EKS-ORL-00302

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00302

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	332.5	1.7E-99	46	296	251

Status

Unreviewed

Ensembl Protein

ENSORLP00000000284

UniProt Accession

H2L3G5;

Protein Name

Protein Synonyms/Alias

Gene Name

NUAK2

Gene Synonyms/Alias

NUAK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000000229	ENSORLP00000000284	ENSORLT00000000284

Organism

Oryzias latipes

Functional Description

Protein Length

614

Protein Sequence
(FASTA)

AESLSMDEPI SAAGRSPASA GTVPPSPGKK QAVKRHHHKH NLKHRYEFLE TLGKGTYGKV 60

KKAKERSGRL VAVKSIRKEK IKDEQDLVHI RREIEIMSSM CHPHIISIYE VFENKDKIVI 120

VMEYASRGDL YDYICEKRRL SEREARHFFR QIVSAVHYCH QNGIVHRDLK LENILLDDRG 180

NVKIADFGLS NLFYGDEFLQ TFCGSPLYAS PEIVNGRPYR GPEVDTWSLG VLLYTLVHGN 240

MPFDGNNHKT LVQQISTGNY RKPNNPSDAC GLIRWMLMVN PERRATIEEI AGHWWLNWGY 300

QQPLLCETKN GVVDQSVTPP PPPTTHSTGL TSVATWLRRT SRPLLENGSK MRCLLRSQAG 360

GGDVVRQRSL RRSRKENNVS QTVHDGNTDS RPYKGILKRR NSIKQKAGSE STAASVEPQS 420

TSGASAQGHG PSTALLPRKG ILKKSAEQES GYYSSSPESS DSGVLLQTKQ CPSAPTHRKG 480

ILKRNGKFSS GGFQEFGSLD QLAASLPRRG PRSRPSMAIS DDSILSSESF DQLDLPDPVG 540

PSMEMNRSAK AGMRGCVSAD NLLDIADSGI VADGLMRPWN CYESGVADSA FSITDCDNVT 600

EAYKQAMVIR GPAA 614

Nucleotide Sequence
(FASTA)

