGCAT GCTGGATGAG 3600

TCGTACACGG TGAAGGTGGC GGACTTTGGC ATGGCCAGAG ATGTTTTCGA TAAGGAATAT 3660

TACAGTGTTC AGGACCACAG GAAGGCTAAA CTGCCTGTCA AGTGGATGGC CATCGAGAGT 3720

CTGCAAACAC AAAAATTTAC CTCCAAGTCA GACGTGTGGT CCTTTGGTGT TCTGATGTGG 3780

GAAATGCTGA CCAGAGGAGC AAGCCCCTAC CCAGAGGTGG ACCCATACGA TATAACGCAC 3840

TATTTACTGA AGGGCAGGAG GCTTCCTCAG CCACAGTACT GCCCTGACCC TTTGTATAGC 3900

ATTATGCTCC AGTGCTGGGA CCCAGATCCA GAGTTGAGGC CCAGCTTTGC TACACTGGTG 3960

TCAGCTGTCT CCACCATACT GTCTGGCCTG GAAGGAGAGC ACTACATCAG TCTGAATGTC 4020

ACCTACGTCA ACCTTGACCA GCCTCATCCC TATCCTGCCC TGACTGAATC CGCTGATGAG 4080

TATGACTCCA CAGACGTTGA AGACTCAGGC TCAATGTCTT CTTGA 4125

Domain Profile

S: 1     vdkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhp  60

         v+k+++iGkGhfG+vy+g ++ds++++i++avksl+ritd+e+ve+fl+eg++mk+++h

Q: 1064  VQKHRIIGKGHFGTVYHGYFTDSNNREIHCAVKSLNRITDVEEVEQFLKEGIIMKGFHHS  1123

         67899*******************************************************

S: 61    nvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylas  120

         nvlsllG+ l++eglplvvlpymk+Gdl++fir e+rn+tvkdl++f+lqvakgmeyla+

Q: 1124  NVLSLLGVLLPQEGLPLVVLPYMKHGDLRHFIRCEKRNPTVKDLIGFGLQVAKGMEYLAQ  1183

         ************************************************************

S: 121   kkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqt  180

         kkfvhrdlaarnc+lde++tvkvadfG+ardv+dke+y+v+++r+a+lpvkw+a+eslqt

Q: 1184  KKFVHRDLAARNCMLDESYTVKVADFGMARDVFDKEYYSVQDHRKAKLPVKWMAIESLQT  1243

         ************************************************************

S: 181   fkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvm  240

         +k ft+ksdvwsfGvl+we+ltrga+py+ev+++d+t+yl +grrl++p+ycpd ly +m

Q: 1244  QK-FTSKSDVWSFGVLMWEMLTRGASPYPEVDPYDITHYLLKGRRLPQPQYCPDPLYSIM  1302

         **.*********************************************************

S: 241   lkcwkakpaerpqfsdlvsiis  262

         l+cw ++p+ rp+f+ lvs +s

Q: 1303  LQCWDPDPELRPSFATLVSAVS  1324

         ******************9986

Domain Sequence
(FASTA)

VQKHRIIGKG HFGTVYHGYF TDSNNREIHC AVKSLNRITD VEEVEQFLKE GIIMKGFHHS 60

NVLSLLGVLL PQEGLPLVVL PYMKHGDLRH FIRCEKRNPT VKDLIGFGLQ VAKGMEYLAQ 120

KKFVHRDLAA RNCMLDESYT VKVADFGMAR DVFDKEYYSV QDHRKAKLPV KWMAIESLQT 180

QKFTSKSDVW SFGVLMWEML TRGASPYPEV DPYDITHYLL KGRRLPQPQY CPDPLYSIML 240

QCWDPDPELR PSFATLVSAV S 261

Keyword

ATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007275	; P:multicellular organismal development
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016244	; Tyr_kinase_HGF/MSP_rcpt.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 2.

SMARTs

SM00429	; IPT; 3.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013