GCGGAGAGCC TCAGCATGGA CGAGCCGATC TCCGCCGCCG GCCGGTCTCC GGCGTCTGCC 60

GGGACAGTCC CACCGTCCCC GGGGAAGAAA CAAGCCGTGA AGAGACACCA CCACAAACAT 120

AACCTGAAGC ACCGGTACGA GTTTCTGGAG ACGCTGGGCA AAGGAACCTA CGGAAAAGTC 180

AAGAAAGCCA AGGAGAGATC GGGACGCCTG GTTGCTGTGA AATCCATCAG GAAGGAAAAG 240

ATCAAAGATG AGCAGGATCT GGTCCACATC CGCAGAGAAA TTGAGATCAT GTCCTCCATG 300

TGTCACCCGC ACATCATCAG CATATATGAA GTGTTTGAAA ACAAAGACAA AATAGTGATT 360

GTGATGGAGT ACGCCAGCCG AGGAGATCTG TACGACTACA TTTGTGAAAA GAGGAGACTC 420

TCTGAACGAG AGGCCCGGCA TTTCTTCAGG CAGATCGTTT CCGCTGTTCA CTACTGCCAT 480

CAGAATGGAA TAGTGCACAG AGATCTGAAA CTGGAGAATA TTTTGCTAGA CGACAGGGGA 540

AATGTAAAGA TTGCAGACTT CGGCCTGTCA AACCTCTTCT ACGGCGACGA GTTTCTACAG 600

ACGTTTTGCG GGAGCCCTCT GTATGCCTCC CCAGAGATCG TCAACGGACG GCCATACCGC 660

GGCCCAGAGG TGGACACCTG GTCGCTCGGC GTGCTTCTGT ACACATTGGT TCATGGAAAT 720

ATGCCTTTTG ATGGAAACAA CCACAAAACT CTGGTCCAGC AGATCAGCAC TGGAAACTAT 780

CGCAAACCTA ACAACCCCTC TGATGCCTGC GGACTCATCC GTTGGATGTT AATGGTGAAC 840

CCTGAGCGCA GAGCCACAAT AGAAGAAATT GCTGGGCATT GGTGGCTCAA CTGGGGCTAC 900

CAGCAGCCAT TACTGTGTGA AACAAAGAAC GGTGTGGTTG ATCAGAGCGT CACGCCGCCA 960

CCTCCACCAA CAACACATTC CACAGGCCTG ACTAGTGTTG CTACGTGGCT GCGACGCACT 1020

TCTCGACCTT TACTGGAGAA TGGTTCCAAA ATGCGCTGTC TGCTCCGCTC GCAGGCTGGC 1080

GGCGGGGATG TGGTCCGACA GAGATCCCTG CGAAGGTCTC GTAAGGAGAA TAACGTCTCC 1140

CAGACGGTGC ACGATGGAAA CACAGACTCC AGGCCCTACA AGGGCATCCT AAAGAGACGA 1200

AACAGCATCA AACAGAAGGC AGGGAGTGAA AGCACCGCTG CTTCAGTGGA ACCTCAGAGC 1260

ACTTCGGGTG CCTCTGCTCA GGGTCACGGC CCTTCAACAG CATTGTTGCC CCGTAAAGGC 1320

ATCCTAAAGA AGTCCGCAGA GCAGGAGTCG GGGTACTACT CCTCTTCTCC TGAAAGCAGT 1380

GATTCTGGCG TGTTACTACA AACTAAACAG TGTCCTTCCG CACCAACTCA CAGAAAGGGC 1440

ATCCTGAAGC GTAATGGGAA GTTCTCTTCT GGTGGCTTCC AAGAGTTTGG CTCTCTAGAT 1500

CAATTGGCGG CCTCTTTACC CCGACGAGGC CCAAGGTCCC GACCAAGCAT GGCCATTAGT 1560

GACGACAGTA TTCTGTCTTC TGAGTCCTTC GACCAGCTCG ATCTACCCGA CCCGGTGGGG 1620

CCCTCCATGG AAATGAACAG ATCAGCCAAG GCGGGCATGA GGGGCTGCGT CTCTGCAGAC 1680

AACCTGCTGG ACATAGCTGA CAGTGGGATT GTTGCCGACG GCTTGATGAG GCCGTGGAAC 1740

TGCTACGAAT CTGGAGTGGC TGACAGTGCC TTTTCTATCA CTGACTGTGA TAATGTCACA 1800

GAGGCTTACA AACAGGCCAT GGTCATACGG GGACCTGCAG CC 1842

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl.seeslekikrEieilkklkhpn  59

         y++l+tlG+g++gkVk+ak++  ++ vavK i+k+k+ +e+ l +i+rEiei++++ hp+

Q: 46    YEFLETLGKGTYGKVKKAKER-SGRLVAVKSIRKEKIkDEQDLVHIRREIEIMSSMCHPH  104

         99***************9987.799**********996777899****************

S: 60    iikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgi  119

         ii+++ev+e+k+k+++v+eyas+g+L+dyi ek+rl+e+ear++f+q+vsav+Y+h++gi

Q: 105   IISIYEVFENKDKIVIVMEYASRGDLYDYICEKRRLSEREARHFFRQIVSAVHYCHQNGI  164

         ************************************************************

S: 120   vHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkv  179

         vHrDlK+eN+lld+++n+kiaDFGl+nlf  ++ l+tfcGsp Ya+Pe+++g++Y+gp+v

Q: 165   VHRDLKLENILLDDRGNVKIADFGLSNLFYGDEFLQTFCGSPLYASPEIVNGRPYRGPEV  224

         ************************************************************

S: 180   DvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpek  239

         D WslGv+Ly+lv g++Pfd++n k+l+++i++g+++ p++ s ++  L+r +L+v+pe+

Q: 225   DTWSLGVLLYTLVHGNMPFDGNNHKTLVQQISTGNYRKPNNPS-DACGLIRWMLMVNPER  283

         ****************************************966.5668************

S: 240   Ratieeilkhewl  252

         Ratieei  h wl

Q: 284   RATIEEIAGHWWL  296

         ************7

Domain Sequence
(FASTA)

YEFLETLGKG TYGKVKKAKE RSGRLVAVKS IRKEKIKDEQ DLVHIRREIE IMSSMCHPHI 60

ISIYEVFENK DKIVIVMEYA SRGDLYDYIC EKRRLSEREA RHFFRQIVSA VHYCHQNGIV 120

HRDLKLENIL LDDRGNVKIA DFGLSNLFYG DEFLQTFCGS PLYASPEIVN GRPYRGPEVD 180

TWSLGVLLYT LVHGNMPFDG NNHKTLVQQI STGNYRKPNN PSDACGLIRW MLMVNPERRA 240

TIEEIAGHWW L 251

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013